1. Articles from Doreen Schmidl

    1-11 of 11
    1. Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

      Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease

      Imaging has become indispensable in the diagnosis and management of diseases in the posterior part of the eye. In recent years, imaging techniques for the anterior segment are also gaining importance and are nowadays routinely used in clinical practice. Ocular surface disease is often synonymous with dry eye disease, but also refers to other conditions of the ocular surface, such as Meibomian gland dysfunction or keratitis and conjunctivitis with different underlying causes, i.e., allergies or infections. Therefore, correct differential diagnosis and treatment of ocular surface diseases is crucial, for which imaging can be a helpful tool. A variety of ...

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    2. Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

      Optical Coherence Tomography Angiography in Diabetes and Diabetic Retinopathy

      Diabetic retinopathy (DR) is a common complication of diabetes mellitus that disrupts the retinal microvasculature and is a leading cause of vision loss globally. Recently, optical coherence tomography angiography (OCTA) has been developed to image the retinal microvasculature, by generating 3-dimensional images based on the motion contrast of circulating blood cells. OCTA offers numerous benefits over traditional fluorescein angiography in visualizing the retinal vasculature in that it is non-invasive and safer; while its depth-resolved ability makes it possible to visualize the finer capillaries of the retinal capillary plexuses and choriocapillaris. High-quality OCTA images have also enabled the visualization of features ...

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    3. Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography

      Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography

      Purpose : Blood flow autoregulation is an intrinsic mechanism of the healthy retinal vasculature to keep blood flow constant when ocular perfusion pressure (OPP) is changed. In the present study, we set out to investigate retinal blood flow in response to an experimental decrease in OPP in healthy participants using Doppler optical coherence tomography. Methods : Fifteen healthy participants aged between 22 and 31 years (mean, 27 ± 3 years) were included in the present open study. IOP was increased stepwise via the suction cup method to induce a decrease in OPP. Retinal blood flow in arteries and veins was assessed using a ...

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    4. Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography

      Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography

      Many different parameters exist for the investigation of tear film dynamics. We present a new tear meniscus segmentation algorithm which automatically extracts tear meniscus area (TMA), height (TMH), depth (TMD) and radius (TMR) from UHR-OCT measurements and apply it to a data set including repeated measurements from ten healthy subjects. Mean values and standard deviations are 0.0174 ± 0.007 mm 2 , 0.272 ± 0.069 mm, 0.191 ± 0.049 mm and 0.309 ± 0.123 mm for TMA, TMH, TMD and TMR, respectively. A significant correlation was found between all respective tear meniscus parameter pairs (all p < 0 ...

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    5. Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing

      Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing

      Purpose To employ ultrahigh‐resolution (UHR) optical coherence tomography (OCT) for investigation of the early wound healing process in corneal epithelium. Methods A custom‐built UHR‐OCT system assessed epithelial healing in human keratoconic cornea after epi‐off crosslinking (CXL) procedure and a wound healing model in rabbits with iatrogenic corneal injury. 3D OCT data sets enhanced obtaining epithelial thickness maps and evaluation of reepithelization stage. Accompanying changes in deeper corneal microarchitecture were analysed. Results The mean central corneal thickness in 40 eyes with keratoconus at baseline was 482.7 ± 38.2 μ m, while mean central epithelial thickness (CET) was ...

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    6. Ultrahigh-resolution OCT imaging of the human cornea

      Ultrahigh-resolution OCT imaging of the human cornea

      We present imaging of corneal pathologies using optical coherence tomography (OCT) with high resolution. To this end, an ultrahigh-resolution spectral domain OCT (UHR-OCT) system based on a broad bandwidth Ti:sapphire laser is employed. With a central wavelength of 800 nm, the imaging device allows to acquire OCT data at the central, paracentral and peripheral cornea as well as the limbal region with 1.2 µm x 20 µm (axial x lateral) resolution at a rate of 140 000 A-scans/s. Structures of the anterior segment of the eye, not accessible with commercial OCT systems, are visualized. These include corneal ...

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    7. Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography

      Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography

      Purpose To compare the effect of a single drop of different lubricant eye gels on tear film thickness (TFT) as measured with ultrahigh-resolution optical coherence tomography (UHR-OCT) in patients with mild-to-moderate dry eye disease (DED). Methods The study followed a randomized, single-masked, observer-blinded parallel group design. Patients received a single dose of either unpreserved trehalose 3% + hyaluronic acid 0.15% (TH), hyaluronic acid 0.2% (HA) or polyethylene glycol 0.4% + propylene glycol 0.3% (PP) eye drops. In total, 60 patients were included and TFT was measured using a custom-built UHR-OCT system. Results The mean TFT at baseline was ...

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    8. Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images

      Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images

      Purpose : To compare retinal vessel calibers extracted from phase-sensitive optical coherence tomography (OCT) images with vessel calibers as obtained from the Retinal Vessel Analyzer (RVA). Methods : Data from previously published studies in 13 healthy subjects breathing room air ( n = 214 vessels) and 7 subjects breathing 100% oxygen ( n = 101 vessels) were used. Vessel calibers from OCT phase images were measured vertically along the optical axis by three independent graders. The data from RVA fundus images were corrected for magnification to obtain absolute values. Results : The average vessel diameter as obtained from OCT images during normoxia was lower than from RVA ...

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    9. In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography

      In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography

      Dry eye syndrome is a highly prevalent disease of the ocular surface characterized by an instability of the tear film. Traditional methods used for the evaluation of tear film stability are invasive or show limited repeatability. Here we propose a new non-invasive fully automated approach to measure tear film thickness based on spectral domain optical coherence tomography and on an efficient delay estimator. Silicon wafer phantom were used to validate the thickness measurement. The technique was applied in vivo in healthy subjects. Series of tear film thickness maps were generated, allowing for the visualization of tear film dynamics. Our results ...

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    10. Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography

      Purpose The aim of this study was to assess the effect of a single drop of hyaluronic acid on tear film thickness (TFT) in healthy subjects. Methods Sixteen healthy subjects (eight male/eight female) aged between 20 and 36 years were included in this randomized, double-masked placebo-controlled study. One eye received a single dose of hyaluronic acid (Olixia pure ® ; Croma Pharma, Korneuburg, Austria) eye drops, and the fellow eye received physiologic saline solution as placebo control. The study eye was chosen randomly. TFT as measured with a custom-built Fourier-domain optical coherence tomography (FD-OCT) system was the main outcome variable and ...

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    11. Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography

      Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography

      Purpose: To visualize the pre-corneal tear film with high resolution spectral domain optical coherence tomography, enabling quantification of tear film thickness in healthy subjects. Methods: A custom built spectral domain optical coherence tomography system comprising a broad band Ti:Sapphire laser operating at 800 nm and a high speed CCD camera with a read out rate of 47 kHz was used for measurement of pre-corneal tear film thickness. The system provides an axial resolution of 1.2 µm in tissue. A total of 26 healthy subjects were included in this study. Measurement was started immediately after blinking and averaged over ...

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    1-11 of 11
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  2. Topics in the News

    1. (9 articles) Medical University of Vienna
    2. (5 articles) Singapore Eye Research Institute
    3. (5 articles) Angelika Unterhuber
    4. (3 articles) Nanyang Technological University
    5. (2 articles) Rainer A. Leitgeb
    6. (1 articles) Wolfgang Drexler
    7. (1 articles) Tilman Schmoll
    8. (1 articles) Bernd M. Hofer
    9. (1 articles) Aneesh Alex
    10. (1 articles) Academic Medical Center at the University of Amsterdam
    11. (1 articles) Jichi Medical University
    12. (1 articles) University of Milan
    13. (1 articles) Bern University Hospital
    14. (1 articles) Capital Medical University
    15. (1 articles) Nanjing University of Science and Technology
    16. (1 articles) Martin S. Zinkernagel
    17. (1 articles) Junya Ako
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    Measurement of Tear Film Thickness Using Ultrahigh Resolution Optical Coherence Tomography Effect of hyaluronic acid on tear film thickness as assessed with ultra-high resolution optical coherence tomography In vivo tear film thickness measurement and tear film dynamics visualization using spectral domain optical coherence tomography Measurement of Retinal Vascular Caliber From Optical Coherence Tomography Phase Images Effect of different lubricant eye gels on tear film thickness as measured with ultrahigh-resolution optical coherence tomography Ultrahigh-resolution OCT imaging of the human cornea Ultrahigh‐resolution anterior segment optical coherence tomography for analysis of corneal microarchitecture during wound healing Automatic assessment of tear film and tear meniscus parameters in healthy subjects using ultrahigh-resolution optical coherence tomography Changes in Retinal Blood Flow in Response to an Experimental Increase in IOP in Healthy Participants as Assessed With Doppler Optical Coherence Tomography Novel Approaches for Imaging-Based Diagnosis of Ocular Surface Disease Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections