1. Articles from Marion R. Munk

    1-24 of 30 1 2 »
    1. Comparison of Indocyanine Green Angiography and Swept-Source Wide-Field Optical Coherence Tomography Angiography in Posterior Uveitis

      Comparison of Indocyanine Green Angiography and Swept-Source Wide-Field Optical Coherence Tomography Angiography in Posterior Uveitis

      Purpose: To compare indocyanine green angiography (ICGA) and swept-source wide-field optical coherence tomography angiography (SS-OCTA) for the assessment of patients with posterior uveitis. Method: SS-OCTA montage images of 5 x 12 x 12 mm or 2 x 15 x 9 mm, covering ~70-90 degree of the retina of consecutive patients with posterior uveitis were acquired. The choriocapillaries and choroidal slabs were compared to findings on ICGA. Results: Sixty-eight eyes of 41 patients were included (mean age 47.2 ± 20.4 years; 58.5% female). In 23 (34%) lesions were visible on OCTA, but not discernable on ICGA. In turn, out ...

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    2. Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Recommendations for OCTA reporting in retinal vascular disease: A Delphi approach by International Experts

      Purpose: To develop a consensus nomenclature for reporting optical coherence tomography angiography (OCTA) findings in retinal vascular disease (e.g., diabetic retinopathy, retinal vein occlusion) by international experts. Design: Delphi-based survey SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Twenty-five retinal vascular disease and OCTA imaging experts METHODS, INTERVENTION, OR TESTING: A Delphi method of consensus development was used, comprising two rounds of online questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-five experts in retinal vascular disease and retinal OCTA imaging were selected to constitute the OCTA Nomenclature in Delphi Study Group for retinal vascular disease. The four main areas of consensus ...

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    3. Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis

      Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis

      Background/aims: To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis. Methods: The modified Delphi process consisted of two rounds of electronic questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-one items were included for discussion. The three main areas of discussion were: wide field OCTA (WF-OCTA), nomenclature of OCTA findings and OCTA signal attenuation assessment and measurement. Seventeen specialists in uveitis and retinal imaging were selected by the executive committee to constitute the OCTA nomenclature in Uveitis Delphi Study Group. The study endpoint was defined by the degree of consensus for ...

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      Mentions: Cleveland Clinic
    4. Assessment of patient specific information in the wild on fundus photography and optical coherence tomography

      Assessment of patient specific information in the wild on fundus photography and optical coherence tomography

      In this paper we analyse the performance of machine learning methods in predicting patient information such as age or sex solely from retinal imaging modalities in a heterogeneous clinical population. Our dataset consists of N = 135,667 fundus images and N = 85,536 volumetric OCT scans. Deep learning models were trained to predict the patient's age and sex from fundus images, OCT cross sections and OCT volumes. For sex prediction, a ROC AUC of 0.80 was achieved for fundus images, 0.84 for OCT cross sections and 0.90 for OCT volumes. Age prediction mean absolute errors of ...

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    5. Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results

      Standardization of optical coherence tomography angiography nomenclature in retinal vascular diseases: first survey results

      Purpose: To develop a consensus nomenclature for optical coherence tomography angiography (OCTA) findings in retinal vascular diseases. Design: Online survey using Delphi Method SUBJECTS, PARTICIPANTS AND/OR CONTROLS: Members of The Retina Society, European Society of Retina Specialists (EURETINA) and the Japanese Retina and Vitreous Society (JRVS). Methods, intervention, or testing: An online questionnaire on OCTA terminology in retinal vascular diseases was sent to members of The Retina Society, EURETINA and the JRVS. The respondents were divided into two groups (experts vs users) based on the number of their publications in this field. The respondents who had more than 5 ...

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    6. Comparison of Drusen Volume Assessed by Two Different OCT Devices

      Comparison of Drusen Volume Assessed by Two Different OCT Devices

      To compare drusen volume between Heidelberg Spectral Domain (SD-) and Zeiss Swept-Source (SS) PlexElite Optical Coherence Tomography (OCT) determined by manual and automated segmentation methods. Thirty-two eyes of 24 patients with Age-Related Macular Degeneration (AMD) and drusen maculopathy were included. In the central 1 and 3 mm ETDRS circle drusen volumes were calculated and compared. Drusen segmentation was performed using automated manufacturer algorithms of the two OCT devices. Then, the automated segmentation was manually corrected and compared and finally analyzed using customized software. Though on SD-OCT, there was a significant difference of mean drusen volume prior to and after manual ...

