1. Articles from Michele Carbonelli

    1-11 of 11
    1. Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

      Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

      To evaluate differences in macular and optic disc circulation in patients affected by Wolfram Syndrome (WS) employing optical coherence tomography-angiography (OCTA) imaging. In this retrospective study, 18 eyes from 10 WS patients, 16 eyes of 8 patients affected by type I diabetes and 17 eyes from 17 healthy controls were enrolled. All patients were imaged through OCT and OCTA and vascular parameters, as perfusion density (PD) and vessel length density (VLD) were measured. OCTA showed reduced PD in WS patients at the macular superficial capillary plexus (SCP, 27.8 ± 5.3%), deep vascular complex (DVC, 33.2 ± 1.9%) and ...

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    2. Patterns of retinal ganglion cell damage in neurodegenerative disorders: parvocellular vs magnocellular degeneration in OCT studies

      Patterns of retinal ganglion cell damage in neurodegenerative disorders: parvocellular vs magnocellular degeneration in OCT studies

      Many neurodegenerative disorders, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), are characterized by loss of retinal ganglion cells (RGCs) as part of the neurodegenerative process. Optical coherence tomography (OCT) studies demonstrated variable degree of optic atrophy in these diseases. However, the pattern of degenerative changes affecting the optic nerve can be different. In particular, neurodegeneration is more evident for magnocellular RGCs in AD and multiple system atrophy with a pattern resembling glaucoma. Conversely, in PD and Huntington’s disease the parvocellular RGCs are more vulnerable. This latter pattern closely resembles that of mitochondrial optic neuropathies, possibly ...

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    3. OCT for glaucoma: Today and tomorrow

      OCT for glaucoma: Today and tomorrow

      Spectral-domain optical coherence tomography (SD-OCT) is now an established diagnostic tool for optic nerve diseases such as glaucoma. Since the first studies on glaucomatous eyes were published a decade ago using time-domain OCT (TD-OCT), remarkable advances have been realized. Today ophthalmologists can use SD-OCT to investigate several parameters in cases with any degree of glaucoma. These are derived from the peripapillary retinal nerve fibre layer (RNFL), the optic nerve head (ONH) and the macular ganglion cells (GC). Comprehensive analysis of these data help the clinician in making the diagnosis and following patients up

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    4. Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Purpose: To compare the measurements of the optic nerve head (ONH) parameters provided by time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT). Methods: Four ONH parameters were analyzed: optic disc area, rim area, cup-to-disc area ratio (CDR), and vertical cup-to-disc ratio (VCDR). Stratus OCT and Cirrus HD-OCT were used to obtain measurements by TD-OCT and SD-OCT, respectively. Stratus OCT measurements were collected before and after manual correction of the ONH edges. Results: Twenty healthy participants and 20 patients with glaucomatous eyes were enrolled. Although manual correction of Stratus OCT measurements reduced the differences compared with Cirrus HD-OCT, the latter ...

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    5. Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes

      Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes
      BACKGROUND AND OBJECTIVE To evaluate the repeatability of optic nerve head (ONH) measurements by spectral-domain optical coherence tomography. PATIENTS AND METHODS Three scans were acquired in 32 healthy subjects during one session. Using Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), the cup-to-disc ratio (CDR), disc area, rim area, cup volume, and horizontal and vertical CDRs were investigated. Repeatability was assessed by the coefficient of variation (COV), the test–retest intrasession variability, and the intraclass correlation coefficient (ICC). RESULTS Good repeatability was achieved for all parameters, with a COV of 4.23% or less and ICCs of 0.98 or greater ...
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    6. Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age

      Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age
      Purpose: To measure the retinal nerve fiber layer (RNFL) thickness by means of optical coherence tomography (OCT) in patients with dominant optic atrophy (DOA).Design: Cross-sectional study.Participants: Thirty-three patients from 15 pedigrees with DOA harboring heterozygous mutations in the OPA1 gene and 43 healthy subjects were enrolled.Methods: The RNFLs of DOA patients were studied by OCT and compared with those of 43 healthy subjects matched for age and optic nerve head (ONH) size.Main Outcome Measures: Retinal nerve fiber layer thickness.Results: Dominant optic atrophy patients revealed a significant RNFL thickness reduction in all quadrants, with a preferential ...
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    7. Natural History of Leber's Hereditary Optic Neuropathy: Longitudinal Analysis of the Retinal Nerve Fiber Layer by Optical Coherence Tomography

