1. Articles from Michalina J. Gora

    1-8 of 8
    1. Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

      Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies

      Full-field optical coherence tomography (FFOCT) is an imaging technique of biological tissue based on tissue light reflectance analysis. We evaluated the feasibility of imaging fresh digestive mucosal biopsies after a quick mounting procedure (5 min) using two distinct modalities of FFOCT. In static FFOCT mode, we gained high-resolution images of general gut tissue-specific architecture, such as oesophageal papillae, gastric pits, duodenal villi and colonic crypts. In dynamic FFOCT mode, we imaged individual epithelial cells of the mucosal lining with a cellular or subcellular resolution and identified cellular components of the lamina propria. FFOCT represents a promising dye-free imaging tool for ...

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    2. Steerable OCT catheter for real-time assistance during teleoperated endoscopic treatment of colorectal cancer

      Steerable OCT catheter for real-time assistance during teleoperated endoscopic treatment of colorectal cancer

      When detected early, colorectal cancer can be treated with minimally invasive flexible endoscopy. However, since only specialized experts can delineate margins and perform endoscopic resections of lesions, patients still often undergo colon resections. To better assist in the performance of surgical tasks, a robotized flexible interventional endoscope was previously developed, having two additional side channels for surgical instrument. We propose to enhance the imaging capabilities of this device by combining it with optical coherence tomography (OCT). For this purpose, we have developed a new steerable OCT instrument with an outer diameter of 3.5 mm. The steerable instrument is terminated ...

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    3. Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients

      Tethered capsule endomicroscopy (TCE) is an emerging screening technology that comprehensively obtains microstructural OCT images of the gastrointestinal (GI) tract in unsedated patients. To advance clinical adoption of this imaging technique, it will be important to validate TCE images with co-localized histology, the current diagnostic gold standard. One method for co-localizing OCT images with histology is image-targeted laser marking, which has previously been implemented using a driveshaft-based, balloon OCT catheter, deployed during endoscopy. In this paper, we present a TCE device that scans and targets the imaging beam using a low-cost stepper motor that is integrated inside the capsule. In ...

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    4. The clinical usefulness of optical coherence tomography during cancer interventions

      The clinical usefulness of optical coherence tomography during cancer interventions

      Introduction Tumor detection and visualization plays a key role in the clinical workflow of a patient with suspected cancer, both in the diagnosis and treatment. Several optical imaging techniques have been evaluated for guidance during oncological interventions. Optical coherence tomography (OCT) is a technique which has been widely evaluated during the past decades. This review aims to determine the clinical usefulness of OCT during cancer interventions focussing on qualitative features, quantitative features and the diagnostic value of OCT. Methods A systematic literature search was performed for articles published before May 2018 using OCT in the field of surgical oncology. Based ...

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    5. Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

      In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forward-viewing probes, along with different scanning mechanisms (proximal-scanning versus distal-scanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic ...

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    6. Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy

      Optical coherence tomography (OCT) is an optical diagnostic modality that can acquire cross-sectional images of the microscopic structure of the esophagus, including Barrett’s esophagus (BE) and associated dysplasia. We developed a swallowable tethered capsule OCT endomicroscopy (TCE) device that acquires high-resolution images of entire gastrointestinal (GI) tract luminal organs. This device has a potential to become a screening method that identifies patients with an abnormal esophagus that should be further referred for upper endoscopy. Currently, the characterization of the OCT-TCE esophageal wall data set is performed manually, which is time-consuming and inefficient. Additionally, since the capsule optics optimally focus ...

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    7. Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study

      Background Biopsy surveillance protocols for the assessment of Barrett's esophagus can be subject to sampling errors, resulting in diagnostic uncertainty. Optical coherence tomography is a cross-sectional imaging technique that can be used to conduct volumetric laser endomicroscopy (VLE) of the entire distal esophagus. We have developed a biopsy guidance platform that places endoscopically visible marks at VLE-determined biopsy sites. Objective The objective of this study was to demonstrate in human participants the safety and feasibility of VLE-guided biopsy in vivo. Design A pilot feasibility study. Setting Massachusetts General Hospital. Patients A total of 22 participants were enrolled from January ...

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    8. Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy

      Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy

      Background and Aims In order to overcome limitations of endoscopy, we have integrated a microscopic imaging technology into a tethered capsule that can be swallowed. This new technology, which we term tethered capsule endomicroscopy, provides microscopic information from the entire of esophagus as the pill passes through gastrointestinal (GI) tract. Methods Our tethered capsule endomicroscope implements a second-generation, high-speed form of optical coherence tomography termed optical frequency domain imaging that produces microstructural images with a resolution of 30x30x10μm. The capsule has a dimension of 11x25mm and is connected to 160mm long and 0.8mm thin, flexible tether. Unsedated subjects ...

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    1-8 of 8
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  2. Topics in the News

    1. (7 articles) Michalina J. Góra
    2. (5 articles) Harvard University
    3. (5 articles) Massachusetts General Hospital
    4. (4 articles) Guillermo J. Tearney
    5. (4 articles) Norman S. Nishioka
    6. (2 articles) Claude Boccara
    7. (1 articles) Johns Hopkins University
    8. (1 articles) Brett E. Bouma
    9. (1 articles) Melissa J. Suter
    10. (1 articles) Giovanni J. Ughi
    11. (1 articles) Columbia University
    12. (1 articles) Cardiovascular Research Foundation
    13. (1 articles) Gary S. Mintz
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    Unsedated imaging of human upper GI tract using tethered capsule endomicroscopy Esophageal-guided biopsy with volumetric laser endomicroscopy and laser cautery marking: a pilot clinical study Automated segmentation and characterization of esophageal wall in vivo by tethered capsule optical coherence tomography endomicroscopy Endoscopic optical coherence tomography: technologies and clinical applications [Invited] The clinical usefulness of optical coherence tomography during cancer interventions Optical coherence tomography-guided laser marking with tethered capsule endomicroscopy in unsedated patients Steerable OCT catheter for real-time assistance during teleoperated endoscopic treatment of colorectal cancer Full-field optical coherence tomography: novel imaging technique for extemporaneous high-resolution analysis of mucosal architecture in human gut biopsies Intravascular Imaging-Guided Percutaneous Coronary Intervention: A Universal Approach for Optimization of Stent Implantation Clinical Usefulness of a Novel Optical Coherence Tomography Procedure, “Low Molecular Weight Dextran Infusion Followed by Catheter PUSH (D-PUSH)” Optical Coherence Tomography to Guide Percutaneous Coronary Intervention of the Left Main Coronary Artery: the LEMON study Impact of optical coherence tomography findings on clinical outcomes in ST-segment elevation myocardial infarction patients: a MATRIX (Minimizing Adverse Hemorrhagic Events by Trans-radial Access Site and angioX) OCT sub-study