1. Articles from SRINIVAS SADDA

    1-17 of 17
    1. Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom

      Identification and Characterization of Imaging Technique Errors and Artifacts using Anterior Segment Optical Coherence Tomography for Irido-Corneal Angle Evaluations in Glaucom

      Purpose Anterior segment optical coherence tomography (ASOCT) platforms provide non-invasive and quantifiable evaluations of anterior chamber angle (ACA) anatomy. Even though these ACA measurements have been validated with high repeatability and reproducibility, we are the first study to describe in detail the technique errors and artifacts that may occur during imaging of the ACA. The purpose of this study was to define the different types and quantify the frequency of imaging technique errors and artifacts that are seen in ACA evaluation of a large cohort of patients with open-angle glaucoma. Design Retrospective cross-sectional design. Subjects Five thousand and eighty-two eyes ...

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    2. Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis

      Distinct Retinal Capillary Plexuses in Normal Eyes as Observed in Optical Coherence Tomography Angiography Axial Profile Analysis

      Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes using the Spectralis OCT2 with a full-spectrum, probabilistic OCTA algorithm, that, in marked contrast to split-spectrum approaches, preserves the original high OCT axial resolution also within the resulting OCTA signal ...

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    3. PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: An Optical Coherence Tomographic Angiography Analysis

      PROGRESSION OF MACULAR ATROPHY IN EYES WITH TYPE 1 NEOVASCULARIZATION AND AGE-RELATED MACULAR DEGENERATION RECEIVING LONG-TERM INTRAVITREAL ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY: An Optical Coherence Tomographic Angiography Analysis

      Purpose: To evaluate the size and location of macular atrophy in eyes with Type-1 neovascularization (NV) and age-related macular degeneration receiving chronic intravitreal anti–vascular endothelial growth factor therapy. Methods: A retrospective review of a case series of 27 eyes with Type-1 NV and retinal pigment epithelial detachment (PED) having a minimum of 12 months follow-up was performed. Demographic information and visual acuity at baseline and the final follow-up were collected. Spectral-domain optical coherence tomography (OCT) and near-infrared reflectance were analyzed at 6-month intervals to detect and measure macular atrophy. Location and area (in square millimeter) of macular atrophy were ...

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    4. Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

      Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy

      Aims To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes. Methods Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Quantitative analysis of the perfusion density (PD), vessel length density (VLD) and fractal dimension (FD) was performed. The area under the receiver operating characteristic curve was estimated to assess the ability of each image size ...

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    5. Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy

      Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy

      Aims To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR). Methods This study included 37 eyes of 27 patients (age, 65±10 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). The imaging methods were compared for visible field of view, presence and extent of non-perfused areas (NPAs), presence and number of new blood vessels (NVs), vessel density (VD) and patient comfort level measured by Visual Analogue Scale ...

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    6. Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography

      Assessing Deep Retinal Capillary Ischemia in Paracentral Acute Middle Maculopathy by Optical Coherence Tomography Angiography

      Purpose To assess microvascular blood flow of the deep retinal capillary plexus in eyes with paracentral acute middle maculopathy using optical coherence tomography (OCT) angiography. Design Retrospective, multicenter, observational case series. Methods Clinical and multimodal imaging findings from 8 patients with paracentral acute middle maculopathy were reviewed and analyzed. OCT angiography scans were analyzed and processed, and vessel density was calculated. Results Eight patients (7 male, 1 female, aged 9-82 years) were included. OCT angiography was obtained at either the acute (4 cases) or old stage (4 cases). Scans of the deep capillary plexus showed preservation of perfusion in acute ...

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    7. Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

      Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability

      Purpose : To evaluate the reproducibility of anterior chamber angle measurements obtained by the Zeiss Visante anterior segment optical coherence tomography (AS-OCT). Methods : Twenty eyes from 20 normal subjects with open anterior chamber angles were studied. The anterior chamber angle was imaged using the Visante AS-OCT. The angle-opening distance (AOD 500, AOD 750), trabercular iris space area (TISA 500, TISA 750) and scleral spur angle (SS angle) at the inferior angle location were measured. All the subjects underwent imaging in a darkened room (1 foot candles measured at the eye). Images were graded in a masked fashion by certified Doheny Image ...

