1. Articles from Bumju Kim

    1-7 of 7
    1. Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography

      Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography

      Cutaneous radiation injury (CRI) is a skin injury caused by exposure to high dose ionizing radiation (IR). Diagnosis and treatment of CRI is difficult due to its initial clinically latent period and the following inflammatory bursts. Early detection of CRI before clinical symptoms will be helpful for effective treatment, and various optical methods have been applied with limitations. Here we show that optical coherence tomography angiography (OCTA) could detect changes in the skin during the latent period in CRI mouse models non-invasively. CRI was induced on the mouse hindlimb with exposure to various IR doses and the injured skin regions ...

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      Mentions: Ki Hean Kim
    2. Dermoscopy guided dark-field multi-functional optical coherence tomography

      Dermoscopy guided dark-field multi-functional optical coherence tomography

      Dermoscopy is a skin surface microscopic technique allowing specular reflection free observation of the skin, and has been used to examine pigmented skin lesions. However, dermoscopy has limitations in providing depth information due to lack of 3D resolution. In order to overcome the limitations, we developed dermoscopy guided multi-functional optical coherence tomography (MF-OCT) providing both high-contrast superficial information and depth-resolved structural, birefringent, and vascular information of the skin simultaneously. Dermoscopy and MF-OCT were combined by using a dichroic mirror, and dark-field configuration was adapted for MF-OCT to reduce specular reflection. After characterization, dermoscopy guided MF-OCT was applied to several human ...

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    3. In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy

      Inflammation is a non-specific immune response to injury intended to protect biological tissue from harmful stimuli such as pathogens, irritants, and damaged cells. In vivo optical tissue imaging has been used to provide spatial and dynamic characteristics of inflammation within the tissue. In this paper, we report in vivo visualization of inflammation in the skin at both cellular and physiological levels by using a combination of label-free two-photon microscopy (TPM) and optical coherence tomography (OCT). Skin inflammation was induced by topically applying lipopolysaccharide (LPS) on the mouse ear. Temporal OCT imaging visualized tissue swelling, vasodilation, and increased capillary density 30 ...

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      Mentions: Ki Hean Kim
    4. Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin

      Both polarization sensitive optical coherence tomography (PS-OCT) and second harmonic generation (SHG) microscopy are 3D optical imaging methods providing information related to collagen in the skin. PS-OCT provides birefringence information which is due to the collagen composition of the skin. SHG microscopy visualizes collagen fibers in the skin based on their SHG property. These two modalities have been applied to the same skin pathologies associated with collagen changes, but their relationship has not been examined. In this study, we tried to find the relationship by imaging the same skin samples with both modalities. Various parts of the normal rat skin ...

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      Mentions: Ki Hean Kim
    5. Dark-field polarization-sensitive optical coherence tomography

      Dark-field polarization-sensitive optical coherence tomography

      Polarization-sensitive optical coherence tomography (PS-OCT) is a functional OCT providing both structural and birefringent information of the sample, and it has been applied to the studies of various organs having polarization properties. Fiber-based PS-OCT is sensitive to specular reflection from the sample surface, because signal saturation due to the strong specular reflection can make the polarization measurement difficult. We developed a dark-field PS-OCT which can avoid the specular reflection problem. Dark-field PS-OCT was implemented by adapting a hybrid method of Bessel-beam illumination and Gaussian-beam detection, and a PS-OCT method based on passive delay unit (PDU). The new system was characterized ...

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    6. In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe

      We report multimodal imaging of human oral cavity in vivo based on simultaneous wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography (PS-OCT) with a forward-viewing imaging probe. Wide-field reflectance/fluorescence imaging and PS-OCT were to provide both morphological and fluorescence information on the surface, and structural and birefringent information below the surface respectively. The forward-viewing probe was designed to access the oral cavity through the mouth with dimensions of approximately 10 mm in diameter and 180 mm in length. The probe had field of view (FOV) of approximately 5.5 mm in diameter, and adjustable depth of field (DOF ...

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    7. Combined two-photon microscopy and angiographic optical coherence tomography

      Combined two-photon microscopy and angiographic optical coherence tomography

      A combined two-photon microscopy (TPM) and angiographic optical coherence tomography (OCT) is developed, which can provide molecular, cellular, structural, and vascular information of tissue specimens in vivo . This combined system is implemented by adding an OCT vasculature visualization method to the previous combined TPM and OCT, and then is applied to in vivo tissue imaging. Two animal models, a mouse brain cranial window model and a mouse ear cancer model, are used. Both molecular, cellular information at local regions of tissues, and structural, vascular information at relatively larger regions are visualized in the same sections. In vivo tissue microenvironments are ...

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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) Ki Hean Kim
    2. (2 articles) Yonsei University
    3. (2 articles) Gwangju Institute of Science and Technology
    4. (2 articles) Taejun Wang
    5. (1 articles) Chulmin Joo
    6. (1 articles) Axsun Technologies
    7. (1 articles) Technical University of Denmark (DTU)
    8. (1 articles) Columbia University
    9. (1 articles) Peking University
    10. (1 articles) Capital Medical University
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    Combined two-photon microscopy and angiographic optical coherence tomography In vivo wide-field reflectance/fluorescence imaging and polarization-sensitive optical coherence tomography of human oral cavity with a forward-viewing probe Dark-field polarization-sensitive optical coherence tomography Correlation between polarization sensitive optical coherence tomography and second harmonic generation microscopy in skin In vivo visualization of skin inflammation by optical coherence tomography and two-photon microscopy Dermoscopy guided dark-field multi-functional optical coherence tomography Characterization of early-stage cutaneous radiation injury by using optical coherence tomography angiography A case report of a coronary myocardial bridge with impaired full-cycle ratio during dobutamine challenge Diagnosis of chronic stage of hypertensive retinopathy based on spectral domain optical coherence tomography A Cross-sectional Optical Coherence Tomography Study in Patients on Taxane-based Therapy and A Case Report with the Literature Review Determination of peripapillary vessel density in optic disc drusen using EDI-OCT and OCT angiography Optical coherence tomography features of neovascularization in proliferative diabetic retinopathy: a systematic review