1. Articles from Xincheng Yao

    1-24 of 24
    1. Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to ...

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      Mentions: Xincheng Yao
    2. Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy

      Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy

      This study is to establish quantitative features of vascular geometry in optical coherence tomography angiography (OCTA) and validate them for the objective classification of diabetic retinopathy (DR). Six geometric features, including total vessel branching angle (VBA: θ), child branching angles (CBAs: α1 and α2), vessel branching coefficient (VBC), and children-to-parent vessel width ratios (VWR1 and VWR2), were automatically derived from each vessel branch in OCTA. Comparative analysis of heathy control, diabetes with no DR (NoDR), and non-proliferative DR (NPDR) was conducted. Our study reveals four quantitative OCTA features to produce robust DR detection and staging classification: (ANOVA, P<0.05), VBA ...

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      Mentions: Xincheng Yao
    3. Supervised machine learning based multi-task artificial intelligence classification of retinopathies

      Supervised machine learning based multi-task artificial intelligence classification of retinopathies

      Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to ...

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      Mentions: Xincheng Yao
    4. Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Near infrared oximetry-guided artery–vein classification in optical coherence tomography angiography

      Differential artery–vein analysis is valuable for early detection of diabetic retinopathy and other eye diseases. As a new optical coherence tomography imaging modality, optical coherence tomography angiography provides capillary level resolution for accurate examination of retinal vasculatures. However, differential artery–vein analysis in optical coherence tomography angiography particularly for macular region in which blood vessels are small is challenging. In coordination with an automatic vessel tracking algorithm, we report here the feasibility of using near infrared optical coherence tomography oximetry to guide artery–vein classification in optical coherence tomography angiography of macular region. Impact statement It is known that ...

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      Mentions: Xincheng Yao
    5. PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago

      A PhD position is available in the Biomedical Optics and Functional Imaging group within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), OCT angiography (OCTA), super-resolution ophthalmoscopy, retinal image analysis and classification ( https://yaolab.bioe.uic.edu/ ). The PhD student will be involved for imaging instrument development and/or experimental study of retinal morphology & physiology. The specific study plan of the student can be flexible based on his/her education background and interest. The successful candidate should have a BS/MS degree in Optical ...

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      Mentions: Xincheng Yao
    6. OCT feature analysis guided artery-vein differentiation in OCTA

      OCT feature analysis guided artery-vein differentiation in OCTA

      Differential artery-vein analysis promises better sensitivity for retinal disease detection and classification. However, clinical optical coherence tomography angiography (OCTA) instruments lack the function of artery-vein differentiation. This study aims to verify the feasibility of using OCT intensity feature analysis to guide artery-vein differentiation in OCTA. Four OCT intensity profile features, including i) ratio of vessel width to central reflex, ii) average of maximum profile brightness, iii) average of median profile intensity, and iv) optical density of vessel boundary intensity compared to background intensity, are used to classify artery-vein source nodes in OCT. A blood vessel tracking algorithm is then employed ...

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      Mentions: Xincheng Yao
    7. Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago

      Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for instrument development and retinal study. The successful candidate should have a Ph.D. degree in Optical Engineering, Electrical Engineering, Applied Physics or a related discipline. Experience with optical design and construction is essential. Proficiency in Labview and Matlab programming is expected. Hand-on experience ...

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      Mentions: Xincheng Yao
    8. Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas

      Comparative Optical Coherence Tomography Angiography of Wild-Type and rd10 Mouse Retinas

      Purpose : To conduct longitudinal optical coherence tomography angiography (OCTA) to characterize dynamic changes of trilaminar vascular plexuses in wild-type (WT) and retinal degeneration 10 (rd10) mouse retinas. Methods : Longitudinal in vivo OCT/OCTA measurements of WT and rd10 mouse retinas were conducted at postnatal day 14 (P14), P17, P21, P24, and P28. OCT images were used to quantify retinal thickness changes, while OCTA images were used to investigate vascular dynamics within the trilaminar vascular plexuses, that is, superficial vascular plexus (SVP), intermediate capillary plexus (ICP), and deep capillary plexus (DCP). Blood vessel densities of all three plexus layers were quantitatively ...

