1. Articles from Michael P. Kelly

    1-6 of 6
    1. Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

      Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations

      Purpose To describe optical coherence tomography angiography (OCTA) findings in a patient with aniridia and correlate with representative histopathology. Observations OCTA images of the macula of a pediatric aniridic patient, who has nystagmus and impaired vision bilaterally, demonstrate a complete absence of the foveal avascular zone in both the superficial and deep vascular complexes (SVC and DVC). In addition, larger superficial blood vessels were found to be abnormally diving from the SVC into the DVC. Similarly, immunofluorescence with confocal microscopy imaging of a retinal histopathology specimen from a 2 month old aniridic patient demonstrated larger vessels diving in the same ...

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    2. Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA

      Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA

      BACKGROUND AND OBJECTIVE: To describe the microvascular features of treated, clinically regressed, or reactivated retinoblastoma lesions using an investigational portable optical coherence tomography angiography (OCTA) system. PATIENTS AND METHODS: Single-center, prospective, cross-sectional, consecutive case-series of children with previously treated retinoblastoma who underwent portable OCTA of posterior retinoblastoma lesions. RESULTS: Eight tumors from seven eyes of five children with retinoblastoma were included. Tumors with types 1 (calcified remnant, n = 3), 2 (non-calcified remnant, n = 1), and 3 (both calcified and noncalcified remnants, n = 1) regression revealed persistent intrinsic superficial vasculature on OCTA (five of five lesions; 100%). Lesions with type 4 ...

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    3. Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years

      Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years

      Purpose To determine reference values for the peripapillary retinal nerve fiber layer (pRNFL) and macula in children ages 0-5 years. Design Prospective cross-sectional study Setting Single large academic pediatric ophthalmology practice Study Population Healthy, full-term children ages 0 to <6 years presenting for surgery under general anesthesia were prospectively recruited for participation. Excluded were children with systemic neurologic disease, optic nerve or retinal disease (even if unilateral), or any bilateral ocular disease process, and eyes with amblyopia, ocular disease, or spherical equivalent refractive error outside of -3.00 to +8.00 diopters. Observation Procedure Following general anesthesia, OCT scans of ...

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    4. Imaging infant retinal vasculature with optical coherence tomography angiography

      Imaging infant retinal vasculature with optical coherence tomography angiography

      Study of infant retinal vascular development has been limited to histopathological reports. We report herein depth-resolved visualization of full-term infant parafoveal microvasculature and their similarity to that of young children using a portable optical coherence tomography angiography system.

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    5. Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy

      Paracentral acute middle maculopathy (PAMM) has been described as a hyperreflective band or plaque-like region on spectral-domain optical coherence tomography (SD-OCT) at the level of the inner nuclear layer (INL), which is straddled by the intermediate and deep retinal capillary plexuses. 1,2 PAMM has been reported to cause eccentric wedge-shaped lesions that extend to the edge of the foveal avascular zone. 3 Although these lesions resolve over time, patients are left with irreversible INL atrophy, resulting in a permanent paracentral visual field defect.

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    6. Effect of optical coherence tomography scan pattern and density on the detection of full-thickness macular holes

      Effect of optical coherence tomography scan pattern and density on the detection of full-thickness macular holes

      Purpose To evaluate the impact of different scan patterns and scan densities on small full-thickness macular hole (MH) detection. Design Retrospective cross-sectional analysis. Methods Analysis was performed on 25 eyes from 24 patients with full-thickness MHs imaged with the Heidelberg Spectralis HRA+OCT. Included eyes underwent concurrent imaging with a standard (61-line) raster volume and a 24-line radial pattern. A 6-line radial scan pattern was extrapolated from the higher density radial pattern. Comparisons of the missed hole rate as well as the proportion of individual B-scans demonstrating a full-thickness defect (termed “full-thickness detection index”) were carried out for the three ...

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    1-6 of 6
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  2. Topics in the News

    1. (3 articles) Duke University
    2. (3 articles) Sharon F. Freedman
    3. (2 articles) Miguel A. Materin
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    5. (1 articles) University of Miami
    6. (1 articles) Sander R. Dubovy
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    Effect of optical coherence tomography scan pattern and density on the detection of full-thickness macular holes Widefield en face optical coherence tomography to quantify the extent of paracentral acute middle maculopathy Imaging infant retinal vasculature with optical coherence tomography angiography Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years Microvascular Features of Treated Retinoblastoma Tumors in Children Assessed Using OCTA Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations A PhD position is available in OPIRA laboratory at the Biomedical Engineering Department of the University of Illinois in Chicago A PhD position is available in OPIRA laboratory at the Biomedical Engineering Department of the University of Illinois in Chicago Artifact Rates for 2D Retinal Nerve Fiber Layer Thickness Versus 3D Neuroretinal Rim Thickness Using Spectral-Domain Optical Coherence Tomography Development of Deep Learning Models to Predict Best-Corrected Visual Acuity from Optical Coherence Tomography Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities Applications and Future Directions for Optical Coherence Tomography in Dermatology