1. Articles from Lucas Cahill

    1-5 of 5
    1. Wide-field in vivo oral OCT imaging

      Wide-field in vivo oral OCT imaging

      We have built a polarization-sensitive swept source Optical Coherence Tomography (OCT) instrument capable of wide-field in vivo imaging in the oral cavity. This instrument uses a hand-held side-looking fiber-optic rotary pullback catheter that can cover two dimensional tissue imaging fields approximately 2.5 mm wide by up to 90 mm length in a single image acquisition. The catheter spins at 100 Hz with pullback speeds up to 15 mm/s allowing imaging of areas up to 225 mm 2 field-of-view in seconds. A catheter sheath and two optional catheter sheath holders have been designed to allow imaging at all locations ...

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    2. Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components

      Polarization Sensitive Optical Coherence Tomography (PSOCT) is a functional extension of Optical Coherence Tomography (OCT) that is sensitive to well-structured, birefringent tissue such as scars, smooth muscle and cartilage. In this work, we present a novel completely fiber based swept source PSOCT system using a fiber-optic rotary pullback catheter. This PSOCT implementation uses only passive optical components and requires no calibration while adding minimal additional cost to a standard structural OCT imaging system. Due to its complete fiber construction, the system can be made compact and robust, while the fiber-optic catheter allows access to most endoscopic imaging sites. The 1 ...

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    3. Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

      Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer

      Diagnosis of peripheral lung nodules is challenging because they are rarely visualized endobronchially. Imaging techniques such as endobronchial ultrasound (EBUS) are employed to improve tumor localization. The current EBUS probe provides limited nodule characterization and has an outer diameter of 1.4 mm that restricts access to small peripheral airways. We report a novel co-registered autofluoresence Doppler optical coherence tomography (AF/DOCT) system with a 0.9 mm diameter probe to characterize peripheral lung nodules prior to biopsy in vivo. Method: Patients referred for evaluation of peripheral lung nodules underwent bronchoscopy with examination of standard EBUS and the novel AF ...

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    4. Fiber-Based Polarization Diversity Detection for Polarization-Sensitive Optical Coherence Tomography

      Fiber-Based Polarization Diversity Detection for  Polarization-Sensitive Optical Coherence Tomography

      We present a new fiber-based polarization diversity detection (PDD) scheme for polarization sensitive optical coherence tomography (PSOCT). This implementation uses a new custom miniaturized polarization-maintaining fiber coupler with single mode (SM) fiber inputs and polarization maintaining (PM) fiber outputs. The SM fiber inputs obviate matching the optical lengths of the two orthogonal OCT polarization channels prior to interference while the PM fiber outputs ensure defined orthogonal axes after interference. Advantages of this detection scheme over those with bulk optics PDD include lower cost, easier miniaturization, and more relaxed alignment and handling issues. We incorporate this PDD scheme into a galvanometer-scanned ...

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    5. A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

      We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 µm diameter catheter ‒ consisting of a rotating lens assembly, double-clad fiber (DCF), and torque cable in a stationary plastic tube ‒ was fabricated to allow AF/OCT imaging of small airways ...

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    1-5 of 5
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  2. Topics in the News

    1. (5 articles) Lucas Cahill
    2. (4 articles) British Columbia Cancer Agency
    3. (4 articles) Stephen Lam
    4. (4 articles) Hamid Pahlevaninezhad
    5. (4 articles) Pierre M. Lane
    6. (2 articles) University of British Columbia
    7. (2 articles) Matthew Brenner
    8. (2 articles) Tawimas Shaipanich
    9. (1 articles) Ryerson University
    10. (1 articles) Victor X. D. Yang
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    A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography Fiber-Based Polarization Diversity Detection for  Polarization-Sensitive Optical Coherence Tomography Doppler optical coherence tomography and co-registered autofluorescence imaging of peripheral lung cancer Passive endoscopic polarization sensitive optical coherence tomography with completely fiber based optical components Wide-field in vivo oral OCT imaging Intravitreal Ranibizumab Monotherapy or Combined with Laser for Diabetic Macular Edema (OCT guided study) Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study Clinical validation of the RTVue optical coherence tomography angiography image quality indicators Intraoperative OCT-Assisted Retinal Detachment Repair in the DISCOVER Study: Impact and Outcomes Analysis of Retinal Vascular Density using Optical Coherence Tomography Angiography, to Differentiate Healthy, Glaucoma Suspect and Glaucomatous Eyes (Thesis) Correlation between in vivo near-infrared spectroscopy and optical coherence tomography detected lipid-rich plaques with post-mortem histology Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography