1. Articles from Chih-Wei Lu

    1-10 of 10
    1. Computer-Aided Detection (CADe) System with Optical Coherent Tomography for Melanin Morphology Quantification in Melasma Patients

      Computer-Aided Detection (CADe) System with Optical Coherent Tomography for Melanin Morphology Quantification in Melasma Patients

      Dark skin-type individuals have a greater tendency to have pigmentary disorders, among which melasma is especially refractory to treat and often recurs. Objective measurement of melanin amount helps evaluate the treatment response of pigmentary disorders. However, naked-eye evaluation is subjective to weariness and bias. We used a cellular resolution full-field optical coherence tomography (FF-OCT) to assess melanin features of melasma lesions and perilesional skin on the cheeks of eight Asian patients. A computer-aided detection (CADe) system is proposed to mark and quantify melanin. This system combines spatial compounding-based denoising convolutional neural networks (SC-DnCNN), and through image processing techniques, various types ...

      Read Full Article
    2. Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes

      Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes

      A crystalline-fiber-based Mirau-type full-field optical coherence tomography (FF-OCT) system utilizing two partially coherent illumination modes is presented. Using a diode-pumped Ti:sapphire crystalline fiber with a high numerical aperture, spatially-incoherent broadband emission can be generated with high radiance. With two modes of different spatial coherence settings, either deeper penetration depth or higher B-scan rate can be achieved. In a wide-field illumination mode, the system functions like FF-OCT with partially coherent illumination to improve the penetration depth. In a strip-field illumination mode, a compressed field is generated on the sample, and a low-speckle B-scan can be acquired by compounding pixel lines ...

      Read Full Article
    3. In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi

      Significance: Melanocytic nevi represent the most common dermal melanocytic lesions in humans. Nevus is typically diagnosed clinically with the naked eye or with dermoscopy. However, it is essential to identify the type of nevus by invasive biopsy for histopathological examination. The use of noninvasive imaging tools can be used to evaluate the types of nevi to reduce unnecessary excisions of benign entities. Aim: To evaluate the feasibility of using en face and cross-sectional full-field optical coherence tomography (FF-OCT) in differentiation of melanocytic nevi that can facilitate the reduction of unnecessary excisions of benign entities. Approach: Dual-mode Mirau-type FF-OCT for cross-sectional ...

      Read Full Article
    4. Optical tomography digital impression imaging system and method for use thereof

      Optical tomography digital impression imaging system and method for use thereof

      Provided are an optical tomography digital-impression imaging system and a method for use thereof, said system including: an optical coherence tomography scanner, used for obtaining tomographic slice thicknesses of a plurality of tissue areas of each optical tomography digital image; an information analysis and processing component electrically connected to the optical coherence tomography scanner. The information analysis and processing component has a refractive index compensation and optical path correction functions; by way of analysis and processing, tomographic slice thickness correction values corresponding to the tissue areas are obtained, thus establishing a digital model of the tissue areas

      Read Full Article
    5. Subgingival calculus imaging based on swept-source optical coherence tomography

      Subgingival calculus imaging based on swept-source optical coherence tomography
      We characterized and imaged dental calculus using swept-source optical coherence tomography (SS-OCT). The refractive indices of enamel, dentin, cementum, and calculus were measured as 1.625 ± 0.024, 1.534 ± 0.029, 1.570 ± 0.021, and 2.097 ± 0.094, respectively. Dental calculus leads strong scattering properties, and thus, the region can be identified from enamel with SS-OCT imaging. An extracted human tooth with calculus is covered with gingiva tissue as an in vitro sample for tomographic imaging.
      Read Full Article
    6. Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography

      Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography
      Most of the colorectal cancer has grown from the adenomatous polyp. Adenomatous lesions have a well-documented relationship to colorectal cancer in previous studies. Thus, to detect the morphological changes between polyp and tumor can allow early diagnosis of colorectal cancer and simultaneous removal of lesions. OCT (Optical coherence tomography) has been several advantages including high resolution and non-invasive cross-sectional image in vivo. In this study, we investigated the relationship between the B-scan OCT image features and histology of malignant human colorectal tissues, also en-face OCT image and the endoscopic image pattern. The in-vitro experiments were performed by a swept-source optical ...
      Read Full Article
    7. Optical scanning probe

