1. Articles from James E. Morgan

    1-3 of 3
    1. Optophysiological Characterisation of Inner Retina Responses with High-Resolution Optical Coherence Tomography

      Optophysiological Characterisation of Inner Retina Responses with High-Resolution Optical Coherence Tomography

      Low coherence laser interferometry has revolutionised quantitative biomedical imaging of optically transparent structures at cellular resolutions. We report the first optical recording of neuronal excitation at cellular resolution in the inner retina by quantifying optically recorded stimulus-evoked responses from the retinal ganglion cell layer and comparing them with an electrophysiological standard. We imaged anaesthetised paralysed tree shrews, gated image acquisition, and used numerical filters to eliminate noise arising from retinal movements during respiratory and cardiac cycles. We observed increases in contrast variability in the retinal ganglion cell layer and nerve fibre layer with flash stimuli and gratings. Regions of interest ...

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    2. Adaptive-Weighted Bilateral Filtering and Other Pre-processing Techniques for Optical Coherence Tomography

      Adaptive-Weighted Bilateral Filtering and Other Pre-processing Techniques for Optical Coherence Tomography

      This paper presents novel pre-processing image enhancement algorithms for retinal optical coherence tomography (OCT). These images contain a large amount of speckle causing them to be grainy and of very low contrast. To make these images valuable for clinical interpretation, we propose a novel method to remove speckle, while preserving useful information contained in each retinal layer. The process starts with multi-scale despeckling based on a dual-tree complex wavelet transform (DT-CWT). We further enhance the OCT image through a smoothing process that uses a novel adaptive-weighted bilateral filter (AWBF). This offers the desirable property of preserving texture within the OCT ...

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    3. Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography

      Optical coherence tomography (OCT) has revolutionises the diagnosis of retinal disease based on the detection of microscopic rather than subcellular changes in retinal anatomy. However, currently the technique is limited to the detection of microscopic rather than subcellular changes in retinal anatomy. However, coherence based imaging is extremely sensitive to both changes in optical contrast and cellular events at the micrometer scale, and can generate subtle changes in the spectral content of the OCT image. Here we test the hypothesis that OCT image speckle (image texture) contains information regarding otherwise unresolvable features such as organelle changes arising in the early ...

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    1-3 of 3
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  2. Topics in the News

    1. (2 articles) Cardiff University
    2. (2 articles) Wolfgang Drexler
    3. (1 articles) Medical University of Vienna
    4. (1 articles) Alexandre R. Tumlinson
    5. (1 articles) Vedran Kajic
    6. (1 articles) Bernd M. Hofer
    7. (1 articles) Sara M. Rey
    8. (1 articles) Boris Považay
    9. (1 articles) Academic Medical Center at the University of Amsterdam
    10. (1 articles) Jichi Medical University
    11. (1 articles) University of Milan
    12. (1 articles) Bern University Hospital
    13. (1 articles) Capital Medical University
    14. (1 articles) Nanjing University of Science and Technology
    15. (1 articles) Martin S. Zinkernagel
    16. (1 articles) Junya Ako
    17. (1 articles) Frank D. Verbraak
    18. (1 articles) Giovanni Staurenghi
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    Non-Invasive Detection of Early Retinal Neuronal Degeneration by Ultrahigh Resolution Optical Coherence Tomography Adaptive-Weighted Bilateral Filtering and Other Pre-processing Techniques for Optical Coherence Tomography Optophysiological Characterisation of Inner Retina Responses with High-Resolution Optical Coherence Tomography Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study Longitudinal retinal layer changes in preclinical Alzheimer’s disease Clinical expert consensus document on rotational atherectomy from the Japanese association of cardiovascular intervention and therapeutics Optical coherence tomography features of choroidal neovascularization and their correlation with age, gender and underlying disease Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II