1. Articles from Gregory W. Randolph

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    1. Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Background : Optical coherence tomography(OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Methods : Normal tissues were obtained from patients undergoing surgical treatment. Two new-generations OCT systems including optical frequency domain imaging(OFDI) and µOCT were compared to representative H&E histology. Results : Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic-like microscopic characteristics sufficient for tissue type identification was realized using both ...

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    1. (1 articles) Massachusetts Eye and Ear Infirmary
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