1. Articles from Giacomo Savini

    1-24 of 33 1 2 »
    1. The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

      The Use of Anterior-Segment Optical-Coherence Tomography for the Assessment of the Iridocorneal Angle and Its Alterations: Update and Current Evidence

      The introduction of anterior-segment optical-coherence tomography (AS-OCT) has led to improved assessments of the anatomy of the iridocorneal-angle and diagnoses of several mechanisms of angle closure which often result in raised intraocular pressure (IOP). Continuous advancements in AS-OCT technology and software, along with an extensive research in the field, have resulted in a wide range of possible parameters that may be used to diagnose and follow up on patients with this spectrum of diseases. However, the clinical relevance of such variables needs to be explored thoroughly. The aim of the present review is to summarize the current evidence supporting the ...

      Read Full Article
    2. Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices

      Repeatability of automated measurements by a new anterior segment optical coherence tomographer and biometer and agreement with standard devices

      We assess repeatability of automatic measurements of a new anterior segment optical coherence tomographer and biometer (ANTERION) and their agreement with those provided by an anterior segment-optical coherence tomography device combined with Placido-disk corneal topography (MS-39) and a validated optical biometer (IOLMaster 500). A consecutive series of patients underwent three measurements with ANTERION and one with MS-39. A subgroup of patients underwent biometry also with IOLMaster 500. Repeatability was assessed by means of within-subject standard deviation, coefficient of variation (COV), and intraclass correlation coefficient (ICC). Agreement was investigated with the 95% limits of agreement. Paired t-test and Wilcoxon matched-pairs test ...

      Read Full Article
    3. Agreement Between Two Optical Biometers Based on Large Coherence Length SS-OCT and Scheimpflug Imaging/Partial Coherence Interferometry

      Agreement Between Two Optical Biometers Based on Large Coherence Length SS-OCT and Scheimpflug Imaging/Partial Coherence Interferometry

      PURPOSE: To evaluate the agreement between measurements obtained with a new optical biometer (Argos; Movu Inc) using large coherence length swept-source optical coherence tomography (SS-OCT) and those obtained with an optical biometer with a rotating Scheimpflug camera, combined with partial coherence interferometry (PCI) (Pentacam AXL; Oculus Optikgeräte GmbH) in adults. METHODS: The following measurements were examined and evaluated: axial length, central corneal thickness (CCT), anterior chamber depth (ACD), mean keratometry, J 0 and J 45 vectors, and corneal diameter. Measurements with the two biometers were conducted in triplicate per instrument in a random order by the same examiner. Paired ...

      Read Full Article
      Mentions: Movu
    4. The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging

      The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging

      Purpose To assess the repeatability and reproducibility of swept-source optical coherence tomography (SS-OCT) and Scheimpflug system and evaluate the agreement between the two systems in measuring multiple corneal regions in children. Methods Pachymetric and keratometric maps for both systems were evaluated. Central, midperipheral and peripheral corneal thickness (CT), keratometry and astigmatism power vectors were recorded. The three outcomes yielded by the same observer were used to assess intraobserver repeatability. The differences in the mean values provided by each observer were used to evaluate interobserver reproducibility. Within-subject standard deviation, test-retest repeatability (TRT) and coefficient of variation (CoV) were used to analyze ...

      Read Full Article
    5. Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

      Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

      Purpose . To comprehensively assess the reliability of a new optical biometer (IOLMaster 700), based on swept-source optical coherence tomography (SS-OCT) and comparison with a standard biometer (IOLMaster 500), in healthy children, adults, and cataract patients. Methods . A total of 301 eyes from 301 consecutive subjects were enrolled prospectively. Two experienced operators measured each eye three times consecutively with the IOLMaster 700. The axial length (AL), keratometry (K), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), and white-to-white (WTW) distance were recorded. Intraoperator repeatability and interoperator reproducibility of the IOLMaster 700 were analyzed using the test-retest (TRT), coefficients ...

