1. Articles from Kyeongsoon Park

    1-4 of 4
    1. Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Rationale: Inflammation plays a pivotal role in the pathogenesis of the acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events. Methods: Here, we developed a macrophage mannose receptor (MMR)-targeted theranostic nanodrug (mannose-polyethylene glycol-glycol chitosan-deoxycholic acid-cyanine 7-lobeglitazone; MMR-Lobe-Cy) designed to identify inflammatory activity as well as to deliver peroxisome proliferator-activated gamma (PPARγ) agonist, lobeglitazone, specifically to high-risk plaques based on the high mannose receptor specificity. The MMR-Lobe-Cy was intravenously injected into balloon-injured atheromatous rabbits and serial in vivo optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural-molecular imaging ...

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      Mentions: Korea University
    2. Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

      Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

      Aims Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural–molecular imaging with indocyanine green (ICG) can estimate inflammation in swine coronary artery. Methods and results After administration of clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid coronary imaging (20 mm/s pullback speed) using a fully integrated OCT-NIRF catheter was safely performed in 12 atheromatous Yucatan minipigs and in 7 drug-eluting stent (DES)-implanted Yorkshire pigs. Stronger NIRF activity was identified in OCT-proven high-risk plaque compared ...

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    3. Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels

      In current study, we fully integrated near-infrared fluorescence (NIRF) molecular imaging into intravascular OCT structural imaging. The OCT/NIRF single catheter imaging clearly demonstrated the microstructure of atheromata and simultaneously identified ICG-enhancing macrophage abundant lipid-rich areas of the plaques. Ex vivo NIRF imaging evidently validated in vivo OCT-NIRF imaging. NIRF signals on ex vivo fluorescence reflectance imaging colocalized well with in vivo NIRF imaging. In vitro ICG cell uptake, correlative fluorescence microscopy, and histopathology corroborated the in vivo imaging findings. Herein, our research team have solved the issues critical for application of this OCT/NIRF imaging technology to clinical practice ...

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    4. Fully Integrated High-Speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels

      Fully Integrated High-Speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels

      Background— Lipid-rich inflamed coronary plaques a reprone to rupture. The purpose of this study was to assess lipid-rich inflamed plaques invivo using fully integrated high-speed optical coherence tomography (OCT)/ near-infrared fluorescence (NIRF) molecular imaging with a Food and Drug Administration– a pproved indocyanine green (ICG). Methods a nd Results— A n integrated high-speed intravascular OCT/NIRF imaging c a theter a nd a du a l-mod a l OCT/NIRF system were constructed b a sed on a cl in ic a l OCT pl a tform. For imaging lipid-rich inflamed plaques, the Food and Drug Administration– approved NIRF-emitting ICG ...

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    1-4 of 4
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    1. (4 articles) Korea University
    2. (3 articles) Korea Advanced Institute of Science and Technology
    3. (3 articles) Hanyang University
    4. (2 articles) FDA
    5. (1 articles) South China Normal University
    6. (1 articles) Sun Yat-Sen University
    7. (1 articles) Harvard University
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    Fully Integrated High-Speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo Using a Clinically Available Near-Infrared Fluorescence–Emitting Indocyanine Green to Detect Inflamed Lipid-Rich Atheromata in Coronary-Sized Vessels Feature Of The Week 8/31/14: Fully Integrated High-speed Intravascular OCT/NIRF Structural/Molecular Imaging In Vivo using a Clinically-available NIRF Emitting Indocyanine Green to Detect Inflamed Lipid-rich Atheromata in Coronary-sized Vessels Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents Fluorescein Leakage and Optical Coherence Tomography Angiography Features of Microaneurysms in Diabetic Retinopathy Cross-free in both lateral and axial directions Fourier-domain full-field optical coherence tomography Microperimetry, Humphrey field analyzer, and optical coherence tomography in detecting glaucoma: a comparative performance study Scanning optimization of an electrothermally-actuated MEMS mirror for applications in optical coherence tomography endoscopy Near-infrared active superparamagnetic iron oxide nanoparticles for magnetomotive optical coherence tomography imaging and magnetic hyperthermia therapeutic applications Optical Coherence Tomography Identifies Visual Pathway Involvement Earlier than Visual Function Tests in Children with MRI-Verified Optic Pathway Gliomas Balanced detection spectral-domain optical coherence tomography with a single line-scan camera