1. Articles from Elisabetta Pilotto

    1-10 of 10
    1. Retinal Vascular Abnormalities related to Neurofibromatosis Type 1: Natural History and Classification by OCT Angiography in 473 Patients.

      Retinal Vascular Abnormalities related to Neurofibromatosis Type 1: Natural History and Classification by OCT Angiography in 473 Patients.

      Purpose: To analyze and classify neurofibromatosis type 1 (NF1) related retinal vascular abnormalities (RVAs), their natural history and correlation with disease severity, in a large cohort of patients. Methods: This was an observational longitudinal study with prospective enrollment. Four hundred and seventy-three patients affected by NF1 and 150 age-matched healthy subjects were consecutively enrolled. RVAs were detected by means of near-infrared reflectance and studied by optical coherence tomography angiography (OCTA). The superficial vascular plexus (SVP) and the deep vascular complex (DVC) were quantitatively and qualitatively analyzed. Results: We identified RVAs in 82 of 473 (17%) NF1 patients, but in none ...

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    2. Optical coherence tomography and color fundus photography in the screening of age-related macular degeneration: A comparative, population-based study

      Optical coherence tomography and color fundus photography in the screening of age-related macular degeneration: A comparative, population-based study

      Purpose To analyze the individual value and the contribution of color fundus photography (CFP) and optical coherence tomography (OCT) in the screening of age-related macular degeneration (AMD) of an unselected population. Methods CFP and OCT images of 15957 eyes of 8069 subjects older than 55 years, obtained during a population-based screening for AMD using a single diagnostic non-mydriatic imaging device, were analyzed by a blinded examiner. The two techniques were preliminary evaluated considering the dichotomous parameter "gradable/ungradable", then gradable images were classified. CFP were graded according to the standardized classification of AMD lesions. OCT images were also categorized considering ...

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    3. Hyperreflective Intraretinal Foci as an OCT Biomarker of Retinal Inflammation in Diabetic Macular Edema

      Hyperreflective Intraretinal Foci as an OCT Biomarker of Retinal Inflammation in Diabetic Macular Edema

      We read with great interest the article titled “Association Between Soluble CD14 in the Aqueous Humor and Hyperreflective Foci on Optical Coherence Tomography in Patients with Diabetic Macular Edema” by Lee et al. 1 The authors investigated the expression of soluble CD14 (sCD14) in aqueous humor (AH) samples of patients with diabetic macular edema (DME), and the presence of hyperreflective foci (HF) on spectral-domain optical coherence tomography (SD-OCT) in these eyes. The authors found both higher levels of sCD14, and increased number of HF in the inner retina compared to controls, and concluded that, since sCD14 is released by retinal ...

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    4. Early retinal and choroidal OCT and OCT angiography signs of inflammation after uncomplicated cataract surgery

      Early retinal and choroidal OCT and OCT angiography signs of inflammation after uncomplicated cataract surgery

      Purpose To evaluate, by means of optical coherence tomography (OCT) and OCT angiography (OCTA), early retinal, choroidal and macular perfusion changes induced by a local inflammatory reaction secondary to uncomplicated cataract surgery. Methods Selected eyes undergoing cataract surgery were enrolled in a prospective study. OCT and OCTA were performed before cataract surgery (T0) and at day: 1 (T1), 7 (T7), 30 (T30) and 90 (T90). Inner (IR) and outer retinal (OR) volumes, choroidal volume, hyper-reflective retinal spots (HRS) in IR and OR changes were measured at OCT. Macular perfusion was analysed in superficial (SCP), intermediate (ICP) and deep retinal capillary ...

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    5. Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF

      Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF

      Aims To investigate, with optical coherence tomography angiography (OCTA), short-term changes of type 1 choroidal neovascularisation (CNV), secondary to exudative age-related macular degeneration, after anti-vascular endothelial growth factor (VEGF) treatment. Methods Patients affected by type 1 CNV treated with intravitreal anti-VEGF were consecutively enrolled. All patients underwent OCTA examination before and 48 hours after anti-VEGF treatment. Quantitative and qualitative vascular and morphological macular changes were evaluated. Results Sixteen eyes were included (11 treated with aflibercept and 5 with ranibizumab). Both CNV mean area and pigment epithelium detachment significantly reduced (p=0.0004 and p=0.0007, respectively) after treatment. Cystoid ...

