1. Articles from Jiang You

    1-5 of 5
    1. Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography

      Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography

      Ultrahigh-resolution optical coherence Doppler tomography (μODT) demonstrates great potential for quantitative blood flow imaging owing to its large field of view and capillary resolution. However, μODT only detects the axial flow velocity and requires Doppler angle correction to retrieve the absolute velocity. Although methods for Doppler angle tracking of single or few large vessels have been reported, a method that enables angle correction of the entire 3D microvascular networks remains a challenge. Here, we present a method based on eigenvalue analysis of 3D Hessian matrix to retrieve the orientation of each tubular vessel. As the algorithm is voxel based, it ...

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    2. High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

      High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging

      Noninvasive microvascular imaging using optical coherence Doppler tomography (ODT) has shown great promise in brain studies; however, high-speed microcirculatory imaging in deep brain remains an open quest. A high-speed 1.3 μm swept-source ODT (SS-ODT) system is reported which was based on a 200 kHz vertical-cavity-surface-emitting laser. Phase errors induced by sweep-trigger desynchronization were effectively reduced by spectral phase encoding and instantaneous correlation among the A-scans. Phantom studies have revealed a significant reduction in phase noise, thus an enhancement of minimally detectable flow down to 268.2 μm/s. Further in vivo validation was performed, in which 3D cerebral-blood-flow (CBF ...

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    3. Ultrasensitive quantification of 3D cerebral capillary blood flow network dynamics

      Ultrasensitive quantification of 3D cerebral capillary blood flow network dynamics

      Ultra-high resolution optical Doppler coherence tomography (μODT) is a promising tool for brain functional imaging. However, its sensitivity for detecting slow flows in capillary beds may limit its utility in visualizing and quantifying subtle changes in brain microcirculation. To address this limitation, we developed a novel method called contrast-enhanced μODT (c-μODT) in which intralipid is injected into mouse tail vein to enhance μODT detection sensitivity. We demonstrate that after intralipid injection, the flow detection sensitivity of μODT is dramatically enhanced by 230% as quantified by the fill factor (FF) of microvasculature. More importantly, we show that c-μODT preserves ...

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    4. Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo

      Despite widespread applications of multiphoton microscopy in microcirculation, its small field of view and inability to instantaneously quantify cerebral blood flow velocity (CBFv) in vascular networks limit its utility in investigating the heterogeneous responses to brain stimulations. Optical Doppler tomography (ODT) provides 3D images of CBFv networks, but it suffers poor sensitivity for measuring capillary flows. Here we report on a new method, contrast-enhanced ODT with Intralipid that significantly improves quantitative CBFv imaging of capillary networks by obviating the errors from long latency between flowing red blood cells (low hematocrit ~ 20% in capillaries). This enhanced sensitivity allowed us to measure ...

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    5. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

      Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold;in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Congwu Du
    2. (5 articles) Yingtian Pan
    3. (4 articles) SUNY at Stony Brook
    4. (2 articles) Joseph A. Izatt
    5. (2 articles) Nanyang Technological University
    6. (2 articles) Linbo Liu
    7. (1 articles) National Institutes of Health
    8. (1 articles) James G. Fujimoto
    9. (1 articles) Valery V. Tuchin
    10. (1 articles) Harvard University
    11. (1 articles) University of Kent
    12. (1 articles) Kyushu University
    13. (1 articles) University of Miami
    14. (1 articles) Adrian G. Podoleanu
    15. (1 articles) Yoshiyasu Minami
    16. (1 articles) Sander R. Dubovy
    17. (1 articles) George M. Dobre
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    Optical coherence Doppler tomography for quantitative cerebral blood flow imaging Ultrasensitive detection of 3D cerebral microvascular network dynamics in vivo Ultrasensitive quantification of 3D cerebral capillary blood flow network dynamics High-speed swept source optical coherence Doppler tomography for deep brain microvascular imaging Volumetric Doppler angle correction for ultrahigh-resolution optical coherence Doppler tomography PhD Student and Postdoctoral Associate Positions at the University of Massachusetts Early Detection of Microvascular Changes in Patients with Diabetes Mellitus without and with Diabetic Retinopathy: Comparison between Different Swept-Source OCT-A Instruments In vivo tomographic visualization of intracochlear vibration using a supercontinuum multifrequency-swept optical coherence microscope A Simple Algorithm for Hard Exudate Detection in Diabetic Retinopathy Using Spectral-Domain Optical Coherence Tomography Optical coherence tomography analysis of the recovery of the ellipsoid zone after macular hole surgery: 2-Year results Anterior Segment Applications of Optical Coherence Tomography Angiography Photothermal optical coherence tomography for investigation and imaging photothermal trapping of gold nano-rods in clear media and biological tissue