1. Articles from Giacomo Savini

    1-24 of 30 1 2 »
    1. The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging

      The precision and agreement of corneal thickness and keratometry measurements with SS-OCT versus Scheimpflug imaging

      Purpose To assess the repeatability and reproducibility of swept-source optical coherence tomography (SS-OCT) and Scheimpflug system and evaluate the agreement between the two systems in measuring multiple corneal regions in children. Methods Pachymetric and keratometric maps for both systems were evaluated. Central, midperipheral and peripheral corneal thickness (CT), keratometry and astigmatism power vectors were recorded. The three outcomes yielded by the same observer were used to assess intraobserver repeatability. The differences in the mean values provided by each observer were used to evaluate interobserver reproducibility. Within-subject standard deviation, test-retest repeatability (TRT) and coefficient of variation (CoV) were used to analyze ...

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    2. Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

      Reliability of a New Swept-Source Optical Coherence Tomography Biometer in Healthy Children, Adults, and Cataract Patients

      Purpose . To comprehensively assess the reliability of a new optical biometer (IOLMaster 700), based on swept-source optical coherence tomography (SS-OCT) and comparison with a standard biometer (IOLMaster 500), in healthy children, adults, and cataract patients. Methods . A total of 301 eyes from 301 consecutive subjects were enrolled prospectively. Two experienced operators measured each eye three times consecutively with the IOLMaster 700. The axial length (AL), keratometry (K), anterior chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT), and white-to-white (WTW) distance were recorded. Intraoperator repeatability and interoperator reproducibility of the IOLMaster 700 were analyzed using the test-retest (TRT), coefficients ...

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    3. Effect of orthokeratology on precision and agreement assessment of a new swept-source optical coherence tomography biometer

      Effect of orthokeratology on precision and agreement assessment of a new swept-source optical coherence tomography biometer

      Background To evaluate the effect of orthokeratology on precision of measurements in children using a new swept-source optical coherence tomography (SS-OCT) optical biometer (OA-2000), and agreement between its measurements and those provided by the commonly used IOLMaster based on partial coherence interferometry (PCI). Methods This study recruited fifty-one eyes of 51 normal children (8–16 years). An operator took measurements with the two biometers. Then, a second operator took measurements with the SS-OCT biometer. After orthokeratology was performed for one month, the same operators repeated the same procedures. Axial length (AL), mean keratometry (Km) at 2.5 mm and 3 ...

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    4. Repeatability of anterior segment measurements by optical coherence tomography combined with Placido disk corneal topography in eyes with keratoconus

      Repeatability of anterior segment measurements by optical coherence tomography combined with Placido disk corneal topography in eyes with keratoconus

      Corneal tomography is an important tool to identify and follow up eyes with keratoconus. Our study evaluate the repeatability of the automatic measurements provided in keratoconic eyes by a new anterior-segment optical coherence tomographer (AS-OCT) combined with Placido-disk topography (MS-39, CSO) and assess their agreement with the corresponding measurements taken with a rotating Scheimpflug camera combined with Placido-disk topography (Sirius, CSO). Mean simulated keratometry, posterior and total corneal power, total corneal astigmatism, corneal asphericity, thinnest corneal thickness, epithelial thickness, corneal diameter, and aqueous depth were evaluated. Repeatability was assessed using test–retest variability, the coefficient of variation, and the intraclass ...

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    5. Comparison Of Formulas Accuracy For IOL Power Calculation Based On Measurements By A SWEPT-SOURCE Optical Coherence Tomography Optical Biometer

      Comparison Of Formulas Accuracy For IOL Power Calculation Based On Measurements By A SWEPT-SOURCE Optical Coherence Tomography Optical Biometer

      Purpose To analyze the results of intraocular lens (IOL) power calculation using measurements by a swept-source optical coherence tomography (SS-OCT) optical biometer. Setting IRCCS G.B. Bietti Foundation, Rome, Italy. Design Evaluation of a diagnostic test instrument. Methods Preoperative measurements by the OA-2000 (Tomey Inc.) were taken in a consecutive series of patients undergoing cataract surgery with one IOL model (AcrySof SN60WF, Alcon Laboratories, Inc.). Measurements were entered into the following formulas: Barrett Universal II, EVO, Haigis, Hoffer Q, Holladay 1, Holladay 2, Holladay 2 with axial length adjustment, Kane, Olsen, Panacea, SRK/T, T2 and VRF. When refraction was ...

