1. Articles from Robert Kromer

    1-8 of 8
    1. Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion

      Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion

      Acute central retinal artery occlusion (CRAO) induces a time-dependent increase in retinal thickness. By manually measuring the relative retinal thickness increase (RRTI) in comparison to the contralateral eye based on optical coherence tomography (OCT), ischemia onset within the past 4.5 hours could be determined with 100% sensitivity and 94.3% specificity. To enable examiner-independent and quicker diagnostics, we analyzed the RRTI using the automatic retinal thickness measurement. In this retrospective study, 28 eyes were evaluated with an acute CRAO (<46 hours). All patients received a Spectralis SD-OCT image of both eyes. The RRTI was calculated for the ETDRS sectors ...

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    2. OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

      OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy

      Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals. Methods The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost ( n = 20) compared to surgically treated patients with normal IOP ( n = 22 ...

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    3. Optical coherence tomography‐based determination of ischaemia onset – the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion

      Optical coherence tomography‐based determination of ischaemia onset – the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion

      urpose Acute central retinal artery occlusion (CRAO) induces ischaemic retinal oedema. The purpose of this study was to define sensitivity and specificity of optical coherence tomography (OCT) based retinal thickness analysis in determining ischaemia onset in CRAO. Methods The relative retinal thickness increase (RRTI) in comparison with the fellow eye was analysed retrospectively in OCT scans of 66 patients diagnosed with CRAO between January 2010 and December 2019 within 48 hr of ischaemia onset. The natural course of RRTI and the sensitivity and specificity of OCT‐based determination of ischaemia onset in identifying CRAO within 4.5 hr using the ...

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    4. Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Optical coherence tomography angiography analysis of macular flow density in glaucoma

      Purpose Modifications in ocular blood flow may play a significant role in glaucoma development. Optical coherence tomography angiography (OCT‐A) is based on the detection and analysis of the reflection behaviour of motion in a static environment and therefore is able to quantify the retinal flow density. We used this new technology to examine the density of the active flow vasculature in the macular area in glaucoma patients compared to healthy patients. Methods Thirty patients with primary open‐angle glaucoma (mean age: 72.6 ± 7.1 years) and 21 healthy patients (mean age: 70.3 ± 8.6 years) were recruited ...

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    5. Predicting surgical success in patients with idiopathic epiretinal membrane using the spectral-domain optical coherence tomography segmentation module for single retinal layer analysis

      Predicting surgical success in patients with idiopathic epiretinal membrane using the spectral-domain optical coherence tomography segmentation module for single retinal layer analysis

      Introduction Idiopathic epiretinal membrane (ERM) is a proliferation of cells formed on the internal surface of the retina and may cause a slow decrease in visual acuity (VA). The aim of this study was to evaluate the individual layers of the retina by optical coherence tomography (OCT) before and after vitrectomy with ERM peeling in order to refine surgical decision-making. Methods Forty-seven eyes of 45 patients (aged 55–87 years) with ERM were enrolled retrospectively from a tertiary referral centre. OCT examination was performed preoperatively and at a mean of 3.2 months postoperatively in all cases. Nine retinal surfaces ...

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    6. Association between optical coherence tomography based retinal microvasculature characteristics and myocardial infarction in young men

      Association between optical coherence tomography based retinal microvasculature characteristics and myocardial infarction in young men

      Incident myocardial infarction (MI) is a leading cause of adult mortality in the United States. However, because MI has a relatively low incidence in the young population, little information exists on the disease in younger adults. Because the retina has the unique quality that its vasculature is readily and noninvasively visible, the retina is frequently studied to evaluate correlations between vessels and cardiovascular diseases. In the current study, we evaluated the retinal microvasculature of patients who had experienced an MI before 50 years of age (n = 53 subjects) and age- and sex-matched patients who had not experienced an MI (n ...

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    7. Evaluation of Retinal Vessel Morphology in Patients with Parkinson's Disease Using Optical ...

      Evaluation of Retinal Vessel Morphology in Patients with Parkinson's Disease Using Optical ...

      Purpose The retina has been found affected in Parkinson’s disease (PD). It is unclear if this is due to neurodegeneration of local dopamine-dependent retinal cells, a result of central nervous degeneration including the optic nerve or retinal small vessel disease. This study aimed to detect changes of the retinal vasculature in PD patients compared to controls. Methods We examined 49 PD patients and 49 age- and sex-matched healthy controls by spectral domain optical coherence tomography (SD-OCT) with a circular scan centred at the optic disc. Vessels within the retinal nerve fibre layer were identified by an automated algorithm and ...

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    8. Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT

      Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT

      Introduction: To examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer‘s disease (AD). Material and Methods: This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fibre layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects. Results: Patients with AD ...

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    1-8 of 8
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    Detection of retinal nerve fiber layer defects in Alzheimer‘s disease using SD-OCT Evaluation of Retinal Vessel Morphology in Patients with Parkinson's Disease Using Optical ... Association between optical coherence tomography based retinal microvasculature characteristics and myocardial infarction in young men Predicting surgical success in patients with idiopathic epiretinal membrane using the spectral-domain optical coherence tomography segmentation module for single retinal layer analysis Optical coherence tomography angiography analysis of macular flow density in glaucoma Optical coherence tomography‐based determination of ischaemia onset – the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion OCT angiography analysis of retinal vessel density in primary open-angle glaucoma with and without Tafluprost therapy Determination of Ischemia Onset Based on Automatically Generated Spectralis SD-OCT Values in Acute Central Retinal Artery Occlusion Macular and choroidal perfusion using optical coherence tomography angiography in type-2 diabetic patients without diabetic retinopathy Short-term evaluation of clear corneal incision after phacoemulsification using anterior segment optical coherence tomography Evaluation of the central vault following implantable phakic contact lens and its correlation to horizontal white to white corneal diameter by anterior segment optical coherence tomography Automatic bifurcation detection utilizing pullback characteristics of bifurcation in intravascular optical coherence tomography