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      Mentions: Xincheng Yao
    9. Functional optical coherence tomography of retinal photoreceptors

      Functional optical coherence tomography of retinal photoreceptors

      Age-related macular degeneration (AMD) is the leading cause of severe vision loss and legal blindness. It is known that retinal photoreceptors are the primary target of AMD. Therefore, a reliable method for objective assessment of photoreceptor function is needed for early detection and reliable treatment evaluation of AMD and other eye diseases such as retinitis pigmentosa that are known to cause photoreceptor dysfunctions. Stimulus-evoked intrinsic optical signal (IOS) changes promise a unique opportunity for objective assessment of physiological function of retinal photoreceptor and inner neurons. Instead of a comprehensive review, this mini-review is to provide a brief summary of our ...

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      Mentions: Xincheng Yao
    10. QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES FOR OBJECTIVE CLASSIFICATION AND STAGING OF DIABETIC RETINOPATHY

      QUANTITATIVE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES FOR OBJECTIVE CLASSIFICATION AND STAGING OF DIABETIC RETINOPATHY

      Purpose: This study aims to characterize quantitative optical coherence tomography angiography (OCTA) features of nonproliferative diabetic retinopathy (NPDR) and to validate them for computer-aided NPDR staging. Methods: One hundred and twenty OCTA images from 60 NPDR (mild, moderate, and severe stages) patients and 40 images from 20 control subjects were used for this study conducted in a tertiary, subspecialty, academic practice. Both eyes were photographed and all the OCTAs were 6 mm × 6 mm macular scans. Six quantitative features, that is, blood vessel tortuosity, blood vascular caliber, vessel perimeter index, blood vessel density, foveal avascular zone area, and foveal avascular ...

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      Mentions: Xincheng Yao
    11. Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography

      Color Fundus Image Guided Artery-Vein Differentiation in Optical Coherence Tomography Angiography

      Purpose : This study aimed to develop a method for automated artery-vein classification in optical coherence tomography angiography (OCTA), and to verify that differential artery-vein analysis can improve the sensitivity of OCTA detection and staging of diabetic retinopathy (DR). Methods : For each patient, the color fundus image was used to guide the artery-vein differentiation in the OCTA image. Traditional mean blood vessel caliber (m-BVC) and mean blood vessel tortuosity (m-BVT) in OCTA images were quantified for control and DR groups. Artery BVC (a-BVC), vein BVC (v-BVC), artery BVT (a-BVT), and vein BVT (a-BVT) were calculated, and then the artery-vein ratio (AVR ...

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      Mentions: Xincheng Yao
    12. Functional optical coherence tomography of neurovascular coupling interactions in the retina

      Functional optical coherence tomography of neurovascular coupling interactions in the retina

      Quantitative evaluation of retinal neurovascular coupling is essential for a better understanding of visual function and early detection of eye diseases. However, there is no established method to monitor coherent interactions between stimulus‐evoked neural activity and hemodynamic responses at high resolution. Here we report a multi‐modal functional optical coherence tomography (OCT) imaging methodology to enable concurrent intrinsic optical signal (IOS) imaging of stimulus‐evoked neural activity and hemodynamic responses at capillary resolution. OCT angiography guided IOS analysis was used to separate neural‐IOS and hemodynamic‐IOS changes in the same retinal image sequence. Frequency flicker stimuli evoked neural ...

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      Mentions: Xincheng Yao
    13. Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography

      Computer-aided classification of sickle cell retinopathy using quantitative features in optical coherence tomography angiography

      As a new optical coherence tomography (OCT) imaging modality, there is no standardized quantitative interpretation of OCT angiography (OCTA) characteristics of sickle cell retinopathy (SCR). This study is to demonstrate computer-aided SCR classification using quantitative OCTA features, i.e., blood vessel tortuosity (BVT), blood vessel diameter (BVD), vessel perimeter index (VPI), foveal avascular zone (FAZ) area, FAZ contour irregularity, parafoveal avascular density (PAD). It was observed that combined features show improved classification performance, compared to single feature. Three classifiers, including support vector machine (SVM), k-nearest neighbor (KNN) algorithm, and discriminant analysis, were evaluated. Sensitivity, specificity, and accuracy were quantified to ...