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    6. Repeatability and reproducibility of optical biometry implemented in a commercially-available optical coherence tomography device and comparison with Lenstar

      Repeatability and reproducibility of optical biometry implemented in a commercially-available optical coherence tomography device and comparison with Lenstar

      P urpose To examine the repeatability and reproducibility of biometry provided by a new anterior-posterior segment spectral-domain optical coherence tomography (SD-OCT) device (Revo NX, Optopol Technology Sp. z o.o., Zawiercie, Poland), and to compare them to those provided by a validated low-coherence optical reflectometry (LCOR) biometer, the Lenstar LS 900. Setting Hygeia Clinic, Gdańsk, Poland Design Prospective evaluation of diagnostic test. Methods Axial length (AL), lens thickness (LT), central corneal thickness (CCT) and anterior chamber depth (ACD, corneal epithelium to lens) were measured in 63 eyes of 63 patients. Two skilled operators, in random order, obtained three measurements with ...

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    7. Comparison of anterior segment measurements obtained using a swept-source optical coherence tomography biometer and a Scheimpflug–Placido tomographer

      Comparison of anterior segment measurements obtained using a swept-source optical coherence tomography biometer and a Scheimpflug–Placido tomographer

      Purpose To assess the repeatability and agreement of anterior segment measurements between an optical biometer (IOLMaster 700) using swept-source optical coherence tomography and a Scheimpflug–Placido tomographer (Sirius) in patients scheduled for corneal refractive surgery. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Prospective case series. Methods The parameters, including the central corneal thickness (CCT), anterior chamber depth (ACD), aqueous depth, keratometry (K) values, astigmatism, J0 (Jackson cross-cylinder with axes at 180 degree and 90 degrees) and J45 vectors (Jackson cross-cylinder with axes at 45 degrees and 135 degrees), and horizontal corneal diameter, were measured 3 times per ...

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    8. Precision of a new ocular biometer in eyes with cataract using swept source optical coherence tomography combined with Placido-disk corneal topography

      Precision of a new ocular biometer in eyes with cataract using swept source optical coherence tomography combined with Placido-disk corneal topography

      The present study was to assess the precision (repeatability and reproducibility) of a new optical biometer (OA-2000, Tomey, Japan) based on swept-source optical coherence tomography (SS-OCT) and Placido disk topography in eyes with cataracts. Seventy-eight eyes from seventy-eight patients with cataracts were evaluated. Axial length (AL), anterior chamber depth (ACD), keratometry (K) over a 2.5 mm and 3.0 mm diameter, lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) distance were measured by 2 skilled operators. OA-2000 measurements were highly repeatable and reproducible for all parameters (intraclass correlation, 0.925 to 1.000). OA-2000 derived K-values with ...

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    9. Accuracy of a New Swept-Source Optical Coherence Tomography Biometer for IOL Power Calculation and Comparison to IOLMaster

      Accuracy of a New Swept-Source Optical Coherence Tomography Biometer for IOL Power Calculation and Comparison to IOLMaster

      PURPOSE: To investigate the accuracy of the measurements provided by a new optical biometer (OA-2000, Tomey Corporation, Nagoya, Japan) for calculating the intraocular lens (IOL) power and to compare the refractive outcomes to those obtained with the IOLMaster 500 (Carl Zeiss Meditec, Jena, Germany). METHODS: In this interventional multicenter study, consecutive patients having cataract surgery were enrolled. Only the IOL model used in the largest sample of patients was selected and the eyes implanted with that IOL were subsequently analyzed. The OA-2000, an optical biometer based on swept-source optical coherence tomography (SS-OCT), was used to measure axial length and corneal ...

