1. Articles from Wolfgang Geitzenauer

    1-17 of 17
    1. The role of the optical coherence tomography in identifying shape and size of idiopathic epiretinal membranes

      The role of the optical coherence tomography in identifying shape and size of idiopathic epiretinal membranes

      AIM Currently, the border of idiopathic epiretinal membranes (iERM) is outlined intraoperatively using vital dyes. Therefore, the authors set out to investigate the role of the preoperative retinal thickness map (RTM) of the optical coherence tomography (OCT) in identifying the shape and the size of the iERMs. Methods 15 eyes of 15 patients with iERM who underwent vitrectomy with indocyanine green-assisted membrane peeling were included in this study. The authors analysed the intraoperative fundus images and preoperative Cirrus HD-OCT to detect the shape and the size of the iERM as well as the shape and the size of each thickness-indicating ...

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    2. RNFL thickness in MS-associated acute optic neuritis using SD-OCT: critical interpretation and limitations

      RNFL thickness in MS-associated acute optic neuritis using SD-OCT: critical interpretation and limitations
      Purpose:  Axonal loss is considered a key prognostic factor in diagnosing and monitoring the progress of multiple sclerosis (MS). The purpose of our research was to determine whether the measurement of retinal nerve fibre layer thickness (RNFLT) as measured with high-resolution spectral-domain optical coherence tomography (SD-OCT) differs between optic nerve injury following acute optic neuritis (ON) or following unregistered subclinical axonal damage in patients with MS.Methods:  High-resolution SD-OCT measurements of RNFLT were initially carried out in the acute phase of ON and again after 3 months, in 25 patients with clinical definite MS and 25 sex- and age-matched healthy ...
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    3. Heterogeneous Pattern of Retinal Nerve Fiber Layer in Multiple Sclerosis. High Resolution Optical Coherence Tomography: Potential and Limitations

      Heterogeneous Pattern of Retinal Nerve Fiber Layer in Multiple Sclerosis. High Resolution Optical Coherence Tomography: Potential and Limitations
      Background Recently the reduction of the retinal nerve fibre layer (RNFL) was suggested to be associated with diffuse axonal damage in the whole CNS of multiple sclerosis (MS) patients. However, several points are still under discussion. (1) Is high resolution optical coherence tomography (OCT) required to detect the partly very subtle RNFL changes seen in MS patients? (2) Can a reduction of RNFL be detected in all MS patients, even in early disease courses and in all MS subtypes? (3) Does an optic neuritis (ON) or focal lesions along the visual pathways, which are both very common in MS, limit ...
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    4. Retinal optical coherence tomography: past, present and future perspectives

      Retinal optical coherence tomography: past, present and future perspectives
      Optical coherence tomography (OCT) has undergone substantial changes since its first use in the 1990s. Although the first generation of OCT systems heralded a new era in the non-invasive diagnostic options in ophthalmology, they did not reveal much detail. Later devices offered more information and helped in the diagnosis and treatment of a variety of pathological conditions, primarily of the retina. With today's spectral-domain type models ophthalmologists are offered a comprehensive tool with the opportunity for early diagnosis and precise monitoring of patients with retinal and glaucomatous pathologies. However, as experience with these new devices grows and demands by ...
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    5. High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      PurposeTo characterize the morphologic changes in vitreomacular traction (VMT) before and after surgery using spectral-domain optical coherence tomography (SD OCT) and to identify patterns relevant to visual function.DesignProspective, interventional case series.ParticipantsThirty eyes of 30 consecutive patients with visual acuity of less than 20/32 resulting from idiopathic VMT.MethodsA conventional 20-gauge 3-port vitrectomy was performed, including removal of the epiretinal membrane (ERM) and internal limiting membrane. Examinations were performed 1 day before surgery and 1 and 3 days as well as 1, 3, 6, 12, and 24 months after surgery. The SD OCT scan sets were analyzed with ...

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    6. High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      High-Resolution Optical Coherence Tomography after Surgery for Vitreomacular Traction: A 2-Year Follow-up

      Purpose: To characterize the morphologic changes in vitreomacular traction (VMT) before and after surgery using spectral-domain optical coherence tomography (SD OCT) and to identify patterns relevant to visual function.Design: Prospective, interventional case series.Participants: Thirty eyes of 30 consecutive patients with visual acuity of less than 20/32 resulting from idiopathic VMT.Methods: A conventional 20-gauge 3-port vitrectomy was performed, including removal of the epiretinal membrane (ERM) and internal limiting membrane. Examinations were performed 1 day before surgery and 1 and 3 days as well as 1, 3, 6, 12, and 24 months after surgery. The SD OCT scan ...

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    7. Comparing Retinal Thickness Measurements From Cirrus Spectral Domain- and Stratus Time Domain-Optical Coherence Tomography

      Purpose: The purpose of this study was to compare retinal measurements obtained using spectral domain-optical coherence tomography with measurements obtained using time domain-optical coherence tomography.Methods: Three hundred and seventy subjects were recruited at three university-based and one community-based retina practice for a cross-sectional observational study. For each subject, one eye was enrolled as the study eye. A Stratus Fast Macular scan was performed, and a Cirrus 200 x 200 Macular Cube scan was performed. Both instruments segment the acquired images to generate retinal thickness values and report averages measured in nine subfields defined by the Early Treatment Diabetic Retinopathy ...

