1. Articles from Gong Je Seong

    1-24 of 29 1 2 »
    1. Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma

      Relationship between N95 Amplitude of Pattern Electroretinogram and Optical Coherence Tomography Angiography in Open-Angle Glaucoma

      Purpose: The pattern electroretinogram (PERG) is useful to detect retinal ganglion cell (RGC) damage in patients with glaucoma. Optical coherence tomography angiography (OCTA) measures retinal vessel density (VD), which is known to be reduced in glaucoma. There may be correlations between parameters of the PERG and OCTA in open-angle glaucoma (OAG). Methods: In total, 95 eyes of 95 OAG patients and 102 eyes of 102 normal controls were included in this study. N35, P50, and N95 latency along with P50 and N95 amplitude were obtained using the PERG. Retinal VD was measured around the peripapillary and macular area according to ...

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    2. Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

      Effect of systemic blood pressure on optical coherence tomography angiography in glaucoma patients

      Background The association between retinal microvascular structure and glaucoma has been revealed in multiple studies using optical tomography angiography (OCTA), but limited information on the macular vessel density (mVD) in patients with glaucoma is available. In this study, we tried to identity the factors that affected macular VD (mVD) in glaucomatous eyes. Methods This retrospective cross-sectional study evaluated OCT and OCTA images from 92 eyes from 58 healthy subjects and 179 eyes from 103 glaucoma patients using the SD-OCT database from July 2017 to July 2018. Glaucomatous eyes were further divided into two groups according to history of disc haemorrhage ...

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    3. Effect of image quality fluctuations on the repeatability of thickness measurements in swept-source optical coherence tomography

      Effect of image quality fluctuations on the repeatability of thickness measurements in swept-source optical coherence tomography

      This study investigated the effect of image quality fluctuations on the repeatability of thickness measurements of the peripapillary retinal nerve fibre (PP-RNFL) and ganglion cell-inner plexiform (GC-IPL) layers using swept-source optical coherence tomography (SS-OCT). Three consecutive OCT scans each were performed on 56 healthy subject. Finally, 168 SS-OCT results were analysed. Based on the tertile values of the mean absolute difference of image quality score, all subjects were divided into the following three groups—low-(LIQD), moderate-(MIQD), and high-(HIQD) image quality score difference groups. A linear mixed model and intraclass correlation coefficients (ICCs) were used for analyses. Despite ...

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    4. Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

      Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes

      Purpose To investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage. Study design Retrospective cross-sectional study. Methods A total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses. Results Age ( P = 0.010) and signal strength ( P < 0.001) were associated with macular vessel density in healthy eyes. In glaucomatous eyes, age, signal strength, ganglion ...

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    5. Diagnostic ability of vessel density measured by spectral-domain optical coherence tomography angiography for glaucoma in patients with high myopia

      Diagnostic ability of vessel density measured by spectral-domain optical coherence tomography angiography for glaucoma in patients with high myopia

      Although early glaucoma detection is important to prevent visual loss due to disease progression, its clinical diagnosis in highly myopic eyes is still difficult. Many studies using optical coherence tomography (OCT) angiography (OCTA) reported decreased vessel density (VD) in glaucomatous eyes compared to normal eyes. We evaluated the diagnostic ability of peripapillary VD and macular VD measured by OCTA, comparing them with conventional valuables such as peripapillary retinal nerve fibre layer (RNFL) thickness and macular ganglion cell-inner plexiform layer (GCIPL) thickness measured by OCT. We also calculated the average VD ratio (VDR) (average outer macular VD/average inner macular VD ...

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    6. Nomogram Using Optical Coherence Tomography and Visual Field Parameters to Predict Brain Lesions in Patients with Bitemporal Hemianopia

      Nomogram Using Optical Coherence Tomography and Visual Field Parameters to Predict Brain Lesions in Patients with Bitemporal Hemianopia

      Purpose : This study aims to develop a nomogram to predict brain lesions in patients with complete or incomplete bitemporal hemianopia by combining results from optical coherence tomography (OCT) and visual field (VF) testing. Material and Methods : We reviewed the medical records of patients who underwent magnetic resonance imaging (MRI) to identify brain lesions due to bitemporal hemianopia between January 2010 and March 2017, retrospectively. The patients were divided into two groups based on MRI findings: brain-lesion (+) group that had brain lesions on MRI ( n = 63), and brain-lesion (-) group without brain lesions on MRI ( n = 16). We compared OCT and VF ...

