1. Articles from Chen Zhao

    1-12 of 12
    1. Risk Stratification in Acute Coronary Syndrome by Comprehensive Morphofunctional Assessment With Optical Coherence Tomography

      Risk Stratification in Acute Coronary Syndrome by Comprehensive Morphofunctional Assessment With Optical Coherence Tomography

      Background: Artificial intelligence enables simultaneous evaluation of plaque morphology and computational physiology from optical coherence tomography (OCT). Objectives: This study sought to appraise the predictive value of major adverse cardiovascular events (MACE) by combined plaque morphology and computational physiology. Methods: A total of 604 patients with acute coronary syndrome who underwent OCT imaging in ≥1 nonculprit vessel during index coronary angiography were retrospectively enrolled. A novel morphologic index, named the lipid-to-cap ratio (LCR), and a functional parameter to evaluate the physiologic significance of coronary stenosis from OCT, namely, the optical flow ratio (OFR), were calculated from OCT, together with classical ...

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    2. A Star Shape Prior Based Regularizer for Vessel Lumen Segmentation in OCT Images

      A Star Shape Prior Based Regularizer for Vessel Lumen Segmentation in OCT Images

      Optical coherence tomography (OCT) is widely used in high-resolution imaging of biological tissues, which can help diagnose coronary heart disease by segmenting the vessel lumen at the pixel-level. However, the lumen shape geometry is not well used in the state-of-the-art techniques for OCT image segmentation, especially the data-driven methods, leaving much room for performance improvement if some geometric features could be exploited to provide prior information. Thanks to the star shape geometry of vessel lumen, in this paper, a new Star Shape Prior based Regularizer (SSP-Regularizer) is proposed to improve segmentation performance. To validate its effectiveness, the proposed SSP-Regularizer is ...

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    3. In vivo detection of plaque erosion by intravascular optical coherence tomography using artificial intelligence

      In vivo detection of plaque erosion by intravascular optical coherence tomography using artificial intelligence

      Plaque erosion is one of the most common underlying mechanisms for acute coronary syndrome (ACS). Optical coherence tomography (OCT) allows in vivo diagnosis of plaque erosion. However, challenge remains due to high inter- and intra-observer variability. We developed an artificial intelligence method based on deep learning for fully automated detection of plaque erosion in vivo , which achieved a recall of 0.800 ± 0.175, a precision of 0.734 ± 0.254, and an area under the precision-recall curve (AUC) of 0.707. Our proposed method is in good agreement with physicians, and can help improve the clinical diagnosis of plaque ...

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    4. Artificial Intelligence—A Good Assistant to Multi-Modality Imaging in Managing Acute Coronary Syndrome

      Artificial Intelligence—A Good Assistant to Multi-Modality Imaging in Managing Acute Coronary Syndrome

      Acute coronary syndrome is the leading cause of cardiac death and has a significant impact on patient prognosis. Early identification and proper management are key to ensuring better outcomes and have improved significantly with the development of various cardiovascular imaging modalities. Recently, the use of artificial intelligence as a method of enhancing the capability of cardiovascular imaging has grown. AI can inform the decision-making process, as it enables existing modalities to perform more efficiently and make more accurate diagnoses. This review demonstrates recent applications of AI in cardiovascular imaging to facilitate better patient care.

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    5. Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques

      Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques

      Background: Intravascular optical coherence tomography (IVOCT) enables detailed plaque characterisation in vivo , but visual assessment is time-consuming and subjective. Aims: This study aimed to develop and validate an automatic framework for IVOCT plaque characterisation using artificial intelligence (AI). Methods: IVOCT pullbacks from five international centres were analysed in a core lab, annotating basic plaque components, inflammatory markers and other structures. A deep convolutional network with encoding-decoding architecture and pseudo-3D input was developed and trained using hybrid loss. The proposed network was integrated into commercial software to be externally validated on additional IVOCT pullbacks from three international core labs, taking the ...

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    6. Is the effect of atorvastatin 60 mg on stabilization of lipid-rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging

      Is the effect of atorvastatin 60 mg on stabilization of lipid-rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging

      Objectives: This study aimed to compare the effect of atorvastatin 60 (AT60) mg to that of rosuvastatin 10 (RT10) mg on the morphological changes in lipid-rich plaques (LRPs) and plaque volume, using serial optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). Background: Intensive lipid lowering therapy by statin provides more clinical benefit compared to that of moderate lipid lowering therapy. Methods: Fifty patients who underwent OCT and IVUS at baseline, 6, and 12 months were grouped by statin therapy into the AT60 mg (n = 27) and RT10 mg (n = 23) groups. The relationships between absolute and percentage changes in ...

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    7. Is the effect of atorvastatin 60 mg on stabilization of lipid‐rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging

      Is the effect of atorvastatin 60 mg on stabilization of lipid‐rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging

      Objectives This study aimed to compare the effect of atorvastatin 60 (AT60) mg to that of rosuvastatin 10 (RT10) mg on the morphological changes in lipid‐rich plaques (LRPs) and plaque volume, using serial optical coherence tomography (OCT) and intravascular ultrasound imaging (IVUS). Background Intensive lipid lowering therapy by statin provides more clinical benefit compared to that of moderate lipid lowering therapy. Methods Fifty patients who underwent OCT and IVUS at baseline, 6, and 12 months were grouped by statin therapy into the AT60 mg ( n = 27) and RT10 mg ( n = 23) groups. The relationships between absolute and percentage changes ...