      Read Full Article
    6. Effect of orthokeratology on precision and agreement assessment of a new swept-source optical coherence tomography biometer

      Effect of orthokeratology on precision and agreement assessment of a new swept-source optical coherence tomography biometer

      Background To evaluate the effect of orthokeratology on precision of measurements in children using a new swept-source optical coherence tomography (SS-OCT) optical biometer (OA-2000), and agreement between its measurements and those provided by the commonly used IOLMaster based on partial coherence interferometry (PCI). Methods This study recruited fifty-one eyes of 51 normal children (8–16 years). An operator took measurements with the two biometers. Then, a second operator took measurements with the SS-OCT biometer. After orthokeratology was performed for one month, the same operators repeated the same procedures. Axial length (AL), mean keratometry (Km) at 2.5 mm and 3 ...

      Read Full Article
    7. Repeatability of anterior segment measurements by optical coherence tomography combined with Placido disk corneal topography in eyes with keratoconus

      Repeatability of anterior segment measurements by optical coherence tomography combined with Placido disk corneal topography in eyes with keratoconus

      Corneal tomography is an important tool to identify and follow up eyes with keratoconus. Our study evaluate the repeatability of the automatic measurements provided in keratoconic eyes by a new anterior-segment optical coherence tomographer (AS-OCT) combined with Placido-disk topography (MS-39, CSO) and assess their agreement with the corresponding measurements taken with a rotating Scheimpflug camera combined with Placido-disk topography (Sirius, CSO). Mean simulated keratometry, posterior and total corneal power, total corneal astigmatism, corneal asphericity, thinnest corneal thickness, epithelial thickness, corneal diameter, and aqueous depth were evaluated. Repeatability was assessed using test–retest variability, the coefficient of variation, and the intraclass ...

      Read Full Article
      Mentions: CSO
    8. Comparison Of Formulas Accuracy For IOL Power Calculation Based On Measurements By A SWEPT-SOURCE Optical Coherence Tomography Optical Biometer

      Comparison Of Formulas Accuracy For IOL Power Calculation Based On Measurements By A SWEPT-SOURCE Optical Coherence Tomography Optical Biometer

      Purpose To analyze the results of intraocular lens (IOL) power calculation using measurements by a swept-source optical coherence tomography (SS-OCT) optical biometer. Setting IRCCS G.B. Bietti Foundation, Rome, Italy. Design Evaluation of a diagnostic test instrument. Methods Preoperative measurements by the OA-2000 (Tomey Inc.) were taken in a consecutive series of patients undergoing cataract surgery with one IOL model (AcrySof SN60WF, Alcon Laboratories, Inc.). Measurements were entered into the following formulas: Barrett Universal II, EVO, Haigis, Hoffer Q, Holladay 1, Holladay 2, Holladay 2 with axial length adjustment, Kane, Olsen, Panacea, SRK/T, T2 and VRF. When refraction was ...

      Read Full Article
    9. Repeatability and reproducibility of optical biometry implemented in a commercially-available optical coherence tomography device and comparison with Lenstar

      Repeatability and reproducibility of optical biometry implemented in a commercially-available optical coherence tomography device and comparison with Lenstar

      P urpose To examine the repeatability and reproducibility of biometry provided by a new anterior-posterior segment spectral-domain optical coherence tomography (SD-OCT) device (Revo NX, Optopol Technology Sp. z o.o., Zawiercie, Poland), and to compare them to those provided by a validated low-coherence optical reflectometry (LCOR) biometer, the Lenstar LS 900. Setting Hygeia Clinic, Gdańsk, Poland Design Prospective evaluation of diagnostic test. Methods Axial length (AL), lens thickness (LT), central corneal thickness (CCT) and anterior chamber depth (ACD, corneal epithelium to lens) were measured in 63 eyes of 63 patients. Two skilled operators, in random order, obtained three measurements with ...

