1. Articles from Antonios P. Antoniadis

    1-4 of 4
    1. Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis

      Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis

      Objectives This study sought to determine whether indocyanine green (ICG)–enhanced near-infrared fluorescence (NIRF) imaging can illuminate high-risk histologic plaque features of human carotid atherosclerosis, and in coronary atheroma of living swine, using intravascular NIRF-optical coherence tomography (OCT) imaging. Background New translatable imaging approaches are needed to identify high-risk biological signatures of atheroma. ICG is a U.S. Food and Drug Administration–approved NIRF imaging agent that experimentally targets plaque macrophages and lipid in areas of enhanced endothelial permeability. However, it is unknown whether ICG can target atheroma in patients. Methods Eight patients were enrolled in the BRIGHT-CEA (Indocyanine Green ...

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    2. Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’

      Aims The association of low endothelial shear stress (ESS) with high-risk plaque (HRP) has not been thoroughly investigated in humans. We investigated the local ESS and lumen remodelling patterns in HRPs using optical coherence tomography (OCT), developed the shear stress score , and explored its association with the prevalence of HRPs and clinical outcomes. Methods and results A total of 35 coronary arteries from 30 patients with stable angina or acute coronary syndrome (ACS) were reconstructed with three dimensional (3D) OCT. ESS was calculated using computational fluid dynamics and classified into low, moderate, and high in 3-mm-long subsegments. In each subsegment ...

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    3. Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image

      Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image

      Objectives The analysis of intracoronary optical coherence tomography (OCT) images is based on manual identification of the lumen contours and relevant structures. However, manual image segmentation is a cumbersome and time-consuming process, subject to significant intra- and inter-observer variability. This study aims to present and validate a fully-automated method for segmentation of intracoronary OCT images. Methods We studied 20 coronary arteries (mean length = 39.7 ± 10.0 mm) from 20 patients who underwent a clinically indicated cardiac catheterization. The OCT images (n = 1812) were segmented manually, as well as with a fully-automated approach. A semi-automated variation of the fully-automated algorithm ...

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    4. Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation

      A 78-year-old female was referred to the Andreas Gruentzig Catheterization Laboratories suffering from angina pain CCS II. Coronary angiography demonstrated a bifurcation lesion in the middle left anterior descending and the first diagonal branch ( Panel A ). Based on these findings, percutaneous coronary intervention (PCI) was performed with implantation of a

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    1-4 of 4
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  2. Topics in the News

    1. (1 articles) University Hospital Zurich
    2. (1 articles) Harvard University
    3. (1 articles) Massachusetts General Hospital
    4. (1 articles) Beth Israel Deaconess Medical Center
    5. (1 articles) University of Michigan
    6. (1 articles) FDA
    7. (1 articles) Brigham and Women’s Hospital
    8. (1 articles) Guillermo J. Tearney
    9. (1 articles) Peter Libby
    10. (1 articles) Thomas F. Luscher
    11. (1 articles) Jikei University School of Medicine
    12. (1 articles) Macquarie University
    13. (1 articles) Medical University of Vienna
    14. (1 articles) University of Florence
    15. (1 articles) National Institutes of Health
    16. (1 articles) Beth Israel Deaconess Medical Center
    17. (1 articles) Giacomo Savini
    18. (1 articles) Bernhard Baumann
    19. (1 articles) Antonia Lichtenegger
    20. (1 articles) Movu
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    Geometrically correct three-dimensional optical coherence tomography: first self-expanding bifurcation stent evaluation Clinical Validation of an Algorithm for Rapid and Accurate Automated Segmentation of Intracoronary Optical Coherence Tomography Image Association of global and local low endothelial shear stress with high-risk plaque using intracoronary 3D optical coherence tomography: Introduction of ‘shear stress score’ Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis Heterogeneity of Neointimal Healing Following Biodegradable-polymer Drug-Eluting Coronary Stent Implantation Swept-source and multimodal OCT technologies offer clinical advantages Early vascular response of ultra-thin bioresorbable polymer sirolimus-eluting stents assessed by optical frequency domain imaging: the EVALUATION study OCT, OCTA show promise in screening for DR Improved Diagnostic Imaging of Brain Tumors by Multimodal Microscopy and Deep Learning Thromboembolic or atherosclerotic? Optical coherence tomography in determining the cause of myocardial infarction with ST-segment elevation Application of Artificial Intelligence in Targeting Retinal Diseases Posterior capsule rupture with FLACS due to erroneous interpretation of a high OCT intensity area in anterior vitreous