1. Articles from Michel Paques

    1-14 of 14
    1. Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images

      Highlighting Directional Reflectance Properties of Retinal Substructures From D-OCT Images

      Optical coherence tomography (OCT), which is routinely used in ophthalmology, enables transverse optical imaging of the retina and, hence, the identification of the different neuronal layers. Directional OCT (D-OCT) extends this technology by acquiring sets of images at different incidence angles of the light beam. In this way, reflectance properties of photoreceptor substructures are highlighted, enabling physicians to study their orientation, which is potentially an interesting biomarker for retinal diseases. Nevertheless, commercial OCT devices equipped to automate D-OCT acquisition do not yet exist, meaning that physicians manually deviate the light beam to acquire a set of D-OCT images sequentially. Therefore ...

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    2. Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Purpose To image retinal blood vessels in patients with Waldenström's macroglobulinemia using optical coherence tomography (OCT). Methods Retrospective case series examining fundus photographs and OCT scans of 16 eyes in eight patients with Waldenström's macroglobulinemia. Analyses included intravascular OCT reflectivity profiles and vessel diameters, and their relation to total immunoglobulin M (IgM) levels. Results In six out of eight patients, cross‐sectional OCT scans of larger retinal vessels (diameter > 100 μm) showed normal intravascular reflectivity and retrovascular shadowing. In two patients with the highest total IgM > 60 g/l, altered intravascular reflectivity, distinct anterior and posterior ...

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    3. Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Cell Motility as Contrast Agent in Retinal Explant Imaging With Full-Field Optical Coherence Tomography

      Purpose : To use cell motility as a contrast agent in retinal explants. Methods : Macaque and mouse retinal explants were imaged with high resolution full field optical coherence tomography (FFOCT) and dynamic FFOCT, coupled with fluorescence imaging. Results : Static and dynamic FFOCT create complementary contrast from different structures within a cell. When imaging in vitro samples, static FFOCT detects steep refractive index gradients to reveal stationary structures including fibers, vessels, collagen, and cell contours, while dynamic FFOCT emphasizes metabolic activity of moving structures that are mainly intracellular, thus creating or enhancing contrast in cells that were previously hidden in noise. Dynamic ...

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    4. Appearance of the Retina With Full-Field Optical Coherence Tomography

      Appearance of the Retina With Full-Field Optical Coherence Tomography

      Purpose : To interpret full-field optical coherence tomography (FFOCT) images of ex vivo retina. Methods : Flatmounted retinas of human, primate, pig, sheep, rat, and mouse were imaged using FFOCT. To identify retinal ganglion and amacrine cells, fixed samples immunolabeled against Tuj1 and Brn3a or live samples labeled in vitro with green fluorescent protein (GFP) were analyzed by combining FFOCT, fluorescence confocal microscopy (FCM), and fluorescence-FFOCT. To investigate postmortem tissue changes, time series were acquired over 48 hours and on fresh versus fixed tissue. Results : With FFOCT, cell types and features such as nerve fiber bundles and RGC somas were resolved without ...

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    5. Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy

      Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy

      Background To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR). Methods Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up. Results Both cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked ...

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      Mentions: Michel Pâques
    6. Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas

      Purpose : To evaluate the performance of a full-field optical coherence tomography (FF-OCT) system in the study of human donor and pathological corneas and assess its suitability for use in eye banks. Methods : Our study was carried out using an FF-OCT system developed for non-invasive imaging of tissue structures in depth with ultrahigh resolution (1 µm in all directions). Images were acquired from eight stored human donor corneas (either edematous or after deswelling) and five surgical specimens of corneas with various diseases (bullous keratopathy, lattice corneal dystrophy, stromal scar after keratitis, keratoconus and Fuchs dystrophy). They were compared with standard histology ...

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    7. Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used method to observe retinal layers and follow pathological events in human. Recently, this technique has been adapted for animal imaging. This non-invasive technology brings a cross-sectional visualization of the retina, which permits to observe precisely each layer. There is a clear expansion of the use of this imaging modality in rodents, thus, a precise characterization of the different outer retinal layers observed by SD-OCT is now necessary to make the most of this technology. The identification of the inner strata until the outer nuclear layer has already been clearly established, while ...

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      Mentions: Michel Pâques
    8. Recognition of Henle's Fiber Layer on OCT Images

      Recognition of Henle's Fiber Layer on OCT Images

      Monés et al made an important observation about how important is to recognize the normal anatomy of the Henle's fiber layer in the optical coherence tomography images (OCT). Spectral-domain (SD) OCT offers the possibility of evaluating retinal architecture at near-histologic levels of resolution. However, clinicians should be aware that optical variations induced by examination conditions might alter the reflectivity of the retinal layers. This consideration is particularly true when imaging the outer plexiform layer (OPL) within the central macula.

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    9. Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade

      Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade

      Purpose: To describe small hyperreflective areas using spectral-domain optical coherence tomography (SD-OCT) imaging in eyes that have had silicone oil tamponade. Methods: Retrospective case series of 11 eyes of 11 patients. The authors retrospectively identified patients who underwent vitrectomy and silicone oil tamponade secondary to a rhegmatogenous retinal detachment (nine patients), panuveitis with retinal necrosis (one patient), or recurrent full-thickness macular hole surgery (one patient) who had manifestations of silicone oil emulsion on SD-OCT imaging. Patients were monitored during the postoperative period by clinical examination and using SD-OCT. A model eye in which emulsified silicone oil had been injected in ...

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    10. Device For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue And Method For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue

      Device For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue And Method For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue

      The invention relates to a device for assisting in detecting anatomical features of at least a portion of a tissue, in particular a retinal tissue, the device comprising means for acquiring images of said portion using optical coherence tomography (OCT), which are taken at separate angles of incidence, and detection means for detecting, in a single area of the portion studied, at least one pattern having at least one feature that varies from one image to another, the pattern being attributable to the presence of anatomical features. The invention likewise relates to a method for assisting in detecting anatomical features ...

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    11. Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography

      Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography
      Accounting for less than 1% of primary intracranial tumors, primary intraocular lymphoma (PIOL) is a subtype of primary central nervous system lymphoma [1–4]. Frequently masqueraded as chronic posterior uveitis, PIOL may involve the vitreous, retina, and/or the optic nerve. To our knowledge, there is no report of the interest of high-resolution optical coherence tomography (OCT) in PIOL. Here, we describe the case of a patient with PIOL in which, following initially successful chemotherapy, relapse was revealed by visual loss associated to diffuse subretinal lymphomatous infiltration. Interestingly, while fundus examination and autofluorescence imaging showed minimal abnormalities, spectral-domain optical coherence ...
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    12. Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging

      Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging
      Purpose. During perfused retinal vein occlusions, patchy retinal opacification due to acute neuronal swelling may be present. This may be difficult to document using conventional imaging techniques. Methods. Three-dimensional topography of focal retinal opacification was documented in a patient with hemiretinal vein occlusion by combining en face adaptive optics (AO) imaging with high-resolution optical coherence tomography (OCT). Results. Patchy retinal opacification in the macula was faintly visible by color fundus photography with no angiographic correlation. Adaptive optics and OCT imaging showed that these areas were located in the plexiform layers while the nerve fiber layer remained spared. During follow-up, visual ...
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      Mentions: Michel Pâques
    13. Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography

      Background Macular edema occurring after retinal vein occlusion (RVO) or diabetic retinopathy (DR) may be due to the development of capillary and/or venous macroaneurysms (MAs). Here, we investigated the respective contribution of fluorescein angiography (FA), of indocyanine green angiography (ICGA) and of high-resolution optical coherence tomography (HR-OCT) to their detection. Methods Review of the charts of six consecutive patients with MAs secondary to RVO (n = 4) or DR (n = 2). For each patient, FA, ICGA and HR-OCT data were analyzed and compared. Results All detectable MAs were detected by ICGA, while in three eyes FA failed to show them ...
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    14. First steps toward 3D high resolution imaging using adaptive optics and full-field optical coherence tomography

      We describe here two parts of our future 3D fundus camera coupling Adaptive Optics and full-field Optical Coherence Tomography. The first part is an Adaptive Optics flood imager installed at the Quinze-Vingts Hospital, regularly used on healthy and pathological eyes. A posteriori image reconstructio ... [Proc. SPIE 7139, 713913 (2008)] published Tue Dec 30, 2008.
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    1-14 of 14
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    1. (13 articles) Michel Pâques
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    3. (3 articles) ESPCI ParisTech
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    Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography Device For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue And Method For Assisting In Detecting Anatomical Features Of At Least A Portion Of A Tissue Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade Recognition of Henle's Fiber Layer on OCT Images Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology Full-Field Optical Coherence Tomography of Human Donor and Pathological Corneas Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy Intravitreal Ranibizumab Monotherapy or Combined with Laser for Diabetic Macular Edema (OCT guided study) Prospective evaluation of drug eluting self‐apposing stent for the treatment of unprotected left main coronary artery disease: 1‐year results of the TRUNC study Clinical validation of the RTVue optical coherence tomography angiography image quality indicators Intraoperative OCT-Assisted Retinal Detachment Repair in the DISCOVER Study: Impact and Outcomes