1. Articles from Yan Chen

    1-6 of 6
    1. Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography

      Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography

      Homozygous familial hypercholesterolemia developed into severe cardiovascular consequences early. Untreated HoFH usually cannot survive over 30 years old. Acute coronary syndrome(ACS) caused by plaque rupture is one of the main causes of death in HoFH. As the highest resolution intravascular imaging technique, optical coherence tomography(OCT) can clearly show the thickness and structural characteristics of atherosclerotic plaque caps. In this study, a Chinese male HoFH received percutaneous coronary intervention for unstable angina . After analyzed his genetic and follow-up data, OCT was performed during interventional therapy . Multiple lipid rich plaques accompanied with inflammatory cell infiltration and a thin-cap fibroatheroma(TCFA ...

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    2. Automatic spectral calibration for polarization-sensitive optical coherence tomography

      Automatic spectral calibration for polarization-sensitive optical coherence tomography

      Accurate wavelength assignment is important for Fourier domain polarizationsensitive optical coherence tomography. Incorrect wavelength mapping between the orthogonal horizontal (H) and vertical (V) polarization channels leads to broadening the axial point spread function and generating polarization artifacts. To solve the problem, we propose an automatic spectral calibration method by seeking the optimal calibration coefficient between wavenumber kH and kV. The method first performs a rough calibration to get the relationship between the wavelength λ and the pixel number x of the CCD for each channel. And then a precise calibration is taken to bring both polarization interferograms in the same k ...

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    3. Depth-dependent dispersion compensation for full-depth OCT image

      Depth-dependent dispersion compensation for full-depth OCT image

      A depth-dependent dispersion compensation algorithm for enhancing the image quality of the Fourier-domain optical coherence tomography (OCT) is presented. The dispersion related with depth in the sample is considered. Using the iterative method, an analytical formula for compensating the depth-dependent dispersion in the sample is obtained. We apply depth-dependent dispersion compensation algorithm to process the phantom images and in vivo images. Using sharpness metric based on variation coefficient to compare the results processed with different dispersion compensation algorithms, we find that the depth-dependent dispersion compensation algorithm can improve image quality at full depth.

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    4. Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Background To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them. Methods Thirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location. Agreement was analyzed by mean difference (AS-OCT minus IVCM), 95 % limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis. Results The average ...

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    5. Full-range Fourier domain polarization-sensitive optical coherence tomography using sinusoidal phase modulation

      Full-range Fourier domain polarization-sensitive optical coherence tomography using sinusoidal phase modulation

      We present a full-range Fourier domain polarization-sensitive optical coherence tomography technique which is able to obtain images of retardance, fast optical axis and intensity of sample. In this technique, the sinusoidal phase modulation is introduced into the spectral interferograms while the probe beam scans over the sample (B-scan). Then the complex horizontal and vertical signals are reconstructed by demodulation. By the Fourier transformation of the two interferograms, the full range images are obtained. Herein, the typical linear phase modulation is modified to sinusoidal phase modulation, which improves the system tolerance of sample movements and avoids sensitivity fall-off along the transverse ...

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    6. Full-range Fourier domain Doppler optical coherence tomography based on sinusoidal phase modulation

      Full-range Fourier domain Doppler optical coherence tomography based on sinusoidal phase modulation

      A novel full-range Fourier domain Doppler optical coherence tomography (full-range FD-DOCT) using sinusoidal phase modulation for B-M scan is proposed. In this sinusoidal B-M scan, zero optical path difference (OPD) position does not move corresponding to lateral scanning points in contrast to linear B-M scan. Since high phase sensitivity arises around the zero OPD position, the proposed full-range FD-DOCT can achieve easily high velocity sensitivity without mirror image around the zero OPD position. Velocity sensitivity dependent on the OPD and the interval of scanning points is examined, and flow velocity detection capability is verified through Doppler imaging of a flow ...

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    1-6 of 6
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  2. Topics in the News

    1. (3 articles) Chinese Academy of Sciences
    2. (1 articles) Capital Medical University
    3. (1 articles) Carl Zeiss Meditec
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    Full-range Fourier domain Doppler optical coherence tomography based on sinusoidal phase modulation Full-range Fourier domain polarization-sensitive optical coherence tomography using sinusoidal phase modulation Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy Depth-dependent dispersion compensation for full-depth OCT image Automatic spectral calibration for polarization-sensitive optical coherence tomography Percutaneous coronary intervention for a Chinese familial hypercholesterolemia homozygous under the guidance of optical coherence tomography The truth about invisible posterior vitreous structures Increased Macrophage-like Cell Density in Retinal Vein Occlusion as Characterized by en Face Optical Coherence Tomography The Influence of Eyelid Position and Environmental Conditions on the Corneal Changes in Early Postmortem Interval: A Prospective, Multicentric OCT Study The Use of Optical Coherence Tomography for Gross Examination and Sampling of Fixed Breast Specimens: A Pilot Study The Role of Widefield and Ultra Widefield Optical Coherence Tomography in the Diagnosis and Management of Vitreoretinal Diseases Acute Idiopathic Blind Spot Enlargement Syndrome-New Perspectives in the OCT Era