1. Articles from Mays A. El-Dairi

    1-19 of 19
    1. Reversal of Cupping in an Infant, Shown by Optical Coherence Tomography

      Reversal of Cupping in an Infant, Shown by Optical Coherence Tomography

      A 10-month-old white male infant with primary congenital glaucoma underwent successful goniotomy in the right eye, lowering intraocular pressure from 34 mm Hg to 11 mm Hg and decreasing axial length from 23.4 mm to 22.8 mm. We used optical coherence tomography (HRA+OCT Spectralis with Flex module [Heidelberg Engineering]) to image the optic nerve preoperatively and at 1 month postoperatively. The cup-disc ratio decreased from 0.6 to 0.4. The reversal of cupping was associated with decreased cup depth and an anterior shift of the Bruch membrane on optical coherence tomography ( Figure ). Notably, the preoperative and ...

      Read Full Article
    2. Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography

      Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography

      Purpose Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be especially advantageous in the diagnosis and monitoring of children with CNV. Methods Eight eyes from eight patients aged 12 months to 18 years were imaged with the investigational Spectralis OCTA (version 6.9, Heidelberg Engineering, Heidelberg, Germany) and the RTVue XR Avanti (Optovue Inc., Fremont, CA, USA). Two patients were imaged during examination under anesthesia while six patients were imaged in the clinic. Demographic information, ocular characteristics, treatment ...

      Read Full Article
    3. Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years

      Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years

      Purpose To determine reference values for the peripapillary retinal nerve fiber layer (pRNFL) and macula in children ages 0-5 years. Design Prospective cross-sectional study Setting Single large academic pediatric ophthalmology practice Study Population Healthy, full-term children ages 0 to <6 years presenting for surgery under general anesthesia were prospectively recruited for participation. Excluded were children with systemic neurologic disease, optic nerve or retinal disease (even if unilateral), or any bilateral ocular disease process, and eyes with amblyopia, ocular disease, or spherical equivalent refractive error outside of -3.00 to +8.00 diopters. Observation Procedure Following general anesthesia, OCT scans of ...

      Read Full Article
    4. Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years

      Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children <5 Years

      Purpose Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children not amenable to traditional imaging. Purpose: to report GCC and RNFL measurements in normal children using HH-OCT. Design Prospective observational study of normal children ≤ 5-years of age. Methods Healthy, full-term children ≤5 years-old undergoing sedation or anesthesia were enrolled. Exclusion criteria: prematurity, pre-existing neurologic, genetic, metabolic or intraocular pathology. Demographic data, axial length (Master-Vu Sonomed Escalon, NY ...

      Read Full Article
    5. Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children

      Handheld Optical Coherence Tomography Normative Inner Retinal Layer Measurements for Children

      Purpose Measurements of the ganglion cell complex (GCC), comprising the retinal nerve fiber (RNFL), ganglion cell, and inner plexiform layers, can be correlated with vision loss caused by optic nerve disease. Handheld optical coherence tomography (HH-OCT) can be used with sedation in children not amenable to traditional imaging. Purpose: to report GCC and RNFL measurements in normal children using HH-OCT. Design Prospective observational study of normal children ≤ 5-years of age. Methods Healthy, full-term children ≤5 years-old undergoing sedation or anesthesia were enrolled. Exclusion criteria: prematurity, pre-existing neurologic, genetic, metabolic or intraocular pathology. Demographic data, axial length (Master-Vu Sonomed Escalon, NY ...

      Read Full Article
    6. Hyperreflective Vitreous Opacities on Optical Coherence Tomography in a Patient With Bilateral Retinoblastoma

      Hyperreflective Vitreous Opacities on Optical Coherence Tomography in a Patient With Bilateral Retinoblastoma

      An investigational, portable spectral-domain optical coherence tomography (SD-OCT) unit revealed small hyperreflective opacities in both eyes of a patient with bilateral retinoblastoma. There was no evidence of vitreous seeding on ophthalmoscopy of either eye. Although the opacities may initially raise concern for potential vitreous seeding, this report suggests alternate potential etiologies for such opacities, which were also seen on imaging of a cohort of normal eyes in pediatric patients.

      Read Full Article
    7. Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Purpose To determine whether the diameter of Bruch’s membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT). Methods The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were reviewed retrospectively. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Transverse horizontal diameter of the BMO and papillary height were measured. Mean BMO, papillary height, and RNFL were compared and receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) and determine ...

