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Articles from Valery V. Tuchin

1-16 of 16
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  1. Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

    Explore Article www3.interscience.wiley.com (Oct 12 2009) Dermatology , Glucose

    Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  2. Principles of Light-Skin Interactions (Book Chapter)

    Explore Article SpringerLink Home (Jun 12 2009) Textbooks

    Principles of Light-Skin Interactions (Book Chapter) Skin is the largest human organ. It covers between 1.5 and 2 m^2, comprising about one-sixth of total body weight. Skin performs a complex role in human physiology. It serves as a barrier to the environment and acts as a channel for communication to the outside world. For example, skin protects us from water loss, ultraviolet (UV) rays of the sun, friction, and impact wounds. It also helps in regulating body temperature and metabolism. All photobiological responses are influenced heavily by the optical properties of skin. Therefore, for the successful development of photomedicine, in-depth knowledge and understanding of light-skin interactions, ... (Read Full Article)

    Comment on Article Mentions:   Saratov State University   Valery V. Tuchin   Massachusetts General Hospital

  3. Laser-induced tissue hyperthermia mediated by gold nanoparticles: toward cancer phototherapy

    Explore Article SPIE Digital Library (Apr 27 2009) Dermatology , Oncology

    We describe an application of plasmonic silica/gold nanoshells to produce a controllable laser hyperthermia in tissues with the aim of the enhancement of cancer photothermal therapy. Laser irradiation parameters are optimized on the basis of preliminary experimental studies using a test-tube phantom ... [J. Biomed. Opt. 14, 021016 (2009)] published Mon Apr 27, 2009. (Read Full Article)

    Comment on Article Mentions:   Saratov State University   Valery V. Tuchin   Russian Academy of Sciences

  4. Circulation and distribution of gold nanoparticles and induced alterations of tissue morphology at intravenous particle delivery

    Explore Article www3.interscience.wiley.com (Mar 19 2009)

    Kinetics, biodistribution, and histological studies were performed to evaluate the particle-size effects on the distribution of 15 nm and 50 nm PEG-coated colloidal gold (CG) particles and 160 nm silica/gold nanoshells (NSs) in rats and rabbits. The above nanoparticles (NPs) were used as a model because of their importance for current biomedical applications such as photothermal therapy, optical coherence tomography, and resonance-scattering imaging. The dynamics of NPs circulation in vivo was evaluated after intravenous administration of 15 nm CG NPs to rabbit, and the maximal concentrations of gold were observed 15-30 min after injection. Rats were injected in the tail ... (Read Full Article)

    Comment on Article Mentions:   Russian Academy of Sciences   Saratov State University   Valery V. Tuchin

  5. The nonlinear relationship between concentration of analyte and its permeability coefficient in ocular tissues

    Explore Article SPIE Digital Library (Feb 23 2009) Glucose

    The nonlinear relationship between concentration of analyte and its permeability coefficient in ocular tissues Monitoring and quantifying the permeability of different drugs and chemical solutions through ocular tissues is of great importance due to its potential use in pharmacological research. In this study, Optical Coherence Tomography, a relatively new innovation in biomedical imaging was used for the functional imaging of glucose diffusion in the sclera of the eye. The permeability coefficient for different glucose concentrations was quantified non-destructively in order to compare the effect of glucose concentration on its rate of diffusion. In these in vitro experiments, fresh New Zealand white rabbit eyes were imaged during the diffusion of different glucose concentrations (10, 15, ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Valery V. Tuchin   Mohamad G. Ghosn

  6. Enhanced OCT imaging of embryonic tissue with optical clearing

    Explore Article SPIE Digital Library (Feb 20 2009)

    Optical coherence tomography (OCT) holds great promise as a routine research tool for 3-D analysis of mammalian embryos. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of differen ... [Proc. SPIE 7168, 71682C (2009)] published Fri Feb 20, 2009. (Read Full Article)

    Comment on Article Mentions:   Valery V. Tuchin   Baylor College of Medicine   Kirill V. Larin

  7. Optical coherence tomography in estimating molecular diffusion of drugs and analytes in ocular tissues

    Explore Article SPIE Digital Library (Feb 18 2009) Ophthalmology

    Aside from other ocular drug delivery methods, topical application and follow up drug diffusion through the cornea and sclera of the eye remain the favored method, as they impose the least pain and discomfort to the patient. However, this delivery route suffers from the low permeability of epithelia ... [Proc. SPIE 7163, 71631H (2009)] published Wed Feb 18, 2009. (Read Full Article)

    Comment on Article Mentions:   Valery V. Tuchin   Mohamad G. Ghosn   Kirill V. Larin

  8. Assessing molecular diffusion in tissues using optical coherence tomography

    Explore Article Home: SPIE.org (Jun 20 2008)

    Assessing molecular diffusion in tissues using optical coherence tomography Advanced imaging near the surface of tissues could assist the development of novel therapeutic agents, drug delivery systems, and diagnostic tests. (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Valery V. Tuchin

  9. Concentration effect on the diffusion of glucose in ocular tissues

    Explore Article ScienceDirect (Jun 17 2008)

    In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10−5 cm/s of 10% glucose solution to (5.08±0.23)×10−6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  10. Functional imaging and assessment of the glucose diffusion rate in epithelial tissues in optical coherence tomography

    Explore Article Institute of Physics (Jun 15 2008)

    Functional imaging, monitoring and quantitative description of glucose diffusion in epithelial and underlying stromal tissues in vivo and controlling of the optical properties of tissues are extremely important for many biomedical applications including the development of noninvasive or minimally invasive glucose sensors as well as for therapy and diagnostics of various diseases, such as cancer, diabetic retinopathy, and glaucoma. Recent progress in the development of a noninvasive molecular diffusion biosensor based on optical coherence tomography (OCT) is described. The diffusion of glucose was studied in several epithelial tissues both in vitro and in vivo. Because OCT provides depth-resolved imaging of ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Saratov State University   Valery V. Tuchin

  11. The effect of solution concentration on diffusion in scleral tissues

    Explore Article SPIE Digital Library (Jun 9 2008) Glucose , Ophthalmology

    Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. The calculation of permeability coefficient of analytes could potentially be used in a variety of basic science and clinical fields, as well as advanced diagnostic imaging. Before this can occur, a more thorough understanding of the diffusion rate of analytes in biological tissues is needed. For thi ... [Proc. SPIE 6791, 679107 (2008)] published Mon Jun 9, 2008. (Read Full Article)

    Comment on Article Mentions:   Mohamad G. Ghosn   Kirill V. Larin   University of Houston

  12. Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera

    Explore Article SPIE Digital Library (Apr 21 2008) Glucose , Ophthalmology

    Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. Imaging of biological tissues with optical coherence tomography (OCT) poses a great interest for its capability to noninvasively outline subsurface microstructures within tissues. However, a major limitation for many optical imaging techniques is inadequate depth penetration of light in turbid media ... [J. Biomed. Opt. 13, 021110 (2008)] published Mon Apr 21, 2008. (Read Full Article)

    Comment on Article Mentions:   Saratov State University   Mohamad G. Ghosn   University of Houston

  13. Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography

    Explore Article SPIE Digital Library (Feb 18 2008) Cardiology , Glucose

    Mohamad G. Ghosn, Esteban Carbajal, Natasha Befrui et al. High in-depth resolution imaging, such as Optical Coherence Tomography, could be the next frontier in noninvasive quantification of diffusion in epithelial tissues. In this study we employed OCT in a method that could help differentiate various forms of atherosclerosis and distinguish between normal ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68471E (2008)] published Mon Feb 18, 2008. (Read Full Article)

    Comment on Article Mentions:   Mohamad G. Ghosn   Kirill V. Larin   University of Houston

  14. Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

    Explore Article opticsinfobase.org (May 22 2006) Glucose

    We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.7310−6 cm/s at the epithelial side to 8.63±0.2710−6 cm/s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40um. (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  15. Coherent-Domain Optical Methods: Biomedical Diagnostics, Environment and Material Science (Book)

    Explore Article Springer US (Oct 15 2004) Textbooks

    Coherent-Domain Optical Methods: Biomedical Diagnostics, Environment and Material Science (Book) For the first time in one set of books, coherent-domain optical methods are discussed in the framework of various applications, which are characterized by a strong light scattering. A few chapters describe basic research containing the updated results on coherent and polarized light non-destructive interactions with a scattering medium, in particular, diffraction, interference, and speckle formation at multiple scattering. These chapters allow for understanding coherent-domain diagnostic techniques presented in later chapters. A large portion of Volume I is dedicated to analysis of various aspects of optical coherence tomography (OCT) - a very new and growing field of coherent optics. Two ... (Read Full Article)

    Comment on Article Mentions:   Valery V. Tuchin   Saratov State University

  16. Nondestructive Quantification of Analyte Diffusion in Cornea and Sclera Using Optical Coherence Tomography

    Explore Article iovs.org (Mar 15 2002) Ophthalmology

    PURPOSE. Noninvasive functional imaging, monitoring, and quantification of analytes transport in epithelial ocular tissues are extremely important for therapy and diagnostics of many eye diseases. In this study the authors investigated the capability of optical coherence tomography (OCT) for noninvasive monitoring and quantification of diffusion of different analytes in sclera and cornea of rabbit eyes. METHODS. A portable time-domain OCT system with wavelength of 1310 ± 15 nm, output power of 3.5 mW, and resolution of 25 µm was used in this study. Diffusion of different analytes was monitored and quantified in rabbit cornea and sclera of whole eyeballs. Diffusion ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

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