1. Articles from Xincheng Yao

    1-24 of 46 1 2 »
    1. Quantitative optical coherence tomography for longitudinal monitoring of postnatal retinal development

      Quantitative optical coherence tomography for longitudinal monitoring of postnatal retinal development

      A better study of the postnatal retinal development is not only essential for the in-depth understanding of the nature of the vision system but also may provide insights for treatment developments of eye conditions, such as retinopathy of premature (ROP). To date, quantitative analysis of postnatal retinal development is primarily limited to end- point histological examination. This study is to validate in vivo optical coherence tomog- raphy (OCT) for longitudinal monitoring of postnatal retinal development in developing mouse eyes. Three-dimensional (3D) frame registration and super averaging were adopted to investigate the fine structure of the retina. Interestingly, a hyporeflective layer ...

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    2. Machine learning in optical coherence tomography angiography

      Machine learning in optical coherence tomography angiography

      Optical coherence tomography angiography (OCTA) offers a noninvasive label-free solution for imaging retinal vasculatures at the capillary level resolution. In principle, improved resolution implies a better chance to reveal subtle microvascular distortions associated with eye diseases that are asymptomatic in early stages. However, massive screening requires experienced clinicians to manually examine retinal images, which may result in human error and hinder objective screening. Recently, quantitative OCTA features have been developed to standardize and document retinal vascular changes. The feasibility of using quantitative OCTA features for machine learning classification of different retinopathies has been demonstrated. Deep learning-based applications have also been ...

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    3. Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer’s disease mice

      Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer’s disease mice

      Significance : As one part of the central nervous system, the retina manifests neurovascular defects in Alzheimer’s disease (AD). Quantitative imaging of retinal neurovascular abnormalities may promise a new method for early diagnosis and treatment assessment of AD. Previous imaging studies of transgenic AD mouse models have been limited to the central part of the retina. Given that the pathological hallmarks of AD frequently appear in different peripheral quadrants, a comprehensive regional investigation is needed for a better understanding of the retinal degeneration associated with AD-like pathology. Aim : We aim to demonstrate concurrent optical coherence tomography (OCT) and OCT angiography ...

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    4. Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography

      Interpretation of anatomic correlates of outer retinal bands in optical coherence tomography

      By providing the sectioning capability to differentiate individual retinal layers, optical coherence tomography (OCT) is revolutionizing eye disease diagnosis and treatment evaluation. A better understanding of the hyper- and hypo-reflective bands in retinal OCT is essential for accurate interpretation of clinical outcomes. In this article, we summarize the interpretations of clinical OCT and adaptive optics (AO) OCT (AO-OCT) of the outer retina in the human eye, and briefly review OCT investigation of the outer retina in animal models. Quantitative analysis of outer retinal OCT bands is compared to established parameters of retinal histology. The literature review and comparative analysis support ...

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    5. Postdoctoral opening in retinal image analysis and classification at the University of Illinois at Chicago

      Postdoctoral opening in retinal image analysis and classification at the University of Illinois at Chicago

      Description: A postdoctoral position is available in the Biomedical Optics and Functional Imaging Laboratory with Dr. Xincheng Yao at the Department of Biomedical Engineering, University of Illinois at Chicago. Dr. Yao’s Biomedical Optics and Functional Imaging Laboratory is housed in the Lions of Illinois Eye Research Institute (LIERI), within the same building with UIC Retina Clinic. In collaboration with experienced ophthalmologists and vision scientists, our lab is focusing on new development of ophthalmic imaging technology to advance retinal study, disease diagnosis and treatment evaluation. Our current research includes ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy ...

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    6. In vivo optoretinography of phototransduction activation and energy metabolism in retinal photoreceptors

      In vivo optoretinography of phototransduction activation and energy metabolism in retinal photoreceptors

      The objective of this study is to verify the anatomic correlate of the second (2nd) outer retina band in optical coherence tomography (OCT), and to demonstrate the potential of using intrinsic optical signal (IOS) imaging for concurrent optoretinography (ORG) of phototransduction activation and energy metabolism in stimulus activated retinal photoreceptors. A custom‐designed OCT was employed for depth‐resolved IOS imaging in mouse retina activated by a visible light flicker stimulation. The spatiotemporal properties of the IOS changes at the photoreceptor outer segment (OS) and inner segment (IS) were quantitatively evaluated. Rapid IOS change was observed at the OS almost ...

