1. Articles from Elizabeth Sidhartha

    1-4 of 4
    1. Factors affecting signal strength in spectral-domain optical coherence tomography

      Factors affecting signal strength in spectral-domain optical coherence tomography

      Purpose To identify ocular factors that affect signal strength in spectral-domain optical coherence tomography (SD-OCT). Methods Data from 1312 participants of the population-based Singapore Malay Eye Study-2 (SiMES-2) were included in the analysis. All participants underwent standardized ophthalmic examination, including measurements of best-corrected visual acuity (BCVA), refractive error, axial length, corneal curvature and presence of cataracts. Optic disc and macular cube scans were acquired using the Cirrus HD-OCT (software version 6.0, Carl Zeiss Meditec, Dublin, CA, USA). Signal strength of the optical coherence tomography (OCT) scan was recorded for each study eye. Multivariable linear regression analyses were performed to ...

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    2. Association of iris surface features with iris parameters assessed by swept-source optical coherence tomography in Asian eyes

      Association of iris surface features with iris parameters assessed by swept-source optical coherence tomography in Asian eyes

      Background/aims To characterise the association of iris surface features (crypts, furrows and colour) with iris volume and curvature assessed by swept-source optical coherence tomography (SSOCT) in Asian eyes. Methods Iris crypts (by number and size) and furrows (by number and circumferential extent) were graded from iris photographs. Iris colour was measured by a customised algorithm written on MATLAB (MathWorks, Natick, Massachusetts, USA). The iris was imaged by SSOCT (SS-1000, CASIA, Tomey, Nagoya, Japan). The associations of surface features with iris parameters were analysed using a generalised estimating equation. Results A total of 1704 subjects (3297 eyes) were included in ...

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    3. A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      A Simplified Method to Measure Choroidal Thickness Using Adaptive Compensation in Enhanced Depth Imaging Optical Coherence Tomography

      Purpose To evaluate a simplified method to measure choroidal thickness (CT) using commercially available enhanced depth imaging (EDI) spectral domain optical coherence tomography (SD-OCT). Methods We measured CT in 31 subjects without ocular diseases using Spectralis EDI SD-OCT. The choroid-scleral interface of the acquired images was first enhanced using a post-processing compensation algorithm. The enhanced images were then analysed using Photoshop. Two graders independently graded the images to assess inter-grader reliability. One grader re-graded the images after 2 weeks to determine intra-grader reliability. Statistical analysis was performed using intra-class correlation coefficient (ICC) and Bland-Altman plot analyses. Results Using adaptive compensation ...

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    4. Determinants of Macular Thickness using Spectral Domain Optical Coherence Tomography in Healthy Eyes: the Singapore Chinese Eye Study

      Determinants of Macular Thickness using Spectral Domain Optical Coherence Tomography in Healthy Eyes: the Singapore Chinese Eye Study

      Purpose:To determine ocular and systemic factors influencing macular thickness measured by SD-OCT in a population-based sample of healthy eyes. Methods:490 Chinese adults aged 40 to 80 years were recruited from the Singapore Chinese Eye Study. All participants underwent a comprehensive eye examination and a standardized interview. SD-OCT (Cirrus HD-OCT, software version 6.0, Carl Zeiss Meditec, Dublin, CA) measured a range of macular thickness parameters (central foveal subfield thickness, average inner macular thickness, average outer macular thickness, overall average macular thickness and overall macular cube volume). Linear regression analyses were performed to examine the effects of various ocular ...

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    1-4 of 4
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  2. Topics in the News

    1. (3 articles) Singapore Eye Research Institute
    2. (3 articles) National University of Singapore
    3. (2 articles) Carl Zeiss Meditec
    4. (1 articles) Tomey Corporation
    5. (1 articles) Northwestern University
    6. (1 articles) Jikei University School of Medicine
    7. (1 articles) Indiana University
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