1. Articles from Seiichi Hirota

    1-8 of 8
    1. Tangential Signal Dropout Mimicking the Appearance of Lipid-rich Plaques and Macrophage Infiltration on Optical Frequency Domain Imaging

      Tangential Signal Dropout Mimicking the Appearance of Lipid-rich Plaques and Macrophage Infiltration on Optical Frequency Domain Imaging

      Aims: This study evaluated the optical frequency domain imaging (OFDI) artifact of tangential signal dropout (TSD), which mimics the appearance of lipid-rich plaque and macrophage (Mø) infiltration. Methods and results: A total of 1,019 histological cross-sections from 23 autopsy hearts were matched with the corresponding OFDI images. Of those, 232 OFDI cross-sections that contained signal-poor regions with diffuse borders were classified as lipid-rich plaques. The angle θ was calculated between the OFDI beam that strikes the edge of the luminal surface of the low-intensity region and that which strikes the surface line of the low-intensity region. On histological evaluation, 182 ...

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      Mentions: Kenichi Fujii
    2. Histopathological validation of optical coherence tomography findings of the coronary arteries

      Histopathological validation of optical coherence tomography findings of the coronary arteries

      Optical coherence tomography (OCT), a catheter-based imaging modality for the visualization of coronary arteries, is widely used during percutaneous coronary intervention to improve the understanding of the anatomy of coronary artery stenosis and to elucidate the mechanisms of atherosclerosis. In this review, we provide a short description of the histopathological validations of OCT for visualizing atherosclerotic plaques and vascular healing response after drug-eluting stent (DES) implantation. Because OCT measures the intensity of light returning from within a tissue, tissue having a higher heterogeneity of optical index of refraction, such as microcalcification deposition and foam cell accumulation on the luminal surface ...

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      Mentions: Kenichi Fujii
    3. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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    4. Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study –

      Background: We performed an ex vivo study to investigate optical coherence tomography (OCT) imaging for differentiating several types of neointimal tissue during the later phases after bare-metal stent (BMS) implantation as compared with histologic results. Methods and Results: OCT imaging was performed in 6 autopsy hearts for 10 BMS with implant duration >4 years. OCT qualitative neointimal tissue characterization was based on tissue structure and classified as homogeneous pattern, heterogeneous pattern with visible struts, or heterogeneous pattern with invisible struts. Corresponding histological analyses of each 2-mm cross-section of the entire BMS were performed. Of 81 cross-sections, histological analysis revealed that ...

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      Mentions: Abbot Kenichi Fujii
    5. Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      An 83-year-old woman was referred to our hospital due to diverticular bleeding of the colon. She had a history of everolimus-eluting stent implantation in the left anterior descending artery (31 months before) and the right coronary artery (20 and 31 months before) because of stable angina. She was prescribed aspirin 100 mg/day and clopidogrel 75 mg/day, followed by single antiplatelet therapy by aspirin during the last 8 months. Aspirin was discontinued for the endoscopic therapy at her admission. Complete blood count showed hemoglobin of 17.5 g/dl and hematocrit of 55.2%, from which polycythemia vera (PV ...

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      Mentions: Abbot Kenichi Fujii
    6. Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study

      Objectives This study sought to assess the accuracy of optical coherence tomography (OCT), gray-scale intravascular ultrasound (IVUS), and their combination for detecting thin-cap fibroatheromas (TCFA). Background The extent to which the imaging characteristics of OCT and IVUS correlate with histologically defined TCFA is unknown. Methods IVUS and OCT examinations identified focal plaques in 165 coronary arteries from 60 autopsy hearts. A total of 685 pairs of images of OCT and IVUS were compared with histology. By OCT, a TCFA was defined as a signal-poor region with diffuse borders and cap thickness <65 μm. By IVUS, a TCFA was defined by ...

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    7. Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy

      An 89-year-old woman who suffered a stroke and congestive heart failure was admitted to our hospital. She died of heart failure and autopsy was performed. Coronary arteries were removed from the heart and used for ex vivo imaging of intravascular ultrasound ([IVUS]; Atlantis, Boston Scientific Corporation, Natick, Massachusetts), optical coherence tomography (LightLab imaging Inc., Westford, Massachusetts), and coronary angioscopy (FiberTech, Tokyo, Japan) within 6 h after death before fixation with 10% buffered formalin. IVUS illustrated a convex lesion with superficial hyperechoic signal accompanied by acoustic shadowing at the left anterior descending artery (Figure 1 , arrows). Optical coherence tomography demonstrated an ...

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    1-8 of 8
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    1. (7 articles) Kenichi Fujii
    2. (3 articles) Abbot
    3. (2 articles) Massachusetts General Hospital
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    In-Stent Thin-Cap Fibroatheroma After Drug-Eluting Stent Implantation: Ex-Vivo Evaluation of Optical Coherence Tomography and Intracoronary Angioscopy Different Findings in a Calcified Nodule Between Histology and Intravascular Imaging Such as Intravascular Ultrasound, Optical Coherence Tomography, and Coronary Angioscopy Accuracy of OCT, Grayscale IVUS, and Their Combination for the Diagnosis of Coronary TCFA An Ex Vivo Validation Study Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings Tissue Characterization of In-Stent Neointima Using Optical Coherence Tomography in the Late Phase After Bare-Metal Stent Implantation – An Ex Vivo Validation Study – Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study Histopathological validation of optical coherence tomography findings of the coronary arteries Tangential Signal Dropout Mimicking the Appearance of Lipid-rich Plaques and Macrophage Infiltration on Optical Frequency Domain Imaging Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma