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Articles from Mary E. Dickinson

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  1. Imaging of mouse embryonic eye development using optical coherence tomography

    Explore Article SPIE Digital Library (Mar 2 2010) Ophthalmology

    Imaging of mouse embryonic eye development using optical coherence tomography Congenital abnormalities are often caused by genetic disorders which alter the normal development of the eye. Embryonic eye imaging in mouse model is important for understanding of normal and abnormal eye development and can contribute to prevention and treatment of eye defects in humans. In this study, we used Swept Source Optical Coherence Tomography (SS-OCT) to image eye structure in mouse embryos at 12.5 to 17.5 days post coitus (dpc). The imaging depth of the OCT allowed us to visualize the whole eye globe at these stages. Different ocular tissues including lens, cornea, eyelids, and hyaloid vasculature were visualized. These ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Baylor College of Medicine   University of Houston

  2. Multiple-cardiac-cycle noise reduction in dynamic optical coherence tomography of the embryonic heart and vasculature

    Explore Article opticsinfobase.org (Nov 20 2009) Cardiology , Developmental Biology

    Multiple-cardiac-cycle noise reduction in dynamic optical coherence tomography of the embryonic heart and vasculature Recent progress in optical coherence tomography (OCT) allows imaging dynamic structures and fluid flow within scattering tissue, such as the beating heart and blood flow in mouse embryos. Accurate representation and analysis of these dynamic behaviors require reducing the noise of the acquired data. Although noise can be reduced by averaging multiple neighboring pixels in space or time, such operations reduce the effective spatial or temporal resolution that can be achieved. We have developed a computational postprocessing technique to restore image sequences of cyclically moving structures that preserves frame rate and spatial resolution. The signal-to-noise ratio (SNR) is improved by ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Baylor College of Medicine   University of Houston

  3. Live imaging of rat embryos with Doppler swept-source optical coherence tomography

    Explore Article Scitation (Oct 1 2009) Developmental Biology , Doppler

    The rat has long been considered an excellent system to study mammalian embryonic cardiovascular physiology, but has lacked the extensive genetic tools available in the mouse to be able to create single gene mutations. However, the recent establishment of rat embryonic stem cell lines facilitates the generation of new models in the rat embryo to link changes in physiology with altered gene function to define the underlying mechanisms behind congenital cardiovascular birth defects. Along with the ability to create new rat genotypes there is a strong need for tools to analyze phenotypes with high spatial and temporal resolution. Doppler OCT ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   University of Houston

  4. Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT

    Explore Article opticsinfobase.org (Mar 18 2009) Cardiology , Doppler

    Hemodynamic measurements from individual blood cells in early mammalian embryos with Doppler swept source OCT The most common and lethal birth defects affect the cardiovascular (CV) system. The mouse is a superior model for identifying and understanding mammalian CV birth defects, but there is a great need for tools that can detect early and subtle deficiencies in cardiac function in mouse embryos. We combined swept source optical coherence tomography (SS-OCT) with live mouse embryo culture protocols to generate structural two-dimensional and three-dimensional imaging and hemodynamic measurements in a live 8.5 day embryo just a few hours after the beginning of a heartbeat. Our data show that individual circulating blood cells can be visualized with structural ... (Read Full Article)

    Comment on Article Mentions:   Kirill V. Larin   Baylor College of Medicine   University of Houston

  5. Enhanced OCT imaging of embryonic tissue with optical clearing

    Explore Article SPIE Digital Library (Feb 20 2009)

    Optical coherence tomography (OCT) holds great promise as a routine research tool for 3-D analysis of mammalian embryos. However, despite the depth penetration afforded by this imaging modality, light attenuation in tissues imposes limitations. Here we studied the optical clearing effect of differen ... [Proc. SPIE 7168, 71682C (2009)] published Fri Feb 20, 2009. (Read Full Article)

    Comment on Article Mentions:   Valery V. Tuchin   Baylor College of Medicine   Kirill V. Larin

  6. Imaging of cardiovascular dynamics in early mouse embryos with swept source optical coherence tomography

    Explore Article SPIE Digital Library (Feb 19 2009) Cardiology

    Congenital cardiovascular defects are very common, occurring in 1% of live births, and cardiovascular failures are the leading cause of birth defect-related deaths in infants. To improve diagnostics, prevention and treatment of cardiovascular abnormalities, we need to understand not only how cells f ... [Proc. SPIE 7168, 71680E (2009)] published Thu Feb 19, 2009. (Read Full Article)

    Comment on Article Mentions:   Baylor College of Medicine   Kirill V. Larin   University of Houston

  7. Live imaging of blood flow in mammalian embryos using Doppler swept-source optical coherence tomography

    Explore Article SPIE Digital Library (Dec 21 2008) Developmental Biology , Doppler

    Irina V. Larina, Narendran Sudheendran, Mohamad Ghosn et al. Studying hemodynamic changes during early mammalian embryonic development is critical for further advances in prevention, diagnostics, and treatment of congenital cardiovascular (CV) birth defects and diseases. Doppler optical coherence tomography (OCT) has been shown to provide sensitive measuremen ... [J. Biomed. Opt. 13, 060506 (2008)] published Fri Dec 19, 2008. (Read Full Article)

    Comment on Article Mentions:   Alex E. Cable   Thorlabs   Kirill V. Larin

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