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    7. Diagnostic Ability of Swept-Source and Spectral-Domain Optical Coherence Tomography for Glaucoma

      Diagnostic Ability of Swept-Source and Spectral-Domain Optical Coherence Tomography for Glaucoma

      Purpose To compare the diagnostic abilities of swept-source optical coherence tomography (OCT) [Deep Range Imaging OCT-1 (DRI-OCT)] and spectral-domain OCT (Cirrus HD-OCT) for glaucoma in Korean adults. Materials and Methods This retrospective study involved measuring peripapillary retinal nerve fiber layer (PP-RNFL) thickness, full macular thickness, and ganglion cell-inner plexiform layer (GC-IPL) thickness on two different OCT systems. We used three-dimensional optic disc scanning of DRI-OCT and included 12 clock-hour sectors for measurement of the PP-RNFL. Areas under receiver operating characteristic curves (AUCs) were calculated and compared to determine how well each system could distinguish control and glaucomatous patients. Results Ninety-one ...

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    8. Repeatability and Agreement of Swept Source and Spectral Domain Optical Coherence Tomography Evaluations of Thickness Sectors in Normal Eyes

      Repeatability and Agreement of Swept Source and Spectral Domain Optical Coherence Tomography Evaluations of Thickness Sectors in Normal Eyes

      Purpose of the Study: The purpose of the study was to evaluate the clinical efficacy of swept-source optical coherence tomography (SS-OCT), we compared the intradevice repeatability of thickness measurements obtained using SS-OCT to that of measurements obtained using spectral domain OCT (SD-OCT), and assessed the interdevice agreement of thickness measurements. Materials and Methods: This cross-sectional prospective study involved 3 consecutive measurements of peripapillary retinal nerve fiber layer (PP-RNFL) and ganglion cell-inner plexiform layer thickness in healthy subjects, using 2 different OCT systems. Intraclass correlation coefficients (ICCs) and coefficients of variability were calculated and compared for repeatability and agreement between study ...

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    9. Thickness in Ganglion Cell-Inner Plexiform Layer on Spectral-Domain Optical Coherence Tomography after Cataract Surgery

      Thickness in Ganglion Cell-Inner Plexiform Layer on Spectral-Domain Optical Coherence Tomography after Cataract Surgery

      Purpose To assess changes in ganglion cell-inner plexiform layer (GCIPL) thickness after cataract surgery using spectral-domain optical coherence tomography (OCT). Methods Forty-three eyes of 33 patients, who underwent cataract surgery were imaged with spectral-domain OCT before and after surgery to measure peripapillary retinal nerve fiber layer (RNFL) and GCIPL thickness, signal strength (SS), quadrant, 12 clock-hour RNFL thickness and sectoral GCIPL thickness. Results The postoperative SS, RNFL and GCIPL thickness were higher than before surgery ( p < 0.05). Multivariate analysis showed that endothelial cell count and preoperative SS were significantly correlated with SS changes in RNFL parameters and preoperative SS ...

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    10. Relationship between Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography and Visual Field Severity Indices

      Relationship between Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography and Visual Field Severity Indices

      Purpose Though there are many reports regarding the structure-function relationship in glaucoma, they are too complicated to apply to the routine clinical setting. The aim of this study was to investigate the direct relationship between peripapillary retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) and visual field (VF) severity indices computed by standard automated perimetry. Methods This cross-sectional comparative study included 104 glaucomatous patients and 59 healthy subjects. Peripapillary RNFL thickness was measured by spectral domain (SD) and time domain (TD) OCTs. Four glaucoma VF severity indices, including mean deviation (MD), pattern standard deviation (PSD), Collaborative ...