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    6. Peripapillary vascular changes in radiation optic neuropathy: an optical coherence tomography angiography grading

      Peripapillary vascular changes in radiation optic neuropathy: an optical coherence tomography angiography grading

      Aims To investigate peripapillary vascular changes secondary to radiation optic neuropathy (RON) using optical coherence tomography angiography (OCT-A) and to propose a clinical grading of RON based on OCT-A findings. Methods Thirty-four patients affected by RON were consecutively included. Each patient underwent best corrected visual acuity measurement (ETDRS score) and OCT-A (Nidek RS-3000 Advance device, Nidek, Gamagori, Japan). The radial peripapillary capillary plexus (RPCP) and the entire peripapillary capillary bed (EPCB) were analysed. Quantitative analysis of the OCT-A images was performed using open-source available ImageJ software (National Institutes of Health, Bethesda, Maryland, USA). Qualitative analysis based on the proposed clinical ...

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    7. Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography

      Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography

      Importance Progressive geographic atrophy (GA) of the retinal pigment epithelium leads to loss of central vision. To identify GA in age-related macular degeneration and assess treatment, correlation of function observed on microperimetry with structure observed on optical coherence tomographic (OCT) images may be of value. Objective To characterize the microperimetric function of GA as identified from en face OCT imaging. Design, Setting, and Participants In a case-series study, 20 patients (22 eyes) entered the study at the University of Padova according to preplanned conditions. From March 1 to July 30, 2014, en face OCT images were obtained at the outer ...

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    8. En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy

      En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy

      Purpose : To detect and quantify geographic atrophy (GA) secondary to age-related macular degeneration using en face optical coherence tomography (OCT) and to correlate it to GA measured with fundus autofluorescence (FAF). Methods : Twenty-four consecutive patients (27 eyes) were studied with both standard (STD)- and enhanced depth imaging (EDI)-OCT. En face OCT images were obtained at the outer retinal layer (OR) and at the choroidal layer (CH) level for both STD- and EDI-OCT. Areas of GA were measured on the en face OCT images and were correlated with the GA areas measured on blue (B)- and near infrared (NIR)-wavelength ...

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    9. Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT

      Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT

      Purpose . To evaluate the presence of hyperreflective spots (HRS) in diabetic patients without clinically detectable retinopathy (no DR) or with nonproliferative mild to moderate retinopathy (DR) without macular edema, and compare the results to controls. Methods . 36 subjects were enrolled: 12 with no DR, 12 with DR, and 12 normal subjects who served as controls. All studied subjects underwent full ophthalmologic examination and spectral domain optical coherence tomography (SD-OCT). SD-OCT images were analyzed to measure and localize HRS. Each image was analyzed by two independent, masked examiners. Results . The number of HRS was significantly higher in both diabetics without and ...

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    10. Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas

      Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas

      Purpose: To compare visual function assessment, optic disc evaluation by indirect ophthalmoscopy and retinal nerve fibres layer analysis by optical coherence tomography (OCT) for the screening of optic pathway gliomas in paediatric patients (2-15 years) affected by neurofibromatosis type-1. Methods: Fifty-seven consecutive patients affected by neurofibromatosis type-1 with recent (<6 moths) orbital/brain MRI were included. Patients underwent visual function assessment (Hyvarinen symbols chart and/or Snellen charts) and optic disc evaluation by indirect ophthalmoscopy by experienced, masked paediatric ophthalmologists. Spectral domain-OCT was performed to assess retinal nerve fibres layer. Results: Fifteen out of fifty-seven enrolled patients were affected by ...

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    1-10 of 10
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    Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT En Face Optical Coherence Tomography to Detect and Measure Geographic Atrophy Microperimetry Features of Geographic Atrophy Identified With En Face Optical Coherence Tomography Peripapillary vascular changes in radiation optic neuropathy: an optical coherence tomography angiography grading Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF Early retinal and choroidal OCT and OCT angiography signs of inflammation after uncomplicated cataract surgery Hyperreflective Intraretinal Foci as an OCT Biomarker of Retinal Inflammation in Diabetic Macular Edema Optical coherence tomography and color fundus photography in the screening of age-related macular degeneration: A comparative, population-based study Retinal Vascular Abnormalities related to Neurofibromatosis Type 1: Natural History and Classification by OCT Angiography in 473 Patients. Non-invasive diagnosis of acquired lymphangiectases using optical coherence tomography Depth-resolved investigation of multiple optical properties and wrinkle morphology in eye-corner areas with multi-contrast Jones matrix optical coherence tomography