1. Articles from Chen-Hsin Sun

    1-4 of 4
    1. Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS

      Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS

      BACKGROUND AND OBJECTIVE: The aim of this study was to assess changes in retinal structure and thickness after subretinal implantation of the Retina Implant Alpha IMS (Retina Implant AG, Reutlingen, Germany). PATIENTS AND METHODS: Spectral-domain optical coherence tomography (SD-OCT) imaging was performed to assess the structure and thickness of the retina anterior to the microphotodiode array preoperatively, within 6 weeks and 6 months ± 1 month after implantation. Thickness measurements were performed using the distance tool of the built-in software. Three thickness measurements were performed in each of the four quadrants of the retina on the microchip within 6 weeks and ...

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    2. Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population

      Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population

      Purpose. To characterize an optical coherence tomography (OCT)–derived parameter, Bruch's membrane opening–minimum rim width (BMO-MRW), and its association with demographic and clinical parameters in normal Chinese subjects. Methods. Right eyes of 466 consecutive healthy subjects from a population-based study of Singaporean Chinese underwent Cirrus OCT imaging. The retinal internal limiting membrane (ILM) and BMO were automatically delineated using the built-in Cirrus algorithm. The standard 36 interpolated radial B-scans (72 BMO points, 5° increments) of each optic nerve head were manually extracted from the central circle (3.46-mm diameter). We used Matlab to measure the shortest distance from ...

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    3. Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)

      Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter)

      Calcific aortic valve disease (CAVD) is still an unsolved medical problem, because the pathogenesis of CAVD is poorly understood and early calcification is hard to identify. The lack of high-resolution imaging tools to study early stage disease further hampers the search for therapeutic targets. Micro-optical coherence tomography (μOCT), which is a new form of OCT, is the highest-resolution cross-sectional OCT technology available today with 1 μm resolution. We used μOCT to visualize detailed cellular and subcellular structure associated with early calcific changes in diseased human and murine aortic valves. The results suggest that μOCT imaging has the potential to provide ...

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    4. Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography

      The presence of cholesterol crystals is a hallmark of atherosclerosis, but until recently, such crystals have been considered to be passive components of necrotic plaque cores. Recent studies have demonstrated that phagocytosis of cholesterol crystals by macrophages may actively precipitate plaque progression via an inflammatory pathway, emphasizing the need for methods to study the interaction between macrophages and crystalline cholesterol. In this study, we demonstrate the feasibility of detecting cholesterol in macrophages in situ using Micro-Optical Coherence Tomography (µOCT), an imaging modality we have recently developed with 1-µm resolution. Macrophages containing cholesterol crystals frequently demonstrated highly scattering constituents in ...

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    1-4 of 4
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  2. Topics in the News

    1. (2 articles) Massachusetts General Hospital
    2. (2 articles) Harvard University
    3. (2 articles) Guillermo J. Tearney
    4. (2 articles) Linbo Liu
    5. (2 articles) National Institutes of Health
    6. (1 articles) Singapore Eye Research Institute
    7. (1 articles) Duke University
    8. (1 articles) Nanyang Technological University
    9. (1 articles) Manabu Kashiwagi
    10. (1 articles) Atsushi Tanaka
    11. (1 articles) Zeiss Cirrus HD-OCT
    12. (1 articles) UT Southwestern Medical Center
    13. (1 articles) UC Davis
    14. (1 articles) University of Southern California
    15. (1 articles) University of Western Australia
    16. (1 articles) John S. Werner
    17. (1 articles) Brian E. Applegate
    18. (1 articles) Ravi S. Jonnal
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    Feasibility of the Assessment of Cholesterol Crystals in Human Macrophages Using Micro Optical Coherence Tomography Innovations in Microscopic Imaging of Atherosclerosis and Valvular Disease (Book Chapter) Determinants of Optical Coherence Tomography–Derived Minimum Neuroretinal Rim Width in a Normal Chinese Population Optical Coherence Tomography in Patients With the Subretinal Implant Retina Implant Alpha IMS UC Davis Receives NIH Grant for Properties of Photoreceptors and Muller Cells Investigated with AO-OCT USC Receives NIH Grant for Optical Imaging Technologies to Identify Residual Cholesteatoma and Improve Ossiculoplasty Outcomes Use of Optical Coherence Tomography (OCT) in Aesthetic Skin Assessment—A Short Review SURGICAL MANAGEMENT OF TRAUMATIC MACULAR HOLE Optical Coherence Tomography Features and Outcomes Patience needed to grow OCTA adoption in practice Intravascular lithotripsy to treat an underexpanded coronary stent: 4‐Month angiographic and OCT follow‐up Postdoctoral Fellow / Research Fellow at The Australian National University, Canberra Stress, anxiety, harassment: huge survey reveals pressures of scientists’ working lives