1. Articles from Bruce Latham

    1-15 of 15
    1. Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...

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    2. Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery

      Inadequate margins in breast-conserving surgery (BCS) are associated with an increased likelihood of local recurrence of breast cancer. Currently, approximately 20% of BCS patients require repeat surgery due to inadequate margins at the initial operation. Implementation of an accurate, intraoperative margin assessment tool may reduce this re-excision rate. This study determined, for the first time, the diagnostic accuracy of quantitative micro-elastography (QME), an optical coherence tomography (OCT)–based elastography technique that produces images of tissue microscale elasticity, for detecting tumor within 1 mm of the margins of BCS specimens. Simultaneous OCT and QME were performed on the margins of intact ...

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    3. Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast

      Three‐dimensional mapping of the attenuation coefficient in optical coherence tomography to enhance breast tissue micro‐architecture contrast

      Effective intraoperative tumor margin assessment is needed to reduce re‐excision rates in breast‐conserving surgery (BCS). Mapping the attenuation coefficient in optical coherence tomography (OCT) throughout a sample to create an image (attenuation imaging) is one promising approach. For the first time, three‐dimensional OCT attenuation imaging of human breast tissue micro‐architecture using a wide‐field (up to ~45 × 45 × 3.5 mm) imaging system is demonstrated. Representative results from three mastectomy and one BCS specimen (from 31 specimens) are presented with co‐registered postoperative histology. Attenuation imaging is shown to provide substantially improved contrast over OCT, delineating ...

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    4. Handheld volumetric manual compression‐based quantitative micro‐elastography

      Handheld volumetric manual compression‐based quantitative micro‐elastography

      Compression optical coherence elastography typically requires a mechanical actuator to impart a controlled uniform strain to the sample. However, for handheld scanning, this adds complexity to the design of the probe and the actuator stroke limits the amount of strain that can be applied. In this work, we present a new volumetric imaging approach that utilises bidirectional manual compression via the natural motion of the user's hand to induce strain to the sample, realising compact, actuator‐free, handheld compression optical coherence elastography. In this way, we are able to demonstrate rapid acquisition of three‐dimensional quantitative micro‐elastography (QME ...

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    5. Handheld probe for quantitative micro-elastography

      Handheld probe for quantitative micro-elastography

      Optical coherence elastography (OCE) has been proposed for a range of clinical applications. However, the majority of these studies have been performed using bulky, lab-based imaging systems. A compact, handheld imaging probe would accelerate clinical translation, however, to date, this had been inhibited by the slow scan rates of compact devices and the motion artifact induced by the user’s hand. In this paper, we present a proof-of-concept, handheld quantitative micro-elastography (QME) probe capable of scanning a 6 × 6 × 1 mm volume of tissue in 3.4 seconds. This handheld probe is enabled by a novel QME acquisition protocol that ...

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    6. Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery

      It has been demonstrated that optical coherence micro-elastography (OCME) provides additional contrast of tumor compared to optical coherence tomography (OCT) alone. Previous studies, however, have predominantly been performed on mastectomy specimens. Such specimens typically differ substantially in composition and geometry from the more clinically relevant wide-local excision (WLE) specimens excised during breast-conserving surgery. As a result, it remains unclear if the mechanical contrast observed is maintained in WLE specimens. In this manuscript, we begin to address this issue by performing a feasibility study of OCME on 17 freshly excised, intact WLE specimens. In addition, we present two developments required to ...

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    7. Optical palpation for the visualization of tumor in human breast tissue

      Optical palpation for the visualization of tumor in human breast tissue

      Accurate and effective removal of tumor in one operation is an important goal of breast‐conserving surgery. However, it is not always achieved. Surgeons often utilize manual palpation to assess the surgical margin and/or the breast cavity. Manual palpation, however, is subjective and has relatively low‐resolution. Here, we investigate a tactile imaging technique, optical palpation, for the visualization of tumor. Optical palpation generates maps of the stress at the surface of tissue under static preload compression. Stress is evaluated by measuring the deformation of a contacting thin compliant layer with known mechanical properties using optical coherence tomography. In ...

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    8. Wide-field quantitative micro-elastography of human breast tissue

      Wide-field quantitative micro-elastography of human breast tissue

      Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing a mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based ...

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    9. Microscale imaging of breast tumor margins using optical coherence elastography

      Microscale imaging of breast tumor margins using optical coherence elastography

      A variant of optical coherence elastography offers a promising method of distinguishing between tumor and breast tissue in lumpectomy specimens in an intraoperative time frame. 1 May 2017, SPIE Newsroom. DOI: 10.1117/2.1201702.006873 Breast-conserving surgery is the most common surgical procedure used in the treatment of early-stage breast cancer. 1 The aim of this surgery is to remove all malignant tissue such that the surgical margin is free of cancer, while preserving the breast and ensuring a good cosmetic outcome. Currently, accurate microscopic margin assessment is only available postoperatively, via histopathological examination, days after the surgery. Of ...

