1. Articles from Takao Shimohama

    1-11 of 11
    1. Novel volumetric analysis for stent expansion after drug‐eluting stent implantation: An optical coherence tomography study

      Novel volumetric analysis for stent expansion after drug‐eluting stent implantation: An optical coherence tomography study

      Objectives To assess the clinical significance of a novel optical coherence tomography (OCT)‐derived volumetric parameter of stent expansion by comparing it with the conventional parameters in real‐world practice. Background The clinical significance of novel parameters in real‐world practice including longer and smaller stents remains to be elucidated. Methods A total of 226 de novo lesion treated with drug‐eluting stents in 208 consecutive patients were enrolled. Stent expansion was retrospectively assessed on the final OCT images after stent implantation. The novel parameter was the minimum expansion index (MEI) calculated using a novel algorithm that yields the ideal ...

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    2. Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

      Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study

      Background High lipoprotein (a) [Lp(a)] levels are an independent factor for worse prognosis in patients with coronary artery disease (CAD). However, the association between serum Lp(a) level and coronary plaque vulnerability remains to be determined. Methods A total of 255 consecutive patients with CAD who underwent optical coherence tomography imaging of culprit lesions were included. Patients were divided into 2 groups according to their Lp(a) levels (the higher Lp(a) group [≥25 mg/dL], n = 87; or the lower Lp(a) group [<25 mg/dL], n = 168). Results The prevalence of thin-cap fibroatheroma (TCFA) was significantly higher ...

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    3. Zero-Contrast Optical Coherence Tomography- and Physiology-Guided Percutaneous Coronary Intervention for Severely Calcified Lesion

      Zero-Contrast Optical Coherence Tomography- and Physiology-Guided Percutaneous Coronary Intervention for Severely Calcified Lesion

      An 80-year-old man with severe kidney dysfunction (estimated glomerular filtration rate, 26 mL/min/1.73 m 2 ) not requiring hemodialysis presented with effort angina. Diagnostic angiography with minimum contrast showed a diffuse lesion in the proximal right coronary artery (RCA; Figure A ). On a later day, optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with dextran injection was performed. Because multiple cracks were seen in the severely calcified lesion after pre-dilation ( Figure B,C ; Supplementary Movie 1 ), an everolimus-eluting stent (3.25–33 mm) was implanted ( Figure D ). The final OCT showed sufficient luminal expansion (minimum stent area ...

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    4. Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study

      Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study

      Background and aims Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown. Methods A total of 340 consecutive patients who underwent optical coherence tomography (OCT) imaging of culprit lesions were included in the study. CC was defined as a thin linear structure with high reflectivity and low signal attenuation on OCT images. The incidence of major adverse cardiovascular events (MACE) at 1-year was compared between patients with CC (CC group) and those without CC (non-CC group). MACE included cardiac ...

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    5. Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease

      Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease

      Background Tendon xanthomas are accumulations of collagen and macrophages which contain cholesterol esters and a marker of high risk for coronary artery disease (CAD). Objective To clarify whether the presence of Achilles tendon thickening (ATT) was associated with disease severity and plaque vulnerability in patients with CAD. Methods A total of 241 consecutive patients who underwent percutaneous coronary intervention and ATT assessment were analyzed. ATT was defined as Achilles tendon thickness of 9 mm or more on radiograph. The severity of CAD and plaque vulnerability were assessed by the findings on angiogram and optical coherence tomography, respectively. Results ATT was ...

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    6. Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation

      Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation

      Background The aim of this study was to investigate whether the underlying plaque type affects the neointimal coverage after drug-eluting stent implantation. Methods A total of 1793 struts in 22 zotarolimus-eluting stents were assessed using optical coherence tomography imaging within 3 months of implantation. Neointimal coverage was evaluated within 5 mm from each stent edge on cross-sectional optical coherence tomography images at every 1-mm interval. The percentage of struts covered by neointima was compared among the normal segment group, the fibrous plaque group, and the lipid plaque group on the basis of the underlying plaque type. Results The percentage of ...

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    7. Neointimal coverage of zotarolimus-eluting stent at 1, 2, and 3 months' follow-up: an optical coherence tomography study

      Neointimal coverage of zotarolimus-eluting stent at 1, 2, and 3 months' follow-up: an optical coherence tomography study

      Incomplete neointimal coverage and malapposed struts after stenting are associated with increased risk of stent thrombosis. We aimed to evaluate neointimal coverage early after Resolute zotarolimus-eluting stent (R-ZES) implantation using optical coherence tomography (OCT). A total of 20 patients with de novo native coronary lesions with R-ZES were enrolled. Among these patients, 20 stented lesions in 19 patients were evaluated at 1, 2, and 3 months after R-ZES implantation. The strut apposition and neointimal coverage were evaluated by OCT. Neointimal hyperplasia (NIH) thickness and percentage of covered struts and the proportion of incompletely apposed struts were measured at 1-mm intervals ...

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    8. Neoatherosclerosis 16 years following bare-metal stent implantation: Different tissue components in different underlying lesions observed with optical coherence tomography

      Neoatherosclerosis 16 years following bare-metal stent implantation: Different tissue components in different underlying lesions observed with optical coherence tomography

      A 61 years old male with a history of multiple treatments of percutaneous coronary intervention (PCI) with bare-metal stents (BMS) was admitted for the treatment of acute coronary syndrome (ACS). Sixteen years prior to this admission when he was 45years old, he experienced inferior ST-elevation myocardial infarction. He received one Palmaz-Schatz Stent (PS) for the treatment of lesion in distal right coronary artery (RCA).

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    9. Two-week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus-eluting stent

      Two-week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus-eluting stent

      Objective : To obtain imaging evidence by 2-week optical coherence tomography (OCT) on the completion of neointimal coverage (NIC; the percentage of stent strut coverage and thickness of the formed neointima) completion after implantation of the Endeavor zotarolimus-eluting stent (E-ZES). Background : Despite the fact that NIC is a cardinal process in the pathomechanism of late stent thrombosis, little imaging information is available on morphological changes thereof on a short-time interval basis. Methods : 27 Japanese patients with stable angina pectoris and de novo native coronary artery lesions were enrolled, and 27 lesions (30 implantations) were examined. OCT was performed at weeks 2 ...

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    1-11 of 11
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  2. Topics in the News

    1. (9 articles) Kitasato University
    2. (9 articles) Junya Ako
    3. (8 articles) Yoshiyasu Minami
    4. (2 articles) University of Rochester
    5. (1 articles) National Institutes of Health
    6. (1 articles) Centre Hospitalier Intercommunal de Créteil
    7. (1 articles) Mount Sinai School of Medicine
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    Two-week interval optical coherence tomography: Imaging evidence on neointimal coverage completion after implantation of the endeavor zotarolimus-eluting stent Neoatherosclerosis 16 years following bare-metal stent implantation: Different tissue components in different underlying lesions observed with optical coherence tomography Neointimal coverage of zotarolimus-eluting stent at 1, 2, and 3 months' follow-up: an optical coherence tomography study Successful Retrieval of Entrapped Balloon With Optical Coherence Tomography Guidance Impact of underlying plaque type on strut coverage in the early phase after drug-eluting stent implantation Unexpected Measurement Error in Optical Coherence Tomography–Guided Percutaneous Coronary Intervention Achilles tendon thickening is associated with disease severity and plaque vulnerability in patients with coronary artery disease Incidence, factors, and clinical significance of cholesterol crystals in coronary plaque: An optical coherence tomography study Zero-Contrast Optical Coherence Tomography- and Physiology-Guided Percutaneous Coronary Intervention for Severely Calcified Lesion Lipoprotein (a) level is associated with plaque vulnerability in patients with coronary artery disease: An optical coherence tomography study Procedural and one-year outcomes of patients treated with orbital and rotational atherectomy with mechanistic insights from optical coherence tomography Myocardial Infarction Complicating Vasospastic Angina in a Female Patient—Case Report