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    8. Automatic and manual segmentation of healthy retinas using high-definition optical coherence tomography

      Purpose: This study compared automatic- and manual segmentation modalities in the retina of healthy eyes using high-definition optical coherence tomography (HD-OCT).Methods: Twenty retinas in 20 healthy individuals were examined using an HD-OCT system (Carl Zeiss Meditec, Inc.). Three-dimensional imaging was performed with an axial resolution of 6 [mu]m at a maximum scanning speed of 25 000 A-scans/second. Volumes of 6 × 6 × 2 mm were scanned. Scans were analysed using a matlab-based algorithm and a manual segmentation software system (3D-Doctor). The volume values calculated by the two methods were compared.Results: Statistical analysis revealed a high correlation between ...
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    9. Alterations of intraretinal layers in acute central serous chorioretinopathy

      Purpose: Optical coherence tomography (OCT) is restricted by its low scanning speed and limited resolution. High-definition raster-scanning OCT (HD-OCT) was used to evaluate changes in retinal microstructure in patients with acute central serous chorioretinopathy (CSCR) and to find new morphological features.Methods: Eighteen patients with subretinal fluid accumulation caused by acute CSCR were imaged in a cross-sectional study design. High-speed frequency-domain HD-OCT was used to image an area of 6 × 6 mm in the macular retina. Three-dimensional analyses were performed using en-face imaging and section analysis of single HD-OCT scans.Results: Detailed information about fluid accumulation can be obtained in ...
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    10. Three-dimensional imaging of an optic disk pit using high resolution optical coherence tomography

      PURPOSE. To clarify the origin of the coexisting fluid in an optic disc pit case by using optical coherence tomography (OCT). METHODS. High resolution OCT (Cirrus™ prototype, Carl Zeiss Meditec) was used for image acquisition; three dimensional segmentation was performed using Food and Drug Administration–approved imaging software (3D-Doctor V4.0, Able software Corp., Lexington, MA) to demonstratethe structural changes of the optic nerve head and the retina. RESULTS. Using high resolution OCT, the authors demonstrated that this case of optic pit had a possible connection between the subretinal and the intraretinal space. CONCLUSIONS. The authors assume that the intraretinal ...
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    11. Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina

      Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina
      Polarization sensitive OCT has recently been shown to provide tissue specific contrast, enabling direct identification of retinal layers based on the intrinsic properties of their interaction with light. However, the capabilities of displaying and analyzing 3D datasets in scientific publications were rather limited. Within the framework of the Interactive Science Publishing project, we present new ways of displaying and analyzing 3D sets of various polarization parameters recorded in healthy and diseased human retinas. These datasets can be interactively explored by the reader. Furthermore, we provide data of the 3D distribution of backscattered Stokes vectors to allow the reader to develop ...
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    12. Quantitative measurement of the degree of polarization uniformity of light backscattered by retinal layers by polarization sensitive OCT

      We report on an extension of our previously presented polarization sensitive optical coherence tomography (PS-OCT) technique towards quantitative measurements and imaging of depolarization of light backscattered by the various layers of the human ocular fundus in vivo. We use a state of the art spec ... [Proc. SPIE 7168, 716814 (2009)] published Tue Feb 24, 2009.
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    13. Imaging the human retina in vivo with combined spectral-domain polarization-sensitive optical coherence tomography and scanning laser ophthalmoscopy

      Polarization-sensitive (PS) optical coherence tomography (OCT) allows for depth-resolved measurement of light polarizing properties of different layers in the human retina. Since their inherent polarizing properties are different, the retinal structures can be identified using PS-OCT. We present an ... [Proc. SPIE 7163, 71630N (2009)] published Wed Feb 18, 2009.
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    14. Evaluation of ranibizumab-induced changes of high-resolution optical coherence tomographic retinal morphology and their impact on visual function

      Purpose: To evaluate the effects of intravitreal ranibizumab on retinal function and morphology and to identify a correlation between anatomy and function by using spectral domain optical coherence tomography (SDOCT). Methods: Twenty three patients affected by neovascular AMD received three monthly injections of ranibizumab and were monitored by assessing best-corrected visual acuity (BCVA), central retinal sensitivity (CRS) and morphologic changes at the level of the retina and the retinal pigment epithelium (RPE) using SDOCT segmentation. These were mean retinal thickness (MRT), central retinal thickness (CRT), area of the RPE pathology (lesion area). Results: BCVA increased from a mean 60.1 ...
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    15. Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography

      Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography
      Erich Götzinger, Michael Pircher, Wolfgang Geitzenauer, Christian Ahlers, Bernhard Baumann, Stephan Michels, Ursula Schmidt-Erfurth, Christoph K. HitzenbergerWe present a new method for identifying and segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous, intensity based segmentation algorithms, our method uses an intrinsic tissue property of ... [Opt. Express 16, 16410-16422 (2008)]
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    16. Segmentation of the retinal pigment epithelium by polarization sensitive optical coherence tomography

      Christoph K. Hitzenberger, Erich Gotzinger, Michael Pircher et al. We report on a new method for segmenting the retinal pigment epithelium (RPE) in polarization sensitive optical coherence tomography (PS-OCT) images of the human retina. Contrary to previous segmentation algorithms that were based on variations of backscattered intensity between individual layers, o ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 684705 (2008)] published Mon Feb 18, 2008.
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    1-17 of 17
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  2. Topics in the News

    1. (17 articles) Medical University of Vienna
    2. (17 articles) Wolfgang Geitzenauer
    3. (17 articles) Ursula Schmidt-Erfurth
    4. (8 articles) Christian Ahlers
    5. (6 articles) Michael Pircher
    6. (6 articles) Erich Götzinger
    7. (6 articles) Christoph K. Hitzenberger
    8. (6 articles) Bernhard Baumann
    9. (5 articles) Carl Zeiss Meditec
    10. (3 articles) Christopher Schütze
    11. (1 articles) Case Western Reserve University
    12. (1 articles) University of Bonn
    13. (1 articles) Toshiro Shinke
    14. (1 articles) Hui Wang
    15. (1 articles) Andrew M. Rollins
    16. (1 articles) Topcon Medical Systems
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