1. Articles from Andreas Ebneter

    1-16 of 16

    1. AUTOMATED RETINAL LAYER SEGMENTATION AND THEIR THICKNESS PROFILES IN HEALTHY SUBJECTS: A Comparison of 55° Wide-field and Conventional 30° Spectral Domain-Optical Coherence Tomography

      Explore LWW Online Ophthalmology
      AUTOMATED RETINAL LAYER SEGMENTATION AND THEIR THICKNESS PROFILES IN HEALTHY SUBJECTS: A Comparison of 55° Wide-field and Conventional 30° Spectral Domain-Optical Coherence Tomography

      Purpose: To assess whether retinal thickness measurements with a standard 30° spectral domain optical coherence tomography (SD- OCT ) are comparable with wide-field 55° SD- OCT . Methods: Thirty-three healthy individuals were scanned using 55° as well as 30° SD- OCT according to a standardized protocol. Automated retinal layer segmentation of standard and wide-field SD-OCTs was assessed using customized software. Results: Both lenses showed a high correlation when analyzing total retinal thickness within the central, the inner, and the outer retinal ring (r = > 0.9). Automated thickness measurements with the 55° system were marginally higher compared with the 30° lens. The thickness ...

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      Mentions: Heidelberg Engineering Sebastian Wolf University of Bern

    2. Comparison of Drusen Volume Assessed by Two Different OCT Devices

      Explore MDPI Open Access Journals Platform Ophthalmology
      Comparison of Drusen Volume Assessed by Two Different OCT Devices

      To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized software. Though on SD-OCT, there was a significant difference of mean drusen volume prior to and after manual ...

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      Mentions: Sebastian Wolf University of Bern Bern University Hospital

    3. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      Explore Nature Publishing Group Ophthalmology
      Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic retinal conditions, the quantity of scans acquired worldwide is surpassing the capacity of retinal specialists to inspect these in meaningful ways. Instead, automated analysis of scans using machine learning algorithms ...

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      Mentions: Sebastian Wolf University of Bern Martin S. Zinkernagel

    4. Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina

      Explore TVST Journal Ophthalmology
      Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina

      Purpose : We evaluated the repeatability of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Methods : Healthy subjects underwent two imaging sessions, on average 8 days apart, with a 100 kHz SS-OCTA instrument. The imaging protocol included a central 3 × 3 and 12 × 12 mm scans of the four quadrants resulting in more than a 70° wide-field OCTA of the posterior pole. Quantitative analysis was performed using the inbuilt Macular Density Algorithm Version v0.6.1 and AngioTool software. Consistency for the foveal avascular zone (FAZ), vessel density, and perfusion density of the superficial and deep capillary ...

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      Mentions: University of Bern Bern University Hospital

    5. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Explore TVST Journal Ophthalmology
      Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16; C+N = Color-encoded image on black background at predefined contrast of 9, and C+H = Color-encoded image on black background at high/maximal contrast of 16), resulting in 180 images ...

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      Mentions: Sebastian Wolf University of Bern Bern University Hospital

    6. Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

      Explore Journals | PLOS Ophthalmology
      Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

      Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. Results Thirteen eyes of 12 patients met the inclusion criteria. There was ...

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      Mentions: Sebastian Wolf University of Bern Bern University Hospital

    7. In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

      Explore jove.com Ophthalmology
      In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

      Spectral domain optical coherence tomography (SD-OCT) and scanning laser ophthalmoscopy (SLO) are extensively used in experimental ophthalmology. In the present protocol, mice expressing green fluorescent protein (gfp) under the promoter of Cx3cr1 (BALB/c-Cx3cr1 gfp/gfp ) were used to image microglia cells in vivo in the retina. Microglia are resident macrophages of the retina and have been implicated in several retinal diseases 1 , 2 , 3 , 4 , 5 , 6 . This protocol provides a detailed approach for generation of retinal B-scans, with SD-OCT, and imaging of microglia cell distribution in Cx3cr1 gfp/gfp mice with SLO in vivo, using an ophthalmic imaging ...

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      Mentions: Bern University Hospital Martin S. Zinkernagel

    8. In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ...

      Explore jove.com Ophthalmology
      In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ...

      This protocol describes how high-resolution imaging techniques such as spectral domain optical coherence tomography and scanning laser ophthalmoscopy can be utilized in small rodents, using an ophthalmic imaging platform system, to obtain information on retinal thickness and microglial cell distribution, respectively.

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      Mentions: Heidelberg Engineering University of Bern Bern University Hospital

    9. OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices

      Explore Journals | PLOS
      OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices

      Article Authors Metrics Comments Related Content Abstract Introduction Methods Results Discussion Supporting information Acknowledgments Author Contributions References Reader Comments (0) Media Coverage Figures Abstract Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment ...

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      Mentions: Optovue Heidelberg Engineering Nidek

    10. Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Explore ScienceDirect Ophthalmology
      Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy

      Anterior ischemic optic neuropathy (AION) is a relatively common cause of visual loss and results from hypoperfusion of the small arteries of the anterior portion of the optic nerve. AION is the leading cause of sudden optic nerve related vision loss with approximately 10 cases per 100′000 in the population over 50 years. To date there is no established treatment for AION and therefore a better understanding of the events occurring at the level of the optic nerve head (ONH) would be important to design future therapeutic strategies. The optical properties of the eye allow the imaging of the ...

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      Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel

    11. Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Explore TVST Journal Ophthalmology
      Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography

      Purpose : Optical coherence tomography angiography (OCT-A) allows noninvasive visualization of retinal vessels in vivo. OCT-A was used to characterize the vascular network of the mouse retina and was compared with fluorescein angiography (FA) and histology. Methods : In the present study, OCT-A based on a Heidelberg Engineering Spectralis system was used to investigate the vascular network in mice. Data was compared with FA and confocal microscopy of flat-mount histology stained with isolectin IB4. For quantitative analysis the National Cancer Institute's AngioTool software was used. Vessel density, the number of vessel junctions, and endpoints were measured and compared between the imaging ...

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      Mentions: National Cancer Institute Sebastian Wolf Bern University Hospital

    12. Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration

      Explore IOVS Journal Ophthalmology
      Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration

      Purpose : To analyze inner retinal changes in patients with geographic atrophy (GA) secondary to age-related macular degeneration and identify morphological cues for progression. Methods : A total of 100 eyes with GA were assessed in this longitudinal, observational case series. Patients with GA and absent confounding pathology were compared with age-matched controls. The retinal layers on spectral-domain optical coherence tomography, acquired in tracking mode, were segmented manually on central scans through the fixation point. Zones of GA were defined based on choroidal signal enhancement from retinal pigment epithelium loss. An area of unaffected temporal retina was used for comparison. Progression of ...

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      Mentions: Sebastian Wolf University of Bern Bern University Hospital

    13. Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Explore IOVS Journal Ophthalmology
      Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy

      Purpose : Selective retina therapy (SRT) is a novel treatment for retinal pathologies, solely targeting the RPE. During SRT, the detection of an immediate tissue reaction is challenging, as tissue effects remain limited to intracellular RPE photodisruption. Time-resolved ultra-high axial resolution optical coherence tomography (OCT) is thus evaluated for the monitoring of dynamic optical changes at and around the RPE during SRT. Methods : An experimental OCT system with an ultra-high axial resolution of 1.78 μm was combined with an SRT system and time-resolved OCT M-scans of the target area were recorded from four patients undergoing SRT. Optical coherence tomography scans ...

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      Mentions: Sebastian Wolf University of Bern Boris Považay

    14. Metrics of the normal anterior sclera: imaging with optical coherence tomography

      Explore Home - Springer Ophthalmology
      Metrics of the normal anterior sclera: imaging with optical coherence tomography

      Background To investigate anterior scleral thickness in a cohort of healthy subjects using enhanced depth imaging anterior segment optical coherence tomography. Methods Observational case series. The mean scleral thickness in the inferonasal, inferotemporal, superotemporal, and superonasal quadrant was measured 2 mm from the scleral spur on optical coherence tomography in healthy volunteers. Results Fifty-three eyes of 53 Caucasian patients (25 male and 28 female) with an average age of 48.6 years (range: 18 to 92 years) were analysed. The mean scleral thickness was 571 μm (SD 84 μm) in the inferonasal quadrant, 511 μm (SD 80 μm) in the ...

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      Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel

    15. Investigation of Retinal Morphology Alterations Using Spectral Domain Optical Coherence Tomography in a Mouse Model of Retinal Branch and Central Retinal Vein Occlusion

      Explore Journals | PLOS Ophthalmology
      Investigation of Retinal Morphology Alterations Using Spectral Domain Optical Coherence Tomography in a Mouse Model of Retinal Branch and Central Retinal Vein Occlusion

      Retinal vein occlusion is a leading cause of visual impairment. Experimental models of this condition based on laser photocoagulation of retinal veins have been described and extensively exploited in mammals and larger rodents such as the rat. However, few reports exist on the use of this paradigm in the mouse. The objective of this study was to investigate a model of branch and central retinal vein occlusion in the mouse and characterize in vivo longitudinal retinal morphology alterations using spectral domain optical coherence tomography. Retinal veins were experimentally occluded using laser photocoagulation after intravenous application of Rose Bengal, a photo-activator ...

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      Mentions: University of Bern Bern University Hospital Martin S. Zinkernagel

    16. Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis

      Explore Informa Healthcare Ophthalmology
      Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis

      Purpose : To report outcomes and assess structural changes in the retina in patients with severe endophthalmitis . Methods : Retrospective, nonrandomized, interventional case series at a tertiary referral centre. Spectral domain optical coherence tomography (OCT) images of both eyes were acquired at least 5 months after pars plana vitrectomy. OCT images were analyzed using retinal layer segmentation. Results : Nine patients (46–80 years of age) were included in this study. Average ETDRS visual acuity before treatment was 23 letters and improved to 74 letters. In our cohort we did not find a generalized reduction of retinal layers using automated layer segmentation. Conclusion ...

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      Mentions: Sebastian Wolf University of Bern Bern University Hospital
    1-16 of 16
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    1. (14 articles) Bern University Hospital
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    Spectral-domain Optical Coherence Tomography Findings after Severe Exogenous Endophthalmitis Investigation of Retinal Morphology Alterations Using Spectral Domain Optical Coherence Tomography in a Mouse Model of Retinal Branch and Central Retinal Vein Occlusion Metrics of the normal anterior sclera: imaging with optical coherence tomography Time-Resolved Ultra–High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy Relationship Between Presumptive Inner Nuclear Layer Thickness and Geographic Atrophy Progression in Age-Related Macular Degeneration Optical Coherence Tomography Angiography in Mice: Comparison with Confocal Scanning Laser Microscopy and Fluorescein Angiography Imaging of macrophage dynamics with optical coherence tomography in anterior ischemic optic neuropathy OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices In Vivo Imaging of Cx3cr1 Reporter Mice with Spectral-domain Optical Coherence Tomography ... In Vivo Imaging of Cx3cr1gfp/gfp Reporter Mice with Spectral-domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago Devices and arrangements for performing coherence range imaging using a common path interferometer