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    10. Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      Re: Goto et al.: Prediction of postoperative intraocular lens position with angle-to-angle depth using anterior segment optical coherence tomography (Ophthalmology. 2016;123:2474-2480)

      To the Editor: We read with interest the study by Goto et al, 1 who described a new formula to predict the postoperative position of the intraocular lens (IOL). Although their results are interesting and might be useful for IOL power calculation, we feel that some comments are necessary. First, comparing what they define as the “postoperative external anterior chamber depth,” either measured or predicted by anterior segment optical coherence tomography, to the IOL position, as predicted by thin lens formulas, is not the proper method. The measurements performed by the authors, in fact, refer to a thick lens system ...

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      Mentions: Giacomo Savini
    11. Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

      Optical coherence tomography angiography of the peripapillary retina and optic nerve head in dominant optic atrophy

      Peripapillar and nerve head vessel density (VD) was measured in 10 patients affected by Dominant optic atrophy (DOA) using optical coherence tomography angiography (OCT-A) and compared to the measurements of 15 age- and gender-matched controls. DOA patients showed VD reduction, mostly in the temporal and inferotemporal peripapillary sectors, according to the preferential involvement of the papillomacular bundle. Despite poor best-corrected visual acuity (BCVA), OCT-A revealed good repeatability. VD correlated with functional (mean deviation of visual field and BCVA) and structural (retinal nerve fiber layer thickness) parameters and could be a non-invasive, quantitative tool for the monitoring of the disease and ...

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    12. Repeatability and interobserver reproducibility of a new optical biometer based on swept-source optical coherence tomography and comparison with IOLMaster

      Repeatability and interobserver reproducibility of a new optical biometer based on swept-source optical coherence tomography and comparison with IOLMaster

      Objective To evaluate the precision of the measurements in healthy subjects obtained with a new optical biometer (OA-2000, Tomey, Nagoya, Japan) using swept-source optical coherence tomography (SS-OCT) and compare these measurements with those provided by the IOLMaster v5.4 (Carl Zeiss Meditec AG, Jena, Germany) using partial coherence interferometry (PCI). Methods Axial length (AL), keratometry (K) over 2.5 mm and 3.0 mm diameters, anterior chamber depth (ACD) (corneal epithelium to lens), lens thickness (LT), central corneal thickness and corneal diameter (CD) were measured with SS-OCT by two experienced operators. Intraobserver repeatability and interobserver reproducibility were assessed. AL, ACD ...

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    13. Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Comparison of a new optical biometer using swept-source optical coherence tomography and a biometer using optical low-coherence reflectometry

      Purpose To investigate agreement between the IOLMaster 700 based on swept-source optical coherence tomography (SS-OCT) and the Lenstar LS 900 based on optical low-coherence reflectometry (OLCR). Setting Private practice, Castrop-Rouxelle, Germany. Design Prospective evaluation of diagnostic test. Methods Axial length (AL), keratometry (K), anterior chamber depth (corneal epithelium to lens) (ACD), lens thickness, and central corneal thickness (CCT) were measured in 183 eyes of 183 patients. Analyses used a paired t test, Pearson correlation coefficient ( r ), and Bland-Altman plots. Intraocular lens (IOL) power calculations were compared using the Hoffer Q, Holladay 1, and SRK/T formulas. Results The difference in ...