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    7. Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Standardisation of optical coherence tomography angiography nomenclature in uveitis: first survey results

      Aim To standardise the nomenclature for reporting optical coherence angiography (OCT-A) findings in the field of uveitis. Methods Members of the International Uveitis Study Group, of the American Uveitis Society and of the Sociedad Panamericana de Infermedades Oculares that choose to participate responded to an online questionnaire about their preferred terminology when reporting on OCT-A findings in uveitis. The response of individuals with several publications on OCT-A (experts) was compared with uveitis specialists (users) who have less than five publications on the field of uveitis and OCT-A. Results A total of 108 uveitis specialists who participated in the survey were ...

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    8. Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy

      Evaluation of different Swept’Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy

      Purpose To compare different Swept‐Source optical coherence tomography angiography (SS‐OCTA) slabs for the detection of features of diabetic retinopathy (DR), to find the most suitable slab for grading. Methods Retrospective cross‐sectional study. Consecutive patients with DR were evaluated using SS‐OCTA. The central 12 × 12 mm scan was used to generate the retinal, superficial and deep slab. The grading results of the slabs were then compared to determine if one specific slab is superior to detect respective features. Results A total of 348 eyes (190 patients; mean age 58.1 ± 14.5 years) were graded for features ...

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    9. Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      Expert-level Automated Biomarker Identification in Optical Coherence Tomography Scans

      In ophthalmology, retinal biological markers, or biomarkers , play a critical role in the management of chronic eye conditions and in the development of new therapeutics. While many imaging technologies used today can visualize these, Optical Coherence Tomography (OCT) is often the tool of choice due to its ability to image retinal structures in three dimensions at micrometer resolution. But with widespread use in clinical routine, and growing prevalence in chronic retinal conditions, the quantity of scans acquired worldwide is surpassing the capacity of retinal specialists to inspect these in meaningful ways. Instead, automated analysis of scans using machine learning algorithms ...

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    10. Optical coherence tomography diagnostic signs in posterior uveitis

      Optical coherence tomography diagnostic signs in posterior uveitis

      A diagnostic sign refers to a quantifiable biological parameter that is measured and evaluated as an indicator of normal biological, pathogenic, or pharmacologic responses to a therapeutic intervention. When used in translational research discussions, the term itself often alludes to a signs used to accelerate or aid in diagnosis or monitoring and provide insight into “personalized” medicine. Many new diagnostic signs are being developed that involve imaging technology. Optical coherence tomography is an imaging technique that provides in vivo quasi-histological images of the ocular tissues and as such it's able to capture the structural and functional modifications that accompany ...

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    11. Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis

      Optical coherence tomography angiography (OCTA) as a new diagnostic tool in uveitis

      Background The broad spectrum of uveitis disorders requires a multimodal imaging approach in the daily practice of an ophthalmologist. As inflammatory conditions, they have in common an alteration in leukocyte migration. In this context, optical coherence tomography angiography (OCTA) might be of great value for diagnosing or following up patients with these disorders. To date, OCTA has rather been used as an additional tool besides the well-established diagnostic imaging tools, but its complementary diagnostic features become increasingly relevant, to follow disease activity and treatment response and for the understanding of pathomechanisms of various uveitis types. This review summarizes the possible ...

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    12. Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina

      Repeatability of Wide-field Optical Coherence Tomography Angiography in Normal Retina

      Purpose : We evaluated the repeatability of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) in healthy subjects. Methods : Healthy subjects underwent two imaging sessions, on average 8 days apart, with a 100 kHz SS-OCTA instrument. The imaging protocol included a central 3 × 3 and 12 × 12 mm scans of the four quadrants resulting in more than a 70° wide-field OCTA of the posterior pole. Quantitative analysis was performed using the inbuilt Macular Density Algorithm Version v0.6.1 and AngioTool software. Consistency for the foveal avascular zone (FAZ), vessel density, and perfusion density of the superficial and deep capillary ...

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    13. Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Comparison of Choroidal Thickness Measurements Using Spectral Domain Optical Coherence Tomography in Six Different Settings and With Customized Automated Segmentation Software

      Purpose : We investigate which spectral domain-optical coherence tomography (SD-OCT) setting is superior when measuring subfoveal choroidal thickness (CT) and compared results to an automated segmentation software. Methods : Thirty patients underwent enhanced depth imaging (EDI)-OCT. B-scans were extracted in six different settings (W+N = white background/normal contrast 9; W+H = white background/maximum contrast 16; B+N = black background/normal contrast 12; B+H = black background/maximum contrast 16; C+N = Color-encoded image on black background at predefined contrast of 9, and C+H = Color-encoded image on black background at high/maximal contrast of 16), resulting in 180 images ...

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    14. Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis

      Swept‐source optical coherence tomography angiography reveals vascular changes in intermediate uveitis

      Purpose To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept‐source optical coherence tomography angiography (OCTA). Methods In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age‐matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated. Results 93 eyes of 58 patients with intermediate uveitis and 33 healthy age‐matched controls were included. The presence of a cystoid ...

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    15. Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

      Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy

      Aim To describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR). Methods This was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central ...

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    16. Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging

      Vascular Abnormalities In Diabetic Retinopathy Assessed With SWEPT-SOURCE Optical Coherence Tomography Angiography Widefield Imaging

      Purpose: To detect vascular abnormalities in diabetic retinopathy using swept-source optical coherence tomography angiography (SS-OCTA) widefield images, and to compare the findings with color fundus photographs (CFPs) using Early Treatment Diabetic Retinopathy Study severity grading. Methods: 3 mm × 3 mm and 12 mm × 12 mm scans were acquired to cover 70° to 80° of the posterior pole using a 100-kHz SS-OCTA instrument. Two masked graders assessed the presence of vascular abnormalities on SS-OCTA and the Early Treatment Diabetic Retinopathy Study level on CFP. The grading results were then compared. Results: A total of 120 diabetic eyes (60 patients) were imaged ...

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    17. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography

      Purpose To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA). Methods This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Wide-field OCTA and en-face OCT images were analysed for the presence of capillary non-perfusion and reduced perfusion, disruption of ellipsoid zone, and abnormalities on en-face wide-field retinal thickness maps, respectively, and compared with fluorescein angiography (FA) findings in a subcohort. Results 164 eyes of 88 patients with intermediate uveitis were included. Areas of capillary non-perfusion and reduced perfusion were more ...

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    18. OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS

      OPTICAL COHERENCE TOMOGRAPHY BIOMARKERS TO DISTINGUISH DIABETIC MACULAR EDEMA FROM PSEUDOPHAKIC CYSTOID MACULAR EDEMA USING MACHINE LEARNING ALGORITHMS

      Purpose: In diabetic patients presenting with macular edema (ME) shortly after cataract surgery, identifying the underlying pathology can be challenging and influence management. Our aim was to develop a simple clinical classifier able to confirm a diabetic etiology using few spectral domain optical coherence tomography parameters. Methods: We analyzed spectral domain optical coherence tomography data of 153 patients with either pseudophakic cystoid ME (n = 57), diabetic ME (n = 86), or “mixed” (n = 10). We used advanced machine learning algorithms to develop a predictive classifier using the smallest number of parameters. Results: Most differentiating were the existence of hard exudates, hyperreflective ...

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    19. Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

      Cataract significantly influences quantitative measurements on swept-source optical coherence tomography angiography imaging

      Purpose To analyze retinal blood flow before and after cataract surgery using swept-source optical coherence tomography angiography (SS-OCTA). Methods Prospective observational study. Consecutive patients were recruited and scanned using SS-OCTA before and after cataract surgery. Laser flare photometry were performed post-surgery. Perfusion and vessel density of superficial (SCP) and deep capillary plexuses (DCP) of the 3 × 3 mm images as well as foveal avascular zone (FAZ) measurements were assessed. Vessel continuity, vessel visibility and presence of artefacts were evaluated by two blinded graders using a predefined grading protocol. Results Thirteen eyes of 12 patients met the inclusion criteria. There was ...

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    20. Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

      Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy

      Importance Patients with birdshot chorioretinopathy (BSCR) can experience a delay in diagnosis owing to the challenges of identifying the condition prior to evolution of characteristic choroidal scars. An objective, noninvasive method for detecting early lesions in BSCR might have an effect on preventing vision loss in these patients. Objective To test the feasibility of swept-source optical coherence tomography angiography (SS-OCTA) in the detection of BSCR choroidal lesions and to use en face image analysis of choroidal layers to localize lesion depth. Design, Setting, and Participants Prospective, longitudinal, observational case series of 3 patients diagnosed as having BSCR at 1 of ...

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    21. Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography

      Acute macular neuroretinopathy: pathogenetic insights from optical coherence tomography angiography

      Aim To describe the optical coherence tomography angiography (OCT-A) features of patients affected by acute macular neuroretinopathy (AMN). Methods This is a prospective, observational, cross-sectional study. Multimodal imaging, including spectral domain OCT (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany) and 6×6 mm swept source OCT-A (ZEISS PLEX Elite 9000; ZEISS, Dublin, California), was performed on all patients. The primary outcome measure was assessment of the vascular alterations of the superficial (SCP) and deep (DCP) capillary plexuses and choriocapillaris (CC). A segmentation of the AMN lesions using enface OCT images of photoreceptors-retinal pigment epithelium complex was used to discriminate intralesional ...

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    22. Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration

      Spectral-Domain Optical Coherence Tomography Associations of Neovascular Conversion in Age-Related Macular Degeneration

      Purpose: To identify spectral-domain optical coherence tomography (SD-OCT) features associated with exudative conversion in fellow eyes of patients treated for neovascular age-related macular degeneration (nAMD) in their first eye. Methods: Retrospective observational study. Spectral-domain optical coherence tomography images of converting fellow eyes (study eyes) from 83 patients with nAMD were compared to fellow eyes of age- and sex-matched patients with nAMD who did not convert (control eyes). Parameters related to drusen, pigment epithelium detachment, hyperreflective foci (HRF), retinal pigment epithelium atrophy, small cystic cavities, and vitreoretinal interface were graded. Longitudinal analysis in study eyes and cross-sectional comparison with control eyes ...

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    23. OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices

      OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices

      Article Authors Metrics Comments Related Content Abstract Introduction Methods Results Discussion Supporting information Acknowledgments Author Contributions References Reader Comments (0) Media Coverage Figures Abstract Purpose To compare the quality of four OCT-angiography(OCT-A) modules. Method The retina of nineteen healthy volunteers were scanned with four OCT-devices (Topcon DRI-OCT Triton Swept-source OCT, Optovue RTVue-XR, a prototype Spectralis OCT2, Heidelberg-Engineering and Zeiss Cirrus 5000-HD-OCT). The device-software generated en-face OCT-A images of the superficial (SCP) and deep capillary plexuses (DCP) were evaluated and scored by 3 independent retinal imaging experts. The SCP vessel density was assessed using Angiotool-software. After the inter-grader reliability assessment ...

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    24. OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY

      OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY

      Background/Purpose: To investigate the retinal and choroidal vasculature in patients with torpedo maculopathy with optical coherence tomography-angiography (OCT-A). Methods: Retrospective case series of four patients who were examined at the department of Ophthalmology at the University Hospital Bern. Main Outcome was the lesion size over time in OCT-A and fundus autofluorescence. Results: Three patients had Type I and 1 patient had Type II torpedo maculopathy. Torpedo maculopathy lesion size remained stable in all patients over a mean period of observation of three years in OCT-A and fundus autofluorescence. The choriocapillaris network was attenuated focally within the lesion in OCT-A ...

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    DIFFERENTIAL DIAGNOSIS OF MACULAR EDEMA OF DIFFERENT PATHOPHYSIOLOGIC ORIGINS BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY Detection and Differentiation of Intraretinal Hemorrhage in Spectral Domain Optical Coherence Tomography A New OCT Finding in Tuberculous Serpiginous-like Choroidopathy Enhanced depth imaging optical coherence tomography of congenital cavitary optic disc anomaly (CODA) Differentiation of Diabetic Macular Edema From Pseudophakic Cystoid Macular Edema by Spectral-Domain Optical Coherence Tomography SPECTRAL DOMAIN-OPTICAL COHERENCE TOMOGRAPHY IMAGE CONTRAST AND BACKGROUND COLOR SETTINGS INFLUENCE IDENTIFICATION OF RETINAL STRUCTURES OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF TORPEDO MACULOPATHY OCT-angiography: A qualitative and quantitative comparison of 4 OCT-A devices Use of En Face Swept-Source Optical Coherence Tomography Angiography in Identifying Choroidal Flow Voids in 3 Patients With Birdshot Chorioretinopathy Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography Optical coherence tomography findings in patients with transfusion-dependent β-thalassemia Higher-order regression three-dimensional motion-compensation method for real-time optical coherence tomography volumetric imaging of the cornea