All Articles from Aniruddha Agarwal -Optical Coherence Tomography News

Articles from Aniruddha Agarwal

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1. Optical coherence tomography features of choroidal neovascularization and their correlation with age, gender and underlying disease
  
  Explore LWW Online Oct 21 2020 Ophthalmology
  
  Purpose: To investigate the influence of age , gender and underlying disease on the optical coherence tomography (OCT) features of choroidal neovascularization (CNV) secondary to Inflammation ( iCNV ), myopia (mCNV) and age -related macular degeneration (AMD-CNV). Methods: Demographic and clinical data of eyes with treatment naïve iCNV , mCNV and type 2 AMD-CNV were collected. OCT images were reviewed to determine the presence of pitchfork sign (PFS), pigment epithelial detachment (PED), subretinal fluid (SRF), intraretinal cysts (IRC), subretinal hyper reflective material (SHRM), atrophy and outer retinal disruption (ORD) graded 1 to 4. The influence of demographics and underlying etiology on OCT signs ...
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  Mentions: University of Milan Giovanni Staurenghi
2. Clear subretinal fluid in a case of non-neovascular early-onset drusen: Swept-source imaging evaluation
  
  Explore SAGE Journals Sep 12 2020 Ophthalmology
  
  A 50-year-old male presented with recent metamorphopsia in the right eye. Fundus examination revealed bilateral multiple cuticular drusen along with few large colloid drusen (phenotype 3 cuticular drusen). No vitelliform material was evident in the macula in either eye. Fluorescein angiography (FA), indocyanine green angiography (ICGA) did not demonstrate a macular neovascularization (MNV) in either eye. Swept-source optical coherence tomography (SS-OCT) revealed sub-retinal pigment epithelial (RPE) drusen and a clear space beneath the inter-digitation zone and above the RPE-Bruch’s complex. SS-OCTA did not reveal MNV in either eye. The patient was kept under observation, and follow-up at 3 months ...
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  Mentions: Giuseppe Querques Vishali Gupta Università Vita-Salute San Raffaele
3. Bacillary layer detachment in tubercular choroidal granuloma: A new optical coherence tomography finding
  
  Explore Indian Journal of Ophthalmology (IJO) Aug 1 2020 Ophthalmology
  
  A 32-year-old Asian Indian male presented with sudden-onset and painless decrease in vision in the right eye (OD) for the past 1 day. On examination, his best-corrected visual acuity was 6/24 in OD and 6/6 in the left eye (OS). Anterior segment was quiescent in both eyes. Fundus examination showed ill-defined yellowish subretinal lesions inferior to fovea with surrounding fluid reaching the inferior arcade in OD. A cystic lesion with well-defined borders was seen in the foveal center. Fluorescein angiography (FA) showed early hypofluorescence and late hyperfluorescence indicating active choroidal inflammation. Pooling of dye was appreciated in the ...
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  Mentions: Vishali Gupta
4. Bacillary Layer Detachment in Acute Vogt-Koyanagi-Harada Disease: A Novel Swept-Source Optical Coherence Tomography Analysis
  
  Explore LWW Online Jul 29 2020 Ophthalmology
  
  Purpose: To report the frequency, optical coherence tomography (OCT) findings, and visual and anatomic outcomes of patients with acute Vogt-Koyanagi-Harada disease (VKH) presenting with bacillary layer detachment (BLD) (intraretinal split at the photoreceptor inner segment myoid). Methods: This was a retrospective analysis of a consecutive series of VKH patients having a minimum follow-up of 6 months. All patients had swept-source (SS)-OCT, fluorescein angiography (FA), and indocyanine green angiography (ICGA) performed at baseline. The characteristics of serial SS-OCT were recorded and analyzed. Results: Sixty-two subjects (42 females; age: 34.2 ± 12 years) with VKH were included. 118 eyes (95.2 ...
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  Mentions: Vishali Gupta K. Bailey Freund
5. Longitudinal Follow-up of Tubercular Serpiginous-Like Choroiditis using Optical Coherence Tomography Angiography
  
