1. Articles from JENNIFER VERBESEY

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    1. Mannitol Infusion Within 15 Min of Cross-Clamp Improves Living Donor Kidney Preservation

      Mannitol Infusion Within 15 Min of Cross-Clamp Improves Living Donor Kidney Preservation

      BACKGROUND: Optical coherence tomography (OCT) revealed that cells lining proximal convoluted tubules of living donor kidneys (LDKs) procured by laparoscopic procedures were very swollen in response to the brief period of ischemia experienced between the time of arterial vessel clamping and flushing the excised kidney with cold preservation solution. Damage to the tubules as a result of this cell swelling resulted in varying degrees of acute tubular necrosis (ATN) that slowed the recovery of the donor kidneys during the first 2 weeks after their transplantation. METHODS: To prevent this cell damage during LDK procurement, we changed the protocol for intravenous ...

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    2. Optical Coherence Tomography of the Living Human Kidney

      Optical Coherence Tomography of the Living Human Kidney

      Acute tubular necrosis (ATN) induced by ischemia is the most common insult to donor kidneys destined for transplantation. ATN results from swelling and subsequent damage to cells lining the kidney tubules. In this study, we demonstrate the capability of optical coherence tomography (OCT) to image the renal microstructures of living human donor kidneys and potentially provide a measure to determine the extent of ATN. We also found that Doppler-based OCT (i.e., DOCT) reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal function. All OCT/DOCT observations were performed in a noninvasive, sterile ...

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    1. (2 articles) University of Maryland
    2. (1 articles) Fujian Normal University
    3. (1 articles) Georgetown University
    4. (1 articles) San Raffaele Scientfic Institute
    5. (1 articles) Carl Zeiss Meditec
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