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    8. Proposed Lexicon for Anatomic Landmarks in Normal Posterior Segment Spectral-Domain Optical Coherence Tomography: The IN•OCT Consensus

      Proposed Lexicon for Anatomic Landmarks in Normal Posterior Segment Spectral-Domain Optical Coherence Tomography: The IN•OCT Consensus

      Purpose To develop a consensus nomenclature for the classification of retinal and choroidal layers and bands visible on spectral-domain optical coherence tomography (SD-OCT) images of a normal eye. Design An international panel with expertise in retinal imaging (International Nomenclature for Optical Coherence Tomography [IN•OCT] Panel) was assembled to define a consensus for OCT imaging terminology. Participants A panel of retina specialists. Methods A set of 3 B-scan images from a normal eye was circulated to the panel before the meeting for independent assignment of nomenclature to anatomic landmarks in the vitreous, retina, and choroid. The outputs were scrutinized, tabulated ...

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    9. Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Purpose: To compare drusen measurements obtained from color fundus and infrared retromode photographs with those derived from spectral-domain optical coherence tomography. Methods: Drusen lesions identified on the planar (color and infrared) imaging modalities were manually segmented by two independent graders using previously described reading center software to produce quantitative measurements of drusen area and number. The corresponding volume Cirrus OCT datasets were analyzed using commercial retinal pigment epithelium analysis algorithms to segment the retinal pigment epithelium band and estimated the drusen area. Drusen numbers were extracted from retinal pigment epithelium elevation maps. Intraclass correlation coefficients assessed agreement between graders; graders ...

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    10. Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis

      Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis

      Purpose To identify visually significant spectral-domain optical coherence tomography (SD-OCT) features of epiretinal membranes (ERM) in patients with uveitis. Design Retrospective cohort and cross-sectional study. Methods Eighty consecutive eyes with uveitis and SD-OCT–documented ERM were included. Clinical data were collected at the time of diagnosis of ERM and at the final visit. SD-OCT images at the last visit were evaluated to identify fovea and ERM configuration and structural changes. Changes of 10% and 20% in central subfield thickness between initial and last SD-OCT were calculated and correlated with visual acuity (VA). An ERM thickness map was created using validated ...

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    11. Image Quality Affects Macular and Retinal Nerve Fiber Layer Thickness Measurements on Fourier-Domain Optical Coherence Tomography

      Image Quality Affects Macular and Retinal Nerve Fiber Layer Thickness Measurements on Fourier-Domain Optical Coherence Tomography
      BACKGROUND AND OBJECTIVE To investigate whether image quality is an important determinant of retinal nerve fiber layer (RNFL) and macular thickness measurements on Fourier-domain optical coherence tomography (OCT). PATIENTS AND METHODS Seventy-five and 56 normal subjects were recruited in RNFL and macular thickness arms of the study, respectively. Each participant was scanned three times using both the 3D OCT-1000 (version 3.01, Mark II; Topcon Corporation, Tokyo, Japan) and the Cirrus OCT (version 3.0, Model 4000; Carl Zeiss Meditec, Inc., Dublin, CA). The scans for each participant were arranged in order of increasing image qualities, which were correlated with ...
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    12. Macular and Retinal Nerve Fiber Layer Thickness Measurements in Normal Eyes With the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000

      Macular and Retinal Nerve Fiber Layer Thickness Measurements in Normal Eyes With the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000
      Purpose: To compare retinal nerve fiber layer (RNFL) and macular thickness measurements using time-domain optical coherence tomography (TD OCT) and 2 Fourier-domain OCTs (FD OCT). Methods: Sixty eyes of 60 normal participants underwent eye examination followed by OCT evaluation with the time-domain Stratus OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and 2 FD OCTs-the Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA) and the 3D OCT-1000 (Topcon Corporation, Tokyo, Japan). Each patient was scanned 3 times on each machine by the same physician examiner. RNFL and macular thickness measurements were compared across the 3 devices using repeated measures analysis of ...
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    13. Comparison of full-thickness traumatic macular holes and idiopathic macular holes by optical coherence tomography

      Comparison of full-thickness traumatic macular holes and idiopathic macular holes by optical coherence tomography
      Background The optical coherence tomography (OCT) and clinical characteristics of traumatic macular holes (TMHs) can be compared to those of idiopathic macular holes (IMHs) to gain insights into the pathogenesis of both. Methods The demographic data and visual acuity of 73 consecutive patients with unilateral, full-thickness TMHs and 182 consecutive patients with idiopathic IMHs were recorded. All patients with TMH and 60 patients with IMH underwent OCT scanning and quantitative measurements. The apical and basal diameters and marginal retinal thicknesses were recorded for each hole. The hole areas and eccentricities were calculated. These parameters were compared between the two types ...
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    14. Impact of Scanning Density on Measurements from Spectral Domain Optical Coherence Tomography