  Explore LWW Online Jul 29 2020 Ophthalmology
  
  Purpose: To analyze and describe serial follow-up of choriocapillaris alterations in tubercular serpiginous like choroiditis (TB SLC) using optical coherence tomography angiography (OCTA) and to compare it with multimodal imaging. Methods: In this prospective cohort study, patients with active TB SLC underwent OCTA using Optovue RTVue XR Avanti® and other imaging including enhanced-depth imaging optical coherence tomography (EDI- OCT ) (Heidelberg Spectralis®), autofluorescence (FAF), fluorescein angiography (FA) and indocyanine green angiography (ICGA). Serial imaging was performed for a total follow-up of 3 months. Choriocapillaris alterations at the site of lesions were analyzed on OCTA imaging and their mean lesion areas (LA ...
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  Mentions: Optovue Vishali Gupta
6. Advances in imaging of uveitis
  
  Explore SAGE Journals Jun 12 2020 Ophthalmology
  
  Advances in multimodal imaging have significantly contributed to the management of many uveitis diseases in recent years. The most significant developments include the use of optical coherence tomography to obtain a more accurate and reproducible assessment of ocular inflammation, the application of optical coherence tomography angiography in choroiditis and retinal vasculitis, new possibilities for studying vitritis with ultrawide field imaging, and the most recent applications of fundus autofluorescence in uveitis. In this review, we provide an overview of the most significant advances in multimodal imaging of uveitis achieved in recent years.
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  Mentions: Giuseppe Querques Vishali Gupta Francesco Bandello
7. Swept-source optical coherence tomography imaging of the retinochoroid and beyond
  
  Explore Taylor & Francis Online Apr 17 2020 Ophthalmology
  
  Introduction : Swept-source optical coherence tomography (SS-OCT) imaging has ushered in an era of rapid and high-resolution imaging of the retinochoroid that provides detailed patho-anatomy of various layers. Areas Covered : In this detailed review, the technology of swept-source imaging including its principles and working have been discussed. The applications of SS-OCT in various conditions including age-related macular degeneration, diabetic retinopathy, pachychoroid spectrum of diseases, and inflammatory vitreoretinal conditions has been elaborated. For each disease, a brief review of literature along with the utility of SS-OCT and optical coherence tomography angiography has been provided with supporting figures. The advantages of SS-OCT over ...
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8. Topographic correlation between multifocal electroretinography, microperimetry, and spectral-domain optical coherence tomography of the macula in patients with birdshot chorioretinopathy
  
  Explore Home - Springer Jan 2 2020 Ophthalmology
  
  Purpose To correlate the findings of retinal function with multifocal electroretinogram (mfERG), microperimetry (MP), and structural assessments with spectral-domain optical coherence tomography (SD-OCT) in topographically corresponding areas of the macula of patients with birdshot chorioretinopathy (BSCR). Methods Patients diagnosed with BSCR by clinical and imaging findings were included in the study. The mfERG was performed using 61 hexagon stimulus patterns grouped into 5 rings (Diagnosys Inc., USA). Individual responses [N1-P1 amplitudes in nanovolt (NV)/degree 2 and P1 implicit time in milliseconds (msec)] for each hexagon in the central 3 rings (R1, 0°–2.3°; R2,2.3°–7.7 ...
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  Mentions: Stanford University
9. Intraoperative optical coherence tomography and proportional reflux hydrodissection-guided pars plana vitrectomy for complex severe proliferative diabetic retinopathy
  
  Explore Indian Journal of Ophthalmology (IJO) Dec 19 2019 Ophthalmology
  
  The study describes the technique of combining microscope-integrated optical coherence tomography (mi-OCT) and proportional reflux hydrodissection (PRH) during pars plana vitrectomy (PPV) in eyes with complex proliferative diabetic retinopathy (PDR) including tractional retinal detachment (TRD), combined retinal detachment (CRD), and taut posterior hyaloid membrane (TPHM). In this technique, PRH is used to create tissue planes between fibrovascular adhesions in areas identified using mi-OCT for insinuating the vitrector, enabling tissue dissection and release of traction. About 46 patients were operated using this technique. 34 eyes had TRD, 9 eyes had CRD, and 3 eyes were diagnosed with TPHM. A second instrument ...
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  Mentions: Carl Zeiss Meditec Vishali Gupta Alcon
10. Swept-source optical coherence tomography angiography of choroidal neovascularization in vertically oriented oval dome-shaped maculopathy
  
  Explore Indian Journal of Ophthalmology (IJO) Jul 1 2019 Ophthalmology
  
  A 48-year-old female presented with complaints of recent onset diminution of vision of the left eye (OS) for the past 2 months. She was highly myopic and was using glasses for the past 30 years. Ocular examination revealed presence of a myopic fundus with high axial lengths in both the eyes. Fundus examination of the OS revealed a myopic tessellated fundus with prominent choroidal vessels and a blunted foveal reflex. There was a small pale whitish lesion just superior to the foveal center. Optical coherence tomography (OCT) scans (both horizontal and vertical) confirmed presence of dome-shaped maculopathy. There was subretinal ...
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  Mentions: Vishali Gupta
11. Commentary: Choroidal thickness in the era of swept-source optical coherence tomography
  
  Explore Indian Journal of Ophthalmology (IJO) Jan 1 2019 Ophthalmology
  
  In this issue of Indian Journal of Ophthalmology , the authors have performed a large study with 119 healthy patients (238 eyes) with an aim to establish a normative database of subfoveal choroidal thickness in Asian Indian eyes using the technology of swept-source (SS) optical coherence tomography (OCT). [1] The authors included subjects with a mean age of 28.7 years (range: 19–45 years). The authors concluded that the mean subfoveal choroidal thickness (in the central 1 mm) was 299.10 ± 131.2 μm compared with 294.8 ± 46.5 μm obtained using spectral-domain (SD) technology. [1] In the era ...
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12. Current role of optical coherence tomography angiography: Expert panel discussion
  
  Explore Indian Journal of Ophthalmology (IJO) Nov 19 2018 Ophthalmology
  
  Optical coherence tomography (OCT) angiography is a promising technique that provides depth resolved images of blood flow in the retina and choroid with levels of detail far exceeding that obtained with older forms of imaging and offers several advantages over conventional angiography to visualize the chorioretinal vasculature in a rapid and noninvasive manner. However, as with any evolving imaging technique, there are ongoing challenges in terms of need for new equipment, limitations of imaging capability and software processing techniques, as well as in understanding the implications of the imaging and its correlation with pathophysiology of the retina and choroid. This ...
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  Mentions: Duke University Cleveland Clinic Vishali Gupta
13. Diurnal variation of choriocapillaris vessel flow density in normal subjects measured using optical coherence tomography angiography
  
  Explore journalretinavitreous.biomedcentral.com Oct 13 2018 Ophthalmology
  
  Background Vessel flow density (VFD) may provide important information regarding perfusion status. Diurnal variation in VFD of choriocapillaris has not been reported in literature. In the index study, optical coherence tomography angiography (OCTA) was used to assess the diurnal variation of the VFD in the choriocapillaris of subjects with no known ocular disease. Methods Fifty eyes with no known ocular disease (25 subjects) were included. OCTA images were acquired using AngioVue (Optovue, Fremont, CA, USA) at two different time points on a single day: 9:00 AM and 6:00 PM. Macular cube scan protocol (3 × 3 mm) centered on ...
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  Mentions: Johns Hopkins University Optovue Stanford University
14. FRACTAL DIMENSION AND OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF THE CENTRAL MACULA AFTER REPAIR OF RHEGMATOGENOUS RETINAL DETACHMENTS
  
  Explore LWW Online Aug 12 2018 Ophthalmology
  
  Purpose: Patients with macula-off rhegmatogenous retinal detachments (RRDs) may have suboptimal visual recovery, despite successful reattachment due to various reasons. This study was performed to evaluate the retinal microvasculature in subjects undergoing surgery for RRD using optical coherence tomography angiography . Methods: In this case–control study, the analysis of optical coherence tomography angiography findings of 19 eyes of 19 patients (15 men) who underwent RRD surgery at a tertiary institute were compared with 19 eyes of 19 age- and sex-matched healthy subjects with no known ocular disease. 3 × 3-mm optical coherence tomography angiography scans were obtained at 3 months postoperatively ...
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  Mentions: Vishali Gupta
15. Type 2 Choroidal Neovascularization in a Choroidal Granuloma Detected Using Swept-Source Optical Coherence Tomography Angiography
  
