1. Articles from Eimear Phelan

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    1. Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Optical coherence tomography imaging during thyroid and parathyroid surgery: A novel system of tissue identification and differentiation to obviate tissue resection and frozen section

      Background : Optical coherence tomography(OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. Methods : Normal tissues were obtained from patients undergoing surgical treatment. Two new-generations OCT systems including optical frequency domain imaging(OFDI) and µOCT were compared to representative H&E histology. Results : Thyroid, fat, muscle, lymph nodes, and parathyroid tissues were evaluated. Histologic-like microscopic characteristics sufficient for tissue type identification was realized using both ...

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    1. (1 articles) Massachusetts Eye and Ear Infirmary
    2. (1 articles) Harvard University
    3. (1 articles) National Institutes of Health
    4. (1 articles) Massachusetts General Hospital
    5. (1 articles) University of São Paulo
    6. (1 articles) Guillermo J. Tearney
    7. (1 articles) Eman Namati
    8. (1 articles) Linbo Liu
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