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Articles from Mohamad G. Ghosn

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  1. Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

    Explore Article www3.interscience.wiley.com (Oct 12 2009) Dermatology , Glucose

    Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  2. Effect of temperature on permeation of low-density lipoprotein particles through human carotid artery tissues

    Explore Article www3.interscience.wiley.com (Mar 11 2009) Cardiology , Glucose

    Quantification of the diffusion of small molecules and large lipid transporting lipoproteins across arterial tissues could be useful in elucidating the mechanism(s) of atherosclerosis. Optical coherence tomography (OCT) was used to determine the effect of temperature on the rate of diffusion of glucose and low-density lipoproteins (LDL) in human carotid endarterectomy tissue in vitro. The permeability rate for glucose was calculated to be (3.51 ± 0.27) × 10-5 cm/s (n = 13) at 20 °C, and (3.70 ± 0.44) × 10-5 cm/s (n = 5) at 37 °C; for LDL the rate was (2.42 ± 0.33) × 10-5 cm/s (n ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Mohamad G. Ghosn

  3. The nonlinear relationship between concentration of analyte and its permeability coefficient in ocular tissues

    Explore Article SPIE Digital Library (Feb 23 2009) Glucose

    The nonlinear relationship between concentration of analyte and its permeability coefficient in ocular tissues Monitoring and quantifying the permeability of different drugs and chemical solutions through ocular tissues is of great importance due to its potential use in pharmacological research. In this study, Optical Coherence Tomography, a relatively new innovation in biomedical imaging was used for the functional imaging of glucose diffusion in the sclera of the eye. The permeability coefficient for different glucose concentrations was quantified non-destructively in order to compare the effect of glucose concentration on its rate of diffusion. In these in vitro experiments, fresh New Zealand white rabbit eyes were imaged during the diffusion of different glucose concentrations (10, 15, ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Valery V. Tuchin   Mohamad G. Ghosn

  4. Quantifying the effect of milli-molar glucose concentration on thickness of rabbit cornea with optical coherence tomography

    Explore Article SPIE Digital Library (Feb 20 2009) Glucose , Ophthalmology

    The cornea contributes about 65% of the eye's ability to refract light. Thus, any fluctuation in corneal thickness can cause noticeable changes in vision. The presence of glucose molecules induces a driving force for water to leave the collagen fibrils in the cornea due to the concentration gradient created, thus changing its thickness. In this study, the effect of various milli-molar glucose concentrations on corneal thickness was explored using Optical Coherence Tomography. Whole rabbit eyes were placed in a specially designed dish while immersed in saline to ensure proper hydration of the eye. The cornea was imaged for 10 minutes. ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Mohamad G. Ghosn   University of Houston

  5. Optical coherence tomography in estimating molecular diffusion of drugs and analytes in ocular tissues

    Explore Article SPIE Digital Library (Feb 18 2009) Ophthalmology

    Aside from other ocular drug delivery methods, topical application and follow up drug diffusion through the cornea and sclera of the eye remain the favored method, as they impose the least pain and discomfort to the patient. However, this delivery route suffers from the low permeability of epithelia ... [Proc. SPIE 7163, 71631H (2009)] published Wed Feb 18, 2009. (Read Full Article)

    Comment on Article Mentions:   Valery V. Tuchin   Mohamad G. Ghosn   Kirill V. Larin

  6. Concentration effect on the diffusion of glucose in ocular tissues

    Explore Article ScienceDirect (Jun 17 2008)

    In this study, optical coherence tomography (OCT) was utilized in the functional imaging of glucose diffusion through scleral tissues. Permeability coefficients for different concentrations of glucose were quantified nondestructively. Obtained results indicate an inverse proportionality between the permeability coefficient and the concentration of the analyte in epithelial tissues: in-depth diffusion of solutions with lower glucose concentration was faster than those with a higher concentration. The permeability coefficient decreased from (1.67±0.17)×10−5 cm/s of 10% glucose solution to (5.08±0.23)×10−6 cm/s of 25% glucose solution. The dependence of the permeability on the concentration of hyperosmotic analytes could potentially be used in various basic ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  7. The effect of solution concentration on diffusion in scleral tissues