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    14. Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

      Quantitative characteristics of sickle cell retinopathy in optical coherence tomography angiography

      Early detection is an essential step for effective intervention of sickle cell retinopathy (SCR). Emerging optical coherence tomography angiography (OCTA) provides excellent three-dimensional (3D) resolution to enable label-free, noninvasive visualization of retinal vascular structures, promising improved sensitivity in detecting SCR. However, quantitative analysis of SCR characteristics in OCTA images is yet to be established. In this study, we conducted comprehensive analysis of six OCTA parameters, including blood vessel tortuosity, vessel diameter, vessel perimeter index (VPI), area of foveal avascular zone (FAZ), contour irregularity of FAZ and parafoveal avascular density. Compared to traditional retinal thickness analysis, five of these six OCTA ...

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      Mentions: Xincheng Yao
    15. In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas

      Intrinsic optical signal (IOS) imaging promises a noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, it is essential to understand anatomic and physiological sources of retinal IOSs and to establish the relationship between IOS distortions and eye diseases. The purpose of this study was designed to demonstrate the feasibility of in vivo IOS imaging of mouse models. A high spatiotemporal resolution spectral domain optical coherence tomography (SD-OCT) was employed for depth-resolved retinal imaging. A custom-designed animal holder equipped with ear bar and bite bar was used to minimize eye movements. Dynamic OCT imaging revealed ...

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      Mentions: Xincheng Yao
    16. Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers

      Blood flow changes are highly related to neural activities in the retina. It has been reported that neural activity increases when flickering light stimulation of the retina is used. It is known that blood flow changes with flickering light stimulation can be altered in patients with vascular disease and that measurement of flicker-induced vasodilatation is an easily applied tool for monitoring functional microvascular alterations. However, details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood due to the limitation of existing techniques. In this study, flickering light stimulation was applied to mouse retinas to ...

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      Mentions: Xincheng Yao
    17. In vivo intrinsic optical signal imaging of mouse retinas

      In vivo intrinsic optical signal imaging of mouse retinas

      Intrinsic optical signal (IOS) imaging is a promising noninvasive method for advanced study and diagnosis of eye diseases. Before pursuing clinical applications, more IOS studies employing animal models are necessary to establish the relationship between IOS distortions and eye diseases. Ample mouse models are available for investigating the relationship between IOS distortions and eye diseases. However, in vivo IOS imaging of mouse retinas is challenging due to the small ocular lens (compared to frog eyes) and inevitable eye movements. We report here in vivo IOS imaging of mouse retinas using a custom-designed functional OCT. The OCT system provided high resolution ...

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      Mentions: Xincheng Yao
    18. Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors

      Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors

      Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection. However, clinical deployment of IOS imaging is challenging due to unclear IOS sources and limited signal-to-noise ratios (SNRs). Here, by developing high spatiotemporal resolution optical coherence tomography (OCT) and applying an adaptive algorithm for IOS processing, we were able to record robust IOSs from single-pass measurements. Transient IOSs, which might reflect an early stage of light phototransduction, are consistently observed in the photoreceptor outer segment almost immediately (<4 ms) after retinal stimulation. Comparative studies of dark- and light-adapted retinas have ...

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    19. Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago

      Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago

      Two postdoctoral positions are available in the Biomedical Optics and Functional Imaging Laboratory, Department of Bioengineering, University of Illinois at Chicago. The first position will be responsible for advanced development of biomedical optics instruments. We have been working on functional OCT , confocal and super-resolution microscopy, etc. for optical imaging of retinal morphology and physiology. The successful candidate should have a Ph.D. degree in Optical Engineering, Electrical Engineering, Applied Physics or a related discipline. Experience with optical instrument construction is essential. Proficiency in Labview and Matlab programming is expected. Hand-on experience in one or more of the following areas is ...