      Purpose: To investigate the relationship between B-scan density and retinal thickness measurements obtained by spectral domain optical coherence tomography (SDOCT) in eyes with retinal disease. Methods: Data were collected from 115 patients who underwent volume OCT imaging with Cirrus HD-OCT using the 512 x 128 horizontal raster protocol. Raw OCT data, including the location of the automated retinal boundaries, were exported from the Cirrus HD-OCT instrument and imported into the Doheny Image Reading Center (DIRC) OCT viewing and grading software, termed "3D-OCTOR". For each case, retinal thickness maps similar to those produced by Cirrus HD-OCT were generated using all 128 ...
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    15. Macular Thickness Measurements in Normal Eyes With Time-Domain and Fourier-Domain Optical Coherence Tomography

      Purpose: To compare macular thickness measurements using time-domain optical coherence tomography (OCT) and Fourier-domain OCT. Methods: Thirty-two eyes from 32 normal patients underwent complete ophthalmic evaluation. Macular scanning using the StratusOCT and the RTVue-100 OCT were performed for a total of three times each on the same visit. The average retinal thicknesses of the nine macular sectors as defined by the Early Treatment Diabetic Retinopathy Study, along with the foveal center point and macular volume, were recorded. The SD, the coefficient of variation, and the intraclass correlation coefficient were calculated for each parameter studied. Comparisons were made between the two ...
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    16. Association Of The Extent Of Diabetic Macular Edema As Assessed By Optical Coherence Tomography With Visual Acuity And Retinal Outcome Variables.

      Purpose: To determine whether the extensiveness of diabetic macular edema using a 10-step scale based on optical coherence tomography explains pretreatment variation in visual acuity and predicts change in macular thickness or visual acuity after laser photocoagulation. Methods: Three hundred twenty-three eyes from a randomized clinical trial of two methods of laser photocoagulation for diabetic macular edema were studied. Baseline number of thickened optical coherence tomography subfields was used to characterize diabetic macular edema on a 10-step scale from 0 to 9. Associations were explored between baseline number of thickened subfields and baseline fundus photographic variables, visual acuity, central subfield ...
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    17. CLASSIFICATION OF FULL-THICKNESS TRAUMATIC MACULAR HOLES BY OPTICAL COHERENCE TOMOGRAPHY.

      Purpose: To describe morphologic features of traumatic macular holes on optical coherence tomography and to correlate them with clinical findings. Methods: Seventy-three consecutive patients diagnosed with full-thickness traumatic macular holes involving the fovea underwent complete ophthalmic evaluation followed by horizontal and vertical li...
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    1-17 of 17
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    1. (17 articles) Srinivas R. Sadda
    2. (10 articles) University of Southern California
    3. (7 articles) UCLA
    4. (6 articles) Carl Zeiss Meditec
    5. (4 articles) Sun Yat-Sen University
    6. (4 articles) Zeiss Cirrus HD-OCT
    7. (3 articles) Optovue
    8. (3 articles) Zeiss Stratus OCT
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    10. (2 articles) Topcon 3D OCT-1000
    11. (1 articles) Tsinghua University
    12. (1 articles) New York Eye and Ear Infirmary
    13. (1 articles) Ping Xue
    14. (1 articles) Richard B. Rosen
    15. (1 articles) Chengming Wang
    16. (1 articles) Ning Zhang
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    Comparison of full-thickness traumatic macular holes and idiopathic macular holes by optical coherence tomography Macular and Retinal Nerve Fiber Layer Thickness Measurements in Normal Eyes With the Stratus OCT, the Cirrus HD-OCT, and the Topcon 3D OCT-1000 Image Quality Affects Macular and Retinal Nerve Fiber Layer Thickness Measurements on Fourier-Domain Optical Coherence Tomography Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis Proposed Lexicon for Anatomic Landmarks in Normal Posterior Segment Spectral-Domain Optical Coherence Tomography: The IN•OCT Consensus Reproducibility of Angle Metrics Using the Time-Domain Anterior Segment Optical Coherence Tomography: Intra-Observer and Inter-Observer Variability Feature Of The Week 07/22/2019: Tsinghua University Demonstrates A “Sparse Sampled” Smart CCD Camera for Compressed Sensing Optical Coherence Tomography. An Unknown Tubular Structure on Optical Coherence Tomography After Revascularization in Chronic Totally Occluded Lesion Automated OCT for after-hours care aids in patient management Lessons Learned From Avastin and OCT–The Great, the Good, the Bad, and the Ugly Investigation of longitudinal spatial coherence for electromagnetic optical fields Use of Vibrational Optical Coherence Tomography to Characterize Skin Lesions and a Congenital Nevus