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  1. Quantification of molecular diffusion in arterial tissues with optical coherence tomography and fluorescence microscopy

    Explore Article SpringerLink Home (Jun 6 2009)

    Abstract Alternations in vascular permeability for different molecules, drugs, and contrast agents might be a significant early marker of development of various diseases such as atherosclerosis. However, up to date experimental studies of molecular diffusion across vascular wall have been limited. Recently, we demonstrated that the Optical Coherence Tomography (OCT) technique could be applied for noninvasive and nondestructive quantification of molecular diffusion in different biological tissues. However, the viability of the OCT-based assessment of molecular diffusion should be validated with established methods. This study focused on comparing molecular diffusion rates in vascular tissues measured with OCT and standard fluorescent microscopy. ... (Read Full Article)

    Comment on Article Mentions:   Saratov State University   University of Houston   Kirill V. Larin

  2. Real-Time Imaging of Circulating Individual Blood Cells in Mammalian Embryos with Doppler SS-OCT

    Explore Article SpringerLink Home (May 20 2009) Cardiology

    Congenital cardiovascular (CV) defects are present in approximately 1% of live births. Moreover, among deaths due to birth defects, cardiovascular failures are the most likely. Therefore, characterization of mammalian embryonic cardio dynamics and understanding of the hemodynamic changes that occur during embryonic development is crucial for improving diagnostics, prevention, and treatment of cardiovascular defects and diseases. In this work, we combined Swept Source Optical Coherence Tomography (SSOCT) with live mouse embryo culture protocols to generate structural 2-D and 3-D imaging and hemodynamic measurements in live 8.5 day embryos. Our data show that individual circulating blood cells can be visualized with ... (Read Full Article)

    Comment on Article Mentions:   University of Houston   Baylor College of Medicine   Kirill V. Larin

  3. Noninvasive monitoring of glucose concentration with optical coherence tomography.

    Explore Article NCBI HomePage (Dec 14 2007) Glucose

    Related Articles Noninvasive monitoring of glucose concentration with optical coherence tomography. Opt Lett. 2001 Jul 1;26(13):992-4 Authors: Esenaliev RO, Larin KV, Larina IV, Motamedi M We have proposed a tested in tissue phantoms and in vivo a novel sensor based on optical coherence tomography (OCT) for noninvasive and continuous monitoring of blood glucose concentration. OCT images were obtained from pig and rabbit skin before and after glucose administration. Slopes of OCT signals decreased substantially (~40% in tissues in vivo) and linearly with the increase of blood glucose concentration from 4 to 30 mM, typical for normal and diabetic subjects. Phantom ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin

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