1. Articles from Zhonglie Piao

    1-8 of 8
    1. 3D cellular-resolution imaging in arteries using few-mode interferometry

      3D cellular-resolution imaging in arteries using few-mode interferometry

      Article Open Access Published: 21 November 2019 3D cellular-resolution imaging in arteries using few-mode interferometry Biwei Yin , Zhonglie Piao , Kensuke Nishimiya , Chulho Hyun , Joseph A. Gardecki , Adam Mauskapf , Farouc A. Jaffer & Guillermo J. Tearney Light: Science & Applications volume 8 , Article number: 104 ( 2019 ) Cite this article Article metrics 3 Altmetric Metrics details Abstract Cross-sectional visualisation of the cellular and subcellular structures of human atherosclerosis in vivo is significant, as this disease is fundamentally caused by abnormal processes that occur at this scale in a depth-dependent manner. However, due to the inherent resolution-depth of focus tradeoff of conventional focusing optics, today ...

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    2. Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging

      Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging

      Optical coherence tomography (OCT) has been a useful clinical tool for diagnosing coronary artery disease through a flexible catheter, but its full promise relies on resolving cellular and sub-cellular structures in vivo. Previously, visualizing cellular structures through an imaging catheter is not possible due to limited depth of focus (DOF) of a tightly focused Gaussian beam: typically, a Gaussian beam with 2-3 μm resolution has a DOF within 100 μm, which is not sufficient for in vivo catheter imaging. Therefore, we developed a self-imaging wavefront division optical system that generates a coaxially-focused multimode (CAFM) beam with a DOF that is ...

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    3. Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study

      Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study

      Background Myocardial bridge (MB) is a myocardial bundle through which coronary segment tunnels and could compress coronary arteries causing myocardial ischemia. However, the characteristic structural findings of MB remain to be fully elucidated. Recently, we demonstrated that optical coherence tomography (OCT) enables us to visualize adventitial vasa vasorum (VV) formation in humans. In this study, we examined adventitial VV formation at the coronary segment with MB in humans using OCT. Methods We examined 15 consecutive patients with suspected angina pectoris and MB in the left anterior descending (LAD) coronary arteries but no angiographic coronary stenosis. MB was detected on coronary ...

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    4. Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

      Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive method for retinal imaging. In this work, we present an in vivo human retinal microvascular network measurement by an intensity-based Doppler variance (IBDV) based on sweptsource OCT. In addition, an automatic three-dimensional (3-D) segmentation method was used for segmenting intraretinal layers. The microvascular networks were divided into six layers by visualizing of each individual layer with enhanced imaging contrast. This method has potential for earlier diagnosis and precise monitoring in retinal vascular diseases.

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    5. Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo

      Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo

      Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase diagnostic accuracy of vulnerable plaques. Here, we introduce an ultrafast optical-ultrasonic dual-modality imaging system and flexible miniaturized catheter, which enables the translation of this technology into clinical practice. This system ...

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    6. In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method

      In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method

      Microvascular network of the retina plays an important role in diagnosis and monitoring of various retinal diseases. We propose a three-dimensional (3-D) segmentation method with intensity-based Doppler variance (IBDV) based on swept-source optical coherence tomography. The automatic 3-D segmentation method is used to obtain seven surfaces of intraretinal layers. The microvascular network of the retina, which is acquired by the IBDV method, can be divided into six layers. The microvascular network of the six individual layers is visualized, and the morphology and contrast images can be improved by using the segmentation method. This method has potential for earlier diagnosis and ...

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    7. Lens-free endoscopy probe for optical coherence tomography

      Lens-free endoscopy probe for optical coherence tomography

      We present an ultrathin fiber-optic endoscopy probe for optical coherence tomography (OCT), which is made of a series of fused optical fibers instead of the conventional scheme based on an objective lens. The large-core fiber with a core diameter of 20 μm was utilized for the probe, while a single-mode fiber of core diameter 8.2 μm mainly delivered the OCT light. Those fibers were spliced with a bridge fiber of an intermediate core size. The guided light was stepwise converted to a beam of a large mode-field diameter to be radiated with a larger depth of focus. We obtained ...

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    1-8 of 8
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    1. (4 articles) UC Irvine
    2. (4 articles) Zhongping Chen
    3. (3 articles) Harvard University
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    6. (3 articles) Biwei Yin
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    Lens-free endoscopy probe for optical coherence tomography Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo Automatic three-dimensional segmentation combined with in vivo microvascular network imaging of human retina by intensity-based Doppler variance optical coherence tomography In vivo microvascular network imaging of the human retina combined with an automatic three-dimensional segmentation method Absence of adventitial vasa vasorum formation at the coronary segment with myocardial bridge - An optical coherence tomography study Cellular-resolution, extended depth of focus optical coherence tomography catheter toward in vivo cardiovascular imaging Micro-Optical Coherence Tomography for Endothelial Cell Visualization in the Coronary Arteries 3D cellular-resolution imaging in arteries using few-mode interferometry Evaluating Retinal and Choroidal Perfusion Changes After Ocular Massage of Healthy Eyes Using Optical Coherence Tomography Angiography Dermal Epidermal Junction Detection for Full-Field Optical Coherence Tomography Data of Human Skin by Deep Learning OctNET: A Lightweight CNN for Retinal Disease Classification from Optical Coherence Tomography Images The Association between Tear Film Thickness as Measured with OCT and Symptoms and Signs of Dry Eye Disease: A Pooled Analysis of 6 Clinical Trials