  Explore Healio.com Jul 20 2018 Ophthalmology
  
  The authors describe the imaging characteristics and progression of a type 2 choroidal neovascular membrane (CNV) using swept-source optical coherence tomography (SS-OCTA). A 27-year-old male presented with an active possible tubercular choroidal granuloma associated with exudative retinal detachment in the right eye. The patient received anti-tubercular drugs, oral corticosteroids, and intravitreal bevacizumab and showed complete resolution in 3 months. At the 7-month follow-up, SS-OCTA imaging revealed a type 2 CNV. SS-OCTA is a very useful tool to detect and monitor the growth of CNV in active and healed posterior uveitis without the risks of dye-based angiography.
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  Mentions: Vishali Gupta
16. DETECTION OF TYPE 1 CHOROIDAL NEOVASCULAR MEMBRANES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN TUBERCULAR POSTERIOR UVEITIS
  
  Explore LWW Online Apr 28 2018 Ophthalmology
  
  Purpose: To study optical coherence tomography angiography (OCTA) and multimodal imaging features of Type 1 inflammatory choroidal neovascularization (CNV) in tubercular serpiginous-like choroiditis and response to anti–vascular endothelial growth factor therapy. Methods: In this study, multimodal imaging was performed using OCTA, enhanced-depth imaging optical coherence tomography, fluorescein angiography, and indocyanine green angiography . Correlation of OCTA with other imaging modalities in the detection of CNV was performed. The changes in CNV configuration after anti–vascular endothelial growth factor therapy were assessed. Results: In this study, nine eyes (8 patients; 5 females; mean age: 32.5 ± 11.57 years) with diagnosis ...
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  Mentions: Vishali Gupta
17. Optical coherence tomography angiography features of bilateral retinopathy associated with Chikungunya fever
  
  Explore Indian Journal of Ophthalmology (IJO) Dec 28 2017 Ophthalmology
  
  A 66-year-old male patient presented with decreased vision in both eyes following episode of Chikungunya fever. Examination revealed bilateral retinal lesions with stippled pigmentary changes at the level of the choriocapillaris, involving the macula in the left eye. The retinopathy consisted of outer retinal disruption and retinochoroidal flow abnormalities detected using with additional imaging, including spectral-domain optical coherence tomography (OCT), autofluorescence, and OCT angiography (OCTA). The index case report describes unique OCTA findings in both eyes of an elderly male secondary to Chikungunya fever. Using the technique of OCTA, insights into the mechanisms of visual damage in viral retinopathies such ...
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  Mentions: Vishali Gupta
18. OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN CYTOMEGALOVIRUS RETINITIS: A Longitudinal Study
  
  Explore LWW Online Dec 14 2017 Ophthalmology
  
  Purpose: To evaluate the vitreal, retinal, and choroidal features using spectral domain optical coherence tomography (SD-OCT) in eyes affected by cytomegalovirus (CMV) retinitis. Methods: Patients diagnosed with either active or inactive CMV retinitis were included in the study. Complete ophthalmic examination, serial color fundus photography, and SD-OCT (with and without enhanced depth imaging function) were performed for all the subjects at baseline and follow-up visits. The SD-OCT images were analyzed by two independent graders to evaluate the structural changes in areas of CMV retinitis. Prevalence data for vitreal, retinal, and choroidal SD-OCT features were collected. Results: Twelve eyes from 9 ...
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  Mentions: University of Milan Giovanni Staurenghi
19. Optical coherence tomography angiography features of acute macular neuroretinopathy in dengue fever
  
  Explore Indian Journal of Ophthalmology (IJO) Nov 1 2017 Ophthalmology
  
  A 39-year-old female with dengue fever presented with decreased vision in both eyes. Visual acuity was 20/200 and 20/80 in the right eye (OD) and left eye (OS), respectively. Fundus showed granular, grayish-white lesions in the parafoveal region in OD. Multimodal imaging including optical coherence tomography angiography (OCTA), optical coherence tomography (OCT), and fluorescein angiography (FA) was performed. FA showed late hyperfluorescence with few microaneurysms in OS. OCT showed hyperreflectivity in various layers, suggestive of acute macular neuroretinopathy (AMN). OCTA showed disruption of retinal capillary plexuses. This case shows how OCTA provides newer insights into the pathogenesis of ...
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  Mentions: Vishali Gupta
20. Evaluation of macular and peripapillary vessel flow density in eyes with no known pathology using optical coherence tomography angiography
  
  Explore journalretinavitreous.biomedcentral.com Aug 7 2017 Ophthalmology
  
  Purpose To assess normal vessel flow density (VFD) in macular and peripapillary regions of eyes with no known ocular pathology using optical coherence tomography angiography (OCTA). Methods AngioVue (Optovue, Fremont, CA, USA) was used to capture OCTA images. A 3 × 3 mm grid and a 4.5 × 4.5 mm grid was used to scan parafoveal and peripapillary regions, respectively. ReVue software was utilized to measure VFD in five sectors within the inner two circles of ETDRS grid in macular region and correlated to retinal thickness of same sectors. At optic disc, VFD was calculated in six sectors based on ...
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  Mentions: Optovue Stanford University Quan Dong Nguyen
21. Analysis of Retinochoroidal Vasculature in Human Immunodeficiency Virus Infection Using Spectral-Domain OCT Angiography
  
  Explore ScienceDirect May 18 2017 Ophthalmology
  
  Purpose To describe the retinochoroidal vascular alterations in patients with human immunodeficiency virus (HIV) infection using en face OCT angiography (OCTA). Design Cross-sectional study. Participants Twenty-six patients with HIV infection (5 women, with and without HIV retinopathy) were included in the study. Nineteen healthy participants (7 women) with no known ocular disease were recruited as healthy controls. Methods Multimodal imaging was performed using OCTA (Optovue RTVue XR Avanti; Optovue, Inc, Fremont, CA), enhanced-depth imaging OCT (Heidelberg Spectralis; Heidelberg Engineering, Heidelberg, Germany), color fundus photography, and fluorescein angiography (FA). Vessel flow density (VFD) was calculated automatically by the OCTA software. Morphologic ...
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  Mentions: Optovue Heidelberg Engineering University of Milan
22. OPTICAL COHERENCE TOMOGRAPHY FINDINGS IN CYTOMEGALOVIRUS RETINITIS: A Longitudinal Study
  
  Explore LWW Online Feb 2 2017 Ophthalmology
  
  Purpose: To evaluate the vitreal, retinal, and choroidal features using spectral domain optical coherence tomography (SD-OCT) in eyes affected by cytomegalovirus (CMV) retinitis. Methods: Patients diagnosed with either active or inactive CMV retinitis were included in the study. Complete ophthalmic examination, serial color fundus photography, and SD-OCT (with and without enhanced depth imaging function) were performed for all the subjects at baseline and follow-up visits. The SD-OCT images were analyzed by two independent graders to evaluate the structural changes in areas of CMV retinitis. Prevalence data for vitreal, retinal, and choroidal SD-OCT features were collected. Results: Twelve eyes from 9 ...
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  Mentions: University of Milan Giovanni Staurenghi
23. Distinguishing features of acute Vogt-Koyanagi-Harada disease and acute central serous chorioretinopathy on optical coherence tomography angiography and en face optical coherence tomography imaging
  
  Explore joii-journal.springeropen.com Jan 17 2017 Ophthalmology
  
  Background The aim of this study is to determine the differences in optical coherence tomography angiography (OCTA) features of acute Vogt-Koyanagi-Harada disease (VKH) and acute central serous chorioretinopathy (CSC). Clinical and imaging data of patients with acute CSC and VKH in a tertiary-care institute were analyzed. Multimodal imaging including fluorescein angiography, indocyanine green angiography (ICGA), and enhanced-depth imaging OCT were performed. OCTA images were analyzed for alterations in retinochoroidal microvasculature. Results Thirty-four eyes (24 patients; 10 with VKH and 14 with CSC) were included. OCTA en face images showed apparent areas of choriocapillaris flow void due to shadowing effect from ...
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  Mentions: Vishali Gupta
24. Morphological differences between optic disc collaterals and neovascularization on optical coherence tomography angiography
  
  Explore Home - Springer Dec 14 2016 Ophthalmology
  
  Background To study morphological features of optic disc venous collaterals (OVCs) and neovascularization of optic disc (NVD) on optical coherence tomography angiography (OCTA). Methods Patients with OVCs and NVDs secondary to ischemic retinal diseases were prospectively enrolled. Multimodal imaging was performed using color fundus photography, fluorescein angiography (FA), and OCTA. Morphological evaluation of en-face structural OCT, cross-sectional and en-face OCTA was performed. Results Twenty eyes (20 patients; OVCs: n = 10 and NVD: n = 10) were included. OVCs appeared as small, loopy vessels distinct from surrounding peripapillary capillaries on OCTA in the radial peripapillary capillary frame. NVDs appeared as a mesh ...
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  Mentions: Vishali Gupta
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