1. Articles from Hugh Barr

    1-4 of 4
    1. Strategies for the prevention of oesophageal adenocarcinoma

      Strategies for the prevention of oesophageal adenocarcinoma

      The incidence of oesophageal adenocarcinoma has increased by 500% over the past 30 years [1] . Improved understanding of the mechanisms of neoplastic progression provides an opportunity to reverse this trend. A thorough review of emerging strategies aiming to prevent the formation of oesophageal malignancy is presented. These include dietary modification, chemoprevention, early endoscopic identification and treatment of premalignant disease, and the potential for a non-endoscopic screening test. Oesophageal adenocarcinoma has become a major public health problem in the West and it is essential that clinicians are fully informed of risk reduction strategies so that they can be actively promoted in ...

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    2. Advanced Endoscopic Imaging in Barrett’s Oesophagus

      Advanced Endoscopic Imaging in Barrett’s Oesophagus

      Barrett's oesophagus is a metaplastic condition with an inherent risk of progression to adenocarcinoma. It is essential to identify dysplastic changes within Barrett's oesophagus in order to individualise surveillance strategies and establish which patients warrant endoscopic treatment. There is a trend towards endoscopic resection of focal high-grade dysplasia followed by whole segment ablation. However, endoscopic identification of dysplastic lesions is unreliable and subjective making targeted therapy extremely difficult. In addition, the current practice of taking random quadrantic biopsies may miss dysplastic disease and intramucosal adenocarcinoma. Several advanced endoscopic imaging techniques have been described and tested in clinical trials ...

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    3. Rapid endoscopic identification and destruction of degenerating Barrett’s mucosal neoplasia

      Rapid endoscopic identification and destruction of degenerating Barrett’s mucosal neoplasia
      There are distinct challenges implicit to the development of minimally invasive endoscopic surgery for the eradication of early neoplasia in Barrett’s oesophagus. Endoscopic resection and ablation of high-grade dysplasia and mucosal cancer offer alternative therapeutic options to those unsuitable or unwilling to contemplate radical surgical excision. It may also become the treatment of choice in the future. Technological developments enable the instantaneous and non-invasive diagnosis of microscopic tissue abnormalities in vivo. This is made possible by improving the level of information that can be obtained from the tissue. As well as the two-dimensional surface morphology image, which the traditional ...
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    4. Multi-channel Fourier domain OCT system with superior lateral resolution for biomedical applications

      Jon Holmes, Simon Hattersley, Nick Stone et al. The lateral resolution of Fourier domain optical coherence tomography (FD-OCT) systems is limited by the depth of focus that can be achieved over the desired imaging depth at the chosen wavelength. Various solutions have been proposed such as Bessel beams and computational methods; however these suf ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68470O (2008)] published Mon Feb 18, 2008.
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    1-4 of 4
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  2. Topics in the News

    1. (2 articles) Gloucestershire Royal Hospital
    2. (1 articles) Michelson Diagnostics
    3. (1 articles) University of Houston
    4. (1 articles) Cardiovascular Research Foundation
    5. (1 articles) Vanderbilt University
    6. (1 articles) University of Pittsburgh
    7. (1 articles) Tokyo Medical & Dental University
    8. (1 articles) Tianjin University
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