1. Articles from Jayanth Sridhar

    1-15 of 15
    1. Application of Optical Coherence Tomography Angiography to Retinal Disease

      Application of Optical Coherence Tomography Angiography to Retinal Disease

      A little over two years ago, a hot new topic in retinal imaging caught the attention of ophthalmologists around the world. Optical coherence tomography angiography (OCTA), an innovative, fast, noninvasive, non-dye-based angiographic technique, quickly became a topic of great interest in major conferences and ophthalmology journals. Inquisitive minds applied the OCTA prototypes to understanding diseases such as macular degeneration, diabetic retinopathy, and glaucoma. The technology’s high resolution and ability to segment the different vascular layers provided novel insight into disease pathogenesis and morphology, providing a unique opportunity to investigate the ocular microvasculature in a level of anatomic detail that ...

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    2. Optical Coherence Tomography Angiography of Punctate Inner Choroidopathy

      Optical Coherence Tomography Angiography of Punctate Inner Choroidopathy

      Purpose . To report a case of bilateral choroidal neovascularization (CNV) in punctate inner choroidopathy (PIC) visualized utilizing optical coherence tomography angiography (OCT-A). Methods . Case report. Results . A 29-year-old woman presented with new visual symptoms in both eyes. Fundoscopic exam revealed bilateral multifocal, small, well-defined lesions consistent with PIC. Optical coherence tomography demonstrated subretinal fluid and retinal pigment epithelium detachments (RPEDs) in both eyes. OCT-A revealed bilateral abnormal increased flow within the RPEDs consistent with CNV. Fluorescein angiography confirmed the presence of bilateral CNV. Conclusion . CNV secondary to PIC may be identified using noninvasive optical coherence tomography angiography.

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    3. Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes with Branch Retinal Vein Occlusion

      Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes with Branch Retinal Vein Occlusion

      Purpose To measure the vascular density and foveal avascular zone (FAZ) area in the deep and superficial retinal vascular networks using optical coherence tomography angiography (OCTA) in patients with branch retinal vein occlusion (BRVO). Design Retrospective observational case series. Methods Patients with unilateral BRVO involving the macula were enrolled. OCTA (RTVue-XR Avanti, Optovue) was performed on the BRVO and fellow eyes. Macular vascular density, FAZ area, and foveal thickness were measured in all eyes. Results Seventeen eyes of 17 patients met inclusion criteria. The mean overall vascular density measured in the entire scan was lower in BRVO eyes compared to ...

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      Mentions: Optovue
    4. In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography

      In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography

      Purpose To quantify density of macular vascular networks over regions of interest in healthy subjects using optical coherence tomography angiography (OCTA). Design Prospective cross-sectional study. Methods Settings: Retina and Oncology Services of Wills Eye Hospital. Subjects with no known systemic disease and without retinal pathology were included. OCTA was performed on a 3×3-mm region centered on the macula (RTVue-XR Avanti, Optovue) and en face angiograms of the superficial and deep vascular networks were acquired. Vascular density was calculated using an automated image thresholding method (ImageJ, National Institutes of Health) over regions of interest. Foveal and parafoveal vascular density were ...

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    5. Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography

      Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography

      Purpose To quantify density of macular vascular networks over regions of interest in healthy subjects using optical coherence tomography angiography (OCTA). Design Prospective cross-sectional study. Methods Settings: Retina and Oncology Services of Wills Eye Hospital. Subjects with no known systemic disease and without retinal pathology were included. OCTA was performed on a 3×3-mm region centered on the macula (RTVue-XR Avanti, Optovue) and en face angiograms of the superficial and deep vascular networks were acquired. Vascular density was calculated using an automated image thresholding method (ImageJ, National Institutes of Health) over regions of interest. Foveal and parafoveal vascular density were ...

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    6. En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging of Taxane-Associated Cystoid Macular Edema

      En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging of Taxane-Associated Cystoid Macular Edema

      The taxanes are chemotherapeutic agents that may, in rare cases, cause cystoid macular edema without leakage on fluorescein angiography. Two patients with evidence of taxane-related macular edema presented and were evaluated using novel en face optical coherence tomography (OCT) and OCT angiography (OCTA) imaging modalities. Although OCTA revealed no flow abnormalities in either patient, en face OCT revealed a striking bilateral symmetric cystic tessellation pattern.