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    11. Frequency, Type and Cause of Artifacts in Swept-Source and Cirrus HD Optical Coherence Tomography in Cases of Glaucoma and Suspected Glaucoma

      Frequency, Type and Cause of Artifacts in Swept-Source and Cirrus HD Optical Coherence Tomography in Cases of Glaucoma and Suspected Glaucoma

      Purpose : To evaluate and compare the frequency , type and cause of imaging artifacts incurred when using swept - source optical coherence tomography (SS OCT) and Cirrus HD OCT in the same patients on the same day. Materials and methods : From left eye OCT results of 72 patients, disc area and macular area data could be compared between the two types of OCT. For each scan, the final printout report and source data were examined. For comparison between the two types of OCT, only source image data were used because of differences in the final printout report format. Results : There were no ...

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    12. Visual Fields and OCT Role in Diagnosis of Glaucoma

      Visual Fields and OCT Role in Diagnosis of Glaucoma

      Purpose: To evaluate the clinical performance of visual field (VF) tests and optical coherence tomography (OCT) in diagnosing glaucoma. Methods: One hundred sets of disc photographs, red-free fundus photographs, VF tests, and OCT images were presented progressively to seven ophthalmologists. Each set was provided in three steps: (1) the disc and red-free fundus photographs were shown first; (2) then, VF tests were also provided; and (3) finally, the OCT results were provided. The same process was repeated on another day. Kappa statistics were used to assess the intraobserver and interobserver agreement, as well as the agreement with the reference standard ...

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    13. A Hierarchical Cluster Analysis of Normal-Tension Glaucoma Using Spectral-Domain Optical Coherence Tomography Parameters

      A Hierarchical Cluster Analysis of Normal-Tension Glaucoma Using Spectral-Domain Optical Coherence Tomography Parameters

      Purpose: Normal-tension glaucoma (NTG) is a heterogenous disease, and there is still controversy about subclassifications of this disorder. On the basis of spectral-domain optical coherence tomography (SD-OCT), we subdivided NTG with hierarchical cluster analysis using optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thicknesses. Patients and Methods: A total of 200 eyes of 200 NTG patients between March 2011 and June 2012 underwent SD-OCT scans to measure ONH parameters and RNFL thicknesses. We classified NTG into homogenous subgroups based on these variables using a hierarchical cluster analysis, and compared clusters to evaluate diverse NTG characteristics. Results: Three ...

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    14. Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Relationship between Visual Acuity and Retinal Structures Measured by Spectral Domain Optical Coherence Tomography in Patients with Open Angle Glaucoma

      Purpose: To assess the relationship between retinal structures measured by spectral-domain optical coherence tomography (OCT) and visual acuity in open-angle glaucoma (OAG) patients. Methods: In this cross-sectional observational study, 186 eyes from 186 OAG patients were included. The participants underwent RTVue OCT for measurement of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell complex (mGCC) thickness. The correlations between best-corrected visual acuity (BCVA) and OCT parameters were evaluated using Pearson's partial correlation test and regression analysis. Receiver operating characteristic (ROC) curve analysis was performed to obtain a cutoff value for OCT parameters in detecting decreased visual ...

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    15. Comparison of the Optic Nerve Imaging by Time-Domain Optical Coherence Tomography and Fourier-Domain Optical Coherence Tomography in Distinguishing Normal Eyes From Those With Glaucoma

      Comparison of the Optic Nerve Imaging by Time-Domain Optical Coherence Tomography and Fourier-Domain Optical Coherence Tomography in Distinguishing Normal Eyes From Those With Glaucoma
      Purpose: To assess agreement in cup-to-disc ratio (CDR) estimation between stereoscopic optic disc photography, time-domain optical coherence tomography (OCT), and Fourier-domain OCT, and to compare the discriminating ability of optic nerve head (ONH) parameters by time-domain OCT and Fourier-domain OCT for glaucoma detection. Methods: Participants underwent stereoscopic photography, Stratus OCT (fast optic disc scan), and RTVue-100 (nerve head mapping), at the same visit. Vertical and horizontal CDRs (VCDR and HCDR) from stereoscopic photography were determined by averaging the results from 2 independent glaucoma specialists. VCDR, HCDR, disc area, cup area, rim area, and cup-to-disc area ratio were acquired from the ...
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    16. Effect of signal strength on reproducibility of circumpapillary retinal nerve fiber layer thickness measurement and its classification by spectral-domain optical coherence tomography

