1. Articles from Nicholas Woolsey

    1-4 of 4
    1. Coherence gated doppler motion sensor and medical applications

      Coherence gated doppler motion sensor and medical applications

      A motion sensor applicable to medical procedures includes a source of light with a wavelength bandwidth and an optical detector. A first optical coupler terminates in a first probe tip and couples the light into the first probe tip. A second optical coupler terminates in a second probe tip and directs onto the detector scattered light returning through the second probe tip. A presentation device outputs a signal that indicates motion in a target volume of a sample in a vicinity of the probe tips based on a Doppler shift of the scattered light. The volume depends on coherence distance ...

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    2. Quantitative analysis of low contrast detectability in optical coherence tomography

      Quantitative analysis of low contrast detectability in optical coherence tomography

      Optical coherence tomography (OCT) is a high resolution imaging technology that is rapidly being adopted as the standard of care for medical applications such as ocular and intravascular imaging. However, clinical translation has been hampered by the lack of standardized test methods for performance evaluation as well as consensus standards analogous to those that have been developed for established medical imaging modalities (e.g., ultrasound). In this study, we address low contrast detectability, specifically, the ability of systems to differentiate between regions exhibiting small differences in scattering coefficient. Based on standard test methods for established medical imaging modalities, we have ...

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    3. Three-dimensional printing of tissue phantoms for biophotonic imaging

      Three-dimensional printing of tissue phantoms for biophotonic imaging

      We have investigated the potential of tissue phantoms fabricated with thermosoftening- and photopolymerization-based three-dimensional (3D) printers for use in evaluation of biophotonic imaging systems. The optical properties of printed polymer samples were measured and compared to biological tissues. Phantoms with subsurface channels as small as 0.2 mm in diameter were fabricated and imaged with microscopy, x-ray microtomography, and optical coherence tomography to characterize morphology. These phantoms were then implemented to evaluate the penetration depth of a hyperspectral reflectance imaging system used in conjunction with a near-infrared contrast agent. Results indicated that 3D printing may provide a suitable platform for ...

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    4. Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping

      Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping

      In biophotonic imaging, turbid phantoms that are low-cost, biologically-relevant, and durable are desired for standardized performance assessment. Such phantoms often contain inclusions of varying depths and sizes in order to quantify key image quality characteristics such as penetration depth, sensitivity and contrast detectability. The emerging technique of rapid prototyping with three-dimensional (3D) printers provides a potentially revolutionary way to fabricate these structures. Towards this goal, we have characterized the optical properties and morphology of phantoms fabricated by two 3D printing approaches: thermosoftening and photopolymerization. Material optical properties were measured by spectrophotometry while the morphology of phantoms incorporating 0.2-1.0 ...

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    1-4 of 4
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  2. Topics in the News

    1. (4 articles) University of Maryland
    2. (4 articles) Chia-Pin Liang
    3. (4 articles) Yu Chen
    4. (2 articles) FDA
    5. (1 articles) ´╗┐Florida International University
    6. (1 articles) Anant Agrawal
    7. (1 articles) Joseph M. Schmitt
    8. (1 articles) Abbot
    9. (1 articles) University of Melbourne
    10. (1 articles) Dresden University of Technology
    11. (1 articles) University of Washington
    12. (1 articles) University of Bonn
    13. (1 articles) Ruikang K. Wang
    14. (1 articles) Julia Walther
    15. (1 articles) Frank G. Holz
    16. (1 articles) Edmund Koch
    17. (1 articles) Steffen Schmitz-Valckenberg
    18. (1 articles) Heidelberg Engineering
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    Quantitative assessment of biophotonic imaging system performance with phantoms fabricated by rapid prototyping Three-dimensional printing of tissue phantoms for biophotonic imaging Quantitative analysis of low contrast detectability in optical coherence tomography Coherence gated doppler motion sensor and medical applications Carotid Disease and Retinal Optical Coherence Tomography Angiography Parameters in Type 2 Diabetes: The Fremantle Diabetes Study Phase II Retinal Vascular Density on Optical Coherence Tomography Angiography and Age-related Central and Peripheral Hearing Loss in a Southern Italian Older Population Optical coherence tomography outcomes from SPRINT-MS, a multicenter, randomized, double-blind trial of ibudilast in progressive multiple sclerosis Microvascular alterations in children with optic disk drusen evaluated by optical coherence tomography angiography Polarization sensitive optical coherence tomography for imaging microvascular information within living tissue without polarization-induced artifacts Validation of an Automated Quantification of Relative Ellipsoid Zone Reflectivity on Spectral Domain-Optical Coherence Tomography Images In Vivo Endoscopic Optical Coherence Tomography of the Healthy Human Oral Mucosa: Qualitative and Quantitative Image Analysis Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis