1. Articles from Jose-Alain Sahel

    1-18 of 18
    1. Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Optical Coherence Tomography Findings in Tamoxifen Retinopathy

      Purpose To describe optical coherence tomography (OCT) findings in two cases of typical tamoxifen retinopathy. Design Observational cases report. Methods Two patients with tamoxifen retinopathy were imaged with fluorescein angiography and OCT 3. Results Fluorescein angiography showed foveolar hyperfluorescence. OCT revealed a foveolar cystoid space with focal disruption of the photoreceptor line. There was no evidence of macular edema or thickening. Conclusions In both cases, OCT findings are not consistent with previous descriptions of tamoxifen retinopathy, based on fundus examination and fluorescein angiography, which include a description of macular edema. This new imaging suggests that tamoxifen maculopathy may include a ...

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    2. ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      ATTENUATION OUTER RETINAL BANDS ON OPTICAL COHERENCE TOMOGRAPHY FOLLOWING MACULAR EDEMA: A Possible Manifestation of Photoreceptor Misalignmen

      Purpose: Macular edema is a common retinal disease which may leave important anatomical and functional sequelaes. Directional fundus imaging consists of comparing on- and off-axis images to reveal angle-dependent reflectance properties of fundus structures, which may be related to misaligned photoreceptors . Here, we analyzed directional optical coherence tomography (OCT) and flood-illumination adaptive optics ophthalmoscopy images to detect evidence of misaligned photoreceptors following macular edema . Methods: Transversal, observational study. Nine patients having recovered a normal macular profile after macular edema due to retinal vein occlusion were included. For each patient, a reference OCT scan (i.e., with the incident beam normal ...

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    3. NEW OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS ON AN INTRARETINAL VASCULAR PROCESS SECONDARY TO TOXOPLASMA RETINOCHOROIDITIS 2 CASE REPORTS

      NEW OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS ON AN INTRARETINAL VASCULAR PROCESS SECONDARY TO TOXOPLASMA RETINOCHOROIDITIS 2 CASE REPORTS

      Background/Purpose: To determine which retinal layer is primarily involved in intraretinal vascular processes associated with Toxoplasma retinochoroiditis using multimodal imaging, including optical coherence tomography angiography ( OCTA ). Methods: Toxoplasma retinal lesions were analyzed through multimodal imaging, including color fundus photographs, fluorescein angiography, indocyanine green angiography, spectral-domain OCT, and OCTA . Results: Two patients with atypical features of Toxoplasma retinochoroiditis are described in the acute phase. The first patient presented with a primary episode of acute Toxoplasma retinitis associated with an intraretinal abnormal vascular process that was detected at the acute phase by indocyanine green angiography and was better delineated by OCTA ...

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    4. Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      Probing dynamic processes in the eye at multiple spatial and temporal scales with multimodal full field OCT

      We describe recent technological progress in multimodal en face full-field optical coherence tomography that has allowed detection of slow and fast dynamic processes in the eye. We show that by combining static, dynamic and fluorescence contrasts we can achieve label-free high-resolution imaging of the retina and anterior eye with temporal resolution from milliseconds to several hours, allowing us to probe biological activity at subcellular scales inside 3D bulk tissue. Our setups combine high lateral resolution over a large field of view with acquisition at several hundreds of frames per second which make it a promising tool for clinical applications and ...

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    5. In vivo high resolution human corneal imaging using full-field optical coherence tomography

      In vivo high resolution human corneal imaging using full-field optical coherence tomography

      We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman’s layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet’s membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 µm and relatively large field-of-view of 1.26 mm x 1.26 mm – a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless ...

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    6. Full-field OCT technique for high speed event-based optical flow and particle tracking

      Full-field OCT technique for high speed event-based optical flow and particle tracking

      This article introduces a method to extract the speed and density of microparticles in real time at several kHz using an asynchronous event-based camera mounted on a full-field optical coherence tomography (FF-OCT) setup. These cameras detect significant amplitude changes, allowing scene-driven acquisitions. They are composed of an array of autonomously operating pixels. Events are triggered when an illuminance change at the pixel level is significant at 1 μs time precision. The event-driven FF-OCT algorithm relies on a time-based optical flow computation to operate directly on incoming events and updates the estimation of velocity, direction and density while reducing both computation ...

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      Mentions: Kate Grieve
    7. Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy

      Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy

      Background To report functional and high-resolution retinal imaging abnormalities, including adaptive optics (AO) throughout the course of acute macular neuroretinopathy (AMNR). Methods Two female patients (four eyes) with a diagnosis of AMNR were observed at the Clinical Investigation Center, CHNO des Quinze-Vingts, Paris, France. The patients underwent detailed ophthalmic examination including best-corrected visual acuity, slit-lamp examination, kinetic and static perimetry, full-field and multifocal electroretinogram, infrared reflectance, autofluorescence imaging and spectral-domain optical coherence tomography (SD-OCT) and AO fundus imaging at presentation and during follow-up. Results Both cases showed concomitant loss of integrity of the outer retinal structures on SD-OCT, and marked ...

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      Mentions: Michel Pâques
    8. "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

      "EN FACE" OPTICAL COHERENCE TOMOGRAPHY IMAGING IN TYPE 2 IDIOPATHIC MACULAR TELANGIECTASIA

      Purpose: To comprehensively evaluate the retinal and choroidal changes in eyes with Type 2 idiopathic macular telangiectasia using “en face” and B-scan spectral domain optical coherence tomography (OCT), and to compare their respective contributions to this evaluation. Methods: Eyes with a diagnosis of proliferative or nonproliferative Type 2 macular telangiectasia were prospectively studied. All patients underwent an extensive ophthalmologic examination including biomicroscopic fundus examination, color photography, fundus autofluorescence, fluorescein angiography, B-scan and en face spectral domain OCT. Results: Twenty eyes of 10 patients were included in this study. En face OCT C-scans and conventional B-scans were both able to show ...

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    9. Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography of the Rodent Eye: Highlighting Layers of the Outer Retina Using Signal Averaging and Comparison with Histology

      Spectral-Domain Optical Coherence Tomography (SD-OCT) is a widely used method to observe retinal layers and follow pathological events in human. Recently, this technique has been adapted for animal imaging. This non-invasive technology brings a cross-sectional visualization of the retina, which permits to observe precisely each layer. There is a clear expansion of the use of this imaging modality in rodents, thus, a precise characterization of the different outer retinal layers observed by SD-OCT is now necessary to make the most of this technology. The identification of the inner strata until the outer nuclear layer has already been clearly established, while ...

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      Mentions: Michel Pâques
    10. “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

      Purpose . The recent use of “en-face” enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS). Methods . Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan (“en-face”) EDI SD-OCT at the initial visit and during follow-up. Results . C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and “en-face” OCT helped identify the acute microstructural damages in ...

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    11. RETINAL INNER NUCLEAR LAYER MICROCYSTIC CHANGES IN OPTIC NERVE ATROPHY: A Novel Spectral-Domain OCT Finding

      RETINAL INNER NUCLEAR LAYER MICROCYSTIC CHANGES IN OPTIC NERVE ATROPHY: A Novel Spectral-Domain OCT Finding

      Purpose: Optic atrophy constitutes the final stage in the evolution of optic neuropathy. The aim of this study was to describe the presence of macular microcystic changes or pseudocysts in patients with advanced optic atrophy. Methods: The medical records of 24 patients who had retinal pseudocysts in association with optic atrophy have been analyzed. All patients underwent a complete neuro-ophthalmologic assessment; peripapillary retinal nerve fiber layer thickness and macular screening with spectral-domain optical coherence tomography and optical coherence tomography "en face" imaging analysis were also performed. Results: A total of 36 eyes were included in the study. Patients' mean age ...

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    12. Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade

      Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade

      Purpose: To describe small hyperreflective areas using spectral-domain optical coherence tomography (SD-OCT) imaging in eyes that have had silicone oil tamponade. Methods: Retrospective case series of 11 eyes of 11 patients. The authors retrospectively identified patients who underwent vitrectomy and silicone oil tamponade secondary to a rhegmatogenous retinal detachment (nine patients), panuveitis with retinal necrosis (one patient), or recurrent full-thickness macular hole surgery (one patient) who had manifestations of silicone oil emulsion on SD-OCT imaging. Patients were monitored during the postoperative period by clinical examination and using SD-OCT. A model eye in which emulsified silicone oil had been injected in ...

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    13. En Face OCT Imaging for the Diagnosis of Outer Retinal Tubulations in Age-Related Macular Degeneration

      En Face OCT Imaging for the Diagnosis of Outer Retinal Tubulations in Age-Related Macular Degeneration

      Purpose. "En face" is an emerging imaging technique derived from spectral domain optical coherence tomography (OCT). It produces frontal sections of retinal layers, also called "C-scan OCT." Outer retinal tubulations (ORTs) in age-related macular degeneration (AMD) are a recent finding evidenced by spectral-domain OCT. The aim of this study is to characterize the morphology of ORT according to the form of AMD, using "en-face" spectral domain OCT. Methods. "En face" OCT imaging was prospectively performed in 26 consecutive eyes with AMD that also had ORT. Results. There were 15 neovascular, 8 atrophic, and 3 eyes with a mixed (fibrotic and ...

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    14. Spectral domain optical coherence tomography evolutive features in acute macular neuroretinopathy

      Spectral domain optical coherence tomography evolutive features in acute macular neuroretinopathy

      Purpose. To demonstrate the usefulness of spectral domain optical coherence tomography (SD-OCT) in investigating the evolution of the retinal outer lesions seen in acute macular neuroretinopathy (AMN). Methods. A 32-year-old woman presented with a 1-day history of paracentral dark spot in the left eye, preceded by a flulike illness. A full ophthalmologic examination, color vision, visual field examination, and conventional imaging of the retina were done. Scanning laser ophthalmoscopic infrared imaging and SD-OCT of the macular region were performed. Results. Best-corrected visual acuity was 20/20 in both eyes. Slit-lamp examination as well as retinal photographs were unrevealing. Scanning laser ...

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    15. Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography

      Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography
      Accounting for less than 1% of primary intracranial tumors, primary intraocular lymphoma (PIOL) is a subtype of primary central nervous system lymphoma [1–4]. Frequently masqueraded as chronic posterior uveitis, PIOL may involve the vitreous, retina, and/or the optic nerve. To our knowledge, there is no report of the interest of high-resolution optical coherence tomography (OCT) in PIOL. Here, we describe the case of a patient with PIOL in which, following initially successful chemotherapy, relapse was revealed by visual loss associated to diffuse subretinal lymphomatous infiltration. Interestingly, while fundus examination and autofluorescence imaging showed minimal abnormalities, spectral-domain optical coherence ...
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    16. Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging

      Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging
      Purpose. During perfused retinal vein occlusions, patchy retinal opacification due to acute neuronal swelling may be present. This may be difficult to document using conventional imaging techniques. Methods. Three-dimensional topography of focal retinal opacification was documented in a patient with hemiretinal vein occlusion by combining en face adaptive optics (AO) imaging with high-resolution optical coherence tomography (OCT). Results. Patchy retinal opacification in the macula was faintly visible by color fundus photography with no angiographic correlation. Adaptive optics and OCT imaging showed that these areas were located in the plexiform layers while the nerve fiber layer remained spared. During follow-up, visual ...
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      Mentions: Michel Pâques
    17. Imaging of macroaneurysms occurring during retinal vein occlusion and diabetic retinopathy by indocyanine green angiography and high resolution optical coherence tomography

      Background Macular edema occurring after retinal vein occlusion (RVO) or diabetic retinopathy (DR) may be due to the development of capillary and/or venous macroaneurysms (MAs). Here, we investigated the respective contribution of fluorescein angiography (FA), of indocyanine green angiography (ICGA) and of high-resolution optical coherence tomography (HR-OCT) to their detection. Methods Review of the charts of six consecutive patients with MAs secondary to RVO (n = 4) or DR (n = 2). For each patient, FA, ICGA and HR-OCT data were analyzed and compared. Results All detectable MAs were detected by ICGA, while in three eyes FA failed to show them ...
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    18. First steps toward 3D high resolution imaging using adaptive optics and full-field optical coherence tomography

      We describe here two parts of our future 3D fundus camera coupling Adaptive Optics and full-field Optical Coherence Tomography. The first part is an Adaptive Optics flood imager installed at the Quinze-Vingts Hospital, regularly used on healthy and pathological eyes. A posteriori image reconstructio ... [Proc. SPIE 7139, 713913 (2008)] published Tue Dec 30, 2008.
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    1-18 of 18
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    Topography of patchy retinal whitening during acute perfused retinal vein occlusion by optical coherence tomography and adaptive optics fundus imaging Subretinal lymphomatous infiltration in primary intraocular lymphoma revealed by optical coherence tomography Spectral domain optical coherence tomography evolutive features in acute macular neuroretinopathy En Face OCT Imaging for the Diagnosis of Outer Retinal Tubulations in Age-Related Macular Degeneration Using Spectral-Domain Optical Coherence Tomography Imaging to Identify the Presence of Retinal Silicone Oil Emulsification After Silicone Oil Tamponade RETINAL INNER NUCLEAR LAYER MICROCYSTIC CHANGES IN OPTIC NERVE ATROPHY: A Novel Spectral-Domain OCT Finding Functional and high-resolution retinal imaging monitoring photoreceptor damage in acute macular neuroretinopathy In vivo high resolution human corneal imaging using full-field optical coherence tomography Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation Swept-source and multimodal OCT technologies offer clinical advantages Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study OCT, OCTA show promise in screening for DR