      Effect of signal strength on reproducibility of circumpapillary retinal nerve fiber layer thickness measurement and its classification by spectral-domain optical coherence tomography

      Abstract Purpose  To assess the effect of signal strength (SS) on the reproducibility of circumpapillary retinal nerve fiber layer (cpRNFL) thickness measurement (measurement agreement) and its color-coded classification (classification agreement) by Cirrus spectral-domain optical coherence tomography (OCT). Methods  Seven hundred and eighty-nine participants, consecutively enrolled from December 2009 to August 2010, underwent two repeated Cirrus OCT scans to measure cpRNFL thickness (optic disc cube 200 × 200). Intraclass correlation (ICC) and linear-weighted kappa coefficient (κ) were calculated as indicators for cpRNFL measurement and classification agreement. The difference in cpRNFL thickness measurements between repeated OCT scans (inter-scan measurement difference) was correlated with mean ...

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    17. Factors Associated with False Positives in Retinal Nerve Fiber Layer Color Codes from Spectral-Domain Optical Coherence Tomography

      Factors Associated with False Positives in Retinal Nerve Fiber Layer Color Codes from Spectral-Domain Optical Coherence Tomography

      Purpose: To determine the factors that contribute to false-positive retinal nerve fiber layer (RNFL) color code results from spectral-domain optical coherence tomography (OCT).Design: A prospective, cross-sectional study.Participants: This study included 149 eyes from 77 healthy participants.Methods: Participants, who were consecutively enrolled from June 2009 to December 2009, underwent Cirrus OCT. Recorded demographic and clinical factors included age, gender, eye side, intraocular pressure, central corneal thickness, spherical equivalent, axial length, anterior chamber depth, disc area, and the extent of retinal vasculature.Main Outcome Measures: An abnormal finding in RNFL color codes was defined as ≥1 yellow or red ...

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    18. Inter-Device Agreement of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Cirrus HD OCT

      Inter-Device Agreement of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Cirrus HD OCT
      Purpose To assess the inter-device agreement of peripapillary retinal nerve fiber layer (RNFL) thickness measurements by 2 spectral domain Cirrus HD optical coherence tomography (OCT) devices in healthy Korean subjects. Methods Eleven eyes of 11 healthy volunteers were enrolled in the present study. Each eye was scanned with the Optic Disc Cube 200 × 200 scan of 2 Cirrus HD OCT devices for peripapillary RNFL thickness calculation. The inter-device agreements of the 2 Cirrus HD OCTs for average, quadrant, and clock-hour RNFL thickness values were determined with Wilcoxon signed rank test, Friedman test, Cronbach's alpha (α), intraclass correlation coefficient (ICC ...
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    19. Determinants of perimacular inner retinal layer thickness in normal eyes measured by Fourier-domain optical coherence tomography

      Determinants of perimacular inner retinal layer thickness in normal eyes measured by Fourier-domain optical coherence tomography

      Purpose: To determine the effects of age, gender, spherical equivalent, axial length, anterior chamber depth, optic disc area, and central corneal thickness on perimacular inner retinal layer thickness in the normal human eye as measured by Fourier-domain optical coherence tomography (FD-OCT). Methods: In this cross-sectional observational study, 182 Korean normal subjects aged from 22 to 84 years were included. To obtain the inner retinal layer thickness, perimacular ganglion cell complex (GCC) thickness, which extends from the internal limiting membrane to the inner nuclear layer, was measured by FD-OCT (RTVue-100; Optovue Inc, Fremont, CA) on one randomly selected eye of each ...