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      Mentions: Giacomo Savini UCLA
    14. The Repeatability Assessment of Three-Dimensional Capsule-Intraocular Lens Complex Measurements by Means of High-Speed Swept-Source Optical Coherence Tomography

      The Repeatability Assessment of Three-Dimensional Capsule-Intraocular Lens Complex Measurements by Means of High-Speed Swept-Source Optical Coherence Tomography

      Purpose To rebuild the three-dimensional (3-D) model of the anterior segment by high-speed swept-source optical coherence tomography (SSOCT) and evaluate the repeatability of measurement for the parameters of capsule-intraocular lens (C-IOL) complex. Methods Twenty-two pseudophakic eyes from 22 patients were enrolled. Three continuous SSOCT measurements were performed in all eyes and the tomograms obtained were used for 3-D reconstruction. The output data were used to evaluate the measurement repeatability. The parameters included postoperative aqueous depth (PAD), the area and diameter of the anterior capsule opening (Area and D), IOL tilt (IOL-T), horizontal, vertical, and space decentration of the IOL, anterior ...

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      Mentions: Giacomo Savini
    15. Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Corneal Power Measurement Obtained by Fourier-Domain Optical Coherence Tomography: Repeatability, Reproducibility, and Comparison With Scheimpflug and Automated Keratometry Measurements

      Purpose: To assess the repeatability and reproducibility of corneal power values obtained by a Fourier-domain optical coherence tomography (FD-OCT) system (RTVue) and to compare them with the values obtained by a Scheimpflug camera system (Pentacam HR) and by automated keratometry (IOL Master). Methods: Thirty-two eyes from 32 healthy subjects were included in this prospective study. Two experienced observers measured each eye 3 consecutive times with the Pentacam, IOLMaster, and RTVue centered on either the pupil or corneal vertex. The conventional keratometry equivalent (CKE) and anterior (Ka), posterior (Kp), and net (Kn) corneal power values were determined. Results: The corneal power ...

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    16. Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Anterior chamber depth measurements using Scheimpflug imaging and optical coherence tomography: Repeatability, reproducibility, and agreement

      Purpose To determine the repeatability, reproducibility, and agreement of anterior chamber depth (ACD) measurements obtained with 3 Scheimpflug cameras and an anterior segment optical coherence tomography (AS-OCT) device. Setting Eye Hospital of Wenzhou Medical University, Zhejiang, China. Design Observational cross-sectional study. Methods Two observers took 3 consecutive measurements in healthy right eyes using each device to assess intraoperator repeatability. The mean values obtained at different sessions by the first operator were used to determine the intersession reproducibility. Three consecutive measurements obtained by the first operator at the first session were averaged and used to assess agreement. Results The ACD measurements ...

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    17. Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Central and midperipheral corneal thickness measured with scheimpflug imaging and optical coherence tomography

      Purpose To compare corneal thickness measurements using Pentacam (Oculus, Germany), Sirius (CSO, Italy), Galilei (Ziemer, Switzerland), and RTVue-100 OCT (Optovue Inc., USA). Methods Sixty-six eyes of 66 healthy volunteers were enrolled. Three consecutive measurements were performed with each device. The mean value of the three measurements was used for subsequent analysis. Central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT; measured at superior, inferior, nasal, and temporal locations with a distance of 1 mm (CT 2mm ) or 2.5 mm (CT 5mm ) from the corneal apex) were analyzed. Differences and agreement between measurements were assessed using ...

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    18. A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      A Comparison between Scheimpflug Imaging and Optical Coherence Tomography in Measuring Corneal Thickness

      Purpose To assess the repeatability and reproducibility of 3 rotating Scheimpflug cameras, the Pentacam (Oculus, Wetzlar, Germany), Sirius (Costruzione Strumenti Oftalmici, Florence, Italy), and Galilei (Ziemer, Biel, Switzerland), and 1 Fourier-domain optical coherence tomography (FD-OCT) system, the RTvue-100 OCT (Optovue Inc., Fremont, CA), in measuring corneal thickness. Design Evaluation of diagnostic test. Participants Sixty-six right eyes of 66 healthy volunteers, whose mean age ± standard deviation (SD) was 35.39±10.06 years (range, 18–55 years). Methods Corneal thickness measurements obtained by each system included central corneal thickness (CCT), thinnest corneal thickness (TCT), and midperipheral corneal thickness (MPCT), measured at ...

