1. Articles from Muhammad Hammadah

    1-8 of 8
    1. Sex Differences in Nonculprit Coronary Plaque Microstructures on Frequency-Domain Optical Coherence Tomography in Acute Coronary Syndromes and Stable Coronary Artery Disease

      Sex Differences in Nonculprit Coronary Plaque Microstructures on Frequency-Domain Optical Coherence Tomography in Acute Coronary Syndromes and Stable Coronary Artery Disease

      Background— Numerous reports suggest sex-related differences in atherosclerosis. Frequency-domain optical coherence tomography has enabled visualization of plaque microstructures associated with disease instability. The prevalence of plaque microstructures between sexes has not been characterized. We investigated sex differences in plaque features in patients with coronary artery disease. Methods and Results— Nonculprit plaques on frequency-domain optical coherence tomography imaging were compared between men and women with either stable coronary artery disease (n=320) or acute coronary syndromes (n=115). A greater prevalence of cardiovascular risk factors was observed in women. Nonculprit plaques in women with stable coronary artery disease were more likely ...

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    2. Plaque Microstructures in Patients with Coronary Artery Disease who Achieved Very Low Low-Density Lipoprotein Cholesterol Levels

      Plaque Microstructures in Patients with Coronary Artery Disease who Achieved Very Low Low-Density Lipoprotein Cholesterol Levels

      Objective Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favourably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below current recommended targets remains unknown. Frequency-domain optical coherence tomography (FD-OCT) enables visualization of plaque microstructures associated with plaque instability. We investigated plaque morphologies in patients with low LDL-C levels by using FD-OCT. Methods 293 and 122 non-obstructive lipid and fibrous plaques in 280 stable statin-treated CAD patients were evaluated by FD-OCT imaging in vessels requiring percutaneous coronary intervention ...

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      Mentions: E. Murat Tuzcu
    3. Plaque vulnerability at non-culprit lesions in obese patients with coronary artery disease: Frequency-domain optical coherence tomography analysis

      Plaque vulnerability at non-culprit lesions in obese patients with coronary artery disease: Frequency-domain optical coherence tomography analysis

      Background Obesity is associated with adverse atherosclerotic cardiovascular events. While various metabolic abnormalities associated with obesity promote plaque formation, the morphological phenotype of atherosclerotic plaque has not been well characterized in the setting of obesity. Frequency-domain optical coherence tomography (FD-OCT) enables in vivo visualization of plaque microstructures associated with vulnerability. We characterized plaque microstructures in obese patients. Methods FD-OCT imaging was performed in 308 patients with coronary artery disease undergoing percutaneous coronary intervention. Patients were stratified according to the presence or absence of obesity (body mass index > 30 kg/m 2 ). Plaques in obese ( n  = 129) and non-obese ( n  = 179 ...

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    4. Cholesterol Crystals Associate With Coronary Plaque Vulnerability In Vivo

      Cholesterol Crystals Associate With Coronary Plaque Vulnerability In Vivo

      The high local concentration of cholesterol in foam cells has been reported to formulate cholesterol crystals, which trigger a local inflammatory response ( 1 ). Intracellular crystals also induce apoptosis of foam cells, leading to further attraction of macrophages and development of a lipid-rich necrotic core 2 . These effects may suggest a potential contribution of cholesterol crystals to plaque destabilization. Frequency-domain optical coherence tomography (FD-OCT) enables visualization of cholesterol crystals in vivo ( 3 ). We investigated the impact of cholesterol crystals on plaque vulnerability in stable patients with coronary artery disease.

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    5. Spotty calcification and plaque vulnerability in vivo: frequency domain optical coherence tomography analysis

      Spotty calcification and plaque vulnerability in vivo: frequency domain optical coherence tomography analysis

      Background: Spotty calcification is a morphological characteristic of a vulnerable plaque phenotype. While this calcium pattern is considered an active process, promoted by inflammation, it is unknown whether spotty calcification associates with development of microstructures observed in vulnerable plaques. As frequencydomain optical coherence tomography (FD-OCT) enables visualization of microstructures associated with plaque vulnerability, we investigated the association between spotty calcification and plaque microstructures by using FD-OCT. Methods: A total of 300 patients with stable coronary artery disease (CAD), having clinical indication for percutaneous coronary intervention (PCI), were analyzed. Totally 280 non-culprit lipid plaques within the target vessel requiring PCI were ...

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    6. Frequency-Domain Optical Coherence Tomographic Analysis of Plaque Microstructures at Non-culprit Narrowings in Patients Receiving Potent Statin Therapy

      Frequency-Domain Optical Coherence Tomographic Analysis of Plaque Microstructures at Non-culprit Narrowings in Patients Receiving Potent Statin Therapy

      Potent statin therapy has been demonstrated to reduce cardiovascular events. While statins have been considered to stabilize atherosclerotic plaque, this effect has not been well characterized in vivo. We investigated the relationship between potent statin therapy and plaque microstructures imaged by frequency-domain optical coherence tomography (FD-OCT). 290 non-culprit lipid plaques in 275 patients with stable coronary artery disease receiving atorvastatin or rosuvastatin were analyzed. Patients were stratified into no statin, low- and high-dose statin group. Plaques in the high-dose statin group demonstrated a smaller lipid arc (p=0.02) and a greater fibrous cap thickness (p=0.01). In patients ...

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    1-8 of 8
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    1. (5 articles) E. Murat Tuzcu
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    Frequency-Domain Optical Coherence Tomographic Analysis of Plaque Microstructures at Non-culprit Narrowings in Patients Receiving Potent Statin Therapy Spotty calcification and plaque vulnerability in vivo: frequency domain optical coherence tomography analysis Cholesterol Crystals Associate With Coronary Plaque Vulnerability In Vivo Plaque vulnerability at non-culprit lesions in obese patients with coronary artery disease: Frequency-domain optical coherence tomography analysis Plaque Microstructures in Patients with Coronary Artery Disease who Achieved Very Low Low-Density Lipoprotein Cholesterol Levels Sex Differences in Nonculprit Coronary Plaque Microstructures on Frequency-Domain Optical Coherence Tomography in Acute Coronary Syndromes and Stable Coronary Artery Disease Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Vulnerable Plaque Features With Statin Therapy in Diabetic Patients With Coronary Artery Disease : Frequency-Domain Optical Coherence Tomography Analysis Triglyceride-to-High-Density Lipoprotein Cholesterol Ratio and Vulnerable Plaque Features With Statin Therapy in Diabetic Patients With Coronary Artery Disease: Frequency-Domain Optical Coherence Tomography Analysis Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals Intravascular ultrasound or optical coherence tomography-defined anatomic severity and hemodynamic severity assessed by coronary physiologic indices