      Read Full Article
    10. Comparison of anterior segment measurements obtained using a swept-source optical coherence tomography biometer and a Scheimpflug–Placido tomographer

      Comparison of anterior segment measurements obtained using a swept-source optical coherence tomography biometer and a Scheimpflug–Placido tomographer

      Purpose To assess the repeatability and agreement of anterior segment measurements between an optical biometer (IOLMaster 700) using swept-source optical coherence tomography and a Scheimpflug–Placido tomographer (Sirius) in patients scheduled for corneal refractive surgery. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Prospective case series. Methods The parameters, including the central corneal thickness (CCT), anterior chamber depth (ACD), aqueous depth, keratometry (K) values, astigmatism, J0 (Jackson cross-cylinder with axes at 180 degree and 90 degrees) and J45 vectors (Jackson cross-cylinder with axes at 45 degrees and 135 degrees), and horizontal corneal diameter, were measured 3 times per ...

      Read Full Article
    11. Precision of a new ocular biometer in eyes with cataract using swept source optical coherence tomography combined with Placido-disk corneal topography

      Precision of a new ocular biometer in eyes with cataract using swept source optical coherence tomography combined with Placido-disk corneal topography

      The present study was to assess the precision (repeatability and reproducibility) of a new optical biometer (OA-2000, Tomey, Japan) based on swept-source optical coherence tomography (SS-OCT) and Placido disk topography in eyes with cataracts. Seventy-eight eyes from seventy-eight patients with cataracts were evaluated. Axial length (AL), anterior chamber depth (ACD), keratometry (K) over a 2.5 mm and 3.0 mm diameter, lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) distance were measured by 2 skilled operators. OA-2000 measurements were highly repeatable and reproducible for all parameters (intraclass correlation, 0.925 to 1.000). OA-2000 derived K-values with ...

      Read Full Article
    12. Accuracy of a New Swept-Source Optical Coherence Tomography Biometer for IOL Power Calculation and Comparison to IOLMaster

      Accuracy of a New Swept-Source Optical Coherence Tomography Biometer for IOL Power Calculation and Comparison to IOLMaster

      PURPOSE: To investigate the accuracy of the measurements provided by a new optical biometer (OA-2000, Tomey Corporation, Nagoya, Japan) for calculating the intraocular lens (IOL) power and to compare the refractive outcomes to those obtained with the IOLMaster 500 (Carl Zeiss Meditec, Jena, Germany). METHODS: In this interventional multicenter study, consecutive patients having cataract surgery were enrolled. Only the IOL model used in the largest sample of patients was selected and the eyes implanted with that IOL were subsequently analyzed. The OA-2000, an optical biometer based on swept-source optical coherence tomography (SS-OCT), was used to measure axial length and corneal ...

      Read Full Article
    13. Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      To the Editor: We read with interest the study by Goto et al, 1 who described a new formula to predict the postoperative position of the intraocular lens (IOL). Although their results are interesting and might be useful for IOL power calculation, we feel that some comments are necessary. First, comparing what they define as the “postoperative external anterior chamber depth,” either measured or predicted by anterior segment optical coherence tomography, to the IOL position, as predicted by thin lens formulas, is not the proper method. The measurements performed by the authors, in fact, refer to a thick lens system ...

      Read Full Article
    14. Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

      Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

      Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and ...

      Read Full Article
    15. Repeatability and interobserver reproducibility of a new optical biometer based on swept-source optical coherence tomography and comparison with IOLMaster

      Repeatability and interobserver reproducibility of a new optical biometer based on swept-source optical coherence tomography and comparison with IOLMaster

      Objective To evaluate the precision of the measurements in healthy subjects obtained with a new optical biometer (OA-2000, Tomey, Nagoya, Japan) using swept-source optical coherence tomography (SS-OCT) and compare these measurements with those provided by the IOLMaster v5.4 (Carl Zeiss Meditec AG, Jena, Germany) using partial coherence interferometry (PCI). Methods Axial length (AL), keratometry (K) over 2.5 mm and 3.0 mm diameters, anterior chamber depth (ACD) (corneal epithelium to lens), lens thickness (LT), central corneal thickness and corneal diameter (CD) were measured with SS-OCT by two experienced operators. Intraobserver repeatability and interobserver reproducibility were assessed. AL, ACD ...

      Read Full Article
    16. Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Purpose To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR). Setting Private practice, Castrop-Rouxelle, Germany. Design Prospective evaluation of diagnostic test. Methods Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients. Analyses used a paired t test, Pearson correlation coefficient ( r ), and Bland-Altman plots. Intraocular lens (IOL) power calculations were compared using the Hoffer Q, Holladay 1, and SRK/T formulas. Results The difference in ...

      Read Full Article
      Mentions: UCLA
    17. The Repeatability Assessment of Three-Dimensional Capsule-Intraocular Lens Complex Measurements by Means of High-Speed Swept-Source Optical Coherence Tomography

      The Repeatability Assessment of Three-Dimensional Capsule-Intraocular Lens Complex Measurements by Means of High-Speed Swept-Source Optical Coherence Tomography

      Purpose To rebuild the three-dimensional (3-D) model of the anterior segment by high-speed swept-source optical coherence tomography (SSOCT) and evaluate the repeatability of measurement for the parameters of capsule-intraocular lens (C-IOL) complex. Methods Twenty-two pseudophakic eyes from 22 patients were enrolled. Three continuous SSOCT measurements were performed in all eyes and the tomograms obtained were used for 3-D reconstruction. The output data were used to evaluate the measurement repeatability. The parameters included postoperative aqueous depth (PAD), the area and diameter of the anterior capsule opening (Area and D), IOL tilt (IOL-T), horizontal, vertical, and space decentration of the IOL, anterior ...

      Read Full Article
    18. Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Purpose: To assess the repeatability and reproducibility of corneal power values obtained by a Fourier-domain optical coherence tomography (FD-OCT) system (RTVue) and to compare them with the values obtained by a Scheimpflug camera system (Pentacam HR) and by automated keratometry (IOL Master). Methods: Thirty-two eyes from 32 healthy subjects were included in this prospective study. Two experienced observers measured each eye 3 consecutive times with the Pentacam, IOLMaster, and RTVue centered on either the pupil or corneal vertex. The conventional keratometry equivalent (CKE) and anterior (Ka), posterior (Kp), and net (Kn) corneal power values were determined. Results: The corneal power ...

      Read Full Article
    19. Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Purpose To determine the repeatability, reproducibility, and agreement of anterior chamber depth (ACD) measurements obtained with 3 Scheimpflug cameras and an anterior segment optical coherence tomography (AS-OCT) device. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Observational cross-sectional study. Methods Two observers took 3 consecutive measurements in healthy right eyes using each device to assess intraoperator repeatability. The mean values obtained at different sessions by the first operator were used to determine the intersession reproducibility. Three consecutive measurements obtained by the first operator at the first session were averaged and used to assess agreement. Results The ACD measurements ...

      Read Full Article
    20. Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Purpose To compare corneal thickness measurements using Pentacam (Oculus, Germany), Sirius (CSO, Italy), Galilei (Ziemer, Switzerland), and RTVue-100 OCT (Optovue Inc., USA). Methods Sixty-six eyes of 66 healthy volunteers were enrolled. Three consecutive measurements were performed with each device. The mean value of the three measurements was used for subsequent analysis. Central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT; measured at superior, inferior, nasal, and temporal locations with a distance of 1 mm (CT 2mm ) or 2.5 mm (CT 5mm ) from the corneal apex) were analyzed. Differences and agreement between measurements were assessed using ...

      Read Full Article
    21. A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      Purpose To assess the repeatability and reproducibility of 3 rotating Scheimpflug cameras, the Pentacam (Oculus, Wetzlar, Germany), Sirius (Costruzione Strumenti Oftalmici, Florence, Italy), and Galilei (Ziemer, Biel, Switzerland), and 1 Fourier-domain optical coherence tomography (FD-OCT) system, the RTvue-100 OCT (Optovue Inc., Fremont, CA), in measuring corneal thickness. Design Evaluation of diagnostic test. Participants Sixty-six right eyes of 66 healthy volunteers, whose mean age ± standard deviation (SD) was 35.39±10.06 years (range, 18–55 years). Methods Corneal thickness measurements obtained by each system included central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT), measured at ...