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    20. Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Spectral vs. Time Domain Optical Coherence Tomography

      Comparison of Peripapillary Retinal Nerve Fiber Layer Thickness Measured by Spectral vs. Time Domain Optical Coherence Tomography
      Purpose: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral and time domain optical coherence tomography (OCT). Patients and Methods: One hundred and eighty-eight subjects (normal tension glaucoma, n=80; primary open angle glaucoma, n=49; healthy controls, n=59) were included in this study. Peripapillary RNFL thickness was measured by an Optic Disc Cube 200×200 scan of the spectral domain Cirrus HD OCT and by a Fast RNFL scan of the time domain Stratus OCT. They were compared using linear regression (R2), Bland-Altman plots, weighted Kappa (Kw) coefficients, and areas under the receiver operating ...
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    21. Effect of Signal Strength on Agreements for Retinal Nerve Fiber Layer Thickness Measurement and Its Color Code Classification Between Stratus and Cirrus Optical Coherence Tomography

      Effect of Signal Strength on Agreements for Retinal Nerve Fiber Layer Thickness Measurement and Its Color Code Classification Between Stratus and Cirrus Optical Coherence Tomography
      Purpose: To assess the effect of signal strength (SS) on concordance rate or agreement on retinal nerve fiber layer (RNFL) thickness measurement (measurement agreement) and its color code classification (classification agreement) between Stratus optical coherence tomography (OCT) and Cirrus OCT. Patients and Methods: From 300 participants who underwent both Stratus and Cirrus OCT scans at the same visit (SS >=6), intraclass correlation and weighted [kappa] coefficients were calculated as indicators for RNFL measurement agreement and classification agreement between 2 OCTs. Results: In inferior and superior quadrants, agreements were excellent (intraclass correlation) or good ([kappa]) and neither the measurement nor the ...
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    22. Spectral-Domain Optical Coherence Tomography for Detection of Localized Retinal Nerve Fiber Layer Defects in Patients With Open-Angle Glaucoma

      Spectral-Domain Optical Coherence Tomography for Detection of Localized Retinal Nerve Fiber Layer Defects in Patients With Open-Angle Glaucoma
      Objective  To evaluate and compare time-domain (Stratus) and spectral-domain (Cirrus; both Carl Zeiss Meditec, Dublin, California) optical coherence tomography (OCT) for the detection of localized retinal nerve fiber layer (RNFL) defects in patients with open-angle glaucoma. Methods  Patients with localized RNFL defects and age-matched normal control participants were consecutively enrolled from July 1 to December 31, 2008. Sixty-six eyes from 66 patients and 66 eyes from 66 normal controls were imaged with Stratus OCT (fast RNFL scan mode) and Cirrus OCT (optic disc cube mode). The ability to detect the RNFL defect by using quadrant clock-hour maps from both OCTs ...
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    23. Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia

      Comparing the ganglion cell complex and retinal nerve fibre layer measurements by Fourier domain OCT to detect glaucoma in high myopia
      Aim To compare the diagnostic ability to detect glaucomatous changes between peripapillary retinal nerve fibre layer (RNFL) thickness and the macular ganglion cell complex (GCC) in highly myopic patients using Fourier domain optical coherence tomography. Methods Participants, consecutively enrolled from January 2009 to June 2009, were imaged with RTVue-100 (NHM4 and MM7 scan). The sensitivity and specificity of a colour code less than 5% (red or yellow) for glaucoma diagnosis were calculated. Area under the receiver operator characteristic (AUROC) curves were generated to assess the ability of each parameter to detect glaucomatous changes. Results 73 normal controls and 77 glaucoma ...
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    24. Structure-function Relationship and Diagnostic Value of Macular Ganglion Cell Complex Measurement using Fourier-domain OCT in Glaucoma

      Structure-function Relationship and Diagnostic Value of Macular Ganglion Cell Complex Measurement using Fourier-domain OCT in Glaucoma
      Purpose: To assess the relationship between visual function and macular ganglion cell complex (GCC) thickness measured by RTVue-100 (Optovue Inc, Fremont, CA) and to evaluate the diagnostic value of GCC thickness for detecting early, moderate, and severe glaucoma. Methods: Participants underwent reliable standard automated perimetry testing and optical coherence tomography (OCT) imaging with optic nerve head (ONH) mode and GCC mode within a single day. The relationship between structure and function was evaluated by comparing GCC thickness with MD and visual field index (VFI) by regression analysis; results were compared with those obtained for retinal nerve fiber layer (RNFL) thickness ...
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    1-24 of 29 1 2 »
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    1. (28 articles) Gong Je Seong
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