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    19. Choroidal Thickness Measurements

      Choroidal Thickness Measurements

      We read with interest recent article by Branchini et al, entitled “Reproducibility of choroidal thickness measurements across 3 spectral domain optical coherence tomography systems.” We commend the authors for their efforts in comparing these instruments, but we feel that their statistical methods may lead to invalid conclusions. The authors claimed to have investigated the reproducibility of choroidal thickness measurements by 3 different spectral domain optical coherence tomography devices, stating there is “good reproducibility among choroidal thickness measurements of images acquired with Cirrus, Spectralis, and RTVue.” The conclusion was based upon the result that there was a high correlation between repeated ...

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    20. OCT for glaucoma: Today and tomorrow

      OCT for glaucoma: Today and tomorrow

      Spectral-domain optical coherence tomography (SD-OCT) is now an established diagnostic tool for optic nerve diseases such as glaucoma. Since the first studies on glaucomatous eyes were published a decade ago using time-domain OCT (TD-OCT), remarkable advances have been realized. Today ophthalmologists can use SD-OCT to investigate several parameters in cases with any degree of glaucoma. These are derived from the peripapillary retinal nerve fibre layer (RNFL), the optic nerve head (ONH) and the macular ganglion cells (GC). Comprehensive analysis of these data help the clinician in making the diagnosis and following patients up

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    21. Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Comparison of Optic Nerve Head Parameter Measurements Obtained by Time-domain and Spectral-domain Optical Coherence Tomography

      Purpose: To compare the measurements of the optic nerve head (ONH) parameters provided by time-domain (TD) and spectral-domain (SD) optical coherence tomography (OCT). Methods: Four ONH parameters were analyzed: optic disc area, rim area, cup-to-disc area ratio (CDR), and vertical cup-to-disc ratio (VCDR). Stratus OCT and Cirrus HD-OCT were used to obtain measurements by TD-OCT and SD-OCT, respectively. Stratus OCT measurements were collected before and after manual correction of the ONH edges. Results: Twenty healthy participants and 20 patients with glaucomatous eyes were enrolled. Although manual correction of Stratus OCT measurements reduced the differences compared with Cirrus HD-OCT, the latter ...

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    22. Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes

      Repeatability of Optic Nerve Head Parameters Measured by Spectral-Domain OCT in Healthy Eyes
      BACKGROUND AND OBJECTIVE To evaluate the repeatability of optic nerve head (ONH) measurements by spectral-domain optical coherence tomography. PATIENTS AND METHODS Three scans were acquired in 32 healthy subjects during one session. Using Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA), the cup-to-disc ratio (CDR), disc area, rim area, cup volume, and horizontal and vertical CDRs were investigated. Repeatability was assessed by the coefficient of variation (COV), the test–retest intrasession variability, and the intraclass correlation coefficient (ICC). RESULTS Good repeatability was achieved for all parameters, with a COV of 4.23% or less and ICCs of 0.98 or greater ...
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    23. Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age

      Retinal Nerve Fiber Layer Thickness in Dominant Optic Atrophy: Measurements by Optical Coherence Tomography and Correlation with Age
      Purpose: To measure the retinal nerve fiber layer (RNFL) thickness by means of optical coherence tomography (OCT) in patients with dominant optic atrophy (DOA).Design: Cross-sectional study.Participants: Thirty-three patients from 15 pedigrees with DOA harboring heterozygous mutations in the OPA1 gene and 43 healthy subjects were enrolled.Methods: The RNFLs of DOA patients were studied by OCT and compared with those of 43 healthy subjects matched for age and optic nerve head (ONH) size.Main Outcome Measures: Retinal nerve fiber layer thickness.Results: Dominant optic atrophy patients revealed a significant RNFL thickness reduction in all quadrants, with a preferential ...
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    1-24 of 30 1 2 »
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    1. (25 articles) Giacomo Savini
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