1. Articles from Jun Chen

    1-4 of 4
    1. Balanced detection spectral-domain optical coherence tomography with a single line-scan camera

      Balanced detection spectral-domain optical coherence tomography with a single line-scan camera

      This paper describes a balanced detection spectral-domain optical coherence tomography (BD-SD-OCT) system for suppressing autocorrelation (AC) artifacts and increasing the signal-to-noise ratio (SNR). The system employed three optical fiber couplers to generate two phase-opposed interference spectra that were acquired by a single line-scan camera simultaneously. When compared with conventional unbalanced detection SD-OCT systems, the developed BD-SD-OCT system improved the SNR by 5.4-6 dB and suppressed the AC term by 5-10 dB. The imaging quality of the BD-SD-OCT system was evaluated by in vivo imaging of human nail folds and retinas.

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    2. Non-invasive optical methods for melanoma diagnosis

      Non-invasive optical methods for melanoma diagnosis

      Cutaneous melanoma is one of the most common malignancies with increased incidence in the past few decades, making it a significant public health problem. The early diagnosis of melanoma is a major factor in improving patient’s survival. The traditional pathway to melanoma diagnosis starts with a visual diagnosis, followed by subsequent biopsy and histopathologic evaluation. Recently, multiple innovative optical technology-based methods, including dermoscopy, reflectance confocal microscopy, optical coherence tomography, multiphoton excited fluorescence imaging and stepwise two-photon excited fluorescence (dermatofluoroscopy), have been developed to increase the diagnostic accuracy for the non-invasive melanoma diagnosis. Some of them have already been applied ...

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    3. Plaque characteristics in patients with ST-segment elevation myocardial infarction and early spontaneous reperfusion

      Plaque characteristics in patients with ST-segment elevation myocardial infarction and early spontaneous reperfusion

      Background: Early spontaneous reperfusion (ESR) is not an uncommon phenomenon in clinical settings. Aims: To detect potential mechanisms of early spontaneous reperfusion in patients with STEMI. Methods: This prospective study enrolled a total of 241 consecutive patients with STEMI undergoing optical coherence tomography (OCT) from July 2016 to August 2019. Forty-five (18.7%) met angiographic ESR criteria (TIMI-3 flow on the initial angiogram). Among those without ESR (TIMI-0 flow on initial angiogram), 45 patients were assigned into the control group according to propensity score matching with the ESR group. Results: Although the group’s baseline characteristics were comparable, non-ruptured plaque ...

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    4. Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis

      Experimental autoimmune uveoretinitis (EAU) in mice is a model for human autoimmune uveitis. Longitudinal follow-up is only possible by non-invasive techniques, but the information obtained by visual fundus examination can be limited. We therefore evaluated the efficacy of optical coherence tomography (OCT) and electroretinography (ERG) to monitor pathological and functional changes of the retina in vivo. OCT imaging and ERG recording as a measure of visual function were compared with visual fundoscopic imaging and histology findings in the same mouse. Our results showed that OCT imaging of the retina was well correlated with clinical and histological observations in mice during ...

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    1-4 of 4
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  2. Topics in the News

    1. (2 articles) Sun Yat-Sen University
    2. (1 articles) National Institutes of Health
    3. (1 articles) Capital Medical University
    4. (1 articles) National Eye Institute
    5. (1 articles) Shanghai Jiao Tong University
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    Use of Optical Coherence Tomography and Electroretinography to Evaluate Retinal Pathology in a Mouse Model of Autoimmune Uveitis Plaque characteristics in patients with ST-segment elevation myocardial infarction and early spontaneous reperfusion Non-invasive optical methods for melanoma diagnosis Balanced detection spectral-domain optical coherence tomography with a single line-scan camera New insights from non-invasive imaging: from prospection of skin photodamages to training with mobile application Short-sighted woman assumes debilitating headaches mean she needs new glasses but discovers she has multiple sclerosis Shedding light on the impact of microplastics on lentil seedling growth Comparison of radial peripapillary capillary density results of individuals with and without Helicobacter pylori infection Ai, Oct Operate in Tandem to Detect Plaque Erosion in the Heart Noninvasive, in vivo, characterization of cutaneous metastases using a novel multimodal RCM-OCT imaging device: A case-series Mimickers of punctate inner retinal toxoplasmosis on optical coherence tomography Measuring collagen injury depth for burn severity determination using polarization sensitive optical coherence tomography