1. Articles from Bradley A. Bower

    1-23 of 23
    1. Compact multimodality optical coherence tomography imaging systems

      Compact multimodality optical coherence tomography imaging systems

      Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture ...

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    2. Linearized variable-dispersion spectrometers and related assemblies

      Linearized variable-dispersion spectrometers and related assemblies

      Wavenumber linear spectrometers are provided including an input configured to receive electromagnetic radiation from an external source; collimating optics configured to collimate the received electromagnetic radiation; a dispersive assembly including first and second diffractive gratings, wherein the first diffraction grating is configured in a first dispersive stage to receive the collimated electromagnetic radiation and wherein the dispersive assembly includes at least two dispersive stages configured to disperse the collimated input; and an imaging lens assembly configured to image the electromagnetic radiation dispersed by the at least two dispersive stages onto a linear detection array such that the variation in frequency ...

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    3. Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods, systems and computer program products for diagnosing conditions using unique codes generated from a multidimensional image of a sample

      Methods of providing a diagnosis using a digital code associated with an image are provided including collecting a multidimensional image, the multidimensional image having at least two dimensions; extracting a two dimensional subset of the multidimensional image; reducing the multidimensional image to a first code that is unique to the multidimensional image based on the extracted two dimensional image; comparing the first unique code associated with the subject to a library of reference codes, each of the reference codes in the library of reference codes being indicative of a class of objects; determining if the subject associated with the first ...

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    4. Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection

      Methods, systems and computer program products for collapsing volume data to lower dimensional representations thereof using histogram projection

      Methods of collapsing volume data to a lower dimensional representation of the volume data are provided. The methods include collapsing volume data to a lower dimensional representation of the volume data using histogram projection. Related systems and computer program products are also provided.

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    5. Systems for processing images generated using fourier domain optical coherence tomography (FDOCT)

      Systems for processing images generated using fourier domain optical coherence tomography (FDOCT)

      Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired ...

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    6. Systems for extended depth frequency domain optical coherence tomography (FDOCT) and related methods

      Systems for extended depth frequency domain optical coherence tomography (FDOCT) and related methods

      Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

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    7. Systems for Processing Images Generated Using Fourier Domain Optical Coherence Tomography (FDOCT)

      Systems for Processing Images Generated Using Fourier Domain Optical Coherence Tomography (FDOCT)

      Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired ...

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    8. Systems for Extended Depth Frequency Domain Optical Coherence Tomography (FDOCT) and Related Methods

      Systems for Extended Depth Frequency Domain Optical Coherence Tomography (FDOCT) and Related Methods

      Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

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    9. Methods, systems and computer program products for processing images generated using Fourier domain optical coherence tomography (FDOCT)

      Methods, systems and computer program products for processing images generated using Fourier domain optical coherence tomography (FDOCT)

      Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired ...

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    10. Systems for extended depth fourier domain optical coherence tomography (FDOCT) and related methods

      Systems for extended depth fourier domain optical coherence tomography (FDOCT) and related methods

      Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.

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    11. Compact Multimodality Optical Coherence Tomography Imaging Systems And Related Methods And Computer Program Products

      Compact Multimodality Optical Coherence Tomography Imaging Systems And Related Methods And Computer Program Products

      Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture ...

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    12. Depth-encoded spectral domain phase microscopy for simultaneous multi-site nanoscale optical measurements

      Depth-encoded spectral domain phase microscopy for simultaneous multi-site nanoscale optical measurements
      Spectral domain phase microscopy (SDPM) is an extension of spectral domain optical coherence tomography (SDOCT) that exploits the extraordinary phase stability of spectrometer-based systems with common-path geometry to resolve sub-wavelength displacements within a sample volume. This technique has been implemented for high resolution axial displacement and velocity measurements in biological samples, but since axial displacement information is acquired serially along the lateral dimension, it has been unable to measure fast temporal dynamics in extended samples. Depth-encoded SDPM (DESDPM) uses multiple sample arms with unevenly spaced common path reference reflectors to multiplex independent SDPM signals from separate lateral positions on a ...
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    13. Systems For Extended Depth Frequency Domain Optical Coherence Tomography (FDOCT) And Related Methods

      Systems For Extended Depth Frequency Domain Optical Coherence Tomography (FDOCT) And Related Methods
      Systems for extended depth frequency domain optical coherence tomography are provided including a detection system configured to sample spectral elements at substantially equal frequency intervals, wherein a spectral width associated with the sampled spectral elements is not greater than one-half of the frequency interval. Related methods are also provided herein.
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    14. Methods, Systems And Computer Program Products For Biometric Identification By Tissue Imaging Using Optical Coherence Tomography (Oct) (Wo 2010/062883)

