1. Articles from Yue Dong

    1-9 of 9
    1. Deformation velocity imaging using optical coherence tomography and its applications to the cornea

      Deformation velocity imaging using optical coherence tomography and its applications to the cornea

      Optical coherence tomography (OCT) can monitor human donor corneas non-invasively during the de-swelling process following storage for corneal transplantation, but currently only resultant thickness as a function of time is extracted. To visualize and quantify the mechanism of de-swelling, we present a method exploiting the nanometer sensitivity of the Fourier phase in OCT data to image deformation velocities. The technique was demonstrated by non-invasively showing during de-swelling that osmotic flow through an intact epithelium is negligible and removing the endothelium approximately doubled the initial flow at that interface. The increased functional data further enabled the validation of a mathematical model ...

      Read Full Article
      Mentions: Yalin Zheng
    2. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating ...

      Read Full Article
    3. Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography

      Optical coherence tomography (OCT) has recently been demonstrated to measure the film coating thickness of pharmaceutical tablets and pellets directly. The results enable the analysis of inter- and intra-tablet coating variability at an off-line and in-line setting. To date, only a few coating formulations have been tried and there is very little information on the applicability of OCT to other coatings. As it is well documented that optical methods including OCT are prone to scattering leading to limited penetration, some pharmaceutical coatings may not be measurable altogether. This study presents OCT measurements of 22 different common coatings for the assessment ...

      Read Full Article
    4. Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography

      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for direct quantification of thin film coatings that cannot easily be resolved with other techniques. While previous studies with SD-OCT have estimated the intra-tablet coating uniformity, the estimates were based on limited number of B-scans. In order to obtain a more accurate estimate, a greater number of B-scans are required that can quickly lead to an overwhelming amount of data. To better manage the data so as to generate a more accurate representation of the intra-tablet coating ...

      Read Full Article
    5. High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

      High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography

      We report the development of a Spectral Domain Line Field Optical Coherence Tomography (LF-OCT) system, using a broad bandwidth and spatial coherent Super-Continuum (SC) source. With conventional quasi-Continuous Wave (CW) setup we achieve axial resolutions up to 2.1 μm in air and 3D volume imaging speeds up to 213 kA-Scan/s. Furthermore, we report the use of a single SC pulse, of 2 ns duration, to temporally gate an OCT B-Scan image of 70 A-Scans. This is the equivalent of 35 GA-Scans/s. We apply the CW setup for high resolution imaging of the fine structures of a human ...

      Read Full Article
      Mentions: Yalin Zheng
    6. Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      Nondestructive analysis of automotive paints with spectral domain optical coherence tomography

      We have demonstrated for the first time, to our knowledge, the use of optical coherence tomography (OCT) as an analytical tool for nondestructively characterizing the individual paint layer thickness of multiple layered automotive paints. A graph-based segmentation method was used for automatic analysis of the thickness distribution for the top layers of solid color paints. The thicknesses measured with OCT were in good agreement with the optical microscope and ultrasonic techniques that are the current standard in the automobile industry. Because of its high axial resolution (5.5 μm), the OCT technique was shown to be able to resolve the ...

      Read Full Article
      Mentions: Yalin Zheng
    7. Development of spectral domain optical coherence tomography for pharmaceutical and medical application

      Development of spectral domain optical coherence tomography for pharmaceutical and medical application

      Spectral-domain optical coherence tomography (SD-OCT) is a type of non-destructive imaging technique that is capable of resolving the inner structure of a sample with micrometre spatial resolution. SD-OCT is based on low coherence interferometry. It utilises a spectrometer to grab the spectral interferogram between the back reflected/scattered light from a reference mirror and a sample. The depth profile, which carries the sample inner structure information, is then generated by a data interpolation and Fourier Transform (FT). Functional coating of solid oral dosage forms optimises the release profile of active pharmaceutical ingredient (API) and results in a desirable API absorption ...

      Read Full Article
    8. Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

      Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation

      Spectral domain optical coherence tomography (SD-OCT) has recently attracted a lot of interest in the pharmaceutical industry as a fast and non-destructive modality for quantification of thin film coatings that cannot easily be resolved with other techniques. Due to the relative infancy of this technique, much of the research to date has focused on developing the in-line measurement technique for assessing film coating thickness. To better assess OCT for pharmaceutical coating quantification, this paper evaluates tablets with a range of film coating thickness measured using OCT and terahertz pulsed imaging (TPI) in an off-line setting. In order to facilitate automated ...

      Read Full Article
    9. Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography

      Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography

      Full-field optical coherence tomography (FF-OCT) using a conventional light-emitting diode and a complementary metal-oxide semiconductor camera has been developed for characterising coatings on small pellet samples. A set of en-face images covering an area of 700 × 700 μm 2 was taken over a depth range of 166 μm. The three-dimensional structural information, such as the coating thickness and uniformity, was subsequently obtained by analysis of the recorded en-face images. Drug-loaded pharmaceutical sustained-release pellets with two coating layers and of a sub-millimetre diameter were studied to demonstrate the usefulness of the developed system. We have shown that both coatings can be ...

      Read Full Article
    1-9 of 9
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (5 articles) University of Cambridge
    2. (3 articles) Yalin Zheng
    3. (1 articles) Daniel Markl
  3. Popular Articles

  4. Picture Gallery

    Non-Destructive Evaluation of Polymer Coating Structures on Pharmaceutical Pellets Using Full-Field Optical Coherence Tomography Quantifying pharmaceutical film coating with optical coherence tomography and terahertz pulsed imaging: an evaluation Development of spectral domain optical coherence tomography for pharmaceutical and medical application Nondestructive analysis of automotive paints with spectral domain optical coherence tomography High resolution corneal and single pulse imaging with line field spectral domain optical coherence tomography Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography Pharmaceutical film coating catalogue for spectral-domain optical coherence tomography Investigating Intra-Tablet Coating Uniformity With Spectral-Domain Optical Coherence Tomography Deformation velocity imaging using optical coherence tomography and its applications to the cornea Changes in the OCT angiographic appearance of type 1 and type 2 CNV in exudative AMD during anti-VEGF treatment Optical coherence angiography for pre-treatment assessment and treatment monitoring following photodynamic therapy: a basal cell carcinoma patient study Computational aberration correction in spatiotemporal optical coherence (STOC) imaging