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    7. Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptor

      Functional optoretinography: concurrent OCT monitoring of intrinsic signal amplitude and phase dynamics in human photoreceptor

      Intrinsic optical signal (IOS) imaging promises a noninvasive method for objective assessment of retinal function. This study demonstrates concurrent optical coherence tomography (OCT) of amplitude-IOS and phase-IOS changes in human photoreceptors. A new procedure for differential-phase-mapping (DPM) is validated to enable depth-resolved phase-IOS imaging. Dynamic OCT revealed rapid amplitude-IOS and phase-IOS changes, which occur almost right away after the stimulus onset. These IOS changes were predominantly observed within the photoreceptor outer segment (OS), particularly two boundaries connecting to the inner segment and retinal pigment epithelium. The comparative analysis supports that both amplitude-IOS and phase-IOS attribute to transient OS morphological change ...

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    8. Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors

      Functional intrinsic optical signal imaging for objective optoretinography of human photoreceptors

      Functional mapping of photoreceptor physiology is important for better disease diagnosis and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light-evoked pupillary response, promises a unique biomarker of photoreceptor physiology for objective optoretinography with high resolution. This study is to test the feasibility of non-mydriatic IOS mapping of retinal photoreceptors in awake human. Depth-resolved optical coherence tomography verified outer segment (OS) as the anatomic origin of fast photoreceptor-IOS. Dynamic IOS changes are primarily confined at OS boundaries connected with inner segment and retinal pigment epithelium, supporting transient OS shrinkage due to phototransduction process as the mechanism of the ...

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    9. Vascular morphology and blood flow signatures for differential artery-vein analysis in optical coherence tomography of the retina

      Vascular morphology and blood flow signatures for differential artery-vein analysis in optical coherence tomography of the retina

      Differential artery-vein (AV) analysis is essential for retinal study, disease detection, and treatment assessment. This study is to characterize vascular reflectance profiles and blood flow patterns of retinal artery and vein systems in optical coherence tomography (OCT) and OCT angiography (OCTA), and establish them as robust signatures for objective AV classification. A custom designed OCT was employed for three-dimensional (3D) imaging of mouse retina, and corresponding OCTA was reconstructed. Radially resliced OCT B-scans revealed two, i.e. top and bottom, hyperreflective wall boundaries in retinal arteries, while these wall boundaries were absent in OCT of retinal veins. Additional OCTA analysis ...

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    10. Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago

      Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago

      Two postdoctoral positions are immediately available in the Biomedical Optics and Functional Imaging Laboratory ( yaolab.bioe.uic.edu ) at the Department of Bioengineering, University of Illinois at Chicago. In collaboration with experienced ophthalmologists and vision scientists, our group is focusing on quantitative retinal imaging to advance eye disease diagnosis and treatment evaluation. One candidate will support instrumentation development of OCT and super-resolution ophthalmoscopy. Another candidate is responsible for quantitative OCT/OCTA analysis and machine learning image classification. The selected candidates will have excellent opportunities to interact with researchers in Engineering, Ophthalmology and Vision Sciences for a multidisciplinary training. The successful ...

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    11. Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

      Functional optical coherence tomography enables in vivo optoretinography of photoreceptor dysfunction due to retinal degeneration

      Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a unique biomarker for objective optoretinography (ORG) of photoreceptor function. We report here the first-time in vivo ORG detection of photoreceptor dysfunction due to retinal degeneration. A custom-designed optical coherence tomography (OCT) was employed for longitudinal ORG monitoring of photoreceptor-IOS distortions in retinal degeneration mice. Depth-resolved OCT analysis confirmed the outer segment (OS) as the physical source of the photoreceptor-IOS. Comparative ERG measurement verified the phototransduction activation as the physiological correlator of the photoreceptor-IOS. Histological examination ...

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    12. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Purpose : To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy. Methods : A deep-learning convolutional neural network (CNN) architecture, VGG16, was employed for this study. A transfer learning process was implemented to retrain the CNN for robust OCTA classification. One dataset, consisting of images of 32 healthy eyes, 75 eyes with diabetic retinopathy (DR), and 24 eyes with diabetes but no DR (NoDR), was used for training and cross-validation. A second dataset consisting of 20 NoDR and 26 DR eyes was used for external validation. To demonstrate the feasibility of using artificial ...

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    13. Functional optical coherence tomography of photoreceptor outer and inner segments in living eye.

      Functional optical coherence tomography of photoreceptor outer and inner segments in living eye.