      Methods, Systems And Computer Program Products For Biometric Identification By Tissue Imaging Using Optical Coherence Tomography (Oct) (Wo 2010/062883)
      Optical coherence tomography (OCT) imaging systems for imaging uniquely identifiable structure are provided including a source having an associated source arm path and having an associated reference arm path coupled to the source path, the reference arm path having an associated reference arm path length. A sample having an associated sample arm path coupled to the source arm and reference arm paths is provided. Processing methods to convert the depth-dependent image data to a uniquely identifiable code are provided. Related methods and computer program products are also provided.
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    15. Method and system of coregistrating optical coherence tomography (oct) with other clinical tests

      A method/system preserves annotations of different pathological conditions or changes that are recognized on cross-sections within a three dimensional volume of a patient's eye so that the annotations are maintained in a visible state in an en face projection produced with a SVP technique. it is thus possible to coregister the annotated conditions or changes with other types of two dimensional en face images such as images from other ophthalmic devices (e.g., angiography device, microperimetry device, autofluorescence device, fundal photography device.). The annotations are also maintained in a visible state in the coregistered image.
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    16. Depth-encoded spectral domain phase microscopy for simultaneous multisite nanoscale optical measurements of nerve activation

      Spectral Domain Phase Microscopy (SDPM) is a recent extension of Spectral Domain Optical Coherence Tomography (SDOCT) that exploits the extraordinary phase stability of spectrometer-based systems with common-path geometry to resolve sub-wavelength displacements within a sample volume. This technique has been implemented for high resolution axial displacement and velocity measurements in biological samples, but since axial displacement information is acquired serially, has been unable to measure fast temporal dynamics in extended samples. Depth-Encoded SDPM (DESDPM) uses multiple sample arms with unevenly spaced common path reference reflectors to multiplex independent SDPM signals from separate lateral positions on a sample simultaneously using a ...
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    17. Functional Spectral Domain Optical Coherence Tomography Imaging (Thesis)

      Functional Spectral Domain Optical Coherence Tomography Imaging (Thesis)
      Spectral Domain Optical Coherence Tomography (SDOCT) is a high-speed, high resolution imaging modality capable of structural and functional resolution of tissue microstructure. SDOCT fills a niche between histology and ultrasound imaging, providing non-contact, non-invasive backscattering amplitude and phase from a sample. Due to the translucent nature of the tissue, ophthalmic imaging is an ideal space for SDOCT imaging. Structural imaging of the retina has provided new insights into ophthalmic disease. The phase component of SDOCT images remains largely underexplored, though. While Doppler SDOCT has been explored in a research setting, it remains to catch on in the clinic. Other, functional ...
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    18. Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography

      We present in vivo human total retinal blood flow measurements using Doppler Fourier domain optical coherence tomography (OCT). The scan pattern consisted of two concentric circles around the optic nerve head, transecting all retinal branch arteries and veins. The relative positions of each blood vessel in the two OCT conic cross sections were measured and used to determine the angle between the OCT beam and the vessel. The measured angle and the Doppler shift profile were used to compute blood flow in the blood vessel. The flows in the branch veins was summed to give the total retinal blood flow ...

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    19. METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR PROCESSING IMAGES GENERATED USING FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY (FDOCT) (WO 2008/088868)

      Methods, systems and computer program products for managing frequency domain optical coherence tomography (FDOCT) image resolution. A spectrum used to acquire an image of a subject is calibrated and default dispersion correction parameters are set. Default dispersion management parameters associated with a region of the image of the subject are also set. The image of the subject is acquires after setting the default dispersion correction parameters and the default dispersion management parameters. A quality of the acquired image is compared to a quality metric for the acquired image. The dispersion correction parameters are adjusted if the quality of the acquired ...
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    20. Correlation Of Pathologic Features In Spectral Domain Optical Coherence Tomography With Conventional Retinal Studies.

      We delineated pathologic features within three-dimensional spectral domain optical coherence tomography volumes and projected marked sites of pathologic features onto clinically useful two-dimensional localization maps to be overlaid on conventional clinical images.Page: 298DOI: 10.1097/IAE.0b013e3181567798Authors: STOPA, MARCIN MD *+; BOWER, BRADLEY A. BSE +++; DAVIES, Emily BS *; IZATT, JOSEPH A. PhD *++; TOTH, CYNTHIA A. MD *++
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    1-23 of 23
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    1. (23 articles) Bradley A. Bower
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