      Read Full Article
    8. Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Bruch’s membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema

      Purpose To determine whether the diameter of Bruch’s membrane opening (BMO) can distinguish mild papilledema from pseudopapilledema using optical coherence tomography (OCT). Methods The medical records of pediatric patients with pseudopapilledma due to optic nerve head (ONH) drusen, patients with papilledema, and normal control subjects were reviewed retrospectively. All eyes underwent OCT imaging of the BMO and retinal nerve fiber layer (RNFL). Transverse horizontal diameter of the BMO and papillary height were measured. Mean BMO, papillary height, and RNFL were compared and receiver operating characteristic (ROC) curves were used to calculate the area under the curve (AUC) and determine ...

      Read Full Article
    9. Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies

      Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies

      Limited cooperation and attention span often lead to poorly reliable assessments of visual acuity and visual fields in children, making diagnosis and monitoring of pediatric optic neuropathies challenging. As a noninvasive imaging modality, optical coherence tomography (OCT) could offer particular utility in this patient population. OCT provides high-resolution characterization of the optic nerve head, peripapillary retinal nerve fiber layer, and cellular layers of the macula, all of which can be used to assess the severity of optic nerve disease qualitatively and quantitatively. Application of OCT to pediatric patients has been limited by technical factors and lack of pediatric normative databases ...

      Read Full Article
      Mentions: Duke University
    10. Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema

      New Spectralis (Heidelberg, Germany) segmentation software allows automatic quantitation of the thickness of each macular layer. We evaluated the role of Spectralis spectral domain optical coherence tomography (SD-OCT) segmentation in children during acute papilledema to predict the subsequent development of optic atrophy.

      Read Full Article
    11. Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features

      Nonglaucomatous Cupping: Fundus Photography and Spectral Domain Optical Coherence Tomography Imaging Features

      Nonglaucomatous cupping is commonly encountered in neuro-ophthalmic practice. However, the progression of clinical and imaging findings over time has not been well described. We present serial fundus photographs and spectral domain optical coherence tomography from a pediatric patient with neuromyelitis optic spectrum disorder, which demonstrated progression of both cupping and optic atrophy in the setting of normal intraocular pressure.

      Read Full Article
      Mentions: Duke University
    12. Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography

      Background: To apply automated spectral domain optical coherence tomography (SD-OCT) segmentation to eyes with resolving papilledema. Methods: Ninety-four patients with idiopathic intracranial hypertension seen at the Duke Eye Center neuro-ophthalmology clinic between November 2010 and October 2011 were reviewed. Excluded were eyes with papilledema with Frisen grade >2, other optic neuropathies or retinopathies, and those that did not have SD-OCT imaging. The remaining 43 patients were split into 2 groups: non-atrophic papilledema and atrophic papilledema. Automated SD-OCT segmentation was performed on patients with non-atrophic papilledema and age-matched controls for each of the 9 regions of the Early Treatment Diabetic Retinopathy ...

      Read Full Article
    13. Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography

      Purpose To characterize optic nerve head (ONH) morphology and parameters, including vertical disk diameter, vertical cup diameter, and vertical cup/disk ratio in healthy, full-term newborns using a handheld spectral domain optical coherence tomography (SD-OCT) device. Methods In this prospective observational case series, healthy white, black, and Hispanic full-term newborns delivered at the Duke Birthing Center between August 2010 and May 2011 underwent dilated fundus examination and SD-OCT imaging of the optic nerve in each eye. OCT parameters were calculated and compared for each group of infants. Results A total of 58 consecutive newborns of white (n = 22), black (n ...

      Read Full Article
    14. Correction of Ocular Shape in Retinal Optical Coherence Tomography and Effect on Current Clinical Measures

      Correction of Ocular Shape in Retinal Optical Coherence Tomography and Effect on Current Clinical Measures

      Purpose To address the misrepresentation of the eye in retinal optical coherence tomography (OCT) images and to examine the effect of this misrepresentation on retinal thickness measurements. Design Prospective case series. Methods Five subjects with recent orbital magnetic resonance imaging (MRI) scans and normal eye examinations were consented from the clinics of the Duke Eye Center. Each subject had both eyes imaged using a retinal spectral-domain OCT system and ocular biometry measured. Two types of individualized optical models of the subject eyes—numerical and analytical—were used to determine the spatial paths of the OCT A-scans. These paths were used ...

      Read Full Article
    15. Longitudinal reproducibility of optical coherence tomography measurements in children

      Longitudinal reproducibility of optical coherence tomography measurements in children
      Introduction: In healthy eyes of children, optical coherence tomography (OCT) measurements of macular and retinal nerve fiber layer (RNFL) thickness are reproducible within the same day and average RNFL has been correlated with axial length (AL). We evaluated longitudinal reproducibility of OCT measurements in children as AL changed.
      Read Full Article
    16. Optical coherence tomography in the evaluation of neurofibromatosis type 1 subjects with optic pathway gliomas

      Introduction: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and associated with optic pathway gliomas (OPGs) in ∼15% of affected children. OPGs can be difficult to detect on clinical inspection, often requiring neuro-imaging. Optical coherence tomography (OCT) has been shown to be a useful diagnostic technology in several pediatric eye conditions including glaucoma and idiopathic intracranial hypertension. Our prospective case-series evaluates OCT findings of retinal nerve fiber layer (RNFL) loss from optic atrophy due to OPGs in pediatric NF1 subjects.
      Read Full Article
    17. Reproducibility of OCT in children with glaucoma

      Introduction: Optical Coherence Tomography(OCT) has been proven to be a useful clinical tool in the follow-up of adult glaucoma(IOVS2008;49:4886-4892.). Its use in pediatric glaucoma is limited because reproducibility has been assessed only in normal children and on the same visit (AJO,2007;143:484–488). This study's purpose is to evaluate the reproducibility of OCT in children with stable glaucoma in a clinical setting.
      Read Full Article
    18. Subclinical foveal hypoplasia in normal children detected by OCT

      Introduction: Foveal hypoplasia is usually associated with significant visual dysfunction and an absent foveal reflex on biomicroscopy. Optical coherence tomography(OCT) easily provides accurate images of the foveal anatomy. Among a group of normal children having OCT for the development of a normative database (Arch Ophthalmol 2009;127), we identified a few with underdeveloped foveal architecture despite normal clinical examination. This study's purpose is to characterize the prevalence and features of subclinical foveal hypoplasia in the eyes of normal children.
      Read Full Article
    19. Optical Coherence Tomography in the Eyes of Normal Children

      Objective To collect a normative database of macular thickness, retinal nerve fiber layer (RNFL) thicknesses, and optic nerve topography in the healthy eyes of children aged 3 to 17 years using optical coherence tomography (OCT) measurements. Methods Scans were obtained for 286 healthy children (black, 114; white, 154; other, 18). Each child had a dilated eye examination, an axial length measurement using the IOL Master (Carl Zeiss Meditec, Dublin, California), and OCT measurements using the fast macular map, fast RNFL thickness, and fast optic disc protocols of the Stratus OCT (OCT-3; Carl Zeiss Meditec). Results Black children had smaller macular ...
      Read Full Article
    1-19 of 19
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (15 articles) Duke University
    2. (10 articles) Sharon F. Freedman
    3. (5 articles) Cynthia A. Toth
    4. (3 articles) Sanjay G. Asrani
    5. (3 articles) Heidelberg Engineering
    6. (2 articles) Stephanie J. Chiu
    7. (2 articles) Sina Farsiu
    8. (1 articles) Anthony N. Kuo
    9. (1 articles) Joseph A. Izatt
    10. (1 articles) Carl Zeiss Meditec
    11. (1 articles) Institute of Applied Physics
    12. (1 articles) Medical University of Vienna
    13. (1 articles) Kyungpook National University
    14. (1 articles) Singapore Eye Research Institute
    15. (1 articles) University of Western Australia
    16. (1 articles) Stefan G. Sacu
    17. (1 articles) Brendan F. Kennedy
    18. (1 articles) Yongyang Huang
    19. (1 articles) Jeehyun Kim
    20. (1 articles) Ursula Schmidt-Erfurth
  3. Popular Articles

  4. Picture Gallery

    Longitudinal reproducibility of optical coherence tomography measurements in children Correction of Ocular Shape in Retinal Optical Coherence Tomography and Effect on Current Clinical Measures Racial variation in optic nerve head parameters quantified in healthy newborns by handheld spectral domain optical coherence tomography Retinal Atrophy in Eyes With Resolved Papilledema Detected by Optical Coherence Tomography Optical coherence tomography macular segmentation as predictor for optic atrophy in children with acute papilledema Emerging Applications of Optical Coherence Tomography in Pediatric Optic Neuropathies Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis) Optical coherence tomography for characterization of nanocomposite materials (Thesis) In Vivo Corneal Microstructural Changes in Herpetic Stromal Keratitis: A Spectral-Domain Optical Coherence Tomography Analysis Non-invasive optical screening of Streptococcus Pneumonia based inflammatory changes of the tympanic membrane and mastoid mucosa in guinea pig otitis media using optical coherence tomography Visual function tests including the role of optical coherence tomography in neurofibromatosis