    Explore Article SPIE Digital Library (Jun 9 2008) Glucose , Ophthalmology

    Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. The calculation of permeability coefficient of analytes could potentially be used in a variety of basic science and clinical fields, as well as advanced diagnostic imaging. Before this can occur, a more thorough understanding of the diffusion rate of analytes in biological tissues is needed. For thi ... [Proc. SPIE 6791, 679107 (2008)] published Mon Jun 9, 2008. (Read Full Article)

    Comment on Article Mentions:   Mohamad G. Ghosn   Kirill V. Larin   University of Houston

  8. Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera

    Explore Article SPIE Digital Library (Apr 21 2008) Glucose , Ophthalmology

    Mohamad G. Ghosn, Esteban F. Carbajal, Natasha A. Befrui et al. Imaging of biological tissues with optical coherence tomography (OCT) poses a great interest for its capability to noninvasively outline subsurface microstructures within tissues. However, a major limitation for many optical imaging techniques is inadequate depth penetration of light in turbid media ... [J. Biomed. Opt. 13, 021110 (2008)] published Mon Apr 21, 2008. (Read Full Article)

    Comment on Article Mentions:   Saratov State University   Mohamad G. Ghosn   University of Houston

  9. Permeability of hyperosmotic agent in normal and atherosclerotic vascular tissues

    Explore Article SPIE Digital Library (Feb 28 2008) Cardiology

    Noninvasive cardiovascular imaging could lead to the early detection and timely treatment of complex atherosclerotic lesions responsible for major cardiovascular events. Recent investigations have suggested that optical coherence tomography (OCT) is an ideal diagnostic tool due to the high resolution this technology achieves in discriminating the different features of atherosclerotic lesions based on structural imaging. We explore the capability of OCT for functional imaging of normal and atherosclerotic aortic tissues based on time- and depth-resolved quantification of the permeability of biomolecules through these tissues. The permeability coefficient of 20% aqueous solution of glucose was found to be (6.80±0.18)×10−6 cm/s in ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Mohamad G. Ghosn

  10. Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography

    Explore Article SPIE Digital Library (Feb 18 2008) Cardiology , Glucose

    Mohamad G. Ghosn, Esteban Carbajal, Natasha Befrui et al. High in-depth resolution imaging, such as Optical Coherence Tomography, could be the next frontier in noninvasive quantification of diffusion in epithelial tissues. In this study we employed OCT in a method that could help differentiate various forms of atherosclerosis and distinguish between normal ... [Proc. SPIE Int. Soc. Opt. Eng. 6847, 68471E (2008)] published Mon Feb 18, 2008. (Read Full Article)

    Comment on Article Mentions:   Mohamad G. Ghosn   Kirill V. Larin   University of Houston

  11. Depth-resolved monitoring of glucose diffusion in tissues by using optical coherence tomography

    Explore Article opticsinfobase.org (May 22 2006) Glucose

    We demonstrate the capability of the optical coherence tomography (OCT) technique for depth-resolved monitoring and quantifying of glucose diffusion in fibrous tissues (sclera). The depth-resolved and average permeability coefficients of glucose were calculated. We found that the glucose diffusion rate is not uniform throughout the tissue and is increased from approximately 2.39±0.7310−6 cm/s at the epithelial side to 8.63±0.2710−6 cm/s close to the endothelial side of the sclera. Results demonstrated that the OCT technique is capable of depth-resolved monitoring and quantification of glucose diffusion in sclera with a resolution of approximately 40um. (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

  12. Nondestructive Quantification of Analyte Diffusion in Cornea and Sclera Using Optical Coherence Tomography

    Explore Article iovs.org (Mar 15 2002) Ophthalmology

    PURPOSE. Noninvasive functional imaging, monitoring, and quantification of analytes transport in epithelial ocular tissues are extremely important for therapy and diagnostics of many eye diseases. In this study the authors investigated the capability of optical coherence tomography (OCT) for noninvasive monitoring and quantification of diffusion of different analytes in sclera and cornea of rabbit eyes. METHODS. A portable time-domain OCT system with wavelength of 1310 ± 15 nm, output power of 3.5 mW, and resolution of 25 µm was used in this study. Diffusion of different analytes was monitored and quantified in rabbit cornea and sclera of whole eyeballs. Diffusion ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston   Saratov State University

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