1. Articles from Rene Werkmeister

    1-3 of 3
    1. Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging

      Single-pulse CARS based multimodal nonlinear optical microscope for bioimaging

      Noninvasive label-free imaging of biological systems raises demand not only for high-speed three-dimensional prescreening of morphology over a wide-field of view but also it seeks to extract the microscopic functional and molecular details within. Capitalizing on the unique advantages brought out by different nonlinear optical effects, a multimodal nonlinear optical microscope can be a powerful tool for bioimaging. Bringing together the intensity-dependent contrast mechanisms via second harmonic generation, third harmonic generation and four-wave mixing for structural-sensitive imaging, and single-beam/single-pulse coherent anti-Stokes Raman scattering technique for chemical sensitive imaging in the finger-print region, we have developed a simple and nearly ...

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    2. Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

      Hybrid single-source online Fourier transform coherent anti-Stokes Raman scattering/optical coherence tomography

      We demonstrate a multimodal optical coherence tomography (OCT) and online Fourier transform coherent anti-Stokes Raman scattering (FTCARS) platform using a single sub-12 femtosecond (fs) Ti:sapphire laser enabling simultaneous extraction of structural and chemical (“morphomolecular”) information of biological samples. Spectral domain OCT prescreens the specimen providing a fast ultrahigh ( 4 × 12     μ m axial and transverse) resolution wide field morphologic overview. Additional complementary intrinsic molecular information is obtained by zooming into regions of interest for fast label-free chemical mapping with online FTCARS spectroscopy. Background-free CARS is based on a Michelson interferometer in combination with a highly linear piezo stage, which allows ...

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    3. Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography

      Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography

      Purpose: To visualize the pre-corneal tear film with high resolution spectral domain optical coherence tomography, enabling quantification of tear film thickness in healthy subjects. Methods: A custom built spectral domain optical coherence tomography system comprising a broad band Ti:Sapphire laser operating at 800 nm and a high speed CCD camera with a read out rate of 47 kHz was used for measurement of pre-corneal tear film thickness. The system provides an axial resolution of 1.2 µm in tissue. A total of 26 healthy subjects were included in this study. Measurement was started immediately after blinking and averaged over ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Medical University of Vienna
    2. (3 articles) Wolfgang Drexler
    3. (3 articles) Angelika Unterhuber
    4. (2 articles) Boris Hermann
    5. (2 articles) Boris Považay
    6. (2 articles) Tschackad Kamali
    7. (1 articles) Tilman Schmoll
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