      Purpose : This study is to investigate stimulus-evoked intrinsic optical signal (IOS) changes in photoreceptor outer segment (OS) and inner segment (IS), and thus to demonstrate the potential of functional IOS imaging of phototransduction and metabolic integrity of retinal photoreceptor. Methods : A custom-designed optical coherence tomography (OCT) was used for in vivo imaging of transient IOS changes in the retina of wild-type mice (C57BL/6J). A near-infrared superluminescent diode (SLD) was used as the light source for OCT imaging, and a visible light-emitting diode (LED) was employed for retinal stimulation. Depth-resolved IOSs were calculated at individual retina layers, based on the ...

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    14. Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago

      Postdoctoral opening in optical instrumentation and retinal imaging at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging Laboratory , Department of Bioengineering , University of Illinois at Chicago (UIC). The Biomedical Optics and Functional Imaging Laboratory is affiliated with the Lions of Illinois Eye Research Institute (LIERI), within the same building with UIC Ophthalmology and Retina Clinic. In collaboration with experienced ophthalmologists and vision scientists, our ongoing research includes ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, machine learning based image analysis and classification. The postdoctoral fellow will support optical instrument developments, such as fundus camera, OCT and confocal ophthalmoscopy, for retinal imaging of ...

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    15. VASCULAR COMPLEXITY ANALYSIS IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF DIABETIC RETINOPATHY

      VASCULAR COMPLEXITY ANALYSIS IN OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF DIABETIC RETINOPATHY

      Purpose: This study aimed to verify the feasibility of using vascular complexity features for objective differentiation of controls and nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) patients. Methods: This was a cross-sectional study conducted in a tertiary, subspecialty, academic practice. The cohort included 20 control subjects, 60 NPDR patients, and 56 PDR patients. Three vascular complexity features, including the vessel complexity index, fractal dimension, and blood vessel tortuosity, were derived from each optical coherence tomography angiography image. A shifting-window measurement was further implemented to identify local feature distortions due to localized neovascularization and mesh structures in PDR. Results ...

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    16. AV-Net: Deep learning for fully automated artery-vein classification in optical coherence tomography angiography

      AV-Net: Deep learning for fully automated artery-vein classification in optical coherence tomography angiography

      This study is to demonstrate deep learning for automated artery-vein (AV) classification in optical coherence tomography angiography (OCTA). The AV-Net, a fully convolutional network (FCN) based on modified U-shaped CNN architecture, incorporates enface OCT and OCTA to differentiate arteries and veins. For the multi-modal training process, the enface OCT works as a near infrared fundus image to provide vessel intensity profiles, and the OCTA contains blood flow strength and vessel geometry features. A transfer learning process is also integrated to compensate for the limitation of available dataset size of OCTA, which is a relatively new imaging modality. By providing an ...

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    17. Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group ( https://yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Our research lab is working on ultra-wide field fundus photography, functional optical coherence tomography (OCT), super-resolution ophthalmoscopy, retinal image analysis and classification. The postdoctoral fellow will be responsible for quantitative analysis of OCT/OCTA and machine learning based image classification. This position will be supported by a NIH project entitled differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy . The successful candidate should have a Ph.D. degree in ...

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    18. Quantitative optical coherence tomography angiography: A review

      Quantitative optical coherence tomography angiography: A review

      As a new optical coherence tomography (OCT) modality, OCT angiography (OCTA) provides a noninvasive method to detect microvascular distortions correlated with eye conditions. By providing unparalleled capability to differentiate individual plexus layers in the retina, OCTA has demonstrated its excellence in clinical management of diabetic retinopathy, glaucoma, sickle cell retinopathy, diabetic macular edema, and other eye diseases. Quantitative OCTA analysis of retinal and choroidal vasculatures is essential to standardize objective interpretations of clinical outcome. Quantitative features, including blood vessel tortuosity, blood vessel caliber, blood vessel density, vessel perimeter index, fovea avascular zone area, fovea avascular zone contour irregularity, vessel branching ...

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    19. Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice

      Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice

      The hyaloid vascular system (HVS) is known to have an important role in eye development. However, physiological mechanisms of HVS regression and their correlation with developmental eye disorders remain unclear due to technical limitations of conventional ending point examination with fixed tissues. Here, we report comparative optical coherence tomography (OCT) and OCT angiography (OCTA) monitoring of HVS regression in wild-type and retinal degeneration 10 (rd10) mice. Longitudinal OCTA monitoring revealed accelerated regression of hyaloid vessels correlated with retinal degeneration in rd10. Quantitative OCT measurement disclosed significant distortions of both retinal thickness and the vitreous chamber in rd10 compared to WT ...

