1. Articles from Stephen J. Vincent

    1-9 of 9
    1. Anterior segment optical coherence tomography (AS-OCT) image analysis methods and applications: A systematic review

      Anterior segment optical coherence tomography (AS-OCT) image analysis methods and applications: A systematic review

      Background: Anterior segment optical coherence tomography (AS-OCT) constitutes an important imaging modality to examine the anterior eye, which is commonly used in research and clinical practice. Since its introduction, a range of image analysis methods have been developed to quantify these images using different analysis techniques for various applications. This systematic review aims to provide an in-depth summary and to classify image analysis techniques found in the literature applied to AS-OCT images. Methods: Scopus and Engineering Village databases were searched to retrieve relevant studies up to and including January 2022. Customized search statements were used along with cross reference and ...

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    2. Anterior segment optical coherence tomography scanning protocols and corneal thickness repeatability

      Anterior segment optical coherence tomography scanning protocols and corneal thickness repeatability

      Purpose To examine the influence of anterior segment optical coherence tomography imaging protocols on the intraobserver and intrasession repeatability of epithelial, stromal, and total corneal thickness measurements. Methods Repeated anterior segment optical coherence tomography (AS-OCT) images (Spectralis, Heidelberg) were obtained from 15 adults using single 8.3 mm wide horizontal line scans with an average of 2, 10, 20, 30, 50 and 100 B-scans. Volumetric scans consisting of nine 8.3 mm horizontal line scans encompassing a 1.3 mm vertical region were also captured (with 20 B-scans per line scan). Single point thickness measures (at the normal to the ...

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    3. Automatic choroidal segmentation in OCT images using supervised deep learning methods

      Automatic choroidal segmentation in OCT images using supervised deep learning methods

      The analysis of the choroid in the eye is crucial for our understanding of a range of ocular diseases and physiological processes. Optical coherence tomography (OCT) imaging provides the ability to capture highly detailed cross-sectional images of the choroid yet only a very limited number of commercial OCT instruments provide methods for automatic segmentation of choroidal tissue. Manual annotation of the choroidal boundaries is often performed but this is impractical due to the lengthy time taken to analyse large volumes of images. Therefore, there is a pressing need for reliable and accurate methods to automatically segment choroidal tissue boundaries in ...

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    4. Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Background To examine the repeatability of choroidal thickness measurements across a 55° field, in a sample of healthy young adults using wide‐field enhanced‐depth imaging optical coherence tomography. Methods High‐resolution wide‐field volumetric enhanced‐depth imaging scans were obtained from the right eye of 27 adults (mean age 27 ± 5 years) during two sessions, separated by 19 ± 15 days, using the follow‐up feature of the Spectralis instrument, while controlling for confounding factors known to influence choroidal thickness. Semi‐automatic segmentation of the choroidal boundaries was corrected by a single masked observer. This process was repeated on images ...

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    5. Choroidal changes in human myopia: insights from optical coherence tomography imaging

      Choroidal changes in human myopia: insights from optical coherence tomography imaging

      The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically ...

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    6. Impact of image averaging on wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Impact of image averaging on wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography

      Background The aim of this study was to examine the influence of B‐scan averaging on choroidal thickness using wide‐field enhanced‐depth imaging optical coherence tomography. Methods Six high‐resolution trans‐foveal horizontal enhanced‐depth imaging line scans (spanning a 60° field) were acquired consecutively from the right eye of 10 healthy adults (mean age 30 ± 5 years), with each line scan an average of 10, 20, 30, 40, 50 or 100 B‐scans, using the automated real‐time image averaging and follow‐up features of a Spectralis device. The impact of B‐scan averaging on regional measures of ...

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    7. Optical coherence tomography and scleral contact lenses: clinical and research applications

      Optical coherence tomography and scleral contact lenses: clinical and research applications

      Anterior segment optical coherence tomography (OCT) provides a wealth of opportunities for modern contact lens practice. OCT imaging has numerous clinical and research applications related to the tear film, cornea, conjunctiva, sclera and ocular adnexae, in addition to soft, rigid, and hybrid contact lenses. This review summarises the potential use of OCT imaging in modern scleral contact lens practice including initial lens selection, assessing the scleral contact lens fit with respect to the cornea and sclera, and accurately quantifying the ocular response to lens wear. Recent advances in the understanding of anterior segment metrics including scleral thickness, curvature, toricity, and ...

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    8. Tissue thickness calculation in ocular optical coherence tomography

      Tissue thickness calculation in ocular optical coherence tomography

      Thickness measurements derived from optical coherence tomography (OCT) images of the eye are a fundamental clinical and research metric, since they provide valuable information regarding the eye’s anatomical and physiological characteristics, and can assist in the diagnosis and monitoring of numerous ocular conditions. Despite the importance of these measurements, limited attention has been given to the methods used to estimate thickness in OCT images of the eye. Most current studies employing OCT use an axial thickness metric, but there is evidence that axial thickness measures may be biased by tilt and curvature of the image. In this paper, standard ...

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    9. Choroidal thickness in myopic and non-myopic children assessed with enhanced depth imaging optical coherence tomography

      Choroidal thickness in myopic and non-myopic children assessed with enhanced depth imaging optical coherence tomography

      Purpose: To examine choroidal thickness (ChT) and its topographical variation across the posterior pole in myopic and non-myopic children. Methods: One hundred and four children aged 10-15 years of age (mean age 13.1±1.4 years) had ChT measured using enhanced depth imaging optical coherence tomography (OCT). Forty one children were myopic (mean spherical equivalent -2.4±1.5D) and 63 were non-myopic (mean +0.3±0.3D). ChT was assessed in a series of 6 radial OCT line scans centred on the fovea for each child. Subfoveal ChT and ChT across a series of parafoveal zones over the ...

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    1-9 of 9
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    Choroidal thickness in myopic and non-myopic children assessed with enhanced depth imaging optical coherence tomography Tissue thickness calculation in ocular optical coherence tomography Optical coherence tomography and scleral contact lenses: clinical and research applications Impact of image averaging on wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography Choroidal changes in human myopia: insights from optical coherence tomography imaging Repeatability of wide‐field choroidal thickness measurements using enhanced‐depth imaging optical coherence tomography Automatic choroidal segmentation in OCT images using supervised deep learning methods Anterior segment optical coherence tomography scanning protocols and corneal thickness repeatability Anterior segment optical coherence tomography (AS-OCT) image analysis methods and applications: A systematic review PREcise Percutaneous Coronary Intervention for Stent OptimizatION in Treatment of COMPLEX Lesion (PRECISION-COMPLEX) Real-Time Risk Score for Glaucoma Mass Screening by Spectral Domain Optical Coherence Tomography: Development and Validation Macrophages in close proximity to the vitreoretinal interface are potential biomarkers of inflammation during retinal vascular disease