      Optical scanning probe
      An optical scanning probe is provided and includes a housing, a diaphragm disposed in the housing, a rotor, a conduit, an optical fiber module, and a reflector disposed on the rotor, wherein the diaphragm and the housing forms a chamber. The rotor is movably disposed in the chamber and has several fans. The conduit is disposed in the housing to conduct fluid into the chamber, thus impelling the fans and the rotor. The optical fiber module is disposed in the housing and through the diaphragm to transmit a light beam. The reflector rotates with the rotor and reflects the light ...
      Read Full Article
    8. Delineation of an oral cancer lesion with swept-source optical coherence tomography

      We demonstrate the ex vivo imaging of an oral cancerous sample with a swept-source optical coherence tomography (SS-OCT) system. With the axial resolution of 8μm in free space and system sensitivity of 108dB, we can well distinguish the normal and abnormal tissue portions in a sample. In particular, we analyze the lateral variation of A-scan profiles to show two parameters of SS-OCT signal for delineating an oral cancer lesion. One of the parameters is the decay constant in the exponential fitting of the SS-OCT signal intensity along depth. This decay constant decreases as the A-scan point moves laterally ...

      Read Full Article
    9. Measurement of the hemoglobin oxygen saturation level with spectroscopic spectral-domain optical coherence tomography

      We report the measurement of the hemoglobin (Hb) oxygen saturation level in human blood with a spectroscopic spectral-domain optical coherence tomography (SSD-OCT) system based on the crossover behavior of Hb and oxyhemoglobin (HbO_2) absorption coefficients around 800 nm. By calculating the ratio ... [Opt. Lett. 33, 416-418 (2008)]
      Read Full Article
    10. Tissue birefringence of hypercholesterolemic rat liver measured with polarization-sensitive optical coherence tomography

      We measure in vitro tissue birefringence in the liver of hypercholesterolemic rats with polarization-sensitive optical coherence tomography. Tissue birefringence is determined by measuring the phase retardation as a function of tissue depth. The birefringence of such a sample is usually due to the narrow fibrous structures that cannot be resolved by a standard optical coherence tomography system. Anisotropic structures are formed in the hypercholesterolemic rat liver, which is quite different from the isotropic nature of healthy liver. Birefringence is evaluated to give an order of magnitude of 4.48×104 at 790nmin hypercholesterolemic rat liver. The infiltration ...

      Read Full Article
    1-10 of 10
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (6 articles) National Taiwan University
    2. (3 articles) Chang Gung University
    3. (2 articles) National Yang-Ming University
    4. (1 articles) Apollo Medical Optics
    5. (1 articles) University of Houston
    6. (1 articles) Cardiovascular Research Foundation
    7. (1 articles) Vanderbilt University
    8. (1 articles) University of Pittsburgh
    9. (1 articles) Tokyo Medical & Dental University
    10. (1 articles) Tianjin University
    11. (1 articles) Visionix
    12. (1 articles) Nidek
    13. (1 articles) Forssmann
    14. (1 articles) Abbott
  3. Popular Articles

  4. Picture Gallery

    Optical scanning probe Study on image feature extraction and classification for human colorectal cancer using optical coherence tomography Subgingival calculus imaging based on swept-source optical coherence tomography Optical tomography digital impression imaging system and method for use thereof In vivo dual-mode full-field optical coherence tomography for differentiation of types of melanocytic nevi Mirau-type full-field optical coherence tomography with switchable partially spatially coherent illumination modes Computer-Aided Detection (CADe) System with Optical Coherent Tomography for Melanin Morphology Quantification in Melasma Patients Macular and choroidal perfusion using optical coherence tomography angiography in type-2 diabetic patients without diabetic retinopathy Short-term evaluation of clear corneal incision after phacoemulsification using anterior segment optical coherence tomography Evaluation of the central vault following implantable phakic contact lens and its correlation to horizontal white to white corneal diameter by anterior segment optical coherence tomography Automatic bifurcation detection utilizing pullback characteristics of bifurcation in intravascular optical coherence tomography An IoT based predictive modeling for Glaucoma detection in optical coherence tomography images using hybrid genetic algorithm