1. Articles from Nora D. Volkow

    1-2 of 2
    1. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves quantitative CBFv imaging of capillary networks by obviating the errors from long latency between flowing red blood cells (low hematocrit ~ 20% in capillaries). This enhanced sensitivity allowed us to measure ...

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    2. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold;in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular ...

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    1-2 of 2
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  2. Topics in the News

    1. (6 articles) National Institutes of Health
    2. (3 articles) Center for Ophthalmic Optics and Lasers
    3. (3 articles) Oregon Health & Science University
    4. (3 articles) David Huang
    5. (2 articles) SUNY at Stony Brook
    6. (2 articles) Congwu Du
    7. (2 articles) Yingtian Pan
    8. (2 articles) Harvard University
    9. (2 articles) Massachusetts General Hospital
    10. (2 articles) University of Southern California
    11. (2 articles) Brett E. Bouma
    12. (2 articles) Johannes F. de Boer
    13. (2 articles) Mohamed Abou Shousha
    14. (1 articles) National Institutes of Health
    15. (1 articles) Joseph A. Izatt
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