1. Articles from Sunwon Kim

    1-7 of 7
    1. Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery

      Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery

      Coronary plaque destabilization involves alterations in microstructure and biochemical composition; however, no imaging approach allows such comprehensive characterization. Herein, the authors demonstrated a simultaneous microstructural and biochemical assessment of high-risk plaques in the coronary arteries in a beating heart using a fully integrated optical coherence tomography and fluorescence lifetime imaging (FLIm). It was found that plaque components such as lipids, macrophages, lipids+macrophages, and fibrotic tissues had unique fluorescence lifetime signatures that were distinguishable using multispectral FLIm. Because FLIm yielded massive biochemical readouts, the authors incorporated machine learning framework into FLIm, and ultimately, their approach enabled an automated, quantitative imaging ...

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    2. Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

      Rationale: Inflammation plays a pivotal role in the pathogenesis of the acute coronary syndrome. Detecting plaques with high inflammatory activity and specifically treating those lesions can be crucial to prevent life-threatening cardiovascular events. Methods: Here, we developed a macrophage mannose receptor (MMR)-targeted theranostic nanodrug (mannose-polyethylene glycol-glycol chitosan-deoxycholic acid-cyanine 7-lobeglitazone; MMR-Lobe-Cy) designed to identify inflammatory activity as well as to deliver peroxisome proliferator-activated gamma (PPARγ) agonist, lobeglitazone, specifically to high-risk plaques based on the high mannose receptor specificity. The MMR-Lobe-Cy was intravenously injected into balloon-injured atheromatous rabbits and serial in vivo optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural-molecular imaging ...

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      Mentions: Korea University
    3. Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

      Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

      Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic µOCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 µm and 3.38 µm in air, respectively. Furthermore, the depth of focus of the µOCT imaging probe was extended two-fold using ...

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    4. Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging

      Comprehensive imaging of both the structural and biochemical characteristics of atherosclerotic plaque is essential for the diagnosis and study of coronary artery disease because both a plaque’s morphology and its biochemical composition affect the level of risk it poses. Optical coherence tomography (OCT) and fluorescence lifetime imaging (FLIm) are promising optical imaging methods for characterizing coronary artery plaques morphologically and biochemically, respectively. In this study, we present a hybrid intravascular imaging device, including a custom-built OCT/FLIm system, a hybrid optical rotary joint, and an imaging catheter, to visualize the structure and biochemical composition of the plaque in an ...

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    5. Single cardiac cycle three-dimensional intracoronary optical coherence tomography

      Single cardiac cycle three-dimensional intracoronary optical coherence tomography

      While high-speed intracoronary optical coherence tomography (OCT) provides three-dimensional (3D) visualization of coronary arteries in vivo , imaging speeds remain insufficient to avoid motion artifacts induced by heartbeat, limiting the clinical utility of OCT. In this paper, we demonstrate development of a high-speed intracoronary OCT system (frame rate: 500 frames/s, pullback speed: 100 mm/s) along with prospective electrocardiogram (ECG) triggering technology, which enabled volumetric imaging of long coronary segments within a single cardiac cycle (70 mm pullback in 0.7 s) with minimal cardiac motion artifact. This technology permitted detailed visualization of 3D architecture of the coronary arterial wall ...

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    6. Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

      Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery

      Aims Inflammation plays essential role in development of plaque disruption and coronary stent-associated complications. This study aimed to examine whether intracoronary dual-modal optical coherence tomography (OCT)-near-infrared fluorescence (NIRF) structural–molecular imaging with indocyanine green (ICG) can estimate inflammation in swine coronary artery. Methods and results After administration of clinically approved NIRF-enhancing ICG (2.0 mg/kg) or saline, rapid coronary imaging (20 mm/s pullback speed) using a fully integrated OCT-NIRF catheter was safely performed in 12 atheromatous Yucatan minipigs and in 7 drug-eluting stent (DES)-implanted Yorkshire pigs. Stronger NIRF activity was identified in OCT-proven high-risk plaque compared ...

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    7. Coronary Stent Fracture Complicated Multiple Aneurysms Confirmed by 3-Dimensional Reconstruction of Intravascular-Optical Coherence Tomography in a Patient Treated With Open-Cell Designed Drug-Eluting Stent

      Coronary Stent Fracture Complicated Multiple Aneurysms Confirmed by 3-Dimensional Reconstruction of Intravascular-Optical Coherence Tomography in a Patient Treated With Open-Cell Designed Drug-Eluting Stent

      A 55-year-old man with a previous history of cerebral infarct and hypertension presented to our cardiovascular center complaining of angina in November 2011. Chronic total occlusion in the proximal left anterior descending artery was identified by coronary angiography (Figure 1A). The patient subsequently underwent percutaneous coronary intervention. Wiring was done successfully with a tapered stiff wire (Conquest Pro 20; ASAHI INTECC). After multiple predilation, a single drug-eluting stent (3.0 × 18 mm) of an open-cell design and bioabsorbable polymer (Nobori; Terumo, Tokyo, Japan) was implanted using a 3.5-mm noncompliant balloon (inflation pressure, 24 atmospheric pressure; Quantum Maverick Balloon; Boston ...

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    1-7 of 7
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  2. Topics in the News

    1. (9 articles) National Institutes of Health
    2. (5 articles) Korea University
    3. (5 articles) Korea Advanced Institute of Science and Technology
    4. (4 articles) Hanyang University
    5. (2 articles) Duke University
    6. (2 articles) Harvard University
    7. (2 articles) Massachusetts General Hospital
    8. (2 articles) Columbia University
    9. (1 articles) Philips Healthcare
    10. (1 articles) Harvard University
    11. (1 articles) Massachusetts General Hospital
    12. (1 articles) Terumo Corporation
    13. (1 articles) Boston Scientific
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    16. (1 articles) Ryerson University
    17. (1 articles) State University of New York at Buffalo
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    Coronary Stent Fracture Complicated Multiple Aneurysms Confirmed by 3-Dimensional Reconstruction of Intravascular-Optical Coherence Tomography in a Patient Treated With Open-Cell Designed Drug-Eluting Stent Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural–molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery Single cardiac cycle three-dimensional intracoronary optical coherence tomography Comprehensive intravascular imaging of atherosclerotic plaque in vivo using optical coherence tomography and fluorescence lifetime imaging Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque Comprehensive Assessment of High-Risk Plaques by Dual-Modal Imaging Catheter in Coronary Artery Precision of attenuation coefficient measurements by optical coherence tomography Machine learning classification of multiple sclerosis in children using optical coherence tomography Duke University Receives NIH Grant for Intraoperative OCT Guidance of Intraocular Surgery Duke University Receives NIH Grant for OCTA and Glaucoma Progression in the Non-Human Primate University of Alabama at Birmingham Receives NIH Grant for Development of a supercontinuum laser source interferometer with sub-micron resolution to understand tear film structure and function in dry eye disease