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    7. Optical coherence tomography angiography (OCT-A) of type 2 retinal arteriovenous malformation

      Optical coherence tomography angiography (OCT-A) of type 2 retinal arteriovenous malformation

      Retinal arteriovenous malformations (AVMs) are a rare congenital, nonhereditary vascular abnormality. They are typically unilateral and asymptomatic, ranging from a single arteriovenous communication to a complex anastomotic system. 1,2 The lesions most commonly involve the superotemporal arcade (41%), papillomacular bundle (34%), and optic disc (6%) 2,3 and are classified into 3 groups by Archer on the basis of capillary characteristics and systemic findings. 1 Characteristically, the lesions demonstrate rapid filling without capillary leakage on fluorescein angiography.

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    8. Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography Features of Paracentral Acute Middle Maculopathy

      Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography Features of Paracentral Acute Middle Maculopathy

      Purpose To characterize the optical coherence tomography (OCT) angiography, en face OCT, and microperimetry features of paracentral acute middle maculopathy in both the acute phase and after resolution, and to propose a classification of distinct subtypes of this entity. Design Retrospective observational case series. Methods Clinical histories, high-resolution digital color imaging, spectral-domain OCT images, fluorescein angiography, OCT angiography images, and en face OCT images of 16 patients with paracentral acute middle maculopathy were evaluated. Microperimetry was available in 6 patients. Results The most common referring diagnoses were isolated branch retinal arterial occlusion (5/16), combined central retinal vein and cilioretinal ...

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    9. En Face Optical Coherence Tomography of Subfoveal Perfluorocarbon Liquid

      En Face Optical Coherence Tomography of Subfoveal Perfluorocarbon Liquid

      A 49-year-old man with history of complicated tractional retinal detachment repair presented with long-standing 20/400 visual acuity in the right eye. Ophthalmoscopy revealed subfoveal perfluorocarbon liquid (PFCL) bubbles (top left). En face optical coherence tomography (OCT; Avanti RTVue XR, Optovue, Fremont, CA) at the level of the middle retina demonstrated large areas of hyporeflectivity corresponding to the PFCL with surrounding stippled hyporeflectivity likely representing inner nuclear layer microcysts.

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      Mentions: Optovue
    10. Spectral-domain optical coherence tomography imaging of macula-off rhegmatogenous retinal detachment

      Spectral-domain optical coherence tomography imaging of macula-off rhegmatogenous retinal detachment

      The timing of repair and the utility of spectral-domain optical coherence tomography (SD-OCT) for macula-off retinal detachment remains a controversial issue. Four patients who presented with macula-off retinal detachment underwent repair at various time points after symptom onset. Postoperative SD-OCT of the macula demonstrated correlation with final visual acuity

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    1-15 of 15
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  2. Topics in the News

    1. (5 articles) Thomas Jefferson University
    2. (4 articles) Optovue
    3. (3 articles) University of Miami
    4. (3 articles) Carol L. Shields
    5. (2 articles) National Institutes of Health
    6. (1 articles) Tufts University
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    Spectral-domain optical coherence tomography imaging of macula-off rhegmatogenous retinal detachment En face optical coherence tomography and angiography of talc retinopathy En Face Optical Coherence Tomography of Subfoveal Perfluorocarbon Liquid Optical Coherence Tomography Angiography and En Face Optical Coherence Tomography Features of Paracentral Acute Middle Maculopathy Optical coherence tomography angiography (OCT-A) of type 2 retinal arteriovenous malformation En Face Optical Coherence Tomography and Optical Coherence Tomography Angiography Imaging of Taxane-Associated Cystoid Macular Edema En Face Optical Coherence Tomography of Bilateral Myopic Macular Retinoschisis Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography In Vivo Assessment of Macular Vascular Density in Healthy Human Eyes Using Optical Coherence Tomography Angiography Quantitative Optical Coherence Tomography Angiography Features and Visual Function in Eyes with Branch Retinal Vein Occlusion Evaluation of Age-related Skin Changes and Instrument Reliability Using Clinical Probe Measurements and Imaging Modalities HP-OCT™ wins Victorian AEEA award – nominated for Sir William Hudson award