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    10. Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes

      Background Evaluation of lymph node involvement is an important factor in detecting metastasis and deciding whether to perform axillary lymph node dissection (ALND) in breast cancer surgery. As ALND is associated with potentially severe long term morbidity, the accuracy of lymph node assessment is imperative in avoiding unnecessary ALND. The mechanical properties of malignant lymph nodes are often distinct from those of normal nodes. A method to image the micro-scale mechanical properties of lymph nodes could, thus, provide diagnostic information to aid in the assessment of lymph node involvement in metastatic cancer. In this study, we scan axillary lymph nodes ...

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    11. Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins

      Incomplete excision of malignant tissue is a major issue in breast-conserving surgery, with typically 20 - 30% of cases requiring a second surgical procedure arising from postoperative detection of an involved margin. We report advances in the development of a new intraoperative tool, optical coherence micro-elastography, for the assessment of tumor margins on the micro-scale. We demonstrate an important step by conducting whole specimen imaging in intraoperative time frames with a wide-field scanning system acquiring mosaicked elastograms with overall dimensions of ~50 × 50 mm, large enough to image an entire face of most lumpectomy specimens. This capability is enabled by a ...

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    12. Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

      Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography

      Surgical treatment of breast cancer aims to identify and remove all malignant tissue. Intraoperative assessment of tumor margins is, however, not exact; thus, re-excision is frequently needed, or excess normal tissue is removed. Imaging methods applicable intraoperatively could help to reduce re-excision rates whilst minimizing removal of excess healthy tissue. Optical coherence elastography (OCE) has been proposed for use in breast-conserving surgery; however, intraoperative interpretation of complex OCE images may prove challenging. Observations of breast cancer on multiple length scales, by OCE, ultrasound elastography, and atomic force microscopy, have shown an increase in the mechanical heterogeneity of malignant breast tumors ...

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    13. Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue

      Accurate intraoperative identification of malignant tissue is a challenge in the surgical management of breast cancer. Imaging techniques that help address this challenge could contribute to more complete and accurate tumor excision, and thereby help reduce the current high re-excision rates without resorting to the removal of excess healthy tissue. Optical coherence micro-elastography (OCME) is a three-dimensional, high-resolution imaging technique that is sensitive to micro-scale variations of the mechanical properties of tissue. As tumor modifies the mechanical properties of breast tissue, OCME has the potential to identify, on the micro-scale, involved regions of fresh, unstained tissue. OCME is based on ...

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    14. Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

      Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure

      We present optical coherence micro-elastography, an improved form of compression optical coherence elastography. We demonstrate the capacity of this technique to produce en face images, closely corresponding with histology, that reveal micro-scale mechanical contrast in human breast and lymph node tissues. We use phase-sensitive, three-dimensional optical coherence tomography (OCT) to probe the nanometer-to-micrometer-scale axial displacements in tissues induced by compressive loading. Optical coherence micro-elastography incorporates common-path interferometry, weighted averaging of the complex OCT signal and weighted least-squares regression. Using three-dimensional phase unwrapping, we have increased the maximum detectable strain eleven-fold over no unwrapping and the minimum detectable strain is 2 ...

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    15. Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues

      Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues

      Optical coherence elastography (OCE) is an emerging imaging technique that probes microscale mechanical contrast in tissues with the potential to differentiate healthy and malignant tissues. However, conventional OCE techniques are limited to imaging the first 1 to 2 mm of tissue in depth. We demonstrate, for the first time, OCE measurements deep within human tissues using needle OCE, extending the potential of OCE as a surgical guidance tool. We use needle OCE to detect tissue interfaces based on mechanical contrast in both normal and malignant breast tissues in freshly excised human mastectomy samples, as validated against histopathology. Further, we demonstrate ...

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    1-15 of 15
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    Needle optical coherence elastography for the measurement of microscale mechanical contrast deep within human breast tissues Optical coherence micro-elastography: mechanical-contrast imaging of tissue microstructure Investigation of optical coherence micro-elastography as a method to visualize cancers in human breast tissue Simplifying the assessment of human breast cancer by mapping a micro-scale heterogeneity index in optical coherence elastography Wide-field optical coherence micro-elastography for intraoperative assessment of human breast cancer margins Investigation of optical coherence micro-elastography as a method to visualize micro-architecture in human axillary lymph nodes Microscale imaging of breast tumor margins using optical coherence elastography Wide-field quantitative micro-elastography of human breast tissue Clinical feasibility of optical coherence micro-elastography for imaging tumor margins in breast-conserving surgery Feature Of The Week 04.26.2020: Diagnostic Accuracy of Quantitative Micro-Elastography for Margin Assessment in Breast-Conserving Surgery Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review Retinal microvascular metrics in untreated essential hypertensives using optical coherence tomography angiography