      Purpose: To investigate by optical coherence tomography (OCT) the topographic pattern and temporal sequence of fiber loss in the peripapillary retinal nerve fiber layer (RNFL) of patients with Leber's hereditary optic neuropathy (LHON) in a longitudinal follow-up.Design: Cohort study.Participants: Six eyes of 4 patients with molecularly defined LHON were enrolled before the subacute period of visual loss.Methods: Subjects were studied by StratusOCT (Carl Zeiss Meditec, Inc., Dublin, CA) during a 9-month follow-up starting from the presymptomatic stage of the disease. Examinations were carried out at 4 different time points: presymptomatic stage, time of visual loss, and ...
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    8. Retinal Nerve Fiber Layer Thickness Measurement by Fourier-domain Optical Coherence Tomography: A Comparison Between Cirrus-HD OCT and RTVue in Healthy Eyes

      Purpose: To compare retinal nerve fiber layer (RNFL) thickness measurements by 2 Fourier-domain optical coherence tomography (OCT) instruments: Cirrus-HD OCT and RTVue. Materials and Methods: Twenty-three eyes of 23 healthy participants underwent RNFL thickness measurement using both devices on the same day. The NMH4 and Optic Disk Cube 200x200 protocols were used, respectively, for scan acquisition with RTVue and Cirrus-HD OCT. Measurements were compared by means of a paired t test. Results: RTVue gave higher mean RNFL thickness values than Cirrus-HD OCT in the superior (128.44+/-22.48 vs. 119.73+/-18.22 [mu], P=0.0002), inferior (137 ...
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    9. Agreement Between Stratus and Visante Optical Coherence Tomography Systems in Tear Meniscus Measurements.

      Aim: To compare the tear meniscus height (TMH) measurements provided by the Stratus and Visante optical coherence tomography systems. Methods: A cross-section image of the lower tear meniscus was captured with both instruments in 26 volunteers. An external application was used to manually measure the TMH as imaged by the Stratus; measurements by the Visante were analyzed by the internal software. Only 1 eye for each subject was considered for statistical analysis. Results: The mean (±SD) TMH was higher when measured by the Visante (0.28 ± 0.12 mm) compared with the Stratus (0.23 ± 0.07 mm, P = 0 ...
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    10. Agreement between optical coherence tomography and digital stereophotography in vertical cup-to-disc ratio measurement

      Abstract Background  Given the increasing popularity of optical coherence tomography in the diagnosis of glaucoma, we aimed to assess agreement between StratusOCT and stereophotography in measuring the vertical cup-to-disc ratio (VCDR) and examine whether it can be improved by changing the StratusOCT cup-offset. Methods  In group 1 (79 eyes), VCDR measurements obtained by StratusOCT (using the default cup-offset of 150 μm above the retinal pigment epithelium) and stereophotography were compared. For each eye, the cup-offset was moved upward or downward until the difference disappeared and an adjusted cup-offset was identified. In group 2 (41 eyes), the stereophotography VCDR was compared ...
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    11. Retinal nerve fiber layer thickness in nonarteritic anterior ischemic optic neuropathy: OCT characterization of the acute and resolving phases

      Abstract Background  To evaluate longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography (OCT). Methods  Prospective, observational case series study. Sixteen eyes from 15 consecutive patients affected with NAION were analyzed. The fellow unaffected eyes served as controls. Patients were divided into three different study groups: (1) patients with visual field (VF) defect confined to the inferior hemifield (five eyes), (2) patients with diffuse VF loss (seven eyes), and (3) patients with central or centrocecal scotoma (four eyes). The main outcome was peripapillary RNFL thickness measurement by ...
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    1-11 of 11
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    1. (7 articles) Carl Zeiss Meditec
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    Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography OCT for glaucoma: Today and tomorrow Patterns of retinal ganglion cell damage in neurodegenerative disorders: parvocellular vs magnocellular degeneration in OCT studies Postdoctoral Fellows/Research Scientists at University of Washington, Seattle Perimeter Medical Imaging AI Announces Publication of Peer-Reviewed Journal Article Validating Potential Use of Wide-Field Optical Coherence Tomography (WF-OCT) in Head and Neck Surgeries Association of retinal thickness and microvasculature with cognitive performance and brain volumes in elderly adults A Deep Learning Framework for the Detection and Quantification of Reticular Pseudodrusen and Drusen on Optical Coherence Tomography Quantitative assessment of textural features in the early detection of diabetic retinopathy with optical coherence tomography angiography Line-field confocal optical coherence tomography of fibroepithelioma of Pinkus Assessment of demineralized tooth lesions using optical coherence tomography and other state-of-the-art technologies: a review