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    8. Automatic Characterisation of Human Atherosclerotic Plaque Composition from Intravascular Optical Coherence Tomography Using Artificial Intelligence

      Automatic Characterisation of Human Atherosclerotic Plaque Composition from Intravascular Optical Coherence Tomography Using Artificial Intelligence

      Background Intravascular optical coherence tomography (IVOCT) enables detailed plaque characterisation in-vivo, but visual assessment is time-consuming and subjective. Aims This study aims to develop and validate an automatic framework for IVOCT plaque characterisation using artificial intelligence (AI). Methods IVOCT pullbacks from 5 international centres were analysed in a corelab, annotating basic plaque components, inflammatory markers and other structures. A deep convolutional network with encoding-decoding architecture and pseudo-3D input was developed and trained using hybrid loss. The proposed network was integrated into commercial software to be externally validated on additional IVOCT pullbacks from three international corelabs, taking the consensus among corelabs ...

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    9. Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography

      Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography

      Purpose : To examine the changes of non-arteritic anterior ischemic optic neuropathy (NAION) by serial morphometry using Fourier domain optical coherence tomography (FD-OCT). Materials and methods : Retrospective study in patients with newly diagnosed NAION ( n =33, all unilateral) and controls ( n =75 unilateral NAION patients with full contralateral eye vision) who underwent FD-OCT of the optic disk, optic nerve head (ONH), and macula within 1 week of onset and again 1, 3, 6, and 12 months later. The patients showed no improvement in vision during follow-up. Results : Within 1 week of onset, all NAION eyes exhibited severe ONH fiber crowding and ...

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    10. Feature Of The Week 01/04/2015: Zhejiang University Investigates Ultrawide-Field SD-OCT for NDE of Large Glass Surfaces

      Feature Of The Week 01/04/2015: Zhejiang University Investigates Ultrawide-Field SD-OCT for NDE of Large Glass Surfaces

      Due to its merits of nondestruction and high-resolution, the use of OCT in material industry is increased recently. Besides profilometry of metal, monitoring of printed electronics, nondestructive inspection of glass is another important application. Material defects such as bubbles, impurities, and distortion affect the quality of glass. To realize quality control of glass, a technique for nondestructive inspection of glass is required. Given the large amount of glass productions, a large field-of-view (FOV) is necessary for the system to achieve high-speed inspection. However, as the required FOV becomes large, conventional OCT system always encounters the problem of image distortion because ...

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    11. Ultrawide-field parallel spectral domain optical coherence tomography for nondestructive inspection of glass

      Ultrawide-field parallel spectral domain optical coherence tomography for nondestructive inspection of glass

      Aiming at the requirements of real-time inspection in material industry, an ultrawide-field parallel SD-OCT system capable of visualizing cross-sectional image of internal structures by a single shot of a 2-D CMOS camera is developed. To achieve ultrawide-field parallel detection, one meniscus lens with negative dioptric is introduced as an additional relay lens and imaging optics including sample arm, relay lenses and spectrometer are optimized as a whole for desirable imaging quality. The developed system has an ultrawide-field of 35 mm and an axial range of 8 mm in air. The maximum on-axis sensitivity and the axial resolution are experimentally determined ...

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    12. Visualization of the ocular pulse in the anterior chamber of the mouse eye in vivo using phase-sensitive optical coherence tomography

      Visualization of the ocular pulse in the anterior chamber of the mouse eye in vivo using phase-sensitive optical coherence tomography

      We report on a phase-based method for accurately measuring the ocular pulse in the anterior chamber in vivo . Using phase-sensitive optical coherence tomography with optimized scanning protocols and equations for compensating bulk motion and environmental vibrations, a high sensitivity of 0.9     μ m / s minimal velocity is demonstrated at a wide detection band of 0 to 380 Hz. The pulsatile relative motion between cornea and crystalline lens in rodents is visualized and quantified. The relative motion is most likely caused by respiration (1.6 Hz) and heartbeat (6.6 Hz). The velocity amplitude of the relative motion is 10.3 ...

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    1-12 of 12
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  2. Topics in the News

    1. (6 articles) Harbin Medical University
    2. (3 articles) Zhejiang University
    3. (2 articles) National University of Ireland, Galway
    4. (2 articles) Shanghai Jiao Tong University
    5. (1 articles) Cardiovascular Research Foundation
    6. (1 articles) Chinese Academy of Sciences
    7. (1 articles) Aarhus University
    8. (1 articles) Wakayama Medical University
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    Visualization of the ocular pulse in the anterior chamber of the mouse eye in vivo using phase-sensitive optical coherence tomography Ultrawide-field parallel spectral domain optical coherence tomography for nondestructive inspection of glass Feature Of The Week 01/04/2015: Zhejiang University Investigates Ultrawide-Field SD-OCT for NDE of Large Glass Surfaces Change of Retinal Nerve Layer Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy Revealed by Fourier Domain Optical Coherence Tomography Automatic Characterisation of Human Atherosclerotic Plaque Composition from Intravascular Optical Coherence Tomography Using Artificial Intelligence Is the effect of atorvastatin 60 mg on stabilization of lipid-rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging Is the effect of atorvastatin 60 mg on stabilization of lipid‐rich plaque equivalent to that of rosuvastatin 10 mg? A serial optical coherence tomography combined with intravascular ultrasound imaging Artificial Intelligence—A Good Assistant to Multi-Modality Imaging in Managing Acute Coronary Syndrome Artificial intelligence and optical coherence tomography for the automatic characterisation of human atherosclerotic plaques In vivo detection of plaque erosion by intravascular optical coherence tomography using artificial intelligence A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography Quantitative assessment of textural features in the early detection of diabetic retinopathy with optical coherence tomography angiography