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      Mentions: Xincheng Yao
    20. Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments

      Dynamic near infrared microscopy has revealed transient retinal phototropism (TRP) correlated with oblique light stimulation. Here, by developing a hybrid confocal microscopy and optical coherence tomography (OCT), we tested sub-cellular source of the TRP in living frog retina. Dynamic confocal microscopy and OCT consistently revealed photoreceptor outer segments as the anatomic source of the TRP. Further investigation of the TRP can provide insights in better understanding of Stiles–Crawford effect (SCE) on rod and cone systems, and may also promise an intrinsic biomarker for early detection of eye diseases that can produce photoreceptor dysfunction.

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    21. Postdoctoral Position in Biomedical Optics Instrument and Retinal Imaging University of Alabama at Birmingham

      Postdoctoral Position in Biomedical Optics Instrument and Retinal Imaging University of Alabama at Birmingham

      A postdoctoral position is available in the biomedical optics and functional imaging group within the Department of Biomedical Engineering, University of Alabama at Birmingham. Our research lab is focused on optical imaging of retinal morphology and physiology. We are currently working on functional OCT , confocal and super-resolution microscopy of intrinsic optical signal ( IOS ) dynamics correlated with retinal physiological kinetics. The successful candidate should have a Ph.D. degree in Optical Engineering, Electrical Engineering, Applied Physics or a related discipline. Experience with optical instrument construction is essential. Proficiency in Labview and Matlab programming is expected. Knowledge with animal handling is desirable ...

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    22. Breaking diffraction limit of lateral resolution in optical coherence tomography

      Breaking diffraction limit of lateral resolution in optical coherence tomography

      Quantitative imaging of biomedical specimens is essential in biomedical study and diagnosis. Given excellent capability in three-dimensional (3D) imaging, optical coherence tomography (OCT) has been extensively used in ophthalmic imaging, vascular medicine, dermatological study, etc. Lateral resolution of the OCT is light diffraction limited, which precludes the feasibility of quantitative assessment of individual cells. In this paper, we demonstrated the feasibility of breaking diffraction-limit in OCT imaging through virtually structured detection (VSD). OCT examination of optical resolution target verified resolution doubling in the VSD based OCT imaging. Super-resolution OCT identification of individual frog photoreceptors was demonstrated to verify the potential ...

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    23. En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup

      En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup

      This study was designed to test the feasibility of en face mapping of the transient intrinsic optical signal (IOS) response at photoreceptor outer segments and to assess the effect of spatial resolution on functional IOS imaging of retinal photoreceptors. A line-scan optical coherence tomography (LS-OCT) was constructed to achieve depth-resolved functional IOS imaging of living frog eyecups. Rapid en face OCT revealed transient IOS almost immediately ( < 3     ms ) after the onset of visible light flashes at photoreceptor outer segments. Quantitative analysis indicated that the IOS kinetics may reflect dynamics of G-protein binding and releasing in early phases of visual transduction ...

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    24. Noninvasive functional imaging of the retina at cellular resolution

      Noninvasive functional imaging of the retina at cellular resolution
      Intrinsic optical signal imaging allows noninvasive identification of localized retinal neural dysfunction, promising early diagnosis of eye diseases. It is well established that many eye diseases, such as age-related macular degeneration, retinitis pigmentosa, glaucoma and diabetic retinopathy are associated with pathological changes in the retina in multiple cell classes. Different eye diseases affect different types of retinal cells, some of which occur in localized areas of the retina in the early stage of the disease. Accurate identification of retinal dysfunction at the local, cellular level is essential for early disease detection and reliable treatment evaluation. However, given the delicate structure ...
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    1-24 of 24
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    Noninvasive functional imaging of the retina at cellular resolution En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup Breaking diffraction limit of lateral resolution in optical coherence tomography Postdoctoral Position in Biomedical Optics Instrument and Retinal Imaging University of Alabama at Birmingham Functional optical coherence tomography reveals transient phototropic change of photoreceptor outer segments Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors Optical coherence tomography angiography of stimulus evoked hemodynamic responses in individual retinal layers Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago AI-Assisted In Situ Detection of Human Glioma Infiltration Using a Novel Computational Method for Optical Coherence Tomography Motorized capsule for shadow-free OCT imaging and synchronous beam control