      Read Full Article
    22. Choroidal Thickness Measurements

      Choroidal Thickness Measurements

      We read with interest recent article by Branchini et al, entitled “Reproducibility of choroidal thickness measurements across 3 spectral domain optical coherence tomography systems.” We commend the authors for their efforts in comparing these instruments, but we feel that their statistical methods may lead to invalid conclusions. The authors claimed to have investigated the reproducibility of choroidal thickness measurements by 3 different spectral domain optical coherence tomography devices, stating there is “good reproducibility among choroidal thickness measurements of images acquired with Cirrus, Spectralis, and RTVue.” The conclusion was based upon the result that there was a high correlation between repeated ...

      Read Full Article
    23. OCT for glaucoma: Today and tomorrow

      OCT for glaucoma: Today and tomorrow

      Spectral-domain optical coherence tomography (SD-OCT) is now an established diagnostic tool for optic nerve diseases such as glaucoma. Since the first studies on glaucomatous eyes were published a decade ago using time-domain OCT (TD-OCT), remarkable advances have been realized. Today ophthalmologists can use SD-OCT to investigate several parameters in cases with any degree of glaucoma. These are derived from the peripapillary retinal nerve fibre layer (RNFL), the optic nerve head (ONH) and the macular ganglion cells (GC). Comprehensive analysis of these data help the clinician in making the diagnosis and following patients up

      Read Full Article
    24. Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Purpose: To compare the measurements of the optic nerve head (ONH) parameters provided by time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT). Methods: Four ONH parameters were analyzed: optic disc area, rim area, cup-to-disc area ratio (CDR), and vertical cup-to-disc ratio (VCDR). Stratus OCT and Cirrus HD-OCT were used to obtain measurements by TD-OCT and SD-OCT, respectively. Stratus OCT measurements were collected before and after manual correction of the ONH edges. Results: Twenty healthy participants and 20 patients with glaucomatous eyes were enrolled. Although manual correction of Stratus OCT measurements reduced the differences compared with Cirrus HD-OCT, the latter ...

      Read Full Article
    1-24 of 33 1 2 »
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (10 articles) Carl Zeiss Meditec
    2. (8 articles) Wenzhou Medical College
    3. (5 articles) University of Bologna
    4. (5 articles) University of Southern California
    5. (5 articles) Optovue
    6. (3 articles) Tomey Corporation
    7. (2 articles) UCLA
    8. (2 articles) CSO
    9. (2 articles) Heidelberg Engineering
    10. (1 articles) Center for Ophthalmic Optics and Lasers
    11. (1 articles) FDA
    12. (1 articles) Optos
    13. (1 articles) Avinger
    14. (1 articles) Voxeleron
    15. (1 articles) Perimeter Medical Imaging
  3. Popular Articles

  4. Picture Gallery

    Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography Choroidal Thickness Measurements Clinical Trials Critical for the Evaluation of Advanced Medical Imaging Tools Voxeleron Welcomes Manabu Tokunaga as new Director of Software Accuracy of Diabetic Retinopathy Staging with a Deep Convolutional Neural Network Using Ultra-Wide-Field Fundus Ophthalmoscopy and Optical Coherence Tomography Angiography A longitudinal comparison in cynomolgus macaques of the effect of brimonidine on optic nerve neuropathy using diffusion tensor imaging magnetic resonance imaging and spectral domain optical coherence tomography Design of 1300-nm spectral domain optical coherence tomography angiography system for iris microvascular imaging Perimeter Medical Imaging AI Announces Important Milestone in ATLAS AI Project with Standalone AI Algorithm Achieving Key Performance Metrics Towards ‘automated gonioscopy’: a deep learning algorithm for 360° angle assessment by swept-source optical coherence tomography Intraoperative Observation of a Macular Holes Using Optical Coherence Tomography