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    20. Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Transfer Learning for Automated OCTA Detection of Diabetic Retinopathy

      Purpose: To test the feasibility of using deep learning for optical coherence tomography angiography (OCTA) detection of diabetic retinopathy (DR). Methods: A deep learning convolutional neural network (CNN) architecture VGG16 was employed for this study. A transfer learning process was implemented to re-train the CNN for robust OCTA classification. In order to demonstrate the feasibility of using this method for artificial intelligence (AI) screening of DR in clinical environments, the re-trained CNN was incorporated into a custom developed GUI platform which can be readily operated by ophthalmic personnel. Results: With last nine layers re-trained, CNN architecture achieved the best performance ...

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    21. Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago

      A postdoctoral position is available in the Biomedical Optics and Functional Imaging group with Dr. Xincheng Yao ( yaolab.bioe.uic.edu ) within the Department of Bioengineering, University of Illinois at Chicago. Dr. Yao’s Biomedical Optics and Functional Imaging Laboratory is housed in the Lions of Illinois Eye Research Institute (LIERI), within the same building with UIC Retina Clinic. In collaboration with experienced ophthalmologists and vision scientists, our lab is focusing on new development of ophthalmic instrumentation and imaging technology to advance retinal study, disease diagnosis and treatment evaluation. Our current research includes ultra-wide field fundus photography, functional optical coherence ...

      Read Full Article
    22. Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye

      Functional OCT angiography reveals early physiological dysfunction of hyaloid vasculature in developing mouse eye

      Hyaloid vascular system (HVS) is a transient capillary network nourishing developing eye. Better study of the HVS regression correlated with eye development is essential for in-depth understanding of the nature of vision system. In this study, we demonstrate the feasibility of longitudinal optical coherence tomography (OCT) and OCT angiography (OCTA) monitoring of the HVS in C57BL/6J mice. OCT enables morphological monitoring of the HVS regression, and OCTA allows physiological assessment of the HVS involution correlated with eye development. Functional OCTA reveals early physiological dysfunction before morphological regression of the hyaloid vasculature in developing mouse eye. We anticipate that noninvasive ...

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    23. Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Supervised Machine Learning Based Multi-Task Artificial Intelligence Classification of Retinopathies

      Artificial intelligence (AI) classification holds promise as a novel and affordable screening tool for clinical management of ocular diseases. Rural and underserved areas, which suffer from lack of access to experienced ophthalmologists may particularly benefit from this technology. Quantitative optical coherence tomography angiography (OCTA) imaging provides excellent capability to identify subtle vascular distortions, which are useful for classifying retinovascular diseases. However, application of AI for differentiation and classification of multiple eye diseases is not yet established. In this study, we demonstrate supervised machine learning based multi-task OCTA classification. We sought 1) to differentiate normal from diseased ocular conditions, 2) to ...

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    24. Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy

      Fully automated geometric feature analysis in optical coherence tomography angiography for objective classification of diabetic retinopathy

      This study is to establish quantitative features of vascular geometry in optical coherence tomography angiography (OCTA) and validate them for the objective classification of diabetic retinopathy (DR). Six geometric features, including total vessel branching angle (VBA: θ), child branching angles (CBAs: α1 and α2), vessel branching coefficient (VBC), and children-to-parent vessel width ratios (VWR1 and VWR2), were automatically derived from each vessel branch in OCTA. Comparative analysis of heathy control, diabetes with no DR (NoDR), and non-proliferative DR (NPDR) was conducted. Our study reveals four quantitative OCTA features to produce robust DR detection and staging classification: (ANOVA, P<0.05), VBA ...

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    1-24 of 46 1 2 »
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    Noninvasive functional imaging of the retina at cellular resolution En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup Breaking diffraction limit of lateral resolution in optical coherence tomography Postdoctoral Position in Biomedical Optics Instrument and Retinal Imaging University of Alabama at Birmingham Two postdoctoral Positions in Biomedical Optics Instrumentation and Retinal Imaging At the University of Illinois at Chicago Postdoctoral opening in retinal imaging instrumentation within the Department of Bioengineering, University of Illinois at Chicago PhD Studentship in Biomedical Optics and Retinal Imaging at The University of Illinois at Chicago Postdoctoral Research Associate - Biomedical Optics and Functional Imaging Laboratory at University of Illinois at Chicago Postdoctoral opening in quantitative retinal imaging and analysis at University of Illinois at Chicago Postdoctoral Openings in Biomedical Optics and Retinal Imaging Laboratory at University of Illinois at Chicago Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography